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Transcript of NEW PRE FEASIBILITY REPORT US AMINO...
PRE FEASIBILITY REPORT
OF
M/S- US AMINO PVT. LTD. Aaraji No. 588 Village- Ladana, patwar mandal- Vasani kala Tehsil- Mavali
Dist.- Udaipur (Raj.)313205
FOR
BULK DRUGS UNIT
Page 20 of 51
Pre-Feasibility Report
1.0 EXECUTIVE SUMMARY
M/S- US AMINO PVT. LTD. was incorporated to produce bulk drugs at registered address Aaraji
no. 588 Village- Ladana, patwar mandal- Vasani kala Tehsil- Mavali Dist.- Udaipur (Raj.)313205.
The company proposes for expansion of its bulk drug and intermediate manufacturing capacity in
same premises.
S. NO PARAMETER DESCRIPTION
1. Category of
Project as per
EIA Notification
&Amendments
5(f) “A” (Proposed project located outside the notified
industrial area)
2. Project cost for
Expansion
85.0 lacs
3. Plot area 4129.00 SQM
4. Existing
Products
S.
No.
Product Existing
capacity
(TPA)
Expansion
Proposed
(TPA)
Total
(TPA)
1 Carnitine
Tratrote
60.00 MT - 60.00 MT
2 Cystine 12.00 MT - 12.00 MT
3 L- Lysine
HCL
240.00 MT - 240.00 MT
4 N-Acetyl L
cystine
60.00 MT - 60.00 MT
5 Proposed
products
S.
No.
Product Proposed Capacity
(TPA)
1 Methotrexate 6.0 MT
2 Rosuvastatin calcium 2.4 MT
3 Telmisartan 12.0 MT
4 Sucralfate 6.0 MT
5 Arteemether 6.0 MT
6 Arteether 6.0 MT
Page 21 of 51
Pre-Feasibility Report
6. Resources
I Electricity
Requirement
Existing 90 KVA Proposed 60 KVA
Total – 150 KVA
Source of
electricity
Ajmer Vidyut Vitran Nigam Limited, Rajasthan
D. G. Sets
(Stand by)
Existing :
1. 62.5 KVA
Proposed: Nil
II Water
consumption
Existing : 4.5 KLD
Proposed : 3.5 KLD
Total: 8.0 KLD
Source of water By Tanker (out sourcing)
Waste water
generation
Existing 1.9 KLD Proposed 2.4 KLD
Total- 4.3 KLD
Mode of disposal Zero Discharge System
III Boiler Existing :
1. Baby boiler (0.6 TPH)
Proposed- Nil
IV Fuel Existing:
1. 1.5 lph HSD
2. WOOD BRIQUETTES -100 KG/ Hr
6. Solid waste
generation
Existing:
1. Spent carbon- 0.59 MT/Annum
Proposed: 1. ETP Sludge- 1.0 MT/Annum
S.
No
Name of the Solid
Waste
Disposal Method
1. Spent carbon CTDF Udaipur
2. ETP Sludge
CTDF Udaipur
7. Nearest Highway State Highway No. 9 - (1.0 KM) North
8. Nearest Railway
Station
Fatehnagar- 5.0 KM
9. Nearest Air Port Maharana Pratap Air Port (Dabok)- 30.0 KMs
Page 22 of 51
Pre-Feasibility Report
2.0 INTRODUCTION OF THE PROJECT/BACKGROUND INFORMATION
2.1 Identification of Project and Project Proponent
S. No. Name of partner
1 Mr. Rajesh Vora
Director
Experience in Bulk drugs Sales- APP.-25 Years
2 Mr. Nitin Kumawat
Managing Director
Mob: +919414555529
The partners of the company have good experience in handling the production management,
financial management and all the allied areas.
2.2 Brief description of nature of the project-
M/s – US AMINO PVT. LTD is Directorship concern and proposed project was established
as Bulk Drugs Manufacturing Unit on Feb. 2015 and registered under the District Industries
Center (DIC) at Khasara no. 588 Village- Ladana, Patwar mandal-Vasni Kala Tehsil-
Mavali Dist. Udaipur, Rajasthan. Rajasthan State Pollution Control Board had issued the
Consent To Operate vide letter No. file no. : F(Tech)/Udaipur(Mavli)/2561(1)/2015-
2016/1808-1809, Copies of the same are attached.
