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PHSlNlHlOD Permit No. G-291

Vol. 17, iJo. 13 Apr i l 8, 1988

Vol. 17, No. 13, April 8 , 1988

NOTICES

NUMBERS OF COPIES OF APPLICATIONS TO BE SUBMITTED FOR AIDS EXPEDITED REVIEW ........................................................... 1 National Institutes of Health Alcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTE OF HEALTH

ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

HUMAN SUBJECT (IRB) CERTIFICATIONS AND ANIMAL SUBJECT (IACUC) VERIFICATIONS -AIDS EXPEDITED REVIEW ...................................................... 1 National Institutes of Health Alcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTES OF HEALTH

ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

RECEIPT DEADLINES FOR AIDS RESEARCH AND AIDS RESEARCH CENTER GRANT APPLICATIONS ......................................................... 2 Alcohol, Drug Abuse, and Mental Health Administration Index: ALCOHOL, DRUG ABIJSE, AND MENTAL HEALTH ADMINISTRATION

APPLICATION ASSIGNMENT SIJGGESTIONS ......................................... 3 Division of Research Grants Index: DIVISION OF RESEARCH GRANTS

NIH REGIONAL SEMINAR IN GRANTS ADMINISTRATION .............................. 4 National Institutes of HealthIndex: NATIONAL INSTITUTES OF HEALTH

DATED ANNOUNCEMENTS (RFAs AND RFPs)

LEARNING DISABILITIES: MULTIDISCIPLINARY RESEARCH CENTERS (RFA) . . . . . . . . . . . 4 National Institute of Child Health and Human DevelopmentNational Institute of Neurological and Communicative Disorders and Stroke Index: CHILD HEALTH AND HUMAN DEVELOPMENT

NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE

INVESTIGATION OF TISSUE COMPOSITION AND FUNCTION BY MRI USING PARAMAGNETIC AND/OR SUPERPARAMAGNETIC CONTRAST AGENTS (RFA) ............................. 5 National Cancer Institute Index: CANCER

-ONGOING PROGRAM ANNOUNCEMENTS

BASIC STUDIES IN BONE MARROW TRANSPLANTATION (PA) .......................... 6 National Institute of Allergy and Infectious Diseases Index: ALLERGY AND INFECTIOUS DISEASES

NO? ICES

NUMBERS OF COPIES OF APPLICATIONS TO BE SUBMITTED FOR AIDS EXPEDITED REV’W

1 P.T. 34; K.W. 0715120, 1014002

N a t i o n a l I n s t i t u t e s o f Hea l th Alcohol , Drug Abuse, and Mental Hea l th Admin i s t r a t ion

The number o f c o p i e s o f a p p l i c a t i o n s r e q u i r e d f o r i n v e s t i g a t o r - i n i t i a t e d AIDS r e s e a r c h p r o j e c t g r a n t (R01) o r F i r s t Independent Research Suppor t and T r a n s i t i o n (FIRST) award (R29) a p p l i c a t i o n s f o r exped i t ed review h a s been i n c r e a s e d t o f a c i l i t a t e fas ter p r o c e s s i n g . Commencing wi th t h e May 2 , 1988, r e c e i p t d a t e , a p p l i c a n t s t o N I H and ADAMHA must now submit t h e o r i g i n a l a p p l i c a t i o n p l u s 32 l e g i b l e c o p i e s i f t h e y wish t h e a p p l i c a t i o n s t o r e c e i v e e x p e d i t e d r ev iew. The number o f c o p i e s o f appendix m a t e r i a l s remains a t 6 . A p p l i c a n t s f o r o t h e r mechanisms o f AIDS r e s e a r c h , development and t r a i n i n g suppor t shou ld refer t o e a r l i e r n o t i c e s from t h e N I H and ADAMHA i n t h e Guide f o r Gran t s and C o n t r a c t s (Vol. 17, No. 9, March 1 1 , 19881, f o r t h e c o r r e c t numbers o f c o p i e s t o be submi t t ed and o t h e r r e l e v a n t i n fo rma t ion .

