Nidrajanana drugs a scientific review
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Transcript of Nidrajanana drugs a scientific review
WEL COME1
Dr.Bidhan MahajonDr.Bidhan Mahajon
2
3
4
"Nidraajanana" "Nidraajanana" DrugsDrugs
A scientific reviewA scientific review
5
ScholarScholar
Dr.Bidhan MahajonDr.Bidhan Mahajon
GuideGuide
Dr. Remadevi.R. MD(AYU) Dr. Remadevi.R. MD(AYU)
Professor and H.O.D Professor and H.O.D
Department of Dravyaguna VijnanamDepartment of Dravyaguna Vijnanam V.P.S.V. Ayurveda CollegeV.P.S.V. Ayurveda College
Kottakkal Kottakkal 6
ContentsContents IntroductionIntroduction
Modern view of sleep, Insomnia & its managementModern view of sleep, Insomnia & its management
Ayurvedic view of Nidra,Anidra & its managementAyurvedic view of Nidra,Anidra & its management
Pharmacodynamics of Nidrajanana DrugsPharmacodynamics of Nidrajanana Drugs
Scope of further research Scope of further research
Conclusion Conclusion
7
Prevalence of InsomniaPrevalence of Insomnia
About 30% of adults have insomnia.About 30% of adults have insomnia.
About 10% of adults, severe insomnia.About 10% of adults, severe insomnia.
Less than 10% of adults chronic insomnia.Less than 10% of adults chronic insomnia.
88
9
Demand of Safe Option
20,000 species are being used
40% of Population are depending on alternative or complimentary therapies.
They spent over $27 billion.
10
11
SleepSleep
12
William Dement, founder of Stanford
University's Sleep Research Centre.
"As far as I know, the only reason we need to sleep that is really, really solid is because we get sleepy."
13
DefinitionDefinition
Naturally recurring state characterized by- Naturally recurring state characterized by-
Diminished consciousness Diminished consciousness
Inhibition of sensory activity Inhibition of sensory activity
Inhibition of voluntary musclesInhibition of voluntary muscles
Diminished reaction to stimuli Diminished reaction to stimuli
14
15
16
17
Sleep DurationSleep Duration
““Sleeping for six to seven hours each night, Increase Sleeping for six to seven hours each night, Increase life span.”life span.”
““Sleeping more than 7 to 8 hours per day has been Sleeping more than 7 to 8 hours per day has been consistently associated with increased mortality.” consistently associated with increased mortality.”
““Reduced morbidity only occurs with those who Reduced morbidity only occurs with those who wake naturally, rather than those who use an alarm”.wake naturally, rather than those who use an alarm”.
18
Sleep, Regulated by GeneticsSleep, Regulated by Genetics
ABCC9 ABCC9
DEC2DEC2
((Neurology professor Ying-Hui FuNeurology professor Ying-Hui Fu))19
20
InternationalInternational classification of sleep disorders classification of sleep disorders
Six major categories:Six major categories:
InsomniaInsomnia
Sleep related breathing disordersSleep related breathing disorders
HypersomniasHypersomnias
Circadian rhythm sleep disorderCircadian rhythm sleep disorder
ParasomniaParasomnia
Sleep related movement disordersSleep related movement disorders21
22
InsomniaInsomnia
InsomniaInsomnia
Hard time initiating sleep.Hard time initiating sleep.
Struggle to maintain sleep.Struggle to maintain sleep.
Waking up frequently during the night.Waking up frequently during the night.
Tend to wake up too early. Tend to wake up too early.
Sleep is non restorative or of poor quality. Sleep is non restorative or of poor quality. 23
Types of insomniaTypes of insomnia
Two types of insomnia – Two types of insomnia –
1.Primary- Drug abuse or medications.1.Primary- Drug abuse or medications.
2.Secondary- Primary medical illness, mental 2.Secondary- Primary medical illness, mental disorders or other sleep disorders. disorders or other sleep disorders.