2.3 Need for the project and its importance to the country and or region-
The Company proposed products is essential for human body and must be supplied in the
diet and disease. The project is being set-up for expansion in production capacity by addition
of few new products in existing production plant. The technology is totally proven and safe
in all aspects. The project will help industrial development in the region. Various products
have export potential and will help in own’s economy by generating foreign exchange and
also will be increase employment opportunities in the region. This project will help the
MAKE IN INDIA concept in our own small way.
2.4 Demands-Supply Gap.-
Importance and day to day requirement
Competition in the Indian Chemical market swelled in recent years, with increasing generic
compounds introduction in the domestic market. The price of the products has reduced
substantially which led to less supply of high profit margin products in the market. A
demand- supply gas is created due to less supply of products. To capture this newly created
gap between demand and supply in the domestic market company wishes to introduce low
margin products.
Page 23 of 51
Pre-Feasibility Report
2.5 Imports Vs Indigenous production
Main primary Raw material available in domestic market and rare raw material will be
Import from outside.
2.6 Export Possibility- In this time huge possibility of export of API
The company has great demand from existing as well as new clients for expansion products
in domestic market. Some of the company’s APIs will be exported to Europe, Japan, South-
East Asia and Middle East countries which will generate foreign exchange for the country.
2.7 Domestic/export Markets-
The finished goods will be sold in domestic market primarily and it would be exported to the
Regulated International Market as per demand.
2.8 Employment Generation (Direct and Indirect) due to the project
At present the company has – 09 employees. We have a strong team of manufacturing,
Quality Control and Quality Assurance chemist.
The Details of employment for expansion of product in this unit shown in below
Table.
TABLE 2.1: EMPLOYMENT REQUIREMENTS FOR EXPANSION
Particulars No. of employees Functional Area
Key managerial staff 3 Finance, Marketing, Production, Quality
control, R&D, Logistics etc
Administration 2 Office work
Skilled and semi-
Skilled
15 Production Process, Maintenance,
stores, Safety.& Un skilled workers
Total 20
3.0 PROJECT DESCRIPTION
3.1 Type of Project
M/s US Amino Pvt. Ltd. Proposes new products for expansion in the existing premises
situated at Khasara no. 588 Village- Ladana, patwar mandal- Basani kala Tehsil- Mavali
Dist.- Udaipur, Rajasthan. The proposed project is categorized under category B of 5 (F)
{Synthetic Organic Chemical Industry (dyes & dye intermediates; bulk drugs and
intermediates excluding drugs formulations; synthetic rubbers; basic organic chemicals,
other synthetic organic chemicals and chemical intermediates)}.
3.2 Location
The site coordinates are
Latitude: N240 47’ 23.85”
Longitude: E 740 03’ 34.10”
Page 25 of 51
Pre-Feasibility Report
Fig 3.2 Key plan of proposed project on G.T. Sheet
3.3 Details of alternate sites considered
It’s an expansion project in existing premises.
3.4 Size or magnitude of operation
M/s Us Amino Pvt. Ltd. wants to make new products within existing premises. The
proposed enhance production are shown in table 3.1
Page 26 of 51
Pre-Feasibility Report
Table 3.1: Existing product quantity
S. No. Product Existing capacity
1 Carnitine Tratrote 60.00 MT
2 Cystine 12.00 MT
3 L- Lysine HCL 240.00 MT
4 N-Acetyl L cystine 60.00 MT
Table 3.2: Proposed new product quantity
S. No. Product Proposed Capacity
(TPA)
CAS Number
1 Methotrexate 6.0 MT 59-05-2
2 Rosuvastatin calcium 2.4 MT 147098-20-2
3 Telmisartan 12.0 MT 144701-48-4
4 Sucralfate 6.0 MT 54182580
5 Artemether 6.0 MT 71963-77-4
6 Arteether 6.0 MT 75887-54-6
3.5 Project Description with Process Detail
1. METHOTREXATE
Structure
IUPACE NAME (2S)-2-[(4-{[(2,4-Diaminopteridin-6 yl)methyl] (methyl) amino}
benzoyl) amino] pentanedioic acid
Molar mass - 454.44 g/mol
BRIEF MANUFACTURING PROCESS FOR METHOTREXATE
Methotrexate is manufacturing in two step reaction.
