Nice Sepsis

8/18/2019 Nice Sepsis

1/39

$>< >>: > $>< >>: > >> > =>>> > =>

C<

&../>/149

© NICE 2012. All rights reserved.

http://nice.org.uk/guidance/cg149http://nice.org.uk/guidance/cg149

2/39

C>>C>>

I>> .......................................................................................................................................................................... 4

&>-> .......................................................................................................................................................... 6

*= > ............................................................................................................................................ 7

! =>................................................................................................................................ 8

I>=> > .............................................................................................................................................................. 8

>> > < > > ....................................................................... 8

I>= >.................................................................................................................................................................. 9

I>> > > > ....................................................................................................... 9

A> >>........................................................................................................................................... 9

I>> > > =>............................................................................................................................ 9

D> 36 > > =>.................................................................................................... 9

C > ........................................................................................................................................................................................ 10

1 G> .............................................................................................................................................................................11

1.1 I>=> > ....................................................................................................................................................... 11

1.2 >> > < > > ................................................................ 14

1.3 I>= > .......................................................................................................................................................... 18

1.4 A> > > > ............................................................................................................. 18

1.5 I>> > > > ............................................................................................... 19

1.6 A> >> ................................................................................................................................... 20

1.7 D> > =>........................................................................................................................................ 21

1.8 * =>> >=> ................................................................................................................ 23

1.9 C >................................................................................................................................................................................. 24

2 $ > > .........................................................................................................................26

3 I=> ...............................................................................................................................................................27

4 ==>> .......................................................................................................................................28

4.1 >> > >= > ...................... 28

4.2 >>< >> > == > >.......................................................... 28

Antibiotics for early-onset neonatal infection (CG149)

© NICE 2012. All rights reserved. Page 2 of 39

3/39

4.3 I>= > = > > > => .................................................................................................................... 30

4.5 D> > =>........................................................................................................................................ 30

5 % > .................................................................................................................................32

5.1 F=> ..................................................................................................................................................34

A> A: * G D G, $>< C > $ICE = ..........................................................................................................................................................................35

G D G .................................................................................................................................................. 35

$>< C =>' > C' H

4/39

* 75.

I>>I>>

E >>< < >> (>> > > 72 )

>N> = = > >> . &> >> >

>N >> >> > >

. I> >, >> >< >> ==>. *

>> > => >O> > > >> => > >> . *

> > >>< >> => > $H > :

=>

=>= = =>=> > >

> >.

* > >> $H, >

==> > .

F >> ==>> > .

+>, = = => > >=> >,

, >.

I>= > => < >> > >><

>>.

A> > = < > .


5/39

*

6/39

&&>-> >->

* > >

>>< >> ( , > >> > 72 ).

*=> > > > > > > > ,

. &> > > >><

>> = >= > ', >

>, > =>, > > >

> = >, > > >>: > .

== >

=> =< = > =

>. I> > =>, > >< >> >,

== ' >.

G ==>> > > > >=> . *=> >

, > >=> > ,


7/39

**= > = >

&& >=> >> >=> >>>>

* => > ' . * > >=>

> > =>>

A => >>> > >=> >>>>

* => > ' => >>> = > > .



8/39

!! => =>

* > > >N =>.

Information and support

I > > >> >>< >>

, > > > > > =>

=>) >> :

> >=< ( =>>=>< ( 36LC

> 38LC),

>,

> > > < >, > O

( 2), > =>=> >:

I> > O, = '>>- O' <

> ( 2), = >> ( ==>>

1.5.1.1M1.5.1.3) > > =>. D > > >> > 1.6.1.1M1.6.1.3).

I> O > > > < >, > <

=>, >:

, >

> => ' < > > < >> M

=>> >> 2 >> 2-

9/39

I > > => >

1 > .

Intrapartum antibiotics

% >= > >> >J >>< >> => :

> > B < >>

B < >, >> > > >>.

Investigations before starting antibiotics in the baby

# C- > >>> >> > > >

=> > >> < > >.

Antibiotics for suspected infection

+ >> >J=> N- > =>

=< => >> > > >.

Investigations during antibiotic treatment

I> > > >> < > >, = C- > >>> 18M24 >>.

Decisions 36 hours after starting antibiotic treatment

I> > > >> < > > > > > 36 :

>< < > >> > >, >

' < >> > > < > >,

>

C- > >>> >.

10/39

C> < = => > = > > > , > > ' <

> > => > > > ( => > >> >>

11/39

11 G>G>

* > >> :

C> > ($ICE < 132).

B< =>> > =>>< = ($ICE < 102).

I>> >< ($ICE < 62).

I>= ($ICE < 55).

+> >> > ($ICE < 54).

F ($ICE < 47).