HUMAN SUBJECT ( I R B ) CERTIFICATIONS AND ANIMAL SUBJECT ( I A C U C ) WRIFICATIONS -AIDS EXPEDITED REVIEW

P.T. 34; K.W. 0715120, 1014003, 0783005

N a t i o n a l I n s t i t u t e s o f Hea l th Alcohol , Drug Abuse, and Mental Hea l th Admin i s t r a t ion

The fo l lowing i n s t r u c t i o n s app ly t o a p p l i c a t i o n s f o r a l l mechanisms o f s u p p o r t f o r AIDS r e s e a r c h submi t t ed t o ADAMHA and N I H f o r e x p e d i t e d rev iew commencingw i t h t h e September 1 , 1988, r e c e i p t d a t e :

o If t h e a p p l i c a n t h a s an approved a s s u r a n c e c o v e r i n g t h e r e s e a r c h ( m u l t i p l e p r o j e c t a s s u r a n c e f o r human s u b j e c t s / f u l l Assurance o f Compliance f o r animal s u b j e c t s ) , t h e a p p l i c a n t should p r o v i d e , w i t h t h e a p p l i c a t i o n , c e r t i f i c a t i o n o f i n s t i t u t i o n a l review board ( I R B )

‘d approva l i f humans are involved and v e r i f i c a t i o n o f i n s t i t u t i o n a l animal care and u s e committee ( I A C U C ) app rova l if an ima l s are invo lved . These rev iews and a p p r o v a l s shou ld occur PRIOR TO SUBMISSION OF t h e a p p l i c a t i o n s f o r award and t h e c e r t i f i c a t i o n s and v e r i f i c a t i o n s shou ld be SUBMITTED WITH t h e a p p l i c a t i o n s . F a i l u r e t o p rov ide r e q u i r e d c e r t i f i c a t i o n s and v e r i f i c a t i o n s w i t h i n a p p l i c a t i o n s cou ld r e s u l t i n d e f e r r a l o r r e j e c t i o n .

o If an ima l s o r humans w i l l be s u b j e c t s o f t h e r e s e a r c h a t PERFORMANCE SITES OTHER THAN THE APPLICANT ORGANIZATION, t h e a p p l i c a n t s must i d e n t i f y , w i t h i n t h e a p p l i c a t i o n s , t h e a s s u r a n c e s t a t u s o f each p a r t i c i p a n t . F a i l u r e t o p rov ide this i n fo rma t ion w i t h i n a p p l i c a t i o n s cou ld r e s u l t i n d e f e r r a l or r e j e c t i o n .

I n q u i r i e s r e g a r d i n g t h e e x p e d i t e d p r o c e s s i n g of AIDS a p p l i c a t i o n s shou ld be addres sed t o t h e a p p r o p r i a t e N I H o r ADAMHA AIDS Coordina tor r

N a t i o n a l I n s t i t u t e o f Ch i ld H e a l t h and DevelopmentD r . Antonio Novel lo Telephone: (301) 496-1848

N a t i o n a l I n s t i t u t e o f General Medical S c i e n c e s D r . E lke Jo rdan Telephone: (301) 496-7061

N a t i o n a l I n s t i t u t e of Diabe te s and Diaestive and Kidnev Diseases-D r . Wal te r S t o l z Telephone: (301) 496-7277

N a t i o n a l I n s t i t u t e o f A r t h r i t i s and Muscu loske le t a l and Sk in Diseases D r . S t even Hausman Telephone: (301 1 496-7495

N a t i o n a l H e a r t , Lung, and Blood I n s t i t u t e d’ D r . F rances P i t l i c k

Telephone: (301) 496-7416

1

N a t i o n a l I n s t i t u t e of Den ta l Research D r . Matthew Kinnard Telephone: (301) 496-7784

D i v i s i o n o f Research Resources D r . James O'Donnell Telephone: (301) 496-6023

N a t i o n a l I n s t i t u t e o f Environmental H e a l t h S c i e n c e s D r . Anne Sassaman Telephone: (919) 541-7723

N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases D r . John Diggs Telephone: (3011 496-7291

D i v i s i o n o f Research Gran t s D r . Hugh Stamper Telephone: (301) 496-7179

N a t i o n a l Cancer I n s t i t u t e D r . Paul Rambaut Telephone: (301) 496-4218

N a t i o n a l I n s t i t u t e of Neuro log ica l and Communicative D i s o r d e r s and S t r o k e D r . John Da l ton Telephone: (301) 496-9248

D i v i s i o n o f C o n t r a c t s and Gran t s M r . C u r t i s T a t e Telephone: (301) 496-4422

N a t i o n a l C e n t e r f o r Nurs ina- Research D r . Jan l ie inrich Telephone: (301) 496-0526

N a t i o n a l Eye I n s t i t u t e D r . J a c k McLaughlinTelephone: ( 3 0 1 ) 496-5983

N a t i o n a l L i b r a r y o f Medicine Mr. Ar thu r B r o e r i n g Telephone: (301) 496-4621

Fogar ty I n t e r n a t i o n a l Cen te r D r . B e t t i e Graham Telephoner (301) 496-6688

N a t i o n a l I n s t i t u t e on AgingD r . Miriam K e l t y Telephone: ( 3 0 1 ) 496-9522

