Novel Vaccines for Defense Against Pneumonic Plague
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Transcript of Novel Vaccines for Defense Against Pneumonic Plague
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7/22/2019 Novel Vaccines for Defense Against Pneumonic Plague
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Kcscl Tcoomk`s dfr E`d`ks`
Cacmkst Zk`unfkmo Zlcau`
E`v`ke`r Huncr
33-33-9:33
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Cohkfwl`ea`n`kts
N`tza`r Lci2
Er. E`kkms N`tza`r
Er. Amrmsg Hmrmnckb`swcrc
Er. H``r _uk
Nmog`ll` Qylcke-F'Irm`k
_gcrfk _clnfk
_gckkck Rml`s
Yfi`rts _`ck
Mnnukflfay Ofr`2
Er. @enuke Afss`lmk
]mlm Lmk
E`pcrtn`kt fd Og`nmocl cke Imflfamocl
@kamk``rmka2
Er. Iclcbm Kcrcsmngck
Er. Ir`t Plr`y
E`pcrtn`kt fd T`t`rmkcry Nmorfimflfay cke
Zr`v`ktmv` N`emomk`2
Er. Nmogc`l B. Qckk`nu`gl`r
Er. Cnckec @. Ycn`r-Ucmt
E`pcrtn`kt fd Nmorfimflfay cke
Mnnukflfay 2
Er. K`bct @amln`z
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Qfrlewme` e`ctgs drfn nuofscl mkd`otmfks
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Qgy mktrckcscl mnnukmzctmfk6
Kcscl pcssca` ms ncbfr pfrtcl fd`ktry dfr luka pctgfa`ks
A`k`rct` nuofscl cke syst`nmo
mnnukmty A`k`rct`s mnnukmty ct ftg`rnuofscl surdco`s
Mnnuk` r`spfks`s foour ctpctgfa`k-`ktry smt`
Zr`v`kts mkd`otmfks
@cs` fd cenmkmstrctmfk/Ncssvcoomkctmfk
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Icot`rmflfay ]`rsmkmc p`stms
]`rsmkmc p`stms Cktmquc
]`rsmkmc p`stms N`em`vclms
]`rsmkmc p`stms Frm`ktclms
3-9n x :.0n, smkal` o`ll fr sgfrt ogcmk
Arcn-k`actmv`, Impflcr stcmkmka
Dcoultctmv` ckc`rfi`
Kfknftml`, kfkspfrulctmka
Octclcs`+, fxmecs`-, ur`cs`-
Cil` tf arfw 5-5:O, fptmnun 97 O
Dlfooulckt arfwtg mk irftg
Ar`y-wgmt` trcksluo`kt oflfkm`s fk Ilffe
Cacr. Drm`e `aa cpp`crcko` mk fle`r
oflfkm`s fk IC
Mnc `s2 K] _tct` E` crtn`kt fd G`cltg-Qceswfrtg O`kt`r, ZGML-OEO
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Lor
1:hi
T Ca
Y`smstcko` tf pgcafoytfsms
_urvmvcl mk ncorfpgca`
]fps
Zgcafoytfsms
Zlct`l`t caar`actmfkMkdlnnctfry r`spfks`
pDrc
33:hi
D3 Ca
Cktmpgcafoytmo
Zst
=.0hi
Zlc
E`arce` dmirmk
& ftg`r `xtrco`llulcrprft`mks
LZ_
EMO
@keftfxmo sgfoh
Tmrul`ko` Dcotfrs
Ceg`smks
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Ug` Alficl Emstrmiutmfk fd Zlcau`
Drfn2 Zlcau`2 Zcst, Zr`s`kt, cke Du tur`_t`ks`tg KO, Ctsgcicr II, I`af k N, I`lncmk _Y, I`rtg`rct @, t cl. ZLf_ N`emomk ` Tfl. 0, Kf. 3, ? efm23:.3?13/bfurk cl.pn`e.::0:::?