24
Types of InsomniaTypes of Insomnia
Adjustment insomniaAdjustment insomnia
Behavioural insomniaBehavioural insomnia
Idiopathic insomniaIdiopathic insomnia
Inadequate sleep hygieneInadequate sleep hygiene
Paradoxical insomniaParadoxical insomnia
Psychophysiological insomniaPsychophysiological insomnia
25
General Management of General Management of InsomniaInsomnia
26
SedativesSedativesBenzodiazepinesBenzodiazepinesAntipsychoticsAntipsychotics
HypnoticsHypnoticsAntihistaminesAntihistaminesZolpidemZolpidemBenzodiazepines (rapid onset, short t1/2)Benzodiazepines (rapid onset, short t1/2)
AnxiolyticsAnxiolyticsBenzodiazepines (acute)Benzodiazepines (acute)Antidepressants (chronic)Antidepressants (chronic)
2727
““NIDRA”NIDRA”
28
What is nidra? What is nidra?
““Nindyate iti nidra”(Sabdakalpadrumam)Nindyate iti nidra”(Sabdakalpadrumam)
Avasthaa of mind:Avasthaa of mind:
Jaagradavastha Jaagradavastha
Svapnavastha Svapnavastha
Sushuptiavastha Sushuptiavastha
TureeyavasthaTureeyavastha29
Nidra-when and why?Nidra-when and why?
""यदा� तु� मनसि क्ला�न्तु� कम��त्म�न� क्लाम�न्विन्�तु��।यदा� तु� मनसि क्ला�न्तु� कम��त्म�न� क्लाम�न्विन्�तु��।
वि�षय�भ्य� विन�तु�न्तु� तुदा� स्�वि�वितु म�न��॥“वि�षय�भ्य� विन�तु�न्तु� तुदा� स्�वि�वितु म�न��॥“
((चच..��--२१२१//३५३५))
30
Nidra- when and why?Nidra- when and why?
""ह्र्दायम$ च�तुन�स्था�नम�क्तम$ �श्रु�तु दा�वि(न�म$ ह्र्दायम$ च�तुन�स्था�नम�क्तम$ �श्रु�तु दा�वि(न�म$ ||||
तुम�तुम�भि**+तु�भि**+तु� तुस्मिंस्म-स्तु� तुस्मिंस्म-स्तु� विनद्रा�विनद्रा� वि�शवितु दा�वि(नम$॥ वि�शवितु दा�वि(नम$॥
विनद्रा(�तु�स्तुम� त्�0 बो�धन� (�तु�रुच्यतु� विनद्रा(�तु�स्तुम� त्�0 बो�धन� (�तु�रुच्यतु�
स्�*��स्�*�� ए� ए� �� (�तु�र्ग�री8यन$ �रिरीक:त्य�तु�॥�� (�तु�र्ग�री8यन$ �रिरीक:त्य�तु�॥
(Su. Sha.-4(Su. Sha.-4//3535) )
31
According to vaagbhataAccording to vaagbhata
"ला�क�दिदा र्ग�प्र*�� तुम�म�ला�तुम�म�ला� तुम�मय8 तुम�मय8 ��हुल्य�त्तम� री�त्रौA विनद्रा� प्र�य�न जा�यतु� श्ले�ष्म�Eत्त�ष� स्रो�तु�� श्रुम�दु�रीतु�ष� च।इन्द्रिन्द्राय�ष� स्�कम�भ्य� विनद्रा� वि�शवितु दा�वि(न�म$॥"
(As.sa.su 9) (As.sa.su 9)
32
Types of nidra Types of nidra
“ “ तुम�*�� श्ले�ष्म म�द्भ�� चतुम�*�� श्ले�ष्म म�द्भ�� च
मनशरी8री श्रुम म्भ�� च मनशरी8री श्रुम म्भ�� च
