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Transcript of NURS 1950: Pharmacology I 1. Objective 1: describe the relationship of calcium to electrical...
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CARDIOTONICS AND CORONARY VASODILATORS
NURS 1950: Pharmacology I
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Objective 1: describe the relationship of calcium to electrical activity of the heart
Resting: Preload: Afterload:
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Heart dependent upon influx of calcium Ca+ enters channels in the cardiac cell
membrane and go into the cell along with Na
K+ comes out Cardiac cells contract
repolarization
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Objective 2: describe how the ANS affects the heart rate
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The ANS is the primary controller of heart rate
Cholinergic (parasympathetic) vagal fibers are close to the SA node
Stimulation with acetylcholine slows the heart rate
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Sympathetic (adrenergic) nerves also innervate the heart
Stimulation causes norepinephrine to be released.
Increases heart rate, slows refractory period
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Objective 3: describe how cardiac drugs affect cardiac action
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1. Increase or decrease the force of myocardial action
Positive inotropics Negative inotropics
How cardiac drugs work
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2. Increase or decrease heart rate by altering SA node impulse conduction
Positive chronotropics Negative chronotropics
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3. Increase or decrease conduction of AV impulses
Positive dromotropics Negative dromotropics
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Diuretics to decrease blood volume
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Objective 4: identify the action of cardiac glycosides
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Digoxin & relatives come from Natural sources Helpful in CHF Have a positive inotropic effect
Cardiac glycosides
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Increases mechanical efficiency of heart This pumps more blood With increased blood to kidneys, diuresis
occurs, edema reduced Cardiac glycosides also have negative
chronotropic effect, Negative dromotropic effect
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Action Thought that they cause release of free
calcium within the cardiac muscle cell Also change the electrical activity of
myocardium
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Decrease velocity of electrical conduction, prolong refractory period in AV conduction system
Increase vagal tone
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Objective 5: relate how the effects of digitalis are beneficial to the client with CHF
Recall the signs/symptoms of CHF How do you think cardiac glycosides
improve this condition?
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Objective 6: describe the usefulness of digitalis in the treatment of atrial fibrillation
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What is atrial fibrillation? What activity of the cardiac glycosides
improve this condition?
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Chronotropic/dromotropic effects◦ Suppress impulse conduction through the AV node◦ This prevents excessive atrial activity from
reaching ventricles
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Objective 7: list the generic and brand names of the digitalis preparations
Digitalis preparations similar in pharmacological properties, toxic effects
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Digoxin (Lanoxin, Lanoxicaps): oral or IV Onset 30-120 minutes oral Peaks 2-6 hrs Duration 2-4 days Eliminated by kidney
◦ Used most often as rapid onset, short duration
Prototype
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Must take apical pulse 1 minute before administration
Hold if under 60, contact MD Blood levels needed
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Objective 8: define digitalization
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Digitalization is the administration of digitalis that is more than the maintenance dose
This raises the blood level quickly to therapeutic range◦ May also be called a loading dose
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Example◦ Oral dose of digoxin 0.5-0.75 mg◦ 0.25-0.5 mg then given every 6-8 hours until
desired blood level reached◦ Then maintenance dose: 0.125-0.5 mg daily
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Objective 9: list symptoms of digitalis toxicity
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Digitalis toxicity:◦GI distress: N/V, anorexia, and/or diarrhea (flu like symptoms)
◦May have excessive salivation and abdominal pain
◦Neurological: restless, irritable, lethargy, drowsiness, and/or confusion
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May have vision changes, changes in color◦May have halos, amblyopia and diplopia
◦Cardiac effects: development of arrhythmias (bradycardia, primary AV block)
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Objective 10: identify factors which predispose digitalis toxicity
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Toxicity predisposition: hypokalemia as cardiac muscles more sensitive to the glycosides
Renal impairment as 60-90% excreted by kidney
IV administration: rapid accumulation can occur
Contraindications
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Treatment◦ Hold the drug◦ Use digoxin immune fab (Digibind)
Antigen-binding fragments combine with digoxin to neutralize its action