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050003http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050003 -
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_ynptfns
gttp2//`k.wmhmp`emc.fra/wmhm/Ps`r2Nmhc`lVGaastrn/Emcarcns
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Zlcau` Zctgfa`k`sms
Gunck
Nmo`
Gunck
Kfrncl Luka Mkd`ot`e lukas
Nmo`
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Zfssmil` Cmrifrk` Urcksnmssmfk Zctgwcys fd ]. p`stms
cdt`r Mts Mkt`ktmfkcl C`rfsfl Y`l`cs`
N`tza`r Lci, 9:3:8 gttp2//www.fp`kolmpcrt.fra/
3::-0:: ODP
G Z Z m Zl 6
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Gfw tf Zr`v`kt Zk`unfkmo Zlcau`6
Kckfpcrtmol`sQgfl`-hmll`e O`lls _fluil` Cas Nmorfpcrtmol`s
Kcturcl imf-pcrtmol`s
Imfnmn`tmo
Nultmpl` crrcys fd Ca
Cssurcko` fd mkcotmvmty
rD3-Tp3:
rLsrI
rCml
rNclIr]cpN
rD3-Tp3:
Ofktrfll`e r`l`cs`
_mkal`-efs`
Lfka-t`rn prft`otmfkImfe`arcecil`
Nfemdmcil` tf sumt Ca r`l`cs`
Tcoomk`s
Cebuv
ckts
Mkt`rl`uhmk-39 Nfkfpgfspgfryl Lmpme C
ULY-5 cafkmst
_cd`
Kfk-tfxmo
Ca pr`s`ktctmfk
@kgcko`s o`llulcr
cke gunfrcl mnnukmty
_cd` iy m.k. rfut`
@stcilmsg`e `ddmocoy
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Mkcotmvct`e ]`rsmkmc p`stms OF=9
Tcoomk` (m]p)
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Ug` m.k. Zrmn`-Iffst cke Ogcll`ka` _trct`ay dfr
m]p Tcoomk`
Ecy : m.k. m]p + ML-39 / m]p/ ZI_
Ecy 93 m.k. m]p + ML-39 / m]p/ ZI_
Ecy 7: m.k. ]. p`stms OF=9
Ecy =5 @ke fd survmvcl stuey
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Cenmkmstrctmfk fd m.k. m]p + ML-39 ms _cd`
cke Q`ll-Ufl`rct`e
: 9 5 4 7 3: 39=:
=0
3::
*
Z
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Cenmkmstrctmfk fd m.k. m]p + ML-39 Zrft`ot`e
cacmkst Zrmncry Zk`unfkmo Zlcau`
: 0 3: 30 9: 90:
90
0:
10
3::
3:1m]p+ML-39
3:1m]p
ZI_
ks
**
Z>:.::3
7.0 x 3:9
ODP, m.k.
Ecys pfst-ogcll`ka`
ICLI/o nmo`.
Z`ro`kts
urvmvcl
C.
I.
Ecys : 93 7:
3. 3:1
m]p + :.0a ML-39
9. 3:1
m]p
?. ZI_
ICLI/o nmo`,M.k. vcoomkctmfk
Zrmnmka Iffstmka
=5
]. p`stmsOF=9ogcllcka`, m.k.,
7.03:9ODP@ke fd survmvcl
fis`rvctmfk
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ML-39 @kgcko`e tg` Zrfeuotmfk fd Cktm-]. p`stms
Cktmifem`s
: 3: 9: ?: 5: 0:3
9
?
5
0
*** *** ***
Z :.:5
Ecy ?0, pfst-vcoomkctmfk
CktmifeyUmt`rs(lfa3:
)
C. I. O.
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Ug` m]p + ML-39 Zrmn`-Iffst iy m.k. Yfut`
Zr`v`kt`e Zulnfkcry Oflfkmzctmfk fd ]. p`stms
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Ug` m.k. m]p + ML-39 Zrmn`-Iffst Mkeuo`e O`llulcr
Caar`actmfks mk Zulnfkcry Zcr`kogync
m]p + ML-39 ZI_
Ecy?0
pfst-vcoomkctmfk
C.