आर्गन्तु�क: व्या�ध्यन��र्तितु-न8 च$ आर्गन्तु�क: व्या�ध्यन��र्तितु-न8 च$
री�वित्रौ स्�*�� प्र*�� च विनद्रा�री�वित्रौ स्�*�� प्र*�� च विनद्रा� ||”||”
(Ch.su21/58) (Ch.su21/58)
33
3 Types of Nidra3 Types of Nidra
VaishnaviVaishnavi
TaamasiTaamasi
VaikaarikiVaikaariki
34
Effects of NidraEffects of Nidra
“विनद्रा�तु� �वि�तु�क�ला�ध�तु� �म्यतु� इन्द्रिन्द्रात्�म$ ��विQम$
�र्ण�म$ बोला�त्�(म$ �ह्निTदाUन्विVतु करी�वितु वि( ||”
(B.P.5/3-5) (B.P.5/3-5)
35
Unhealthy Nidra habits Unhealthy Nidra habits
‘‘Divaasvapna’Divaasvapna’
‘ ‘Raatrijaagarana’ Raatrijaagarana’
3636
AnidraAnidra
37
ClassificationClassification
SvatantraSvatantra
ParatantraParatantra
38
Anidra, not in all Vata rogas
Diseases where the Shula (pain) exists
Many psychic conditions
39
Samprapti
40
Nidana
41
Aharaja,Viharaja & Anya
Manasika
Increased Vata
Increased pitta
Decreased kapha
Increased satva
Increased raja
Decreased Tama
Kapha kshaya Tama kshaya
Lack of Sleshma Tama avarana to Sanjnavaha srota
Nidra Nasha
ManagementManagement
External and Internal medication
Psychic management (Adravyachikitsa)
Yoga
42
Pharmacodynamics Pharmacodynamics
of of
Nidrajanana drugsNidrajanana drugs
43
44
45
46
47
""विनद्रा�श्ले�ष्मतुम*��“विनद्रा�श्ले�ष्मतुम*��“ Responsible Dosa for Anidra:Responsible Dosa for Anidra:
Vata-NidranashaVata-Nidranasha
Pitta-AlpanidraPitta-Alpanidra
Nidrajanana Drug - Vata, Pitta Nidrajanana Drug - Vata, Pitta samaksamak
48
""ओजा�म�त्मकओजा�म�त्मक……”……”
(Ca.Su-17/76,77)(Ca.Su-17/76,77)
49
50
How madakari dravya induce sleep??How madakari dravya induce sleep??
""बो�भिZला�म्पवितु यदा$द्रा$व्या0 मदाक�रिरी तुदुच्यतु�। बो�भिZला�म्पवितु यदा$द्रा$व्या0 मदाक�रिरी तुदुच्यतु�।
तुम�र्ग�र्णप्रध�न0 तुम�र्ग�र्णप्रध�न0 च यथा� मद्यं0 �री�दिदाकम$॥च यथा� मद्यं0 �री�दिदाकम$॥" "
((श�श�..00..����--४४//२१२१))
5151
Guna of Madakaari Dravya
Laghu, Ushna, Rooksha, Teekshna, Khara etcLaghu, Ushna, Rooksha, Teekshna, Khara etc
र्ग�रु श8तु0 मEदु स्निस्नग्ध0 बो(ला0 मध�री0 स्थिस्थारीम$। र्ग�रु श8तु0 मEदु स्निस्नग्ध0 बो(ला0 मध�री0 स्थिस्थारीम$।
प्रन्नं0 वि�स्थिcला0 श्लेक्ष्र्णप्रन्नं0 वि�स्थिcला0 श्लेक्ष्र्णम�जा�म�जा� दाशर्ग�र्ण0 स्मEतुम$॥ दाशर्ग�र्ण0 स्मEतुम$॥
((चच..सिचसिच--२४२४))
52
How madakari dravya induce sleep??How madakari dravya induce sleep??