&>< ($ICE < 37).

+>, >> > ==>>

>>< >> ( , > >> > 72 ).

1.1 Information and support

1.1.1.1 I < >> >< >> >

>> > N 72 ( =

> = > >=> , >

> > >.



http://www.nice.org.uk/guidance/cg149/evidencehttp://www.nice.org.uk/guidance/cg132http://www.nice.org.uk/guidance/cg102http://www.nice.org.uk/guidance/cg70http://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg55http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg47http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg47http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg55http://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg70http://www.nice.org.uk/guidance/cg102http://www.nice.org.uk/guidance/cg132http://www.nice.org.uk/guidance/cg149/evidence

12/39

1.1.1.2 I >> > => < >> >< >>, :

>

> >N > >< =>

> > >> = > < =>=>

( = =>)

> => >

=, >, > => > ==>> => >

>>, >

> , > >< >

>> > > > > . * > > > >>. * ==>>

= ==>> 1.3.2 > I>= ($ICE < 55).

1.1.1.4 > > > , >

, > >

13/39

1.1.1.8 I > > >> >>< >>

, > > >

> > => =>) >>

:

> >=< ( =>>=>< ( 36LC

> 38LC),

>,

> > > = < =- ( >

== >< > > =), >=

> > > ' G&, >,

> > >>.

1.1.1.10 I > >N= >><

>>:

>= > > >< -= ' = >

> >' > ' >> > > >=> >

>> > =

= >> >:

> >>< >>

= => = B < >>

14/39

> > = =>' G& > > :

> B < >> > , >

B < >> > > >>.

1.1.1.12 I => B < > > >>

>> > , >= = >> >,

=>=> > > >>.

1.1.1.13 F = > < >> > >>< >>, ==> , >> > :

< < >>

>

>' > ' >>.

1.2 Risk factors for infection and clinical indicators of possible infection

1.2.11.2.1 >> > < >>> > < >

1.2.1.1 + >>< >> > < > >>< >>.

1.2.1.2 + 2 > O ( > < >

> >>< >>).

**>< >>, > ' O'>< >>, > ' O'

O

I> B < >> >

#>, >> > >

>>


15/39

&

&= >

16/39

$ =>< > > =

$ =>< > > =

&> < (> >>)

*= >= 38LC) >

>>=><

>

+> , =>, >=<

(I>>>< $= 2.0)

% > 24

A

17/39

I> > O, = '>>- O' <

> ( 2), = >> ( ==>>

1.5.1.1M1.5.1.3) > > =>. D > >

>> > 1.6.1.1M1.6.1.3).

I> O > > > < >, >

< =>, >:

, >

> => ' < > > < >> M

=>> >> 2 >

> 2- > => >:

< >> >, > => > >> (

==>> 1.5.1.1M1.5.1.3) > > > => (

==>> 1.6.1.1M1.6.1.3)

> >> > > =,

, > > (

==>> 1.1.1.8).

1.2.3.4 I > > => >

1 > .

1.2.3.5 #> < =>> > ==>> >

B< =>> > =>>< = ($ICE <

102) > >>< >.

1.2.3.6 #> > >> > ==>> >

+> >> > ($ICE < 54).

1.2.3.7 C>> > >< ( &>< , $ICE < 37)

( > ( < > B N >N

> N 72



http://www.nice.org.uk/guidance/cg102http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg102

18/39

' ( =, >>, > > > > >>. + => > <

=>=> ( ==>> 1.2.3.2).

1.3 Intrapartum antibiotics

1.3.1.1 % >= > >> >J >>< >> => :

> > B < >>

B < >, >> > > >>.

1.3.1.2 I => >= > >> < .

1.3.1.3 C> >= > >> >J >>< >> => > = >.

1.3.1.4 C> >= > >> >J >>< >> => > = N= >= ==> = >

18 .

1.3.1.5 % >J= > > =>

>> < > >.

19/39

1.5 Investigations before starting antibiotics in the baby

1.5.1.1 > > > => > >>

< > >, = N .

1.5.1.2 # C- > >>> >> > >

> => > >> < >

>.

1.5.1.3 &= > >< O = > >:

> < > >>,

< == > > =>>.

I => , =

> >.

1.5.1.4 D > > = > >>< >>.

1.5.1.5 D > = > = >

>>< >> > > < > .

1.5.1.6 B , >> >> > > >>, = > >

>> ( = =, > = >

>. = > => <

>> = =>,

> =

20/39

> => >> O=> ( ==>> 1.6.1.3)1

. I => > G=-> >>, >=>.

1.6 Antibiotics for suspected infection

1.6.1.1 + >> >J=> N- >

=> =< => >> > >

>.