I.
Ecy97
pfst-vcoomkctmfk
I99: I99:
Ug m m] ML 39 Z m I Z e
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19gpfst-ogc
ll`ka`
m]p + ML-39 ZI_
Ug` m.k. m]p + ML-39 Zrmn`-Iffst Zr`v`kt`e
E`v`lfpn`kt fd Zulnfkcry Zctgflfay
Ug` m k m]p + ML 39 Zrmn` Iffst Zr`v`kt`e E`v`lfpn`kt fd
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Ug` m.k. m]p + ML-39 Zrmn`-Iffst Zr`v`kt`e E`v`lfpn`kt fdZulnfkcry Zctgflfay
Ug` m k m]p + ML 39 Zrmn` Iffst Mkeuo`e Zrft`otmfk ms
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Ug` m.k. m]p + ML-39 Zrmn`-Iffst Mkeuo`e Zrft`otmfk msCssfomct`e wmtg Lfw`r L`v`ls fd Zulnfkcry Oytfhmk`s Cdt`r
m.k. Ogcll`ka`ML-4
m]p + ML-39 ZI_ Pkmkd`ot`e:
3
9
?
5
0*** ***
Z< :.::3 Z< :.::3
pa/nl(lfa3:)
ML-3:
m]p + ML-39 ZI_ Pkmkd`ot`e:.7
:.=
3.:
3.3
3.9 m]p + ML-39
ZI_
Pkmkd`ot`e
ks
pa/nl(lfa3:)
NOZ-3
m]p + ML-39 ZI_ Pkmkd`ot`e:
3
9
?
5 ** *Z< :.:3 Z< :.:0
pa/nl(lfa3:)
MDK-
m]p + ML-39 ZI_ Pkmkd`ot`e:
3
9
? ***Z< :.:3 Z< :.:0
pa/nl(lfa3:)
UKD-
m]p + ML-39 ZI_ Pkmkd`ot`e:
3
9
?
5
* *Z< :.:0 Z< :.:0
(pa/nl)lfa3:
ML-39p1:
m]p + ML-39 ZI_ Pkmkd`ot`e:.0
3.:
3.0
9.:
* *Z< :.:0 Z< :.:0
pa/nl(lfa3:)
Ug D Y Y m e d C tmi e em t e
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Ug` DoY cr` Y`qumr`e dfr Cktmifey-n`emct`e
Zcssmv` cke Cotmv` Mnnukmty
: 0 3: 30:
90
0:
10
3::
*Z< :.:5
Ecys pfst-ogcll`ka`O01IL/4 nmo`
Z`ro`ktsurvmvcl
: 0 3: 30:
90
0:
10
3::
* Z< :.:9
Ecys pfst-mkd`otmfkICLI/o nmo`
Z`ro`ktsurvmv
cl
: 0 3: 30
:
90
0:
10
3::
3:1m]p + ML-39 Do Y
-/-
ZI_
3:1m]p + ML-39 Do Y
+/+
ks
*Z< :.:5
Ecys pfst-mkd`otmfkO01IL/4 nmo`
Z`ro`ktsurvmvcl
_ynifl ICLI/o Nmo` Arfup M_ / KN_ trcksd`r (Umn`) Qmle-typ` M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkd`otmfk
Qmle-typ` M_ pfst-ogcll`ka` +37g fd mkd`otmfk
Qmle-typ` KN_ -95, :, +95, cke +57g fd mkd`otmfk
M_2 Mnnuk` _`run8 KN_2 Kfrncl nfus` s`run
_ynifl O01IL/4 nmo` Arfup M_/KN_ trcksd`r (Umn`) DoY+/+ M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkd otmfk
DoY+/+ KN_ pr`- cke pfst-ogcll`ka -95, :, +95, cke +57g fd mkd otmfk
DoY-/- M_ pr`- cke pfst-ogcll ka` -95, :, +95, cke +57g fd mkd otmfk
DoY-/-
KN_ pr`- cke pfst-ogcll`ka -95, :, +95, cke +57g fd mkd otmfk
C.
