Non Homologous End Joining. Homologous Recombination Non Homologous End Joining.

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Non Homologous End Joining

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Transcript of Non Homologous End Joining. Homologous Recombination Non Homologous End Joining.

Page 1: Non Homologous End Joining. Homologous Recombination Non Homologous End Joining.

Non Homologous End Joining

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Homologous Recombination

Non Homologous End Joining

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Differences between HR and NHEJ:

• Error- free / Error- prone• Cell cycle regulated • Varies between species

HR NHEJ

yeast mammalsplants

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HR NHEJ

MHC rearrangementMeiosis

Cell-induced Double Strand Brakes

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V(D)J recombination

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NHEJ Defects

• SCID (Severe Combined Immune Deficiency).

• Cancer – genome instability: rearrangements, deletions, amplifications.

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Ku 70/80 heterodimer

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Ku has a role in telomeres

?

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KU 70/80

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Ku is critical for telomere maintenance

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Ku Plays Several Roles at Telomeres

Telomere addition

Telomeric silencing

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Ku is a multifunctional protein

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HR

NHEJ


DNA break repair by homologous recombination Homologous Recombination · 2007-01-01 · Homologous Recombination target replaced with donor DNA sequence ! induced break ! donor DNA

DNA break repair by homologous recombination Homologous Recombination · 2007-01-01 · Homologous Recombination target replaced with donor DNA sequence ! induced break ! donor DNA

Emerging IC Packaging Technologies - SMTA. Materials HighHigh-End FC End FC. ... Target devices Logics on Si interposer ... Die Joining Adaptive Learning

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DEMONSTRATION OF HOMOLOGOUS RECOMBINATION EVENTS … · DEMONSTRATION OF HOMOLOGOUS RECOMBINATION EVENTS IN THE EVOLUTION OF BOVINE VIRAL DIARRHOEA ... good chance for homologous

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Homologous Series, Formulae & IUPAC

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facilitate homologous recombination and contributes to DSB … · promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin

facilitate homologous recombination and contributes to DSB … · promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin

DNA break repair by homologous recombination Homologous ...mcb.berkeley.edu/courses/mcb110spring/2007L11to13.pdf · Homologous Recombination DNA break repair by homologous recombination

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Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

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CAT’s views on classification of ATMPs: homologous use · Organ transplantation BMT Pancreatic iPSc islest Bone marrow in bone healing CD34 in myocardium . 6 Homologous vs/Non homologous

CAT’s views on classification of ATMPs: homologous use · Organ transplantation BMT Pancreatic iPSc islest Bone marrow in bone healing CD34 in myocardium . 6 Homologous vs/Non homologous

Insights into the non-homologous end joining pathway and ...

Insights into the non-homologous end joining pathway and ...

Development of NTLA-1001: First-in-Class, LNP-CRISPR/Cas9 … · 2020-04-29 · Editing Strategy Relies on Knockout Caused By Error-Prone Non-Homologous End Joining (NHEJ) of a Double-Strand

Development of NTLA-1001: First-in-Class, LNP-CRISPR/Cas9 … · 2020-04-29 · Editing Strategy Relies on Knockout Caused By Error-Prone Non-Homologous End Joining (NHEJ) of a Double-Strand

EVALUATION OF REAGENTS AND METHODS FOR ......mutagenesis via nonhomologous end-joining (NHEJ) and gene targeting via homologous recombination (HR) have been demonstrated in a number

EVALUATION OF REAGENTS AND METHODS FOR ......mutagenesis via nonhomologous end-joining (NHEJ) and gene targeting via homologous recombination (HR) have been demonstrated in a number

Replicação na presença de erros. Recombination at the Molecular Level Breakage and joining also directed by enzymes. Homologous recombination.

Replicação na presença de erros. Recombination at the Molecular Level Breakage and joining also directed by enzymes. Homologous recombination.

ARCHIVES OF...recombination repair (HR), and non-homologous end-joining repair (NHEJ)11. XRCC4 gene is found on the chromosomal 5q14.2 and it is involved in precise end-joining of

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Homologous Recombination (HR)

Homologous Recombination (HR)

"knockout mouse" homologous recombination

"knockout mouse" homologous recombination

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Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts

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Staff Training/Joining time.pdf · take joining time at the end of the vacation. (b) If vacation is combined with leave, joining time shall be regulated under Rule 9.1 (b) (i), if

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