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Objective 11: describe the nursing responsibilities associated with administering cardiac glycosides preparations
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Take apical pulse 1 full minute Hold if under 60, over 100 in adults Report any evidence of irregular rhythm Observe for toxicity S/S Monitor K+ if on diuretics Encourage K+ rich foods
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Teach client to take pulse Teach S/S of toxicity If hypothyroid, sensitive to digitalis Draw blood levels periodically
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Atherosclerosis narrows heart’s vessels Blood flow impeded Demand exceeds supply = anginal pain
Angina
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Objective 12: describe the actions of the antianginal drugs
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Drugs are used to dilate coronary arteries This brings in oxygen and nutrients Supply = demand so no pain
Goals
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Objective 13: identify the drugs used to treat angina pectoris
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Nitroglycerin Calcium channel blockers Beta blockers ACE inhibitors
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Nitroglycerin drugs Works by relaxing arterial and venous
smooth muscle Dilate coronary arteries
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Liquid nitroglycerin unstable, highly volatile Oral tablets stable, non-explosive Can be given sublingual for rapid,
predictable action Can be transmucosal, aerosol translingual
spray, IV, transdermal
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Transdermal
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Ointment: placed on paper with inches marked off
Amount prescribed placed on the paper, taped into place
4-8 hours of action (Nitro-bid, Nitrol)
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Nitroglycerin patches: worn 12-14 hours “Patch-off” period of 6-12 hours Prevents tolerance (Transderm-Nitro, Nitro-Dur)
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IV nitroglycerin in early treatment, then another form
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Long acting forms for prophylaxis◦ Erythrityl tetranitrate (Cardilate)◦ Pentaerythritol tetranitrate (PETN)
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Objective 14: list the side effects of nitroglycerin
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Tolerance Headache Postural hypotension Dizziness Weakness Syncope
◦ Don’t use alcohol with nitros
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Nitrates can increase intraocular and/or intracranial pressure
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Objective 15: identify the nursing responsibilities associated with administering the nitroglycerin preparations
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Teach: when angina occurs, take 3 tabs in 15 min; if no pain relief, call 911
Keep nitro in original container, cap tightly closed
Store in cool, dry place Rotate sites of topical applications Monitor BP during therapy
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Shelf-life is 6 months. If burning/stinging sensation under tongue, drug still potent
Replace 3 months after opening bottle
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Objective 16: identify the beta-adrenergic blocker used to treat angina
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Examples: propranolol, Atenolol Decrease heart rate, contractility
◦ Results in reduction of myocardial oxygen consumption
◦ Better if used with nitrates Can not use in COPD, CHF, heart block,
bradycardia, DM
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When used with nitrates, hypotensive episodes more likely to occur
Drugs used◦ Atenolol (Tenormin)--prototype◦ Metoprolol (Lopressor)◦ Nadolol (Corgard)◦ Propranolol (Inderal)
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Objective 17: identify the calcium channel blockers used to treat angina
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Nifedipine (Adalat, Procardia) Diltiazem HCl (Cardizem, Dilacor SR)--
prototype Verapamil (Calan, Isoptin) Bepridil (Vascor) Nicardipine HCl (Cardene)
Examples: calcium channel blockers
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These drugs create coronary vasodilation, increased coronary blood flow, lowered blood pressure, increased cardiac output, and relax coronary artery spasms
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Objective 18: identify the ACE inhibitors used to treat angina
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The angiotensin-converting enzyme inhibitors decrease myocardial oxygen demands
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Captopril (Capoten) Lisinopril (Prinivil)--prototype Ramipril (Altace)
Examples: ACE inhibitors
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Objective 19: nursing care
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Frequency, nature, precipitants of angina attack
Lifestyle changes made Effectiveness of coronary vasodilators in
relief of pain Monitor VS, esp. BP
Assessment
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Ineffective tissue perfusion, cardiac function RT angina
Risk for injury RT side effects of coronary vasodilators
Deficient knowledge RT health alteration and medication regimen
Nursing diagnoses
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What teaching is done for clients taking nitroglycerin?
What teaching is done for clients taking calcium channel blockers, ACE inhibitors, beta blockers?
What will the nurse monitor when clients are on these medications?
Implementation