Visramsa: “Visramsa: “न्धिfवि�श्ले�ष� र्ग�त्रौ�न�0दान0 दा�षच्य�न0न्धिfवि�श्ले�ष� र्ग�त्रौ�न�0दान0 दा�षच्य�न0 विgय�सिन्नंरी�धश्च विgय�सिन्नंरी�धश्च वि�स्रो0�॥वि�स्रो0�॥””
Vyapada: Vyapada: ““स्तुब्धर्ग�रुर्ग�त्रौतु���तुश�फो��र्ण�*�दा�ग्ला�विनस्तुब्धर्ग�रुर्ग�त्रौतु���तुश�फो��र्ण�*�दा�ग्ला�विन स्तुन्द्रा�स्तुन्द्रा� विनद्रा� विनद्रा� च व्या��न्नं�॥च व्या��न्नं�॥””
Kshaya:Kshaya: ““म+c��म+c��म�0क्षय�म�(� प्रला��� म�0क्षय�म�(� प्रला��� मरीर्णह्निमवितुमरीर्णह्निमवितु च क्षय�॥ च क्षय�॥””
((��..++--१५१५) )
53
How madakari dravya induce sleep??How madakari dravya induce sleep??
Madakari (Madya,Ahiphen etc)
Acts on oja (By opposite guna)
Visramsa(Displaced)
Vyapada(Mixed with dosha)
Nidraa(Vaikariki nidra)
54
Vikaasi Dravya
न्धिfबोf�स्तु�0 भिशसिथाला�न्यत्करी�वितु वि�कभिश तुतु$॥न्धिfबोf�स्तु�0 भिशसिथाला�न्यत्करी�वितु वि�कभिश तुतु$॥
वि�श्ले�ष्य�जाश्चवि�श्ले�ष्य�जाश्च ध�तु�भ्य� यथा� gम�क क�द्रा���॥ ध�तु�भ्य� यथा� gम�क क�द्रा���॥
((श�श�..प्रप्र--४४//२०२०--२१२१))
Kramuka-Areca catechu(L.)Kramuka-Areca catechu(L.)
Arecolin-SedativeArecolin-Sedative55
How milk induce sleep??How milk induce sleep??
Shresta Nidraa janakamShresta Nidraa janakam
56
“.....�थ्य0 ��तुवि�त्त वि�क�रिरीर्ण�म॥" (च.+-१)
How milk induce sleep??How milk induce sleep??
Similar guna with ojaSimilar guna with oja
Acts oja-Acts oja-ओजा��EZ� वि( दा�(स्यओजा��EZ� वि( दा�(स्य तु�विQ��विQबोला�दाय�॥तु�विQ��विQबोला�दाय�॥””
((अअ..विoविo..++--११११//४१४१))
Acts on Kapha-SatvaActs on Kapha-Satva
57
Mode of action of Nidraajanana DrugsMode of action of Nidraajanana Drugs
Acts on tama-imbalance of oja-sleepActs on tama-imbalance of oja-sleep
Acts on kapha-oja-satva-sleepActs on kapha-oja-satva-sleep
58
59
Manasamitra Vataka Manasamitra Vataka
““While the Clonazepam group saw a 67% improved While the Clonazepam group saw a 67% improved disposition, the Manasamitra Vataka group experienced disposition, the Manasamitra Vataka group experienced an average improvement of 73%. The group who also an average improvement of 73%. The group who also received Shirodhara therapy saw the most dramatic received Shirodhara therapy saw the most dramatic change, with a 91% improvement in symptoms”. change, with a 91% improvement in symptoms”.
(NIMHANS) (NIMHANS)
60
Mode of drug selectionMode of drug selection
Kapha vardhaka
Satvaguna vardhaka
61
Mode of drug selectionMode of drug selection
Snigdha,Picchila-SankhapuspiSnigdha,Picchila-Sankhapuspi
Madhura,Snigdha-JathaamaansiMadhura,Snigdha-Jathaamaansi
Snigdha,Madhura,Sheeta-KusmandaSnigdha,Madhura,Sheeta-Kusmanda
Sugandhi,Jivaniya,RasayaniyaSugandhi,Jivaniya,Rasayaniya62
Mode of action of Mode of action of some common some common
drugsdrugs
63
64
Table: Ayurvedic plants proved as sedative
64
65
Table: Ayurvedic plants proved as sedative
65 04/09/23
Vatasamana Drugs
66
Sarpagandha(Amalpori)Sarpagandha(Amalpori)
Rouwolfia serpentina(Kuz.)