N a t i o n a l I n s t i t u t e on Drug Abuse D r . Roy P ickens Telephone : (301 1 443-6697

N a t i o n a l I n s t i t u t e on Alcohol Abuse and Alcoholism M r . S t e v e LongTelephone: (301) 443-1284

N a t i o n a l I n s t i t u t e o f Mental Hea l th D r . Ly le Bivens Telephone: (301) 443-3563

RECEIPT DEADLINES FOR AIDS RESEARCH AND AIDS RESEARCH CENTER GRANT APPLICATIONS

P.T . 34; K . W . 0715120, 1014002

Alcohol , Drug Abuse, and Mental H e a l t h A d m i n i s t r a t i o n

The Alcohol , Drug Abuse, and Mental H e a l t h A d m i n i s t r a t i o n (ADAMHA) reminds a p p l i c a n t s t h a t t h e review s c h e d u l e f o r t h e ADAMHA AIDS program announcements l i s t e d below is no l o n g e r v a l i d .

beA p p l i c a t i o n s submi t t ed i n r e sponse t o ADAMHA -

AIDS program announcements must r e c e i v e d on t h e s p e c i a l r e c e i p t d a t e s (May2, September 1 , J a n u a r y 21, and w i l l be handled i n accordaiice w i t h t h e e x p e d i t e d p r o c e d u r e s d e s c r i b e d i n t h e e a r l i e r ADAMHA n o t i c e on e x p e d i t e d

2

review and award o f i n v e s t i g a t o r - i n i t i a t e d AIDS g r a n t s a p p l i c a t i o n s i n t h e N I H Guide f o r Grants and C o n t r a c t s (Vol . 1 7 , No. 9 , March 1 1 , 1 9 8 8 ) . A p p l i c a t i o n s r e c e i v e d a f t e r t h e AIDS s p e c i a l r e c e i p t d a t e s w i l l be de l ayed u n t i l t h e n e x t rev iew c y c l e .

A p p l i c a n t s shou ld a l s o f o l l o w t h e i n s t r u c t i o n s on number o f a p p l i c a t i o n c o p i e s L d and I R B c e r t i f i c a t i o n s and IACUC v e r i f i c a t i o n s which are d e s c r i b e d i n t h e

above n o t i c e s on e x p e d i t e d r ev iew.

Alcohol , Drug Abuse, and Mental Hea l th Aspec ts o f Acquired Immunodeficiency Syndrome (MH 8 6 - 0 9 )

Research Gran t s on Alcohol and Immunology I n c l u d i n g Acquired Immunodeficiency Syndrome (AA 8 6 - 0 3 )

Treatment o f I n t r a v e n o u s Drug Abusers t o Reduce t h e Spread of AIDS (DA 8 7 - 1 4 )

Acquired Immunodeficiency Syndrome and t h e P reven t ion o f I n t r a v e n o u s DrugAbuse (DA 8 7 - 1 0 )

Drug Abuse Aspec t s o f t h e Acquired Immunodeficiency Syndrome (DA 8 7 - 1 1 )

For t h e N a t i o n a l I n s t i t u t e o f Mental Hea l th ( N I M H ) Request f o r A p p l i c a t i o n s (RFA) p e r t a i n i n g t o AIDS Research Cen te r Gran t s (MH-86-09), t h e June 1 d e a d l i n e w i l l be moved t o Wednesday, May 25, 1 9 8 8 . T h e r e a f t e r , AIDS Research Cente r a p p l i c a t i o n s must b e r e c e i v e d on t h e s p e c i a l AIDS r e c e i p t d a t e s s t a t e d above o r on d a t e s s p e c i f i e d i n p a r t i c u l a r RFAs. N I M H p l a n s t o i s s u e AIDS RFAs i n t a r g e t e d , s u b s t a n t i v e areas.

For f u r t h e r i n f o r m a t i o n about ADAMHA AIDS programs, a p p l i c a n t s shou ld c o n t a c t :

Sue Badman, Ph.D. Deputy D i r e c t o r D i v i s i o n o f Basic Research , N I A A A Room 14C-10 Telephone: ( 3 0 1 ) 443-2530

Chie f , P reven t ion Research Branch, N I D A Room 10A-20 Telephone: (301 443-1514

q b d C l i n i c a l Medicine Branch, N I D A Room 10A-08 Telephone: ( 3 0 1 ) 443-1801

Chie f , Treatment Research Branch, N I D A Room 10A-30 Telephone: ( 3 0 1 ) 443-4060

