Occupational Cancer Research of the Columbia 201220Band.pdf · • POSTCARD REMINDER 2nd week •...
Transcript of Occupational Cancer Research of the Columbia 201220Band.pdf · • POSTCARD REMINDER 2nd week •...
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The Occupational Cancer Research Program of the British Columbia
Cancer Agency: 1982‐2012
UNIVERSITY OF ALBERTA, EDMONTONCLINICAL SCIENCES BUILDING
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CARCINOEMBRYONIC ANTIGEN(CEA)
Correlation suggested between CEAblood titers and degrees of sputumcytology abnormalities.
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Occupational CancerResearch Program
1. Identify occupational cancer risk
2. Identify carcinogens in the workplace
Occupational CancerResearch Program
1. Identify occupational cancer risk
2. Identify carcinogens in the workplace
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DEATH CERTIFICATE
• CAUSE OF DEATH
• USUAL OCCUPATION
• ADDRESS AT DEATH
DEATH CERTIFICATE
• CAUSE OF DEATH
• USUAL OCCUPATION
• ADDRESS AT DEATH
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DEATH CERTIFICATE
• CAUSE OF DEATH
• USUAL OCCUPATION
• ADDRESS AT DEATH
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BC CANCER REGISTRYPATHOLOGY REPORTS
• HOSPITAL
• PATIENT’S NAME, SEX, AGE
• SITE, HISTOLOGY
• PHYSICIAN’S NAME
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FOLLOW‐UP
• POSTCARD REMINDER 2nd week
• PHONE CALLS 4th and 6th week
• INCOMPLETE QUESTIONNAIRE Phone call
QUESTIONNAIRES SENT AND RECEIVEDREASONS FOR NOT RETURNING
Number %
Questionnaires
Sent 25726 100
Received 15463 60.1
Not received 10263 39.9
Patient refusal 5803 56.5
Deceased or too ill 3847 37.5
Lost to follow‐up/Other 613 5.8
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PATIENTS’ CHARACTERISTICS
Mean age SD 64.3 12.9
Caucasian 96%
Married 81%
Education (mean years) 10.1 2.3
Cigarette smoking 81.3%
Alcohol consumption 86.9%
TUMOR SITE DISTRIBUTION
• 1000 + Colon, rectum, lung, non‐melanoma skin, prostate, bladder
• 500‐999 Stomach, melanoma skin, kidney, NHL
• 200‐499 Oral cavity/pharynx, brainlarynx, testis, leukemia
• 100‐199 Esophagus, pancreas, soft tissue sarcoma, Hodgkin’s, multiple myeloma
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JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
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Occupational Cancer Research Program
1. Identify occupational cancer risk factors
2. Identify carcinogens in the workplace
JOB‐EXPOSURE MATRIX(JEM)
Associates chemical and physical exposures to job‐titles in a given industry.
Enables to pool in the analyses, all subjects with the same exposure.
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JOB‐EXPOSURE MATRIX
BC INDUSTRY BASED JEM
HIERARCHICAL CODING SYSTEM
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HIERARCHICAL CODING SYSTEM
• Chemicals coded according to structures and properties
• Substances grouped by chemical class and common constituents
• Allows analysis of individual, classes and broad groups of agents
• Increases statistical power by grouping chemicals with similar structural features
• Differentiates between compounds of similar structure, but different carcinogenic potential
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CASE‐CONTROL STUDY OF PROSTATE CANCER
Identify chemical substances associated with an increased prostate cancer risk.
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CASE (prostate cancer)‐CONTROL (other cancer excluding lung and unknown primary) STUDY
Cases Controls
Total 1516 4994
Studied* 1153 3999
Farmers 113 316
Linked to BC agricultural job‐exposure matrix
* After excluding farmers who worked as farmers outside British Columbia.
AGRICULTURE CHEMICALS SIGNIFICANTLY ASSOCIATED WITH A PROSTATE CANCER RISK
• Organophosphorus
azinphos, diazinon, dimethoate, fenthion, malathion, parathion
• Organochlorine
Aldrin, DDT, dicofol
• Carbamate: carbaryl
• Quinone: dichlone
• Triazine: simazine
AGRICULTURE CHEMICALS SIGNIFICANTLY ASSOCIATED WITH A PROSTATE CANCER RISK
• Inorganic : copper sulphate, copper oxide
• Thiazole : captan
• Bipyridilium : paraquat
• Other : dichloropropane
chinemethionat
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The Occupational Cancer ResearchProgram of the British Columbia
Cancer Agency: 1982‐2012
PUBLICATIONS
Book chapters 7
Peer‐reviewed publications 52
SUPPORT 3 460 000$
BC Worker’s Compensation Board
BC Health Research Foundation
Health Canada (NHRDP)
Director Band PRStatisticians Spinelli J, Coldman A, Le NEpidemiologists Gallagher R, Ward H, Deschamps, MProgrammers Threlfall W, Ng V, Fang RChemical engineers Grace J, Bert J, Anderson, J, Astrakianakis G,
Keefe AIndustrial hygienist Svirchev, LResearch coordinators Moody J, Raynor D, Wong M, Kan D
The Occupational Cancer Research Program of the British Columbia Cancer Agency: 1982‐2012