Family-Apocynaceae
Rasa-Tikta,katu
Guna-Ruksha
Vipaka-Katu
Veerya-Ushna
Useful part-Root
67
""कफो��तु(री� विनद्रा�प्रदा� oEदा��दिदान8कफो��तु(री� विनद्रा�प्रदा� oEदा��दिदान8" " ((*�*�..प्रप्र))
Ashwagandha(Amukkuram)Ashwagandha(Amukkuram)
Withania somnifera(L)Withania somnifera(L)
Family –SolanaceaeFamily –Solanaceae
Rasa-Katu,Tikta,KasayaRasa-Katu,Tikta,Kasaya
Guna-Laghu,SnigdhaGuna-Laghu,Snigdha
Veerya-UshmaVeerya-Ushma
Vipaka-KatuVipaka-Katu
Useful part-RootUseful part-Root
68
"म�रुतुन्धिpन- म�रुतुम$ ��तुवि�क�रीम$ (न्विन्तु" (�.विन)
Ashwagandha(Amukkuram)
GABA mimetic action- Sedative
-Anticonvulsive
(Kulkarni SK, et al)
Stress-induced changes of dopamine Stress-induced changes of dopamine receptors in the corpus striatum.receptors in the corpus striatum.
(Upton R, ed: Amer Herbal Pharmacopoeia 2000:1-25.)(Upton R, ed: Amer Herbal Pharmacopoeia 2000:1-25.)69
70
Jyotismati(Cherupunna)Jyotismati(Cherupunna)
Celastrus paniculatus(L.)
Family- Celastraceae
Rasa-Katu,Tkta
Guna-Ruksha,Tikshna
Vipaka-Katu
Veerya-Ushna
Bha.Pra.
“Vahnibuddhismritiprada”
04/09/23
Jathamansi(Jatamanci)Jathamansi(Jatamanci)
71
Nardostachys grandiflora Nardostachys grandiflora DC.DC.
Family-ValerianaceaeFamily-Valerianaceae
Rasa-Tikta,Kasaya,MadhuraRasa-Tikta,Kasaya,Madhura
Guna-Laghu,SnigdhaGuna-Laghu,Snigdha
Vipaka-KatuVipaka-Katu
Veerya-SheetaVeerya-Sheeta
""म�0सि वितुक्त� कष�य� च म�ध्य� क�न्विन्तु�लाप्रदा�म�0सि वितुक्त� कष�य� च म�ध्य� क�न्विन्तु�लाप्रदा�" " ((*�*�..प्रप्र.. ))
Jathamansi(Jatamanci)Jathamansi(Jatamanci)
Antidepressant activity:Antidepressant activity:
Norepinephrine (NE)Norepinephrine (NE)
Dopamine (DA)Dopamine (DA)
Serotonin (5-HT)Serotonin (5-HT)
5-hydroxyindoleacetic acid (5-HIAA)5-hydroxyindoleacetic acid (5-HIAA)
Gammaaminobutyric acid (GABA)Gammaaminobutyric acid (GABA)
(Prabhu V et al)(Prabhu V et al)
72
Tagara(Tagaram)Tagara(Tagaram)
73
Valeriana officinalis Valeriana officinalis Linn.Linn.
Family-ValerianaceaeFamily-Valerianaceae
Rasa-Tikta,Katu,KasayaRasa-Tikta,Katu,Kasaya
Guna-Laghu,SnigdhaGuna-Laghu,Snigdha
Veerya-UshmaVeerya-Ushma
Vipaka-KatuVipaka-Katu
Karma-Kapha,Vata haraKarma-Kapha,Vata hara
Tagaram...Tagaram...
Anxiolytic - 6-methylapigenin (MA) Anxiolytic - 6-methylapigenin (MA)
Sedative - glycoside 2S (-) hesperidin (HN)Sedative - glycoside 2S (-) hesperidin (HN)
Glycoside linarin (LN)Glycoside linarin (LN)
(Fernández et al) (Fernández et al)
74
Tagaram...Tagaram...