E l l e n Simon S t o v e r . Ph.D. Deputy D i r e c t o r D i v i s i o n of Basic S c i e n c e s , NIMH Room 11-103 Telephoner ( 3 0 1 ) 443-3563

The m a i l i n g a d d r e s s f o r t h e above i n d i v i d u a l s is:

5600 F i s h e r s Lane R o c k v i l l e , Maryland 20857

APILICATION ASSIGNMENT SUGGESTIONS

P.T. 3 4 ; K.W. 0710030, 1014002

D i v i s i o n o f Research Gran t s

I n accordance wi th t h e i n s t r u c t i o n s f o r t h e a p p l i c a t i o n f o r a P u b l i c Hea l th S e r v i c e g r a n t , PHS 398 Rev. 9 / 8 6 (see page 1 1 1 , p r i n c i p a l i n v e s t i g a t o r s of a p p l i c a t i o n s f o r r e s e a r c h g r a n t s , r e s e a r c h c a r e e r development awards, and i n d i v i d u a l p o s t d o c t o r a l and s e n i o r f e l l o w s h i p s may sugges t t h e PHS component t o which it cou ld be a p p r o p r i a t e l y a s s i g n e d and up t o t h r e e i n i t i a l rev iew groups ( s t u d y s e c t i o n s ) t h a t t h e y would p r e f e r t o have rev iew t h e i r a p p l i c a t i o n s . These recommendations must b e submi t t ed i n a l e t t e r o f

A-' t r a n s m i t t a l a t t a c h e d t o t h e o r i g i n a l copy o f t h e a p p l i c a t i o n and shou ld i n c l u d e j u s t i f i c a t i o n s f o r each o f t h e recommendations made. The Referral S e c t i o n , R e f e r r a l and Review Branch o f t h e D i v i s i o n of Research Gran t s w i l l c o n s i d e r t h e s e r e q u e s t s when de te rmin ing t h e ass ignment .

3

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L i s t i n g s o f t h e fund ing components and membership o f review g roups may be found i n N I H Advisory Committees, a p u b l i c a t i o n t h a t is g e n e r a l l y k e p t i n l i b r a r i e s and o f f i c e s of sponsored r e s e a r c h .

N I H REGIONAL SEMINAR I N GRANTS ADMINISTRATION

P.T. 42; K.W. 1014002

N a t i o n a l I n s t i t u t e s o f H e a l t h

A two-day c o n f e r e n c e c o v e r i n g t o p i c s r e l a t e d t o g r a n t s a d m i n i s t r a t i o n a t t h e N a t i o n a l I n s t i t u t e s o f H e a l t h i s planned f o r June 27-28 a t Wel l e s l ey C o l l e g ei n W e l l e s l e y , Massachuse t t s . The c o n f e r e n c e i s t a r g e t e d f o r an aud ience o f r e s e a r c h e r s and r e s e a r c h a d m i n i s t r a t o r s a t i n s t i t u t i o n s i n t h e N o r t h e a s t r e g i o n which i n c l u d e s C o n n e c t i c u t , Maine, Massachuse t t s , N e w Hampshire, Rhode I s l a n d , and Vermont. F a c u l t y and s t a f f from small and m i n o r i t y c o l l e g e s ,f o r - p r o f i t r e s e a r c h o r g a n i z a t i o n s , h o s p i t a l s , u n i v e r s i t i e s , and r e s e a r c h i n s t i t u t e s are i n v i t e d . T h i s two-day c o n f e r e n c e h a s a d u a l f o c u s o f i n t e r e s t t o b o t h r e s e a r c h e r s and g r a n t s a d m i n i s t r a t o r s . D i s c u s s i o n s o f c u r r e n t i s s u e s t h a t a f fec t N I H fund ing and g r a n t s a d m i n i s t r a t i o n a re i n c l u d e d t o g i v ec o n f e r e n c e p a r t i c i p a n t s a comprehensive, up-to-date view o f NIH-sponsoredr e s e a r c h .

