Nutrition & Immunity › global › assets › human-nutrition › ... · 2020-06-26 · 9...

APAC Webinar, June 23rd, 2020

Nutrition & Immunity In the ‘New Normal’

What we will speak to you about today

What is the state of

consumer behavior?

Insights into consumer

needs, priorities,

purchasing behavior

How is the market

developing?

What trends are going

to pave the way for

new opportunities,

to differentiate in an

already crowded space

How can we approach

the immune health space

in the ‘new normal’ ?

Formulating with ingredients

founded in science to meet

consumer needs

Trusted micronutrients and

emerging ingredients

What product solutions

to meet the specific needs

of target consumers?

Some concepts to help inspire

product innovation with the

consumer in mind

2 24.06.2020 | BASF Nutrition & Immunity Webinar APAC

3

Allergens are a major

seasonal challenge for our

immune system with an

impact on the quality of life

24.06.2020 | BASF Nutrition & Immunity Webinar APAC

4

Living in dense

populations exposes

us to pathogens &

makes it difficult

to stay healthy


5

Building a strong

immune system should

start early in life


6

Elderly people have a

natural decline in immune

defense & requires

additional support


7

2020 has been an

extraordinary year

Bringing lastingchanges to our lives


8

Eating healthy, doing exercise & the environment are of higher

priority for consumers, in APAC especially1

Consumers in most countries expect to spend more on

healthcare products & in-home food items2

Consumer behavior changes drastically with the pandemic…

3 Immunity is a key health concern & sales of dietary supplements surges

as consumers seek to proactively care for their immune health



▪ Micronutrients form base of science-backed immune health solutions

▪ Beyond Vitamin C, consider other ingredients which have authorized immunity claims

globally, for example: Vitamins A, B12, B6, C, D, Zinc, Folate, Copper, Iron, Carotenoids

▪ Quality ingredients, clear consumer communications, align with reputable health bodies

Opportunity 1:Science-backed immunity solutions to meet specific consumer needs


▪ Dramatic increase in global searches for the word ‘food’ and ‘immune system’

in between Feb & March 2020

▪ Consumers are looking more to ‘real food’ to get their nutrients daily

▪ An opportunity pocket exists for immune health in functional nutrition

Opportunity 2:Functional foods & beverages plays a key role, on top of dietary supplements

11

New ways of staying fit

Even as gyms and fitness centres re-open, the need

for safe-distancing and new virtual fitness & exercise

solutions could change how we exercise

1

Increased screen time

This will be hard to avoid with more virtual meetings,

home-based learning & more streaming & web-based

entertainment consumption (movies & TV series)

2

Increased instances of working and

studying from home arrangements

Even as some countries start opening up, we move not

‘back-to-normal’ but into a ‘New Normal’

3 Healthier snacking for the family

The importance of choosing healthier snacks takes on

more importance for consumers, especially gate-keepers

who opt for snacks with added benefits for their families


12

The immune system:

What is immunocompetence

The role of nutrition


13

The immune system functions along three main lines of defense

Source: Muller L et al, The Immune System and Its

Dysregulation with Aging, Sprinter Link, 2019

3

1

2

Innate immunity:

▪ Available at birth

▪ Reacts quickly in an

unspecific manner

▪ Key defense during

first-time exposure to

pathogens

▪ Often not fast enough

to prevent symptoms

of disease

2 Adaptive immunity:

▪ Builds up during lifetime

▪ Reacts quickly with

pathogen-specific antibodies

▪ Antibodies produced after

vaccination or first exposure

to pathogens; available for

lifetime or certain period

▪ Pathogens are bound by

antibodies and destroyed by

immune cells before

symptoms of disease occur

3


What is immunocompetence?

▪ To be immunocompetent simply means that the immune system is working properly and that the

body is capable of mounting an appropriate immune response, when necessary.

▪ Identification and protection against

pathogenic microorganisms and toxins

NORMAL RESPONSE

▪ Identifying and removing the damaged,

old or otherwise changed cells

▪ Recognition of own tissues and

maintaining tolerance

ABNORMAL RESPONSE

Overactive e.g. allergy, asthma, eczema etc.

Deficient: immuno-deficiency

▪ Autoimmune diseases: a case of mistaken

identity in which the body's immune

system, which ordinarily attacks intruders

like viruses and bacteria, attacks itself.

▪ Tumor generation or frequent infection etc

Role

Defense

Auto-

tolerance

Immune

Surveillance


Lifestyle factors leading to immuno-compromise during adulthood

▪ The risk of infection is also influenced by gender, early programming, vaccination history,

pathogen exposure, specific health conditions, and diseases.