INTERACTIONS: INTERACTIONS:
May potentiate the effect of alcoholMay potentiate the effect of alcohol
CNS depressantsCNS depressants
Sedatives. Sedatives.
75
76
Vachaa(Vayambu)Vachaa(Vayambu)
Acorus calamus Acorus calamus Linn.Linn.
Family-AraceaeFamily-Araceae
Rasa-Katu,TiktaRasa-Katu,Tikta
Guna-Laghu,TikshnaGuna-Laghu,Tikshna
Veerya-UshnaVeerya-Ushna
Vipaaka-KatuVipaaka-Katu
Vachaa(Vayambu)
Acorus oil - Sedative-tranquillizingactionAcorus oil - Sedative-tranquillizingaction
Roots and Rhizomes CNS depressantRoots and Rhizomes CNS depressant
Leaves analeptic/ CNS stimulant activityLeaves analeptic/ CNS stimulant activity
77
Pitta Samanam Drugs
78
Brahmi (Nirbrahmi)Brahmi (Nirbrahmi)Bacopa monnieri[Linn]Pennel
Family-Scrophulariaceae
Rasa-Tikta,Kasaya.
Guna-Laghu,Sara
Vipaka-Madhura
Veerya-Sheeta
Part use-Whole plant
79""ब्रा�ह्मिw तु� वि�स्निxला�य�ष्य�री�न्म�दावि�न�भिशविन“ब्रा�ह्मिw तु� वि�स्निxला�य�ष्य�री�न्म�दावि�न�भिशविन“ ((��..विनविन))
Adverse reactionsAdverse reactions
Gastrointestinal upset
Nausea.
Drowsiness.
Brahmoside and brahminoside- sedative effects.
80
Mandukaparni(Muttil)Mandukaparni(Muttil) Centella asiatica (Centella asiatica (Linn).Linn).
Family-ApiaceaeFamily-ApiaceaeRasa-Tikta,Kasaya,MadhuraRasa-Tikta,Kasaya,MadhuraGuna-LaghuGuna-LaghuVipaka-MadhuraVipaka-MadhuraVeerya-SheetaVeerya-Sheeta
81
""मन्डू+क�र्णिर्ण-क� लाव्ध8 स्��दु��क� वि(म� री�“मन्डू+क�र्णिर्ण-क� लाव्ध8 स्��दु��क� वि(म� री�“ ((श�श�..विनविन))
ShankhapuspiShankhapuspi
82
Clitoria ternatea Linn.
Rasa-Tikta,Katu,Kasaya
Guna-Teekshna,Laghu
Vipaka-Katu
Veerya-Sheeta
Convolvulus plauricaulis Linn.
Rasa-Tikta
Guna-Snigdha,Picchila
Vipaka-Madhura
Veerya-Sheeta
ShankhapuspiShankhapuspi
83
Madakari Drugs
84
85
Dhatura(Ummath)Dhatura(Ummath) Datura stramonium Linn.Datura stramonium Linn.
Family-SolanaceaeFamily-Solanaceae
Rasa- Tikta,KatuRasa- Tikta,Katu
Guna- Laghu,RukshaGuna- Laghu,Ruksha
Veerya-UshmaVeerya-Ushma
Vipaka-KatuVipaka-Katu
""उन्मत्तउन्मत्त--मदाकE त्��तु$ इवितु उन्मत्तमदाकE त्��तु$ इवितु उन्मत्त"("(विनविन..आआ))
86
BhangaaBhangaa
Cannabis sativa Linn.Cannabis sativa Linn.
Family-CannaacebinaeFamily-Cannaacebinae
Rasa-TiktaRasa-Tikta
Guna-Laghu,TeekshnaGuna-Laghu,Teekshna
Vipaka-KatuVipaka-Katu
Veerya-UshnaVeerya-Ushna
Prabhava-MadakariPrabhava-Madakari
Some Common Some Common Drugs Drugs
We Can UseWe Can Use
87
88
Harichandanam(Manaranjitam)
Artabortys hexapetalus (L.F)Artabortys hexapetalus (L.F) Family- AnnonaceaeFamily- Annonaceae
Leaves is proved sedative Leaves is proved sedative
04/09/23
89
Parasikayavani(Amukkiram)Parasikayavani(Amukkiram) Hyocyamus niger Hyocyamus niger Linn.Linn.