N I H s t a f f w i l l s e r v e as f a c u l t y , r e p r e s e n t i n g s e v e r a l o f t h e i n s t i t u t e s , t h e D i v i s i o n o f Research Gran t s , t h e D i v i s i o n o f Research Resources , and t h e Office o f t h e D i r e c t o r , N I H . P r e p a r a t i o n o f a p r o p o s a l and t h e N I H review p r o c e s s are i n c l u d e d as agenda t o p i c s , a l o n g w i t h s p e c i a l c o n c u r r e n t s e s s i o n s f o r l e s s r e s e a r c h - i n t e n s i v e i n s t i t u t i o n s , case s t u d i e s i n g r a n t a p p l i c a t i o n s ,post-award g r a n t s a d m i n i s t r a t i o n , and c u r r e n t developments i n F e d e r a l p o l i c y .P r e s e n t a t i o n s w i l l cove r review t r e n d s , r e s e a r c h f a c i l i t i e s , manpower programs, f i n a n c i a l management, t h e F l o r i d a Demonstrat ion P r o j e c t , and t h e r e v i s i o n t o OMB C i r c u l a r A-110. Policy and p r o c e d u r a l i s s u e s a f f e c t i n g N I H g r a n t s a d m i n i s t r a t i o n form t h e c o r e o f t h e program and t h i s shou ld be o f i n t e r e s t t o f a c u l t y , d e p a r t m e n t a l a d m i n i s t r a t o r s , sponsored programs s t a f f ,and b u s i n e s s management s t a f f . N I H p a r t i c u l a r l y encourages p a r t i c i p a t i o n byf o u r - y e a r c o l l e g e s and o t h e r l e s s r e s e a r c h - i n t e n s i v e i n s t i t u t i o n s .

Conference materials w i l l b e s a i l e d t o i n s t i t u t i o n s i n t h e N o r t h e a s t Region i n mid-April w i t h a d e a d l i n e f o r confere1,ce r e g i s t r a t i o n on June 8. E l i z a b e t h Lieberman a t W e l l e s l e y C o l l e g e i s i n cha rge o f confe rence a r r angemen t s . For more i n f o r m a t i o n , c o n t a c t h e r o r Ka th leen Stackhouse a t (617 ) 235-0320,Extens ion 2393.

The n e x t s chedu led N I H Regional Seminar i n G r a n t s A d m i n i s t r a t i o n i s November 28-29, 1988, i n San F r a n c i s c o , C a l i f o r n i a . I n f o r m a t i o n conce rn ing t h i s program w i l l b e fo r thcoming .

DATED ANNOUNCEMENTS (RFAs AND RFPs)

LEARNING DISABILITIES: MULTIDISCIPLINARY RESEARCH CENTERS

RFA AVAILABLE: 88-HD/NS-11

P.T. 04; K . W . 0710030, 0414005, 0715130, 0755030, 0415000

N a t i o n a l I n s t i t u t e o f C h i l d Hea l th and Human DevelopmentN a t i o n a l I n s t i t u t e o f N e u r o l o g i c a l and Communicative D i s o r d e r s and S t r o k e

A p p l i c a t i o n R e c e i p t Date: September 20, 1988

SCIENTIFIC PROGRAM OBJECTIVES

The N a t i o n a l I n s t i t u t e of C h i l d H e a l t h and Human Development ( N I C H D ) , t h rough t h e Human Lea rn ing and Behavior Branch ( H L B ) , Cen te r f o r Research f o r Mothers and C h i l d r e n (CRMC) and t h e N a t i o n a l I n s t i t u t e of Neuro log ica l and Communicative D i s o r d e r s and S t r o k e (NINCDS), t h rough t h e Developmental N e u r o l o g i c a l Branch ( D N B I , D i v i s i o n o f Convulsive, Developmental , and Neuromuscular D i s o r d e r s ( D C D N D ) , j o i n t l y i n v i t e program p r o j e c t a p p l i c a t i o n s (PO11 t o deve lop new knowledge i n t h e f i e l d s o f e t i o l o g y , d i a g n o s i s , p r e v e n t i o n , t r e a t m e n t , and a m e l i o r a t i o n o f l e a r n i n g d i s a b i l i t i e s . Programp r o j e c t a p p l i c a t i o n s must i n c l u d e r e s e a r c h on b a s i c b i o l o g i c a l and b e h a v i o r a l f a c t o r s r e l e v a n t t o l e a r n i n g d i s a b i l i t i e s . Four t o s i x program p r o j e c t s mayb e s u p p o r t e d in r e s p o n s e t o t h i s r e q u e s t f o r a p p l i c a t i o n s (RFA).

I-

4

MECHANISM OF SUPPORT

M u l t i d i s c i p l i n a r y r e s e a r c h on l e a r n i n g d i s a b i l i t i e s w i l l be suppor t ed t h r o u g h t h e program p r o j e c t g r a n t mechanism ( P o l ) .

