NP- RD30 · The NP-RD30’s integrated Natoli AIM™Plus data acquisition/analysis and operating...
Transcript of NP- RD30 · The NP-RD30’s integrated Natoli AIM™Plus data acquisition/analysis and operating...
n a t o l i . c o m
NP- RD30r o t a r y R & D t a b l e t p r e s s
D E S I G N E D F O R S C A L E — U P
SOLVE TABLET DEFECTS Discover potential tableting issues before production
MINIMAL API Determine formulation characteristics for successful tableting using minimal API
DWELL TIME Easily replicate dwell time of production presses
NATOLI NP-RD30 R&D TABLET PRESS EASILY SOLVES FORMULATION AND SCALE-UP CHALLENGES
DATA ACQUISITION AND ANALYSIS SOFTWARE SIMPLIFIES SCALE-UP
Natoli Engineering is quickly becoming the leader in R&D tablet presses with this next-generation rotary tablet press. Designed to help solve formulation and scale-up challenges, the NP-RD30 rotary R&D tablet press replicates the design and functionality of a production press. The turret velocity of the NP-RD30 can reach that of production presses, meaning dwell time can be more accurately established during research and development. Five rolling casters allow for easy mobility.
3.50
8.25
5.25 11.0 mm 55 15.0
15.0
0.00 3.37 3.37
3.19 3.19
3.21 3.21
3.16 3.16
3.34 3.34
3.21 3.21
3.22 3.22
0.00
0.00
0.00
0.00
0.00
0.00
55
3.20
3.5
2.5
3.0
2.0
1.5
1.0
0
200
400
600
800
1000
1200
1400
1600
1800
2000
40 80 120 160 200 240 280 320
Direct
GranulesDirect (pre)
Ejec
tion
(N)
Compression (MPa)
The NP-RD30 Natoli AIM™ Plus main data screen provides an easy-to-interpret visual interface for quick assessment of formulation performance. Operator can control press speed and quickly view minimum and maximum pre-compression, compression, and ejection forces in real time.
The NP-RD30’s integrated Natoli AIM™Plus data acquisition/analysis and operating system software is designed to ease formulation and process development and minimize production issues during scale-up.
The NP-RD30 gives you the option to run only the number of stations you need, saving time and amount of formulation used.
• Provides tablet press scalability parameters• Calculates tensile strength for round, convex, and
oblong tablets• Quickly measures and evaluates tablet
formulations and properties• Provides projected data from formulation
changes• Reduces trial and error• Evaluates compaction properties of APIs and
potential formulations• Measures and reports data for tabletability,
compactibility, compressibility, and strain rate profiles
• Generates reports for manually entered data from friability, dissolution, and hardness testers
• Provides data to optimize lubrication levels with ejection/compression profiles (Fig. 1)
Natoli AIM™Plus Capabilities Speed Tablet Scale-up
DATA ACQUISITION• Monitors and records peak values for critical
events during tableting process.
DATA LIBRARY• Includes database of production press
specifications for most press models and manufacturers.
• Provides accurate scale-up data for specific production press using preloaded information and R&D data input.
DWELL TIME ASSESSMENT• Establishes ideal production dwell time for varying
tablet design specifications and tooling head flats.
TANGENTIAL VELOCITY ASSESSMENT• Determines tangential velocity using pitch circle
diameter and RPM ranges.• Analyzes dwell and compaction time at varying
turret speeds.• Provides manufacturers with live R&D data
normalized for their specific production press.
COMPACTION TIME ASSESSMENT• Analyzes tangential velocity, compression roller
diameter, and punch head configuration to calculate compaction time parameters needed in production.
NP-RD30 Features: • Integrated Natoli AIM™ Plus data acquisition and
analytical software
• User-friendly 21" HMI touchscreen
• USB port for easy data transfer
• CFR 21 Part 11–compliant
• Identical pre- and main compression roll diameter
• Pre- and main compression, ejection, and take-off force monitoring
• Independent overload for pre- and main compression
• Automatic and dosing weight control
• Patented Fast-Fill cam design
• Standard batch reporting and error and alarm tracking
• Built-in calibration tool
• Containment-ready separate compression zone
• Dual-paddle, variable-speed feeder design
• Optional security and HID badge capabilities
Natoli AIM™Plus data analysis and operating system software:
Fig. 1 LUBRICATION OPTIMIZATIONThe Natoli AIM™ Plus Lubrication Optimization Feature provides the data to maximize tablet robustness and disintegration while minimizing production issues such as overblending and tablet capping.
RUN ONLY THE NUMBER OF STATIONS
YOU NEED
NATOLI ENGINEERING: Dedicated to Supporting Our Industry
Natoli Engineering Company is the world-renowned leader in tablet press tooling manufacturing. But we are far more. Founded on the uncompromising principle to manufacture and deliver the highest quality products at a fair price with exceptional customer service, Natoli continues to build on 40 years of innovation and industry leadership.
ATTRIBUTES 4+4 STATION 8 STATION 10 STATION
Punch Type EU 19, EU D/TSM B, D EU D/TSM D EU 19/TSM BDepth of Fill 20—22mm (.787—.866") 22mm (.866") 20mm (.787")
Maximum Round Diameter 17.5—23.8mm (.6875—.9375") 23.8mm (.9375") 17.5mm (.6875")
Shaped Major Dimension 19.0—25.4mm (.7500—1.000") 25.4mm (1.000") 19.0mm (.7500")
Pre-compression Force 10kN
Main Compression Force 60kN
Pre- and Main Upper Punch Penetration 0—6mm
Pre-Compression Data Collection 10kN Strain Gage Sensor to accurately collect lower pre-compression data
Vertical Pressure Roller Movement Proper upper and lower punch alignment allowing longer simultaneous dwell
Pitch Circle Diameter 200mm
Dwell Time Range 91—9.1ms
Tangental Velocity Range 105—1047mm/sec
Turret Speed 10-100 RPM
Machine Total Weight 2,835 lbs
Tablets Per Hour 2,400—24,000 4,800—48,000 6,000—60,000
NP-RD30 R&D TABLET PRESS SPECIFICATIONS:
Learn more about Natoli’s NP-RD30 R&D tablet press at www.natoli.com/tablet-presses or contact your Natoli representative today! +1 636.926.8900
Form 1122-N, 6/18 Copyright © 2018, Natoli Engineering Company , Inc.Natoli AIM™ is a trademark of Natoli Engineering Company, Inc.
NATOLI ENGINEERING COMPANY, INC. natoli.com • [email protected] • +1 636.926.8900