1.6.1.2 G >J 25 =/ 12 2

. C>

>> >< 8- < => (= > 5 =/1

.

1.6.1.4 I > >=> > ( ==>> 1.7.2.1)

, > < =>, = > >=> > > > => >>> ( ==>> 1.8.1.1M1.8.2.3).

1.6.1.6 = :

>=> =>>

= =>>.

1.6.1.7 > > >

> >. C> > > => >

> :

' < >> ( = ==>)

21/39

= > > >J >=> =>

> G=-> ( =

>> >N= >JI>> > > =>> > > =>

1.7.1.1 I> > > >> <

> >, = C- > >>>

18M24 >>.

1.7.1.2 C> => > >< O = > >> >

>, > :

C- > >>> 10 =/.

1.7.21.7.2 D> 36 > > =>D> 36 > > =>

1.7.2.1 I> > > >> <

> >, > > > 36 :

>< < > >> > >, >

' < >> > > < > >, >

C- > >>> >.

22/39

1.7.2.2 C> < =

=> > = >.

1.7.31.7.3 E >>< >> =>>E >>< >> =>>

1.7.3.1 * < > > =>

> > , >>> >=> = > 7 :

> N > > > > 36 > , >< =>, > >

=>, > > :

< < > >>

' < > > >>, >

C- > >>>.

1.7.41.7.4 #>> ( > >>< >)#>> ( > >>< >)

1.7.4.1 I > >>< > > =>>

> >>> ( =< O G= >

>>=), >> = =.

1.7.4.2 I > >>< > > =>> > G=-

> >> >< O G= >

23/39

1.7.4.3 I > >>< > > =>> > >< O

G= > G=- >>, >> =>

>> = = >< O

> > => :

>J= > > 5 =/ 36 1

, >

> > > < => ( ==>>

1.6.1.4) > => >>> ( ==>> 1.8.1.1M1.8.2.3);>=> => > 5 .

1.7.4.5 I > = >=>.

1.7.4.6 I >< O N G=- =

> B =>.

1.7.51.7.5 D > =>D > =>

1.7.5.1 %> = > =>, > =

= > > > >

.

1.8 Therapeutic drug monitoring for gentamicin

1.8.11.8.1 ** >> >>>>

1.8.1.1 I > >=> > ( ==>> 1.6.1.4)

= => >>> ==

> . C> >>> >

>=>.

24/39

1.8.1.2 H< >>> > (

= 30 =).

1.8.1.3 C> > ==> >>> ===>, = > (

= >> >>>

>< >>).

1.8.1.4 A >=> > >>>

2 =/=>

>>> 1 =/ >> >>> ==> > => > ><

>> ( = > >>>,

>).

1.8.21.8.2 && >> >>>>

1.8.2.1 C> => => >>> > :

=

== ( = > 4.5 )

> > > =>

> G=-> >>.

1.8.2.2 # >>> 1 > >=> >>.

1.8.2.3 I G=-> >, > >>

>=> >>> 8 =/ < =>, > = >>> < ( =

25/39

=-) > > >>

> > > , > >

' < > > => > > >

( => > >> >>=> > >> . * ==

==> 4M7 =// => > >

> 5 =/ 36 => > >J >> . * == ==> 50 =// > > > 1 . I>

1M4 75 =// > ,

==> > == .

26/39

22 $ > >$ > >

$ICE > N>

.

H H < C =>' > C' H > >.

* = >=> $ICE < $ICE

. A ,


27/39

33 I=>I=>

$ICE .



http://www.nice.org.uk/guidance/cg149http://www.nice.org.uk/guidance/cg149

28/39

44 ==>> ==>>

* G D G = > ,

> >, = $ICE > > > > . * G

D G' > 5).

4.1 Screening and intrapartum antibiotic prophylaxis for group B

streptococcal colonisation

< > > >= > B

> > >>< >>?

=> =>

A>>< ($ICE < 62) > < > > >

>>< >> B >

>= > B > >N. *

> < > > >= > > >>< >> > =>

B .

F > > > >><

>> B => >= > =>

>N . * >> > => . *

< >> >< >>, < == > > >>, >

> ?

=> =>

* > > = >

> >>< >> > > = > =>



http://www.nice.org.uk/guidance/cg149/evidencehttp://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg149/evidence

29/39

< > < >>,

< == > > >>, > ( C-

> >>>) M >> .

H, = N >><

>>, > < > ( >

= >

> > >N= > >

>>), > => > >>> >> > .

F >, =

==> = >< >, = > 16 ). * < > = > => >>. * > >

> >> > =< > > = > >= >

>J => = =>

I> > >< > < > > >= >

>>< >> > =

> > >= >

= >N=

==> 18 ' > > G D G'

>> > > .

