NIGMS Award: 1U54GM104944-01A1

Mountain West Research ConsortiumClinical Translational Research –

Infrastructure Network

The Mountain West CTR-IN

Robert D. Langer, MD, MPHPrincipal Investigator

Research Professor of Allied Health Sciences, UNLVAssociate Dean for Clinical and Translational Research and Professor

of Family Medicine-Las Vegas, UNSOM

What is it?

$20.3m 5 year NIH Grant Proposal under the IDeA Program

Involving 13 universities across the 7 IDeA states in the Mountain West Research Consortium

Support: to foster Clinical and Translational Research

(CTR) according to NIH Definitions

for Core Resources to facilitate the development of researchers moving into CTR

BOOTSTRAP CTR ACROSS THE MOUNTAIN WEST

“a rising tide that … … lifts all ships.”

We will sink or swim based on the increase in “R-level” translational

and clinical research that we achieve across the region over

the next 4 years

Who is in it?

UNLV [host] UNR/UNSOM U. Alaska – Anchorage U. Alaska – Fairbanks U. Hawaii – Manoa Boise State U. Idaho State U. U. Idaho

Montana State U. U. Montana New Mexico State U. U. New Mexico U. Wyoming

What will it do?

Provide pilot grant support of $50,000 - $75,000/year

Support Mini-Sabbatical and Visiting Scholar awards to build collaborations

Provide infrastructure and services through Key Component Activities

Funding preference

Promising Early Career or New Investigators developing clinical or translational research programs

Established Investigators moving from bench to translational or clinical

Projects focused on health issues relevant to the region, including those in rural and vulnerable populations

What will it do?

Use an NIH-style approach to applications and funding

Model the processes that clinical and translational investigators need to master to compete successfully for NIH support

Key Component Activities (KCAs)

Education, Mentoring & Career Development KCA

Study Design & Biostatistics KCA

Pilot Grant KCA

Administrative KCA, including editorial support, award management, Annual Meeting

EducationMentoring

Study DesignBiostat

Annual Meeting

ALL AVAILABLE regardless of whether you’ve received a

competitive award from the CTR-IN

What will it do?

Hold an Annual Meeting to share science, motivate, build collaborations, & conduct study business that will: rotate across the 13 partner institutions feature an annual research theme relevant to

health in the regionbring together supported investigators, interested

researchers from the region, key administrators from partners, external scientists, the regional biostat team, and senior project staff

First Annual Meeting at UNLV June 23 – 25, 2014

free registration, hotel rate ~ $100/night

What’s the current status?

Round 1 Pilot Grants: 24 applications, 6 awarded

Round 1A Pilot Grants: 63 applications, 14 awarded

Year 1 Pilot Grants

Round 1 Round 1A Total

Boise State 0 3 3

Idaho State 0 1 1

Montana State 2 1 3

New Mexico State 0 1 1

U Alaska - Anchorage 0 1 1

U Alaska - Fairbanks 0 1 1

U Idaho 0 1 1

U Montana 2 0 2

U Nevada Las Vegas 1 3 4

U Nevada Reno 1 1 2

U Wyoming 0 1 1

6 14 20

What’s the current status?

Round 2 Pilot Grant RFA for 7/1/14 – 6/30/15:Letters of Intent with Abstacts were due 3/7/14

122 LOIs with Abstracts received

Invitations to submit 3/14/14Applications due 4/25/14Awards announced at Annual Meeting 6/25/14Earliest start date 7/1/14

All information at: ctrin.unlv.edu

U. Alaska Anchorage 8

U. Alaska Fairbanks 5

Boise State U. 3

Idaho State U. 14

U. Idaho 8

Montana State U. 7

U. Montana 5

New Mexico State U. 9

UNR 23

UNLV 30

U. Wyoming 10

Letters of Intent for Year 2 Pilot Grants

Total 122

Visiting Scholars

Call still open

Funds must be expended by 06/30/14

4 applications to-date, all awardedU Montana – to PG Awardee

UNLV – to PG Awardee

U Hawaii

UNLV

PEOPLE!

Your First Call …

the ISU Concierge

Dr. Rex Force

Senior Leadership

Administrative Core

Bob Langer, UNLV, PI

Jim Kenyon, UNR, Proj Coord.

Carl Reiber, UNLV, Assoc. Dir.

John Foreyt, UNSOM, Eval. Dir.

Pilot Grants

Curtis Noonan, UMT, Director

Bill Shuttleworth, UNM, Assoc. Dir.

Education & Mentoring

Jillian Inouye, UNLV, Directorer

Bruce Shiramizu, UH, Mentoring

Pope Moseley, UNM, Mentoring

Merle Kataoki-Yahiro, UH, Educ

Craig Molgaard, UMT, Educ

Design, Epidemiology, Biostat

Pope Moseley, Director

UNM CTSA: Richard Larson

website

ctrin.unlv.edu

NIGMS Award: 1U54GM104944-01A1

What are the 7 Mountain West states?

Alaska

Hawaii

Idaho

Montana

Nevada

New Mexico

Wyoming

What will it do?

Identify, support, and facilitate promising researchers to achieve independent success as with R-level funding from the NIH

Foster collaborations to leverage regional expertise to develop robust clinical and translational programs

Engage the consortium of regional biostatisticians to develop innovative methodology and novel applications of existing tools

Engage successful researchers from outside the region as an External Advisory Committee providing experience and expanded reach

Admin KCARobert Langer, MD, MPH, KCA Director

Carl Reiber, PhD, Assoc. DirectorJim Kenyon, PhD, Project Coordinator

CRDEB KCAPope Moseley, MD, KCA Director

Pilot Grant KCACurtis Noonan, PhD, KCA Director

AFFILIATION COLOR CODEUNLV

UNSOMU. New Mexico

U. MontanaNIH

Other Institutions

Internal Advisory Committee Carolyn Yucha, PhD, Co-Chair

Thomas Schwenk, MD, Co-ChairVPRs of all 13 Partner Universities

Robert Langer, MD, MPH, PI, ex oficioJim Kenyon, PhD, Project Coordinator, ex oficio

External Advisory Committee6 to 10 External Scientists

from outside the 7 state region

Steering CommitteeRobert Langer, MD, MPH, Principal InvestigatorJim Kenyon, PhD, Project Coordinator, Partners

John Foreyt, PhD, Project Coordinator, T&ERafael Gorospe, MD, PhD, Project Officer

Maria Canto, DDS, MS, MPH, Project Scientist

Executive CommitteePI

2 Project Coordinators3 [4 with PI] KCA DirectorsAssoc. Director, Admin KCA

Lead LiaisonCTSC Coordinator

Principal InvestigatorRobert Langer, MD, MPH

Educ & Mentoring KCAJillian Inouye, PhD, KCA Director

Mentoring Unit Education Unit

Regional Biostatistician Network

Mountain West CTR-IN Organizational StructureGovernance and Membership

UNM CTSCRichard Larson, MD, Coord.

Track & Eval UnitJohn Foreyt, PhD,

Project Coordinator

ConciergesJill Zimbelman, Lead Concierge

Regional Network