Family- SolanaceaeFamily- Solanaceae
Rasa-Tikta,Katu,KasayaRasa-Tikta,Katu,Kasaya
Guna-Rooksha,GuruGuna-Rooksha,Guru
Vipaka-KatuVipaka-Katu
Veerya-UshnaVeerya-Ushna
Prabhava-MadakariPrabhava-Madakari
Kapha,VataharaKapha,Vatahara
Useful part-Seed,Leaves,FlowerUseful part-Seed,Leaves,Flower
90
Lajjalu(Thottavati)Mimosa pudica Mimosa pudica Linn.Linn.
Family-MimosaceaeFamily-Mimosaceae
Rasa-Kasaya,TiktaRasa-Kasaya,Tikta
Guna-Laghu,RukshaGuna-Laghu,Ruksha
Vipaka-KatuVipaka-Katu
Veerya- SheetaVeerya- Sheeta
Useful part- Root,LeavesUseful part- Root,Leaves
""लाज्जा��तु8 म�लावि�सिलाVतु ��भिर्ण�लाज्जा��तु8 म�लावि�सिलाVतु ��भिर्ण�........र्गEह्णा�वितु ���न$ भ्रमतु� अवितुघो�री�न$र्गEह्णा�वितु ���न$ भ्रमतु� अवितुघो�री�न$”” ((री�जाम�तु�न्डूरी�जाम�तु�न्डू))
91
Saptaparnah(Elilampala)Saptaparnah(Elilampala)
Alstonia scholaris Linn.Alstonia scholaris Linn. Family- ApocynaceaeFamily- Apocynaceae Rasa-Tikta,KasayaRasa-Tikta,Kasaya Guna-Laghu,snigdhaGuna-Laghu,snigdha Vipaka-KatuVipaka-KatuVeerya- UshnaVeerya- Ushna Tridosa shamanaTridosa shamana (Ra.Ni)(Ra.Ni)
92
Vrikkabeejah(Kasumaavu)Vrikkabeejah(Kasumaavu)
Anacardium occidentale( L.)Anacardium occidentale( L.)
Shaaligraam NighantuShaaligraam Nighantu
- SnigdhaSnigdha
- Kasaya,MadhuramKasaya,Madhuram
- KaphavaataharamKaphavaataharam
Essential oil of the plant is sedativeEssential oil of the plant is sedative
93
Mustaka(MutthangaMustaka(Mutthanga)) Cyperus rotundus(Linn.)Cyperus rotundus(Linn.)
Family-CyperaceaeFamily-Cyperaceae
Rasa-Tikta,Katu,KasayamRasa-Tikta,Katu,Kasayam
Guna-Laghu.RukshaGuna-Laghu.Ruksha
Vipaka-KatuVipaka-Katu
Veerya-SheetaVeerya-Sheeta
Kapha,Pitta haraKapha,Pitta hara
Ni.Ra-MedhyaNi.Ra-Medhya
94
VrikshaadaniVrikshaadani
Viscus album (L.)Viscus album (L.)
Family-LoranthaceaeFamily-Loranthaceae
Bha.Pra-Bha.Pra-
Tikta,Kasaya,Madhura RasaTikta,Kasaya,Madhura Rasa
Sheeta VeeryamSheeta Veeryam
95
Gandhatrina(Inchippollu)Gandhatrina(Inchippollu)
Cymbopogon citratus(B.C)Cymbopogon citratus(B.C)
Family-PoaceaeFamily-Poaceae
Bha.Pra.Ni-Katu,Tikta RasaBha.Pra.Ni-Katu,Tikta Rasa
Laghu,Ruksha-GunaLaghu,Ruksha-Guna
Katu-VipakaKatu-Vipaka
Ushna-VeeryaUshna-Veerya
KaphasamanaKaphasamana
96
Passion fruitPassion fruit
• Passiflora incarnata(L.)Passiflora incarnata(L.)