Source: Maggini et al., 201815 24.06.2020 | BASF Nutrition & Immunity Webinar APAC

Health ingredients have specific functions & strengthen the

immune system

Lower risk of allergies,

respiratory infections,

autoimmune diseases,

chronic inflammation

and an overall

strengthened

immune system

▪ Specific micronutrients work together to reduce the risk, duration and severity of infections. These include

vitamin A, B6, folate, B12, C, D, E, as well as minerals like zinc, copper, iron, magnesium and selenium.


Vitamin D 2‘-Fucosyllactose

• Modulation of immune cells

• Steering lymphocytes to

infected tissues

• Skin, eye, lung, and gut barriers

inhibiting pathogen intrusion

• Promotes growth of healthy

bacteria in the gut

• Inhibits pathogens in the gut

• Modulates immune system in

the gut & systemically



• Anti-inflammatory function

• Stimulation of immune cells,

particularly in elderly people

• Anti-inflammatory function

• Stimulation of immune cells

Vitamin B12Vitamin E DHA/EPA

Vitamin A



• Effectiveness of vaccinations

• Precursor of retinoic acid, key

regulator in the immune system;



• Regulation of anti-microbial

defense proteins

Carotenoids

• Beta-carotene: same effects as

vitamin A

• All carotenoids: antioxidant

function, tissue protection

Summary of selected systematic review and meta-analysis

reporting on Vitamin D and respiratory infections

17 Calder et al 202024.06.2020 | BASF Nutrition & Immunity Webinar APAC

24.06.202018

Vitamin D intake recommendations by scientists

◼ For preventing VD deficiency during lockdown:

“400 – 2000 IU of vitamin D3 supplementation could assist in

preventing vitamin D deficiency during lockdown, without significant

risk for harms” (Alpalhao M et al, 2020)

„Vitamin D3 supplementation, daily or weekly, at daily equivalent doses

of 1000–4000 IU, is advisable. (…) Both accommodate the anticipated

higher needs across the lifespan incurred by lockdown measures,

immobilization, and hospitalization.“ (Chakhtoura M et al, 2020)

◼ For increasing VD levels to recommended optimum:

“To reduce the risk of infection, it is recommended that people at risk of

influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3

for a few weeks to rapidly raise 25(OH)D concentrations, followed

by 5000 IU/d. The goal should be to raise 25(OH)D concentrations

above 40–60 ng/mL (100–150* nmol/L).“(Grant WB et al, 2020; Grant

WB et al, 2020).

For comparison: 75 nmol/L are considered optimum for bone health (Int. Osteoporosis Foundation)| BASF Nutrition & Immunity Webinar APAC

19

HMO: Prebiotic 2’-FL benefits immune system in the gut & beyond

Source: Orczyk-Pawilowicz M & Lis-Kuberka J, 202024.06.2020 | BASF Nutrition & Immunity Webinar APAC

20

The ‘New Normal’

Ideas for addressing

other consumer

health needs


21

The ‘New Normal’ for working adults:

Work-from-home, less time exercising outdoors

What is the market need for this meal

replacement beverage?

▪ More than being just a meal replacement, this beverage provides the proven

benefits of vitamins A, B, D for immunity as well as an energy boost!

▪ Fortified with Tonalin® CLA and protein to help consumers reduce body fat &

achieve fitness goals

▪ This meal replacement beverage with Tonalin® CLA and caffeine is perfectly

suited to start the day or for pre or post-workout consumption, all under

180 calories.

Why Tonalin® & what are the unique benefits?

▪ Each serving contains 1.5g of Tonalin® CLA, half the daily efficacious dose

▪ Sourced from natural safflower oil, Tonalin® CLA is the most clinically

researched CLA ingredient in the market

▪ Tonalin® CLA: helps to reduce body fat, and helps to build and maintain

lean muscle mass

(ADULTS) Booster Cold Brew with Tonalin® CLAThe perfect boost to kickstart your day with the benefits of Tonalin® CLA, Vitamins A, B & D

INGREDIENTS: LOWFAT MILK, WATER, WHEY PROTEIN, CONTAINS 2% OR

LESS OF THE FOLLOWING: COFFEE EXTRACT, SUGAR, CLA (TONALIN® TG

80), CANOLA OIL, PECTIN, NATURAL FLAVOR, POTASSIUM PHOSPHATE,

SUCRALOSE, ACE K, BETA CAROTENE, SODIUM ASCORBATE.

BASF INGREDIENTS IN BOLD

A market launch is subject to local regulatory requirements. ® Registered trademark of BASF in several countries.

Published by BASF Human Nutrition22 24.06.2020 | BASF Nutrition & Immunity Webinar APAC

Concept

*Please contact us

for details on this

concept formulation

What is CLA and where can it be found?

