NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix...

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Has NCCMH lost its way? When you carry out vast numbers of meta- analyses on a small corpus of studies: Mistakes will inevitably occur Criteria for inclusion become difficult to keep track of Meaningful interpretation of the findings becomes difficult It is difficult to see how the result is better than old-fashioned ‘vote-counting’ review articles

Transcript of NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix...

Page 1: NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix 25,…

NICE, NCCMH and bipolar disorder

Peter McKenna

Page 2: NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix 25,…

That NCCMH meta-analysis of relapse

NCCMH Appendix 25, forest plots

Page 3: NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix 25,…

Has NCCMH lost its way? When you carry out vast numbers of meta-

analyses on a small corpus of studies: Mistakes will inevitably occur Criteria for inclusion become difficult to keep track of Meaningful interpretation of the findings becomes

difficult It is difficult to see how the result is better

than old-fashioned ‘vote-counting’ review articles

Page 4: NICE, NCCMH and bipolar disorder Peter McKenna. That NCCMH meta-analysis of relapse NCCMH Appendix 25,…

The fallacy that dare not speak its name When positive findings emerge from

multiple meta-analyses – and without correction for multiple comparisons they always will – there will be an impression of there being a real effect, even if the underlying pattern is difficult to discern clearly.