Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene...

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Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State by Christoph H. Lohmann, David D. Dean, Lynda F. Bonewald, Zvi Schwartz, and Barbara D. Boyan J Bone Joint Surg Am Volume 84(3):411-419 March 1, 2002 ©2002 by The Journal of Bone and Joint Surgery, Inc.

Transcript of Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene...

Page 1: Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State by.

Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles

Depends on Osteoblast Maturation State

by Christoph H. Lohmann, David D. Dean, Lynda F. Bonewald, Zvi Schwartz, and Barbara D. Boyan

J Bone Joint Surg AmVolume 84(3):411-419

March 1, 2002

©2002 by The Journal of Bone and Joint Surgery, Inc.

Page 2: Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State by.

Effect of ultra-high molecular weight polyethylene particles on the number of MG63 osteoblast-like cells (A), OCT-1 osteoblast-like cells (B), and MLO-Y4 osteocyte-like cells (C).

Christoph H. Lohmann et al. J Bone Joint Surg Am 2002;84:411-419

©2002 by The Journal of Bone and Joint Surgery, Inc.

Page 3: Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State by.

Effect of ultra-high molecular weight polyethylene particles on the production of prostaglandin E2 by MG63 osteoblast-like cells (A), OCT-1 osteoblast-like cells (B), and MLO-Y4 osteocyte-like

cells (C).

Christoph H. Lohmann et al. J Bone Joint Surg Am 2002;84:411-419

©2002 by The Journal of Bone and Joint Surgery, Inc.

Page 4: Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State by.

Effect of ultra-high molecular weight polyethylene particles on the production of nitric oxide (NO) by MG63 osteoblast-like cells (A), OCT-1 osteoblast-like cells (B), and MLO-Y4 osteocyte-like

cells (C).

Christoph H. Lohmann et al. J Bone Joint Surg Am 2002;84:411-419

©2002 by The Journal of Bone and Joint Surgery, Inc.