▪ Conjugated Linoleic Acid (CLA) is blend of Omega-6 and Omega-7 polyunsaturated fatty acid isomers.

▪ CLA was discovered in 1979 and identified in 1987.

Where is it found?

▪ CLA naturally exists in ruminant

meat products (beef) and dairy

(especially grass-fed)

▪ CLA consumption has declined

with societal shifts away from beef

and high-fat dairy consumption

▪ Industrially produced CLA is

naturally-sourced from

safflower oil

What are the key isomers?

c9c12 linoleic acid

(non-conjugated)

Eg. corn oil, soybean oil

Product of plants and animals

c9t11 CLA

Product of animals

Anti-inflammatory effect

t10c12 CLA

Product of animals

Body composition effectTonalin®

key

isomers


Tonalin® CLA provides sustainable benefits

Phase I: < 12 weeks

▪ Quick measurable weight loss,

not always fat loss

▪ May be only water loss

Phase II: Long-term

▪ Keeps body fat & weight constant by

managing body fat vs. lean body mass

▪ Prevents yo-yo effect

Long-term

fat loss

Quick weight loss

ingredientsYo-Yo Effect


Meta-analysis demonstrates fat loss benefits of Tonalin®

Whigham, et al. Am J Clin Nutr 2007; 85:1203

A meta-analysis compiled all double-blind, randomized,

placebo controlled clinical trials on CLA featuring a validated

body-composition method (eg. DEXA scan)

▪ Of 20 trials selected, 15 featured Tonalin® CLA

▪ Trials on normal, overweight, and obese populations

▪ n=1191 total clinical trial subjects

▪ Duration 3 – 24 weeks

Overall conclusion: supplementation with CLA is effective

in reducing body fat and maintaining reductions long-term

▪ CLA causes a modest reduction in fat (~90g lost per week or

~1kg lost in 3 months) relative to placebo at a dose of 3.0g CLA/d

▪ Fat loss is linear for 6 months then losses are maintained up to

2 years. This is especially remarkable given the average person

gains about a pound of fat per year.

What was done?

What was found?


Range from 1.0-6.8g/d active CLA isomers

▪ Suggested effective dose 3.0g/d

▪ Minimum effective dose 1.7g/d

Doses tested:

Meta-analysis of RCT‘s: Fat loss vs. time

-3.0

-2.5

-2.0

-1.5

-1.0

-0.5

0.0

0.5

1.0

0 20 40 60 80 100 120

Ch

an

ge

in

fa

t m

as

s

rela

tive

to

pla

ce

bo

(k

g)

Length of treatment (weeks)

Each dot is a treatment group from a

randomized, controlled clinical trial

26

The ‘New Normal’ for kids:

Home-based learning & more screen time

(KIDS & YOUTH) Eye-Shield Chewable Tabs

An appealing format for children & youths increasingly exposed to the harmful effects of blue light

Supplement Facts

Lutein (Xangold®

10% CWD)

(= as free lutein)

Vitamin E

Vitamin B1

Vitamin B2

Vitamin B6

Pantothenic acid

Vitamin B12

Dosage 4

chewables per day

A market launch is subject to local regulatory requirements. ® Registered trademark of BASF in several countries.

Published by BASF Human Nutrition

Blue Light protection formula

What is the market need for this supplement?

▪ More than 1/3 of consumers in APAC are concerned about eye health.

▪ Affinity of electronic devices are very high amongst Asian populations, and

young children are being exposed to electronic earlier, with longer

exposure time per day.

▪ Gate-keepers (mothers) want to protect their children’s eyes but needs an

appealing format to ensure compliance.

Why Xangold® & what are the unique benefits?

▪ Each serving of 4 tabs provides 2.5mg of Xangold® Lutein per day.

▪ Sourced from natural marigold flowers from South America, Xangold®

Lutein esters reduces the damaging effects of blue light to the retina and

improve visual performance

▪ Vitamin E helps to reduce oxidative damage in the eye

▪ B Vitamins may help maintain normal optic nerve function and may support

the treatment of eyestrain


Concept

*Please contact us

for details on this

concept formulation

What is lutein and where can it be found?

▪ It is a plant pigment that plays an important role in photosynthesis

and in the plant’s protection against UV light damage

Where is it found?

▪ Lutein is mainly found in kale, spinach and other green leafy vegetables,

as well as in some yellow / orange fruits. For dietary supplements, lutein

is sourced from the yellow petals of Marigold flowers.

▪ Lutein occurs naturally in 2 different chemical forms:

In the ESTERIFIED form in

yellow / orange fruits as

Lutein Esters

In the non-esterified or FREE

form in dark leafy vegetables as

“Free” Lutein


Close up on lutein and blue light

Blue Light

UV

▪ The macula is responsible for central vision.