For f u r t h e r i n f o r m a t i o n , p o t e n t i a l a p p l i c a n t s may c a l l o r w r i t e t o :

David B . Gray, Ph.D. H e a l t h S c i e n t i s t A d m i n i s t r a t o r , Human Learning Branch N a t i o n a l I n s t i t u t e o f C h i l d Hea l th and Human DevelopmentN a t i o n a l I n s t i t u t e s of Hea l th Execu t ive P l a z a North 633 9000 R o c k v i l l e P i k e Bethesda, Maryland 20892 Telephone: (301) 496-6591

o r

Sarah H. Broman, Ph.D. Hea l th S c i e n t i s t A d m i n i s t r a t o r , Developmental Neurology Branch

and Behavior

D i v i s i o n o f Convulsive, Developmental , and Neuromuscular D i s o r d e r s N a t i o n a l I n s t i t u t e o f Neuro log ica l and Communicative D i s o r d e r s and S t r o k e N a t i o n a l I n s t i t u t e s of H e a l t h F e d e r a l B u i l d i n g , Room 8C06 7550 Wisconsin Avenue Bethesda, Maryland 20892 Telephone: (301) 496-5821

T h i s program is d e s c r i b e d i n t h e Ca ta log o f F e d e r a l Domestic A s s i s t a n c e No. 13.865, Research f o r Mothers and C h i l d r e n and by Nos. 13.853 and 13.854,N a t i o n a l I n s t i t u t e o f Neuro log ica l and Communicative D i s o r d e r s and S t r o k e . Awards w i l l b e made under t h e a u t h o r i t y of t h e P u b l i c H e a l t h S e r v i c e A c t , S e c t i o n 301 (42 USC2411, and a d m i n i s t e r e d under PHS g r a n t p o l i c i e s and F e d e r a l R e g u l a t i o n s 42 CFR P a r t 52 and 45 CFR P a r t 74. T h i s program is n o t s u b j e c t t o review by a H e a l t h Systems Agency.

INVESTIGATION OF TISSUE COMPOSITION AND FUNCTION BY MRI USING PARAMAGNETICAND/OR SUPERPARAMAGNETIC CONTRAST AGENTS

RFA AVAILABLE: 88-CA-10

P.T. 34; K.W. 0706030, 0765035

N a t i o n a l Cancer I n s t i t u t e

A p p l i c a t i o n R e c e i p t D a t e : J u l y 7 , 1988

Thg D i v i s i o n of Cancer Treatment (DCT), o f t h e N a t i o n a l Cancer I n s t i t u t e ( N C I ) , t h rough t h e D i a g n o s t i c Imaging Research Branch o f t h e R a d i a t i o n Research Program, s e e k s a p p l i c a t i o n s f o r s t u d i e s t o improve and demons t r a t e t h e a b i l i t y t o v i s u a l i z e s e l e c t e d t i s s u e s and t o c h a r a c t e r i z e t h e i r composi t ion and f u n c t i o n a l s t a t e s by t h e employment o f paramagnet ic and /o rsupe rpa ramagne t i c r e sonance imaging ( M R I ) c o n t r a s t a g e n t s .

The pr imary o b j e c t i v e of t h i s RFA i s t o promote s t u d i e s employing paramagnet icand superparamagnet ic s u b s t a n c e s i n t h e i n v e s t i g a t i o n o f l o c a l i z a t i o n o f tumors , t i s s u e composi t ion, t i s s u e f u n c t i o n , and q u a n t i t a t i v e measurement o f normal and pathol.ogica1 p r o c e s s e s , e s p e c i a l l y as t h e s e p e r t a i n t o c a n c e r . Although t h e p r i n c i p a l focus o f t h i s RFA i s predominant ly on d e t e c t i o n and d i a g n o s i s , d i a g n o s t i c mon i to r ing of t r e a t m e n t r e sponse is a l s o an a c c e p t a b l e area o f i n v e s t i g a t i o n . The employment o f combined magnetic r e sonance imagingand spec t roscopy i n c o n j u n c t i o n w i t h c o n t r a s t a g e n t s would a l s o f a l l w i t h i n t h e scope o f t h i s s t u d y . A v a r i e t y of paramagnet ic and supe rpa ramagne t i c c o n t r a s t a g e n t s have been developed and can be used i n r e s e a r c h and c l i n i c a l a p p l i c a t i o n s as molecular p robes f o r t h e i d e n t i f i c a t i o n o f s p e c i f i c t i s s u e s and as a g e n t s t o monitor pha rmacok ine t i c behav io r i n t h e assessment of p h y s i o l o g i c f u n c t i o n and pa tho logy ,

The mechanism o f s u p p o r t f o r t h i s award i s N I H g r a n t - i n - a i d f o r a d u r a t i o n of t h r e e y e a r s . The e s t i m a t e d t o t a l budget f o r t h e f i r s t y e a r o f t h i s program is $400,000. It i s a n t i c i p a t e d t h a t approx ima te ly t h r e e s c i e n t i f i c a l l ym e r i t o r i o u s a p p l i c a t i o n s can be funded. T h i s award i s c o n t i n g e r t upon t h e a v a i l a b i l i t y of f u n d s . Non-profi t o r g a n i z a t i o n s and i n s t i t u t i o n s , governments

5

and t h e i r a g e n c i e s , f o r - p r o f i t o r g a n i z a t i o n s , and i n d i v i d u a l s are e l i g i b l e t o a p p l y . The p r e s e n t RFA announcement i s f o r a s i n g l e c o m p e t i t i o n w i t h a s p e c i f i e d d e a d l i n e o f J u l y 7, 1988.

