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4/13/19 © 2019 Carrie Denne1, MPH, RDN 1 The Mediterranean Diet for Nutrition and Health In This Section • What is the Mediterranean diet? • Nutritional components of the Mediterranean diet • Mediterranean diet research • Putting the Mediterranean diet into practice Carrie Dennett, MPH, RDN, CD | Nutrition By Carrie What is the Mediterranean Diet? Carrie Dennett, MPH, RDN, CD | Nutrition By Carrie What is the Mediterranean Diet? “The Mediterranean diet is a plant-based diet that does not say ‘no’ to meat.” ~ AntoniaTrichopoulou, MD, PhD, founder and director of the WHO Collaborating Center for Nutrition at the University of Athens School of Medicine The Traditional Mediterranean Diet High consumption of: • Vegetables + fruits • Pulses (beans and lentils) • Whole grains • Olive oil + nuts Moderate consumption of: • Seafood (mod-high) • Red wine (with meals) Low consumption of: • Red/processed meat • Dairy products (low-mod) Med Diet Foods Illustration courtesy of Oldways

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TheMediterraneanDietforNutritionandHealth

InThisSection•  WhatistheMediterraneandiet?•  NutritionalcomponentsoftheMediterraneandiet•  Mediterraneandietresearch•  PuttingtheMediterraneandietintopractice

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Whatisthe

MediterraneanDiet?

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

WhatistheMediterraneanDiet?

“TheMediterraneandietisaplant-baseddietthat

doesnotsay‘no’tomeat.”~AntoniaTrichopoulou,MD,PhD,founder

anddirectoroftheWHOCollaboratingCenterforNutritionattheUniversityofAthens

SchoolofMedicine

TheTraditionalMediterraneanDietHighconsumptionof:•  Vegetables+fruits•  Pulses(beansandlentils)•  Wholegrains•  Oliveoil+nuts

Moderateconsumptionof:•  Seafood(mod-high)•  Redwine(withmeals)

Lowconsumptionof:•  Red/processedmeat•  Dairyproducts(low-mod)

MedDietFoods

IllustrationcourtesyofOldways

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ThePowerofSynergyTheMediterraneanDietisMoreThantheSumofitsParts

•  Protein•  Heart-healthyfats•  Low-glycemiccarbs•  Vitamins&minerals•  Phytonutrients•  Fiber

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

NutritionalComponentsoftheMediterraneanDiet

SomeofthebeneficialeffectsofMediterranean-styledietsmaybeduetothefocuson

plant-basedfoodsthatprovidealotoffiberandlower

glycemicload

CarbQuality/GlycemicIndex

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

CarbQuality/GlycemicIndex

Grainsarewholeorintheformoffermentedsourdoughbreadsorpastacookedaldente,whichlowersboththe

glycemicindexandglycemicload

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

VegetableIntake/EnergyDensity

HigherMUFA/PUFA-to-SFAratio(fromnutsandoliveoil)andhigherconsumptionoffruitsandvegetables

foroverallreducedenergydensity.

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Noobservedassociationbetweenoliveoilconsumptionandincidence

ofoverweightorobesity.

Thismaybeduetothecaloricbalancefrom

highvegetableintake.

VegetableIntake/EnergyDensity

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

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Phytonutrients Anti-inflammatory

Anti-Inflamatory/GutMicrobiota

WholePlantFoods

PrebioticFiber

HealthyGutMicrobiota

13CarrieDennett,MPH,RDN,CD|NutritionByCarrie

MediterraneanDietResearch

ResearchOverview

Researchtodate:•  Morerobustforreducingchronicdiseaserisk•  Long-termhealthbenefitsarewell-established•  Efficacyforweightlossbeyond12monthsless

established

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

WhatElsetheResearchTellsUsFollowingaMediterranean-styledietislinkedtoreducedriskofseveralchronicdiseases,including:•  Cardiovasculardisease•  Type2diabetes•  Cancer•  Alzheimer’sdisease•  Parkinson’sdisease

16CarrieDennett,MPH,RDN,CD|NutritionByCarrie

PREDIMEDStudy(PREventionconDietaMEDiterranea):•  7,447adultsathighriskforcardiovasculardisease

–  Followedfor8years

•  Meddiet+EVOO,Meddiet+nuts,controldiet•  Meddietgroupshadmuchlowerriskof

–  Heartattack,strokeandCVDdeaths–  Type2diabetes–  Peripheralarterydisease(PAD)

17CarrieDennett,MPH,RDN,CD|NutritionByCarrie

CardiodiabesityType2Diabetes,MetabolicSyndrome,Obesity&CardiovascularDisease

2014literaturereview:strongevidenceofassociation

betweenMeddietadherenceandreducedincidenceof

collectivecardiodiabesityrisk.