1. Hydrolysis
2. Purification
1. Hydrolysis: - Methotrexate ester is hydrolysis with Sodium hydroxide in presence of
acetone as solvent after completion of reaction crude Methotrexate obtained.
2. Purification: - Crude Methotrexate is dissolve with Methanol and heat the mass and
add carbon and filer the mass and cool the mass up to crystallization then centrifuge and
dried and packing.
Page 28 of 51
Pre-Feasibility Report
PROCESS FLOW CHART METHOXATRATE
Production Qty. / Month-500kg
Batch Size in Kg – 100kg
No. of Batches per Month - 5
Methoxatrate ester (1000kg) Acetone (2850kg) Loss (150kg)
Acetone (3000kg) Methoxatrate Acid sulary (3100kg)
Water (2000kg)
HCL 10%(100 KG)
Sodium Hydroxide 10% Soln. (100kg) Methoxatrate sulary (3200 kg.)
Methoxatrate Acid sulary (3100kg)
Methoxatrate sulary (3200 kg.) Methoxatrate wet cacke-1260 kg
Waste water-1940 kg
Methoxatrate wet cacke-1260 kg DRY METHOXATRATE-900 KG
Water Evoporated-360 kg
Acidification
Neutralization
Centrifuge
Drying
Milling
Store
Packing
Page 29 of 51
Pre-Feasibility Report
MATERIAL BALANCE METHOXATRATE
1st Stage
S.No Input Out put
1. Methoxatrate ester (1000kg) Acetone (2850kg) Loss (150kg)
2. Acetone (3000kg) Methoxatrate Acid sulary (3100kg)
3. Water (2000kg)
4. HCL 10%(100 KG)
6100kg 6100 kg.
2nd
Stage
S.No Input Out put
1. Methoxatrate Acid sulary
(3100kg)
DRY METHOXATRATE-900 KG
2. Sodium Hydroxide 10% Soln.
(100kg)
Water loss- 360 Kg
Waste water1940 kg. (Sodium chloride
soln.)
TOTAL-3200 Kg 3200 Kg
2. ROSUVASTATIN CALCIUM
Molecular Formula- C44H64CaF2N8O12S2
Molecular Weight- 1001.14
Route of Synthesis
Rosuvastatin calcium is manufactured by Rosuvasatatin ester and Calcium chloride
and Tolune as a solvent
Page 30 of 51
Pre-Feasibility Report
3
C O Ca
CH H
O N
N
CH3
N N H3C
H C
OH OH O
Pg - 3
ROSUVASTATIN CALCIUM CONDENSATION
F
OH OH O
N O Na
H C CaCl2
SO2CH3 CH3
sodium (3R,5S,E )-7-(4-(4-fluorophenyl)-6-
isopropyl-2-(N-methylmethylsulfonamido) pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
Chemical Formula: C22H27FN3NaO6S
Molecular Weight: 503.52
F
CH3 SO2CH3
SO2CH3 CH3
F
calcium (3R,5S,E )-7-(4-(4-fluorophenyl)-6-isopropyl -2-(N-methylmethylsulfonamido)pyrimidin
-5-yl)-3,5-dihydroxyhept-6-enoate
Chemical Formula: C44H54CaF2N6O12S2
Molecular Weight: 1001.14
(ROSUVASTATIN CALCIUM)
C
N N
H CH
+ 3
H C 3 N N 3 O OH OH
Page 31 of 51
Pre-Feasibility Report
FLOW CHART ROSUVASTATIN CALCIUM
Production Qty. / Month-200kg
Batch Size in Kg – 50kg
No. of Batches per Month – 4
Rosuvastatin Ester (1430 KG) TOLUNE (760 L) LOSS-40 L
METHANOL(300 ) METHANOLIC SOLN. OF ROSUVASATATIN (2460 KG)
TOLUNE (800L)
HYDRCHLORIC ACID 0.3 N (230 L)
SODIUM HYDROXIDE(500.00 KG)
METHANOLIC SOLN. OF ROSUVASATATIN (2460 KG)
HYDRCHLORIC ACID 0.3 N (100 L ) METHANOL(285 L)
. Calcium chloride Soln. (670 l) Rosuvastatin calcium sulary (2945l)
Rosuvastatin calcium sulary (2945l)