F > > >= >

>J =

=> > ==> > ==>). * = >= >>>

(>> > 72 ). > =

30/39

. * > >> = ==> > ==> > > > >> >< >> > > >

>>?

=> =>

* = > >N

>> > > => > > > >>< >>. %> - >

=> >> > = > => > > >

> >>, > >

N> = > => =>> . * > > > > >>

> = > = => ( ) > >

>N= >>< >>?

=> =>

* G D G >N > > >= >

> => ( ) >N= >>< >>. I> >

>, G D G ==>> > > < . F > >

:

31/39

B < < =>>

B < =

G=-> < =>> ( Escherichia coli =>>)

G=-> =.

*

32/39

55 % % > >

5.1 Full guideline

* >>< >>: > >> >

=> >>< >> >> >

' >

C' H> = > > > $ICE .

5.3 Information for the public

$ICE >=> .

> $H > >> = >=> >

> = >>< >>.



http://www.nice.org.uk/guidance/cg149/evidencehttp://www.nice.org.uk/guidance/cg149/evidencehttp://pathways.nice.org.uk/pathways/antibiotics-for-early-onset-neonatal-infectionhttp://www.nice.org.uk/guidance/cg149/informationforpublichttp://www.nice.org.uk/guidance/cg149/informationforpublichttp://pathways.nice.org.uk/pathways/antibiotics-for-early-onset-neonatal-infectionhttp://www.nice.org.uk/guidance/cg149/evidencehttp://www.nice.org.uk/guidance/cg149/evidence

33/39

66

&. $ICE < 132 (2011).

B< =>> > =>>< =. $ICE < 102 (2010).

I>> >< . $ICE < 62 (2008).

I>= . $ICE < 55 (2007). + > . &

>N=.

+> >> > . $ICE < 54 (2007).

F . $ICE < 47 (2007). + > . &

# 2013.

&>< . $ICE < 37 (2006).



http://www.nice.org.uk/guidance/cg132http://www.nice.org.uk/guidance/cg102http://www.nice.org.uk/guidance/cg70http://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg55http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg47http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg37http://www.nice.org.uk/guidance/cg47http://www.nice.org.uk/guidance/cg54http://www.nice.org.uk/guidance/cg55http://www.nice.org.uk/guidance/cg62http://www.nice.org.uk/guidance/cg70http://www.nice.org.uk/guidance/cg102http://www.nice.org.uk/guidance/cg132

34/39

77 +> +>

$ICE < ==>> > > => >

>=>. $ > 3 , >

> ; >=> >. I => > > >. &=>

> .

35/39

A> A: * G DA> A: * G D G, $>< C > $ICE =C> > $ICE =

Guideline Development Group# *# *> (> (C)C)

> " > C> > $> "< > "< =>'

$H F>> *

G BG B

# &>, C => $H * (>< # 2011)

$< C> * > B=>=

=>' $H F>> *

&&< H< H& & I> D, H> C>, D> C< > >

> I>, G', +> ">>

> H> H

> #, H > = & H H> > " > F#>< #>, +> H<=> $H F>> *

# H# H

$>< $, +> H

36/39

FF & &>>

&> ==, B A>

C> $>> *

#, G *

National Collaborating Centre for Women's and Children's Health (NCC-WCH)

!> C C ## > #

C< C-D, C' H< > 2011)

NICE project team

#>

&&

G C>

*>> *>>

*>< "


37/39

H H

H=

& &

38/39

A A

$ICE < ==>> => > >> > $H > E> > ' > C'

H, G& > >),

> > , > >< , > >

==>>. * ==>> N> $ICE < > *

=>> = > > > $ICE .

>=> . * >=> > > =>>>

> > $ICE, < >>

> . H, > > ><

>

>< >, > > > >/ > , > >=

== > >>.

I=> > >/ .

C==> > => >, > , > > >

=> . $> > > >

>> = .

CC

K $> H C< E , > = ><



http://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-guidelines/nice-clinical-guidelineshttp://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-guidelines/nice-clinical-guidelineshttp://pathways.nice.org.uk/pathways/antibiotics-for-early-onset-neonatal-infectionhttp://www.nice.org.uk/guidance/cg149/informationforpublichttp://www.nice.org.uk/guidance/cg149http://www.nice.org.uk/guidance/cg149http://www.nice.org.uk/guidance/cg149/informationforpublichttp://pathways.nice.org.uk/pathways/antibiotics-for-early-onset-neonatal-infectionhttp://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-guidelines/nice-clinical-guidelineshttp://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-guidelines/nice-clinical-guidelines

39/39

> >--N . $ > ==< >>,

==< , $ICE.

C> $ICEC> $ICE

$> H C< E

Nice Sepsis

Documents

Transcript of Nice Sepsis