8/3/2019 NK Cell Melanoma

1/16

Gexuzen K`nnoz Lonn| `g xfo J`mnmcp maIonegmie

z`llezhm]jonn`pefmm'`x

8/3/2019 NK Cell Melanoma

2/16

J`mnmcp ma Gexuzen K`nnoz &GK) Lonn| &@)

Lmirz`|o ejmux 525?/ ma xmxen jnmmh npirfm`h

lonn|

Lfezelxoz`toh rfogmxpr`lennp jp xfo rzo|oglo ma

LH?1 egh xfo nelk ma LH

8/3/2019 NK Cell Melanoma

3/16

J`mnmcp ma Gexuzen K`nnoz Lonn| &@@)

Leg jo h`q`hoh `g xsm ie`g |ujlne||o| s`xf

h`aaozogx ovrzo||`mg rexxozg

LH?1 H`i

LH51 F`cf

LH?1 Jz`cfx

LH51 Nms-Goc

52/ ma jnmmh GKLonn| 02/ ma jnmmh GKLonn|

8/3/2019 NK Cell Melanoma

4/16

J`mnmcp ma Gexuzen K`nnoz Lonn| &@@@)

GK Lonn| ezo `gqmnqoh `g |oqozen rzmlo||4 Zolmcg`to egh k`nn xuimz lonn| egh q`zennp `gaolxoh lonn|

@gqmnqoh `g `iiugo |p|xoi zocunex`mg

@gqmnqoh `g egc`mcogo|`|

X`||uo fmiom|xe|`|

8/3/2019 NK Cell Melanoma

5/16

J`mnmcp ma Gexuzen K`nnoz Lonn| &@Q)

GK |ujlne||o| rm||o| h`aaozogx j`mnmc`l rzma`no4

Rzmn`aozex`qo zo|rmg|o xm @N:

@gxz`g|`l lpxmxmv`l lerel`xp

Elx`qex`gc`gf`j`xmzp GK zolorxmz zorozxm`zo

Ehfo|`mg imnoluno ovrzo||`mg

X`||uo fmi`gc Lpxmk`go rzmhulx`mg

Imgmk`go-Lfoimk`go zolorxmz ovrzo||`mg

8/3/2019 NK Cell Melanoma

6/16

Gexuzen K`nnoz Lonn| egh Ionegmie

Nms k`nn`gc elx`q`xp `g q`xzm

@ire`zoh zo|rmg|o xm `gxozaozmg|

Gmx oaa`l`ogx `g fmi`gc xm ien`cgegx x`||uo|

GK)Lonn hp|auglx`mg `g ehqegloh ionegmie rex`ogx|

Mgnp aos GK)lonn| ezo amugh `g II)ioxe|xe|o|sf`lf `| rmxogx`ennp zoqoz|`jno jp xzoexiogx s`xf @N):

8/3/2019 NK Cell Melanoma

7/16

Iexoz`en egh Ioxfmh|

5: rex`ogx| `g ionegmie |xeco @Q s`xfmuxrzoq`mu| lfoimxfozerp

1 foenxfp hmgmz| &iexlfoh amz eco egh |ov)

Anms Lpxmioxzp egenp|`| amz h`aaozogx imnoluno|

`gqmnqoh `g xfo zocunex`mg ma GKlonn k`nn`gc egh

x`||uo fmi`gc

8/3/2019 NK Cell Melanoma

8/16

Elx`qex`gc Zolorxmz|GKr81

Ovrzo||oh `g zo|x`gc GK lonn|

@gqmnqoh `g ionegmie lonn k`nn`gc

N`cegh ugkgmsg

GKr88

Ovrzo||oh `g elx`qexoh GK lonn| @gqmnqoh `g ionegmie lonn k`nn`gc

N`cegh ugkgmsg

LH88 Zolorxmz amz fpenuzmg`l el`h s`xf xz`ccoz rzmrozx`o|

8/3/2019 NK Cell Melanoma

9/16

@gf`j`xmzp Zolorxmz|

LH6?d

@c |urozaei`np cnplmrzmxo`g| &@NX-N@Z)

\rol`a`l amz e jzmeh zegco ma FNE lne|| @ egx`cog|

GKC:E

Lxpro nolx`g cnplmrzmxo`g|

Zolmcg`to| FNEO lne|| @ cnplmrzmxo`g Amzi| foxozmh`ioz| s`xf LH08

K@Z:HN

8/3/2019 NK Cell Melanoma

10/16

Lfoimk`go Zolorxmz|LVLZ5 Ovrzo||oh jp |oqozen ionegmie lonn n`go|

Xfo`z n`cegh| @N6 egh CZMe ezo rzmhuloh jp h`aaozogx ionegmie lonn n`go|

LV

8/3/2019 NK Cell Melanoma

11/16

K`nn`gc Oaaolxmz Imnoluno|

Czeguno ovmlpxm|`| rexfsep

Rozamz`g Ioijzego h`|zurx`gc rzmxo`g

Czegtpio E

\oz`go rzmxoe|o

Hoexf zolorxmz rexfsep

LH0?N. LH82N. Xze`n

XGA aei`np n`cegh @gqmnqoh `g lonn xezcox ermrxm|`| |`cgen`gc

8/3/2019 NK Cell Melanoma

12/16

Ermrxm|`| Zonexoh Zolorxmz|

Xze`nZ:

Xzeg|ioijzego rzmxo`g s`xf lpxmrne|iex`l hmie`g lmgxe`g| ehoexf hmie`g &HH)

On`l`x eg ermrxmx`l hoexf zo|rmg|o urmg j`gh`gc ma Erm:N-XZE@N

Xze`nZ