• Family-PassifloraceaeFamily-Passifloraceae
• Whole plant-SedativeWhole plant-Sedative
97
ElaaElaa Elettaria cardamomum(Maton)Elettaria cardamomum(Maton)
Family-ScitaminaeFamily-Scitaminae
Rasa-Katu,MadhuramRasa-Katu,Madhuram
Guna-Laghu,Ruksha,SukshmaGuna-Laghu,Ruksha,Sukshma
Veerya-SheetaVeerya-Sheeta
Vipaka-KatuVipaka-Katu
(Bha.Pra.Ni)(Bha.Pra.Ni)
Scope of researchScope of research
98
99
Yastimadhu(Iratti madhuram)Yastimadhu(Iratti madhuram)
Glycyrrhiza glabra(Linn.)Glycyrrhiza glabra(Linn.)
Family-FabaceaeFamily-Fabaceae
Rasa-MadhuraRasa-Madhura
Guna-Guru,SnigdhaGuna-Guru,Snigdha
Vipaka- MadhuraVipaka- Madhura
Veerya-SheetaVeerya-Sheeta
Tridosa haramTridosa haram
(Bha.Pra Ni)(Bha.Pra Ni)
100
Jiraka(Jirakam)Jiraka(Jirakam)
• Cuminum cyminum(Linn.)Cuminum cyminum(Linn.)
• Family-UmbelliferaeFamily-Umbelliferae
• Dhn.Ni- ManognamDhn.Ni- Manognam
HridyamHridyam
• Kai.Ni- MedhyamKai.Ni- Medhyam
101
Varttaki(VazhuthinaVarttaki(Vazhuthina))
Solanum melongena(Linn)Solanum melongena(Linn)
Family-SolanaceaeFamily-Solanaceae
Ra.Ni- NidraluRa.Ni- Nidralu
Rasa-MadhuraRasa-Madhura
Guna-Laghu,TeekshnaGuna-Laghu,Teekshna
Vipaka-KatuVipaka-Katu
Veerya-UshnaVeerya-Ushna
102102
Upodika(VasalachiraUpodika(Vasalachira))
Basella alba(Linn.)Basella alba(Linn.)
Family-BasellaceaeFamily-Basellaceae
(Bha.Pra. & (Bha.Pra. & Kai.Ni,Atreya)-Kai.Ni,Atreya)-
Kapha bardhanam,VatasamakaKapha bardhanam,Vatasamaka
Hanti madamHanti madam
NidraluNidralu
103103
Changeri(Puliyarel)Changeri(Puliyarel) Oxalis corniculata(Linn.)Oxalis corniculata(Linn.)
Family-OxalidaceaeFamily-Oxalidaceae
Rasa-Amla,KasayaRasa-Amla,Kasaya
Guna-Laghu,RukshaGuna-Laghu,Ruksha
Veerya-UshnaVeerya-Ushna
Vipaka-AmlaVipaka-Amla
Kapha, VataharamKapha, Vataharam
(Bha.Pra.Ni) (Dh.Ni)(Bha.Pra.Ni) (Dh.Ni)
104
Scope of research….Scope of research….
The bandanging of the root of Kakamachi or The bandanging of the root of Kakamachi or
Kakajangha or Apamarga or Kokilaksha or Kakajangha or Apamarga or Kokilaksha or
suparnika (Bakuchi) with hair.suparnika (Bakuchi) with hair.
(Ha. Sam. & B.P.)(Ha. Sam. & B.P.)
105
Scope of Research…Scope of Research…
Use of bronze vesselUse of bronze vessel The use of banana leaf The use of banana leaf (Ha. Sam.).(Ha. Sam.).
ConclusionConclusionNidra is natural physiological process
Mode of action of Nidrajanana drugs two way
Nidrajanana should process kapha,oja,satva vardhak property
106
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