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Nimesulide medicine for Osteoarthritis

Nimesulide drug was launched in Italyfor the first time as Aulin and Mesulid in 1985 and is presently

available in more than 50 countries worldwide with different trademarks.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders

including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and

osteoarthritis (joint pains), stiffness.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad

action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg

twice a day, to minimize the risk of hepatotoxicity.

Continuous use of Nimesulide may cause certain side effects like Diarrhea, vomiting, skin rash etc, It also

preffered to use for the age above 12. Women should use the drug with caution during lactation and it is

contraindicated during pregnancy.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age

have negligible effects on Nimesulide pharmacokinetics.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a

sulfonanilide moiety as the acidic group.

It undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful

reductions in pain and inflammation observed within 15 minutes from drug intake.

Nimesulide is contraindicated in children below 12 years and in patients suffering from liver problems.

Nimesulide medicine must be used under supervision by a doctor in accordance with the approved

indications and in compliance with the recommendations

The prescription of a drug is appropriate when the benefit it is able to provide to a specific patient

outweigh the risks associated with its use. A careful evaluation of individual risk factors is therefore of

crucial importance.

Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported

by significant clinical evidence.

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Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions

with the aim of evaluating the analgesic activity of Nimesulide in comparison to placebo and to some of

the most common NSAIDs.

In these studies, it is observed that the efficacy of Nimesulide was consistently superior to placebo with

a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

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for periarthritis