NIH Challenge Grants in Health and Science Research RFA OD-09-003.
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Transcript of NIH Challenge Grants in Health and Science Research RFA OD-09-003.
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NIH Challenge Grants in Health and Science Research
RFA OD-09-003
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Background
• New funds to NIH for 2009 and 2010 as part of the ARRA
• Challenge areas should have a high impact
• Novel research that addresses knowledge gaps, opportunities, new technologies, data generation, or research methods
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Nuts and Bolts• Deadline is April 27, to DEH by April 13th!
• Non-modular budget up to $500,000 / year total cost for two years
• Earliest start date 9/30/09
• Research plan is limited to 12 pages
• NO resubmissions
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Useful websites
• http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-09-003.html
• http://grants.nih.gov/recovery/faqs_challenge.html
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Useful (?) websites
• http://grants.nih.gov/grants/funding/challenge_award/Omnibus.pdf --a 181 page document
• http://www.niehs.nih.gov/recovery/challengegrants.cfm --NIEHS Challenge topics
• http://grants.nih.gov/grants/funding/challenge_award/IC_ChallengeWebPage.htm
--all institutes
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Review Criteria
• The new (2010) criteria will be used for Recovery Act FOAs.
• http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-025.html
• For comparison of current and new criteria
• http://grants.nih.gov/grants/peer/side_by_side_comparison.doc
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Grant preparation
• Project summary / abstract
• Bibliography and references – 1 page
• Biosketch – 2 pages. Limit publications to TEN (10)
• Specific Aims – 1 page
• Research plan—12 pages
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Additional sections• Inclusion Enrollment Report • Protection of Human Subjects • Inclusion of Women and Minorities • Targeted/Planned Enrollment • Inclusion of Children • Vertebrate Animals • Select Agent Research • MPI Leadership Plan • Consortium/ Contractual Arrangements • Letters of Support • Resource Sharing Plans – Data Sharing Plan, Sharing Model
Organisms, and Genome-Wide Association Studies
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Research Plan
• Research area and project title
• The challenge and potential impact
• Approach
• Timeline and milestones
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The Challenge / Potential Impact
• What is the research opportunity, scientific knowledge gap or technology that will be addressed?
• How broad is the potential impact in science and/or health?
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The Challenge / Potential Impact
• Which community will be affected?
• What is the size of the community?
• Will the potential impact be major?
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The Challenge / Potential Impact
• What is the disease or condition that will be studied ?
• What is the hypothesis to be tested concerning mechanisms underlying this disease/condition?
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The Challenge / Potential Impact
• How will the work disrupt the standard paradigm or create a paradigm where none exists?
• How will the results transform our understanding of this disease/condition?
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The Approach •Provide enough information that reviewers can determine what, in general, you areproposing to do, but do not include a detailedexperimental plan.
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The Approach
• If your methodology is novel, what is unconventional and exceptionally innovative about your approach?
• How does your approach differ from what other investigators have attempted to do?
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Timeline and Milestones•Why is the proposed research uniquely suited to the stated goals of the challengeinitiative?
•What is the likelihood of success?
•Provide a timeline for the proposed research.
•To facilitate evaluation of progress reports,describe when you anticipate that essentialcomponents of the project will be completed.
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New Scoring System• 9-point scale (1 = exceptional; 9 = poor)
• Before review meeting, reviewers and discussant will give a 1 – 9 for each area:
• Significance
• Investigator(s)
• Innovation
• Approach
• Environment
You will receive the scores for these criteria, even if your grant is “triaged”
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New Scoring System (cont)
• Priority Scores: Before the review meeting, each reviewer and discussant will give a preliminary impact score for that application.
• This score is evaluation of the overall impact, rather than a weighted average to previous review criteria.
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Other ARRA Concepts• Comparative Effectiveness Research (CER)
» Role of trials versus observational studies» Establishing priorities» Optimally using existing resources» Coordinating federal agencies and other research
collaborators» Improving research methods» What’s the importance of cost?
• Public-Private Partnerships http://ppp.od.nih.gov/
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Caveats!
No plan survives contact with the enemy
“High achievement always takes place in the framework of high expectation.”
–Charles Kettering