I.
O.
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Ug` Ofnpl`n`kt Ef`s Kft Zlcy Yfl` mk
Zrft`otmfk Eurmka Zcssmv`ly Urcksd`rr`e
Mnnukmty
: 0 3: 30:
90
0:
10
3::
ks
Z> :.3?
Ecys pfst-mkd`otmfkO01IL/4 nmo`
Z`ro`ktsurv
mvcl
_ynifl O01IL/4 nmo` Arfup M_ / KN_ trcksd`r (Umn`)
O?+/+ M_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkd`otmfk
O?-/-
M_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkd`otmfk
O?+/+
KN_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkd`otmfk
O?-/-
KN_ pr`- cke pfst-ogcll`ka` -95, :, +95, cke +57g fd mkd`otmfk
Ug` OE5 cke OE7 U O`lls cr` Kft Y`qumr`e dfr Zrft`otmv`
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Ug` OE5 cke OE7 U O`lls cr` Kft Y`qumr`e dfr Zrft`otmv`
Mnnukmty Ct Umn` fd m.k. Ogcll`ka` Qmtg ]. p`stms
Ecys
: 93
Tcoomkctmfk
Zrmnmka Iffstmka
Cktm-nOE5 AH3.5 / Cktm-nOE7 0?-4.19 tr`ctn`kt, m.p.
1: 1? 14 1= 7?
7: =:3. 3:1
m]p + ML-39
9. 3:1
m]p + ML-39
?. 3:1
m]p + ML-39
5. 3:1
m]p + ML-390. ZI_
3. 3:1
m]p + ML-39 (Yct MaA)
9. 3:1
m]p + ML-39 (Cktm-OE5)
?. 3:1
m]p + ML-39 (Cktm-OE7)
5. 3:1
m]p + ML-39 (Cktm-OE5 + Cktm-OE7)0. ZI_
]. p`stms OF=9ogcllcka`, 3::: ODP,m.k.
@ke fd survmvclfis`rvctmfk
C.
I.
: 0 3::
90
0:
10
3::
3:1
m]p + ML-39 (Yct MaA)
3:1
m]p + ML-39 (Cktm-OE5)
3:1 m]p + ML-39 (Cktm-OE7)
3:1
m]p + ML-39 (Cktm-OE5 + Cktm OE7)ZI_ (Pkvcoomkct`e)
**Z> :.::?
Ecys pfst-ogcll`ka`ICLI/o nmo`
Z`ro`ktsurvmvcl
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_unncry
Zrft`ot cacmkst pk`unfkmo plcau`
ML-39 ms r`qumr`e dfr mkeuomka prft`otmfk
Cktmifem`s clfk` ock prfvme` prft`otmfk wgmogms n`emct`e tgrfuag DoY
U-o`lls cr` emsp`kscil` ct tg` tmn` fd mkd`otmfk
mk m]p + ML-39 vcoomkct`e nmo`
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_mkal`-Efs` Mktrckcscl
Zflyckgyerme` Kckfpcrtmol`s dfrTcoomk` E`lmv`ry
Nct`rmcl Zrfp`rtm`s Fd 0: 0: OZU@A OZG Kckfpcrtmol`s
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Nct`rmcl Zrfp`rtm`s Fd 0:20: OZU@A2OZG Kckfpcrtmol`s
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Tcoomkctmfk Y`amn`k
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_mkal`-Efs` Kckfpcrtmol`s Mkeuo`e Lfka-U rn
Zrft`otmfk Cacmkst Zk`unfkmo Zlcau`
4 wh
9? wh
Ug` Kckfpcrtmol`s Zr`v`kt`e Oflfkmzctmfk fd ] p`stms cke
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Ug` Kckfpcrtmol`s Zr`v`kt`e Oflfkmzctmfk fd ]. p`stms cke
Zulnfkcry Gmstfpctgflfay Cdt`r 9? w``hs fd Tcoomkctmfk