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

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PuttingtheMediterraneanDietintoPractice

Pleasure,Satisfaction&Longevity

“TheMediterraneandietandotherheritagedietsareplant-baseddiets,richinwholefoodsandverylittlehighlyprocessedfoods.There’sabigvarietyoffoodstochoosefrom,andsomanydeliciouswaystopreparethesefoods.”

~SaraBaer-Sinnott,presidentofOldways

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Pleasure,Satisfaction&Longevity

•  Satisfyingfatcontent•  Lowenergydensity/high

volume•  Fillingfiber•  Well-being(fromfruits/veggies)•  Flavor&variety

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Greens,GreensandMoreGreens

•  Addtofrittatas,scrambledeggs,soups

•  Sautéwithgarlicandfinishwithasqueezeoflemon

•  Enjoyrawsaladswithanoliveoilvinaigrette

Kale,beetgreens,mustardgreens,collardgreens,dandeliongreens

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

PowerfulPulses

•  Soupsandstews•  Spreads(hummus)•  Socca(chickpeaflourpancake

orcrepe)•  Roastedcookedchickpeasas

asnack

AKAbeans(especiallychickpeasandfavabeans)andlentils

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Herbs&Garlic

•  Pesto!•  Addfreshherbstosalads•  Choporcrushgarlic10-15

minutesbeforeuse

Fantasticflavorwithasideofantioxidantsandphytonutrients

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

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Olives&Capers

•  Tapenade!•  Tossingreensaladsoraddto

tuna/chickensalad•  Addlesssalt(youwon’t

needit)

Twoingredientsthatpumpuptheflavor

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

GoNutsforNuts

•  Eatasasnack•  Chopandaddtosaladsand

otherdishes•  Usetoaddcrunchtoyogurt

Especiallyalmonds,walnuts,pistachiosandhazelnuts

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Lemons

•  Importantingredientinhummus

•  Squeezeonsalads,fish,roastedveggies,cookedbeans,soups

•  Addtodrinkingwater

Freshflavorwithbenefitsforbloodsugar?

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Feta&Yogurt

•  UsefetainaclassicGreeksalad

•  Turnyogurtintotzatzikisauce•  Pairyogurtwithfruitfora

classicMedbreakfast

Fermenteddairyoffersprobioticsalongwithprotein

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

Wheat

•  Usefarro(emmer)insalads,soup,pilafs

•  Usebulgur(crackedwheat)inpilafs,tabboulehandkibbe

•  Sourdoughbreadmadefromstone-groundflour

ThefoundationgrainoftheMediterranean

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

OliveOil

•  Useinavinaigrette•  Useforbothcookingand

baking•  QualityEVOOhasahigher

‘smokepoint’thanyouthink!

ThecommondenominatorinallformsoftheMediterraneandiet

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

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SomeClassicMedDishes•  Vegetablesstewedinoliveoilwithgarlic,onionandherbs,like

parsley,oreganoandbasil•  Soupwithchickpeas,favabeans,lentilsandfarro•  Tzatzki(yogurtmixedwithgarlic,cucumbers,oliveoil,redwine

vinegarandsalt)•  Kibbe(mincedmeatwithbulgurandspices)•  Greensaladsprinkledwithoregano,olives,capersandfetacheese•  Savorypies,tortesortortamadewithdarkleafygreens

CarrieDennett,MPH,RDN,CD|NutritionByCarrie

SomeFavoriteMedResources•  Oldwayswebsite:www.oldwayspt.org•  TheNewMediterraneanDietCookbookbyNancy

HarmonJenkins•  MediterraneanHarvestbyMarthaRoseSchulman•  RecipesforHealthbyMarthaRoseSchulman•  AnythingbyPaulaWolfert•  TheCompleteMediterraneanCookbookbyAmerica’s

TestKitchenCarrieDennett,MPH,RDN,CD|NutritionByCarrie

Questions?


Systematic synergy modeling: understanding drug synergy ...€¦ · Systematic synergy modeling: understanding drug synergy from a systems biology perspective Di Chen1, Xi Liu1, Yiping

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Questions for multifunctionality symposium: 1. Where is the space for synergy in integrated multifunctionality? 2. Where are ‘hard tradeoffs’ unavoidable.

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