A p p l i c a t i o n f o r a P u b l i c H e a l t h S e r v i c e Grant must be submi t t ed on PHS 398 (Rev i sed 9/86) form. A p p l i c a t i o n k i t s are a v a i l a b l e from most i n s t i t u t i o n a l b u s i n e s s o f f i c e s o r may be o b t a i n e d from:

D i v i s i o n of Research Gran t s N a t i o n a l I n s t i t u t e s o f H e a l t h Westwood B u i l d i n g , Room 449 Bethesda, Maryland 20892

A p p l i c a t i o n s must b e r e c e i v e d by J u l y 7, 1988. A p p l i c a t i o n s r e c e i v e d a f t e r t h a t d a t e w i l l b e r e t u r n e d . A l so , t h e DRG w i l l n o t a c c e p t any a p p l i c a t i o n i n r e s p o n s e t o t h i s RFA t h a t . is t h e same as one c u r r e n t l y b e i n g c o n s i d e r e d byt h i s o r any o t h e r N I H Awarding U n i t .

For c o p i e s o f t h e complete RFA o r f o r f u r t h e r i n f o r m a t i o n p l e a s e c o n t a c t :

Roger S. Powell , Program D i r e c t o r D i a g n o s t i c Imaging Research Branch R a d i a t i o n Research ProgramN a t i o n a l Cancer I n s t i t u t e , N I H Execu t ive P l a z a North, S u i t e 800 9000 R o c k v i l l e P ike Bethesda, Maryland 20892 Telephone: (301) 496-9531

O N G O I N G PROGRAM ANNOUNCEMENTS

BASIC STUDIES I N BONE MARROW TRANSPLANTATION

P.T. 34; K.W. 0745065, 0705005, 0710125, 0760020

N a t i o n a l I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseases

The Immunology, A l l e r g i c and Immunologic Diseases Program (IAIDP) o f t h e N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s D i s e a s e s , a component o f t h e N a t i o n a l I n s t i t u t e o f Hea l th , i n v i t e s g r a n t a p p l i c a t i o n s f o r s u p p o r t o f b a s i c ,p r e c l i n i c a l s t u d i e s i n t h e area o f bone marrow t r a n s p l a n t a t i o n .

BACKGROUND INFORMATION

Bone marrow t r a n s p l a n t a t i o n (BMT) is becoming a n i n c r e a s i n g l y impor t an tt h e r a p e u t i c p rocedure f o r t h e t r e a t m e n t o f a wide v a r i e t y o f d i s e a s e s ,i n c l u d i n g a p l a s t i c anemia, leukemia, c o n g e n i t a l immunodeficiencies , and most r e c e n t l y , AIDS. However, even though BMT is u n p a r a l l e l e d i n i t s e f f e c t i v e n e s s i n c u r i n g many f a t a l d i s e a s e s , t h i s t e c h n i q u e s u f f e r s from s e v e r a l s e r i o u s s i d e e f fec ts , i n c l u d i n g g r a f t - v s - h o s t d i s e a s e (GvHD) and prolonged immune d e f i c i e n c y f o l l o w i n g t r a n s p l a n t a t i o n . To overcome t h e problem o f GvHD, T ce l l s have been removed from t h e donor inoculum p r i o r t o t r a n s p l a n t a t i o n .T h i s maneuver v i r t u a l l y e l imina tes GvHD, b u t r e s u l t s i n two new c o m p l i c a t i o n s ,g r a f t f a i l u r e ( i . e . g r a f t r e j e c t i o n ) and a n i n c r e a s e d r a t e o f leukemic r e l a p s e . F u r t h e r , even i n t h e absence o f GvHD, many BMT p a t i e n t s a r e s u s c e p t i b l e t o i n f e c t i o n s f o r as l o n g as one y e a r f o l l o w i n g t r a n s p l a n t a t i o n ,presumably due t o impa i red immune c e l l r e c o n s t i t u t i o n .