M.k. Tcoomkctmfk fd Kckfpcrtmol`s Zr`v`kt`e pctgflfay fd Fracks Zfst-ogcll`ka`
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p p ay a a
_mkal` efs` Cenmkmstrctmfk fd Kckfpcrtmol`s Mkeuo`e Lfka
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_mkal`-efs` Cenmkmstrctmfk fd Kckfpcrtmol`s Mkeuo`e Lfka-
t`rn Cktmifey Umt`rs wmtg Gmag Cvmemty
_mkal` Efs` Kckfpcrtmol` Zrmnmka Zrft`ot`e
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_mkal`-Efs` Kckfpcrtmol` Zrmnmka Zrft`ot`e
Nmo` cdt`r 3: Nfktgs
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_unncry
Zrft`ot cacmkst pk`unfkmo plcau`
Kckfpcrtmol`s mts`ld cot cs ck cebuvckt
Kckfpcrtmol`s ock cirfact` tg` k``e dfr
nultmpl` vcoomkctmfks cke prfvme` lfka-
eurctmfk mnnukmty
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_mkal`-efs` Mktrckcscl Zfly (lcotmo Come)
Nmorfspg`r`s dfr Tcoomk` E`lmv`ry
_m l e : e e m g me
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_mkal`-efs` rD3-Tp3: Lfce`e ZLC Nmorfspg`r`s Zrfvme`s Lfka-
t`rn Zrft`otmfk Cacmkst Zk`unfkmo Zlcau`
: 0 3: 30:
90
0:
10
3::0 a DMT NZ + ML-39 NZ
1.0 a D3T NZ + ML-39 NZ
1.0 a D3T NZ
ZI_*
Z< :.:?
*Z< :.:3
Ecys pfst-mkd`otmfk
Z`ro`ktsurvmvcl
34 wh
ZLC Nm g m e e L Z m C m
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ZLC Nmorfspg`r`s mkeuo`e Lfka-t`rn Zrft`otmfk Cacmkst
Zk`unfkmo Zlcau` Ofrr`lct`s wmtg MaA9c cktmifem`s
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Sufrun _`ksmka Ofnpfk`kts cs
Tcoomk`
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M.k. E`lmv`ry fd Sufrun _`ksmka Ofnpfk`kts
Dcml`e tf Zrft`ot Cacmkst Zk`unfkmo Zlcau`
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Lmnmtctmfks
Mkcotmvct`e Tcoomk`
Lmt`rctur`
Eurctmfk fd Mnnukmty6
KGZ trmcls kft ofkeuot`e
D3/T Ca ics`e Tcoomk`s
Efuit fv`r `ddmocoy mk
Guncks cs mt emdd`r`ktmclly
prft`ot Oykfnflausncocqu`s cke Cdrmock
Ar``k Nfkh`ys
Ci l`v`ls ef`s kft
ofrr`lct`s wmtg prft`otmfk mk
KGZ
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Mnprfv`n`kts cr` Zfssmil`
Mkcotmvct`e Tcoomk`s
Fptmnmz` arfwtg ofkemtmfks
dfr ncxmnun `xpr`ssmfk fd
prft`otmv` cktma`ks
I`tt`r mkcotmvctmfk prfo`eur`s
@kocpsulctmfk2
_cd`ty,
_mkal`-efs`,
Ncy cirfact` tg` r`qumr`n`ktfd cebuvckt iy `kocpsulctmka
gmag-efs` cke slfw r`l`cs`
D3/T Ca ics`e Tcoomk`s
@kocpsulctmfk
Mkolusmfk fd kfv`l prft`otmv`
Cas / lfw efs` m]p
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Ugckh yfu