Newer N-Substituted Anthranilic Acid Derivatives as Potent Antiinflammatory Agents.
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2002 oxadiazole derivatives oxadiazole derivatives R 0290 52 - 125 Newer N-Substituted Anthranilic Acid Derivatives as Potent An- tiinflammatory Agents. — The characteristic features of the route to substituted anthranilic acid derivatives (XIII) consist of substitution at 2- position of bromoanthranilic acid (II) with the oxadiazolyl ring structure, (VII), conversion into benzylidene derivatives (XI), and cyclization into pyrazolines (XIII). Similarly, the thiadiazolyl derivatives are prepared by substitution at 2-position of anthranilic acid (I). Compounds possessing an oxadiazolyl moiety generally show better antiinflammatory property than compounds having a thiadiazolyl ring. Compounds bearing substituents as in (XIIIb) or (XIIIc) elicit a remarkable increase in antiinflammatory activity. — (SHARMA, SHALABH; SRIVASTAVA, VIRENDRA KISHOR; KUMAR, ASHOK; Eur. J. Med. Chem. 37 (2002) 8, 689-697; Dep. Pharmacol., Lala Lajpat Rai Mem. Med. Coll., Meerut 250 004, India; EN) 1
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Transcript of Newer N-Substituted Anthranilic Acid Derivatives as Potent Antiinflammatory Agents.
2002 oxadiazole derivatives
oxadiazole derivativesR 0290
52 - 125Newer N-Substituted Anthranilic Acid Derivatives as Potent An-tiinflammatory Agents. — The characteristic features of the route tosubstituted anthranilic acid derivatives (XIII) consist of substitution at 2-position of bromoanthranilic acid (II) with the oxadiazolyl ring structure, (VII),conversion into benzylidene derivatives (XI), and cyclization into pyrazolines(XIII). Similarly, the thiadiazolyl derivatives are prepared by substitution at2-position of anthranilic acid (I). Compounds possessing an oxadiazolyl moietygenerally show better antiinflammatory property than compounds having athiadiazolyl ring. Compounds bearing substituents as in (XIIIb) or (XIIIc) elicita remarkable increase in antiinflammatory activity. — (SHARMA, SHALABH;SRIVASTAVA, VIRENDRA KISHOR; KUMAR, ASHOK; Eur. J. Med. Chem.37 (2002) 8, 689-697; Dep. Pharmacol., Lala Lajpat Rai Mem. Med. Coll.,Meerut 250 004, India; EN)
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