RESEARCH GOALS AND SCOPE

The N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases ( N I A I D ) i s s o l i c i t i n g i n v e s t i g a t o r i n i t i a t e d r e s e a r c h g r a n t a p p l i c a t i o n s t h a t would l e a d t o c h a r a c t e r i z a t i o n o f t h e mechanisms u n d e r l y i n g t h e i n d u c t i o n o f GvHD, BM e n g r a f t m e n t , marrow r e j e c t i o n and/or t h e g ra f t -vs - l eukemia r e s p o n s e . The proposed r e s e a r c h may c o n s i s t o f i n v i t r o s t u d i e s , s t u d i e s i n animal models, o r bo th , b u t must be p r e c l i n i c a l i n n a t u r e . I n n o v a t i v e approaches are soughtand may a d d r e s s any a s p e c t o f bone marrow p r e t r e a t m e n t , r e j e c t i o n ,g r a f t - v s - h o s t r e a c t i o n , immune c e l l r e c o n s t i t u t i o n , t h e r o l e o f lymphokines o r growth f a c t o r s i n marrow r e c o n s t i t u t i o n and r e j e c t i o n , t h e r o l e o f c e l l s u r f a c e s t r u c t u r e s i n t h i s p r o c e s s , and t h e i n f l u e n c e o f t h e thymus g l and on e n g r a f t m e n t .

MECHANISMS OF SUPPORT

The mechanism o f s u p p o r t w i l l b e t h e i n d i v i d u a l r e s e a r c h p r o j e c t g r a n t ( R o l land t h e F i r s t Independent Research Support and T r a n s i t i o n (FIRST) award (R29).

6

WmJ

‘UUH

P o l i c i e s t h a t govern r e s e a r c h g r a n t programs o f t h e N a t i o n a l I n s t i t u t e s o f Hea l th w i l l p r e v a i l . The award of g r a n t s pu r suan t t o t h i s announcement i s c o n t i n g e n t upon r e c e i p t o f h i g h l y o r i g i n a l p r o p o s a l s o f h i g h s c i e n t i f i c merit,r e spons iveness t o t h i s announcement, relevance t o t h e program, and t h e a v a i l a b i l i t y o f a p p r o p r i a t e d funds .

APPLICATION AND REVIEW PROCEDURES

A p p l i c a n t s shou ld u s e t h e s t a n d a r d r e s e a r c h g r a n t a p p l i c a t i o n form PHS 398 (Rev. 9 / 8 6 ) . For pu rposes o f i d e n t i f i c a t i o n and p r o c e s s i n g , check y e s on item 2 of t h e f a c e page and e n t e r t h e t i t l e : “BASIC STUDIES I N BONE MARROW TRANSPLANTATION”. There are t h r e e r e c e i p t d a t e s f o r new a p p l i c a t i o n s : February 1 , June 1 , and October 1 . A l l a p p l i c a t i o n s w i l l be a s s i g n e d by t h e D i v i s i o n o f Research Gran t s f o r review accord ing t o t h e N I H p r o c e s s f o r r e g u l a r r e s e a r c h g r a n t a p p l i c a t i o n s . A p p l i c a t i o n s recommended f o r approva l w i l l compete f o r a v a i l a b l e funds w i t h a l l o t h e r approved a p p l i c a t i o n s a s s i g n e d t o t h e N I A I D . A b r i e f cove r l e t t e r shou ld be a t t a c h e d i n d i c a t i n g submiss ion i s i n r e sponse t o t h e N I A I D announcement. The o r i g i n a l and s i x c o p i e s o f t h e a p p l i c a t i o n shou ld be submi t t ed t o :

D i v i s i o n o f Research Gran t s N a t i o n a l I n s t i t u t e s of Hea l th Westwood B u i l d i n g , Room 240 Bethesda, Maryland 20892X*

A p p l i c a n t s are r e q u e s t e d t o m a i l a copy of t h e face page t o :

D r . J a n e S. S c h u l t z o r D r . W i l l i a m Duncan Gene t i c s and T r a n s p l a n t a t i o n Biology Branch, IAIDP Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases Westwood B u i l d i n g , Room 754 Bethesda, Maryland 20892 Telephone: (301) 496-5598

Reques ts f o r a d d i t i o n a l i n f o r m a t i o n or q u e s t i o n s r e g a r d i n g t h i s program may b e d i r e c t e d t o e i t h e r o f t h e above.

XSTHE M A I L I N G ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF I N THE WESTWOOD BUILDING I S THE CENTRAL M A I L I N G ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER’S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD B U I L D I N G IS :

5333 Westbard Avenue Bethesda , Maryland 20816

*U.S. COVERNAENT P R I N T I N G OFF ICE:1988-201-770:60J36 7