▪ Dietary Lutein and Zeaxanthin are

deposited in the macula. Blue light reaches human macula and

causes oxidative stress and inflammation.

▪ Lutein is highly concentrated in the back of the eye (macula) where it is highly vulnerable to damaging light

▪ Lutein filters blue light and has antioxidative effects protecting the sensitive cells required for vision


30

Providing the right nutrients

to the right people

at the right time


We are among the largest players in the health field,

offering a wide portfolio

Vitamin A, Bs,

D, E, K

CLA Natural Vitamin E

& Antioxidants

HMOs

Omega-3 Plant Sterols Carotenoids Bioactive Peptides


We are close to our customers & close to their markets

▪ Combining expert know-how of

health and performance ingredients

with state of the art equipment

▪ Deep understanding of local needs,

preferences and habits

▪ Access to local ingredients from

diverse cultures and tastes

Tarrytown

Jacarei

Shanghai

Ballerup

LudwigshafenIllertissen

Singapore

Istanbul


FoodSolid applications Liquid applications

Seniors: Immunity Booster Effervescent Tablets

“I want to be as healthy as I was when I was younger.

My immune system needs an extra boost.”

Health ingredients

What is the market need?

▪ Easy to consume supplements for elderly people, no big capsules

▪ Support of immune system as it naturally declines during aging

What is the consumer benefit?

▪ Provides high-dose beta-carotene, vitamin E and vitamin D3

▪ Beta-carotene is a precursor of retinoic acid, a key regulator in the

immune system; important for barrier functions as first line of

defense against pathogens, and for effectiveness of vaccinations

▪ Vitamin E and vitamin D3 have anti-inflammatory properties and

stimulate immune cells.

… Better immune function while aging

33 24.06.2020 | BASF Nutrition & Immunity Webinar APACA market launch is subject to local regulatory requirements.

® Registered trademark of BASF in several countries.


Concept

*Please contact us for details

on this concept formulation

Orange & Carrot

Curcuma

Red berries

Cinnamon

Kiwi & Spinach

Ginger

Adults: Immunity Power Juice

“I life in a big city and my life is rather stressful.

I want to have a strong immune system”


▪ Beverages for immune support

▪ Good taste, with herbals, fruits & vegetables (“superfoods”)


▪ Provides (pro)vitamin A, E & C in a modern type of “ACE” beverage

▪ Beta-carotene is a precursor of retinoic acid, a key regulator in the

immune system. Vitamin E and Vitamin C have antioxidant, tissue

protective function and stimulate immune cells

▪ Fruits & vegetables are popular “superfoods”

▪ Herbals are traditionally used for immune support

… Better immune function when life is busy




Health ingredients

Concept



Adults: Daily Defense Antioxidant Capsules

Health ingredients


▪ Easy to swallow capsules for daily immune support


▪ Provides 24 mg of antioxidants per capsule including

beta-carotene, lutein, lycopene and vitamin E

▪ Helps to evenly distribute fat-soluble antioxidants in body tissues

▪ Antioxidant combination helps replenish the body’s antioxidant

defence network and supports barrier immune function

▪ In addition, beta-carotene is a precursor of retinoids, which are

key regulators in the immune system.

… Better protection against environmental stressors

“I live in a crowded, polluted city and wonder

how I can protect myself better.”




Concept




▪ Supplements that can be mixed easily into beverages & foods

▪ Neutral taste or, alternatively, fruity taste (lemon, orange)


▪ 2’-FL fosters a healthy gut by facilitating the growth of

beneficial bacteria and supporting intestinal immune functions

▪ Vitamin D3 and vitamin B12 contribute to the normal function

of the immune system

▪ Vitamin B2 contributes to the protection of cells from oxidative

stress

… Better immune function in the gut

Health ingredients

Adults: Prebilac® plus Vitamin Immune Sachet

“I want to take a supplement that helps

boost my gut immune system.”




Lab-tested Concept



This document, or any answers or information provided herein by BASF, does not constitute a legally binding

obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good

faith and believed to be accurate, they are provided for your guidance only. Because many factors may affect

processing or application/use, we recommend that you make tests to determine the suitability of a product for your

particular purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the

products upon delivery or any other obligation. The claims and supporting data provided in this publication have not

been evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be

generally true under other conditions or in other matrices. Users must evaluate what claims and information are

appropriate and comply with a jurisdiction’s regulatory requirements.

NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF

MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS

DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS,

DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS

OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA, OR DESIGNS PROVIDED BE

CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE.

Nutrition & Immunity › global › assets › human-nutrition › ... · 2020-06-26 · 9...

Documents

Transcript of Nutrition & Immunity › global › assets › human-nutrition › ... · 2020-06-26 · 9...