Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list...

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Objectives • Discuss the history of breast cancer. • Describe the pathology of breast cancer and list significant tumor markers. • Differentiate IHC testing from FISH testing for HER2 markers. • List the treatment options for metastatic breast cancer. • Explain how monoclonal antibodies function. • Learn how to administer Herceptin ® (trastuzumab) to patients. • Understand the nurse’s role in HER2 testing and follow-up treatment of metastatic breast cancer.

Transcript of Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list...

Page 1: Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing.

ObjectivesObjectives

• Discuss the history of breast cancer.

• Describe the pathology of breast cancer and list significant tumor markers.

• Differentiate IHC testing from FISH testing for HER2 markers.

• List the treatment options for metastatic breast cancer.

• Explain how monoclonal antibodies function.

• Learn how to administer Herceptin® (trastuzumab) to patients.

• Understand the nurse’s role in HER2 testing and follow-up treatment of metastatic breast cancer.

• Discuss the history of breast cancer.

• Describe the pathology of breast cancer and list significant tumor markers.

• Differentiate IHC testing from FISH testing for HER2 markers.

• List the treatment options for metastatic breast cancer.

• Explain how monoclonal antibodies function.

• Learn how to administer Herceptin® (trastuzumab) to patients.

• Understand the nurse’s role in HER2 testing and follow-up treatment of metastatic breast cancer.

Page 2: Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing.

Breast Cancer OriginsBreast Cancer Origins

Breast profile:A. DuctsB. LobulesC. Dilated section of duct

to hold milkD. NippleE. FatF. Pectoralis major muscleG. Chest wall/rib cage

Enlargement:A. Normal duct cellsB. Basement membraneC. Lumen (center of duct)

Breast profile:A. DuctsB. LobulesC. Dilated section of duct

to hold milkD. NippleE. FatF. Pectoralis major muscleG. Chest wall/rib cage

Enlargement:A. Normal duct cellsB. Basement membraneC. Lumen (center of duct)

Page 3: Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing.

Non-Invasive versus Invasive CancerNon-Invasive versus Invasive Cancer

Normal Cells

Non-Invasive Cells

Invasive Cells

Normal Cells

Non-Invasive Cells

Invasive Cells

Page 4: Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing.

Types of Breast CancerTypes of Breast Cancer

Ductal Carcinoma

in situ (DCIS)

Ductal Carcinoma

in situ (DCIS)

Lobular Carcinoma

in situ (LCIS)

Lobular Carcinoma

in situ (LCIS)

Invasive Ductal

Carcinoma (IDC)

Invasive Ductal

Carcinoma (IDC)

Invasive Lobular

Carcinoma (ILC)

Invasive Lobular

Carcinoma (ILC)


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