Non Classical (Unique) Actions of Hormones Hormonex .
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Transcript of Non Classical (Unique) Actions of Hormones Hormonex .
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Non Classical (Unique) Actions ofNon Classical (Unique) Actions of
HormonesHormones
Hormonex
www.hormonex.com
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Hormone Action
Nuclear Non Nuclear
Genomic Non Genomic Cytosolic
Non Cytosolic
Hormonex
www.hormonex.com
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Hormone ActionsHormone Actions
Hormonex
www.hormonex.com
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Complex( 1st Messenger)
Receptors on Cell Membrane
2nd Messenger RNA
Nuclear RNA
Signal Transduction
Nuclear DNA Transcription
Hormonex
www.hormonex.com
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Non Genomic - Non Classical
By activation Protein Coupled Receptors
Activation of Signal Transducing Kinases
Eg : MAPK – Mitogen Activated Protein Kinases
Protein Transgression - Activation of Cytokines and Growth Factors to translate the Cell – Cell language of Hormone action (Hormonisation of the Milieu Interieur)
Hormonex
www.hormonex.com
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Differences with
Gender Difference - Male, Female Difference of Estradiol,Testosterone, DHT, Androstenedione- Actions
Age Difference - Prepubertal
PreAdolescent
Post Pubertal & Fertility period
Peri & Post Menopausal
Geriatric Age
Hormonex
www.hormonex.com
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In Critical Care Medicines
Where Homeostasis is Turbulantly altered by
Substrate Changes of – Inflammatory
Cascade of Cytokines, Interferones, Prostaglandins & Prostacyclines & other Kinins of Cell Adhsion & Cell Apoptosis
Relevance in the use of Recombnint Growth Hormone (RGH), Anti Thrombin III, Factor VII, Novo Seven in Criticare to Modulate Catabolic ,Protein loss &Healing towards - HEALING !
Hormonex
www.hormonex.com
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We have used the Non Classical Actions of following Hormones in Clinical Medicine
- In Osteopenia,
- Arthropathies (Degenerative &
Immunomodulated Types
Eg :: Osteoarthritis
Rheumatoid Arthritis,
Psoriatic Arthritis
Actions on Endothelium
Osteoid Cells
Osteoid Seam
Vascular & Neuronal Tissues
T Lymphocyties & Monocytes
Estrogen
Hormonex
www.hormonex.com
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Progesterone
- used in Sperm activation before AIH,ECSEI
- Sensitising the Estrogen Receptors for benefits of pain Relieving effects on Bone
- Recurrent Tropical Infections like Malaria Typhoid etc - in cases of severe Epilepsy in Females
On Sperm
Anti Inflammatory Effects
Arthritis
Boosting Immune System
Anti Epileptic – Neuro Sedative effects
Hormonex
www.hormonex.com
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Acute Care Medicine
Case of Multiple Organ Failure
- in Road Traffic Accident (RTA) with Serve Head Injury
- in Cerebro Vascular Accidents (CVA) with complications of DM, CAD
- in Post Traumatic Neurological Damage with Quadri & Para Paresis (Cervical & Lumbar Disc Fractures
Hormonex
www.hormonex.com
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Morbid Obesity-Hypothalamic Obesities with Respiratory insufficiency & Parasomnias (Sleep Disorders)
-Treated with RGH & Anti Obesity Measures
Degenerative Diseases of Skin With Acute Phase Reactions
Two Females of Pemphigus 30 & 34 Yrs Three Cases of Psoriasis with Arthritis – Males (20 to 50 Yrs)Treated with RGH & Gonadal Steroids .
- Like Pemphigus, Psoriasis, Exfoliative Dermatitis
Hormonex
www.hormonex.com
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- Used in Clinical Medicine – Specially T3 (Triodothyronine) in cases of Obesity - Growth problems (Childhood Obesity , Constitutional growth delay, Childhood Behaviour Problems like Enuresis, Strammering and Reading and Writing Defects in Dyslexia
- Used in Oncology as Promoters of Cell Apoptosis in Cencer Theropy
- Given Pre and Post Operatively in Major Surgeries like Total Hip and Knee replacements (3 Cases ) – Coupled with Viscosupplementation (with Hyaluronidase)
Thyroid Hormones (Non Classical Effects of )
Anti Estrogen
Estrogen, Progesterone & RGH
Hormonex
www.hormonex.com
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RGH Use in Acute & Chronic Degenerative Conditions
( Actions of Anti Catabolic, Prohealing , Anti Degenerative Protiein Sparing )
1. Rheumotoid & Degenarative Arthritis with High Morbidisation and
Immbilisation (Knee and Hip Joints) – 3 Cases of Female Patients(40 to
55 Yrs of Peri & Post Menopausal Arthritis treated with RGH & HRT - 3
Cases of Hip and Shoulder and Knee Arthritis in Young (16 , 22, 26 Yrs)
– 2 Male and 1 Female
2. Debilitating Lumbar & Cervical Dorsalgias (6 Cases of Post Menopausal Male and Female cases treated with RGH and HRT
Hormonex
www.hormonex.com
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MOF Cases (Multiple Organ Failure)
In CVA Cases Complicated with DM , CAD and Neuroipathies
(Somatosensory and Autonomic)
1 Case of Cushing Syndrome 22 Yrs old Male in Persistent
Hyperkalemia and Hyperglycimia who developed MOF in
Hospital & Treated with RGH and Supportive Criticare
SurvivedWith normalisation of Cortisolemia & Hyperkalemia
and Hyperglycimia (MOF came as a blessing in this guys to
Downregulate his Hyperactive Adrenals !!)
Hormonex
www.hormonex.com
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Reported (Hitherto ) Failure of RGH Benefits in Criticalcare Most Likely to be – Dose Related (Very High Doses were used ? And Improper selection of cases )
Failure in our cases was Positively Attribuble to the development of DIC & Platelet , Thrombopathies
Becase we have had very Encouraging Results with RGH in Creticare With use of 2 to 5 units 12 Hourly
Propably the on going trials with Factor VII (NOVO Seven) will add to the Positive results and RGH + Amtithrombin III + NOVO Seven seem to be future Blockbuster criticare package towards decreasing Mortality in Critical Care patients.
We have Subciquintly got over this problem by the concurrent use ofAntithrombin III,
Hormonex
www.hormonex.com
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