DM WATER (400L) Waste Waste Water (1495 l)
Wet Cacke Rosuvasatatin (1450 kg)
Wet Cacke Rosuvasatatin (1450 kg) SU Dry Rosuvasatatin Calcium (1000 KG)
WATER EVOPORATE-450 KG
Crystallization
Centrifuge
Drying
Milling
Packing
Store
Page 32 of 51
Pre-Feasibility Report
MATRIAL BALANCE ROSUVASTATIN CALCIUM
Batch Size in Kg 270
Production per month in kg 200
No. of Batches per month 01
Name of the Input Quantity
In kg Name of the out put
Quantity
in Kg
Rosuvastatin ester 1430.00 Rosuavasatatin calcium 1000.00
Hydrochloric acid 0.3 N 330.00 Solvent Recovery
Sodium hydroxide Soln. 5% 500.00 Toluene 760.00
Toluene 800.00 Methanol 285.00
Methanol 300.00 Solvent loss
Calcium chloride 270.00 Toluene 40.00
DM Water 800.00 Methanol 15.00
Waste Water 2230.00
Total 4430.00 4430.00
3. TELMISARTAN
IUPAC name
2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-
yl]methyl}phenyl)benzoic acid
CAS Number - 144701-48-4
Formula C33H30N4O2
Molar mass 514.617 g/mol
Manufacturing Process
2-n-Propyl-4-methyl -6(1-methyl benzimidazole-2-yl) benzimidazole (RM-I) is treated with
methyl-4’-(bromomethyl)-biphenyl-2-carboxylate (RM-II) presence of Methyl iso butyl
ketone as solvent .and Potassium hydroxide to form 4-[4’-methyl - 6- (1- methyl-1H-
benzimidazole-2yl-2-propyl-1H-benzimidazole-1-ylmethyl] biphenyl-2-carboxylic acid
methyl ester which is hydrolyzed with sodium hydroxide in aqueous to give Telmisartan is
purified in metylene di chloride.
Page 33 of 51
Pre-Feasibility Report
N N
O O
N
CH3
N CH3
Chemical Reaction
CH3
KOH, IPA,
RT, 3 hrs
CH3
N
N
CH3
N H
4’-
Bromomethylbiphenyl-2-
carbonitrial
M.W.272.14
CH3
2-n-Propyl-4-methyl-6-(1’-
methylbenzimidazole-2-yl)
benzimidazole
MW 305.0
Telmisartan methyl ester
Methyl 4'-((1,4'-dimethyl-2'-
propyl-2,6'-bi(1H-benzo
[d]imidazol)-1'-
yl)methyl)biphenyl-2-
carboxylate
KOH, IPA, 800C,30 mins.
CH3
N N
N
CH3
MW 514
O OH
N CH3
N CH3
Page 34 of 49
Pre-Feasibility Report
PROCESS FLOW CHART TELMISARTAN
MIBK (2400kg) MIBK (2160kg) Loss (240kg)
Potassium Hydroxide (760kg) Stage-I (1238kg)
RM-I (825kg) Waste Water (6707L)
Water (5000 L) Water evaporation losses-
500 L
RM-II (760kg)
Stage-I (1238kg) N-Butanol (5580kg) Loss (620kg)
N-Butanol (6200kg) Stage-II (1115kg)
Sodium Hydroxide (1060kg) Waste Water (9133L)
Hydoro Chlorice Acid (1000kg) Water evaporation losses-500 L
Water (7450L)
Stage-II (1115kg) Telmisartan Sulary (9465KG)
Methylene di chloride (5600 kg) MDC (5040 kg) Loss (560kg)
Acetic Acid (600kg)
Water (7450L) Ammonia Soln.(300 kg)
Telmistran sulary (9465 kg) Waste water (7765 l)
Telmistran wet cake(1700
kg)
Steam
Telmistran wet cake(1700) Dry Telmistran (1000kg)
Evaporation losses-700 l
Condensation
Oxidization
Crystallization
Centrifuge
Drying
Milling
Packing
Store
Page 35 of 49
Pre-Feasibility Report
MATERIAL BALANCE TELMISARTAN
1st STAGE
S.no Input Out put
1. 2-n-Propyl-4-methyl-6-(1’-methylbenzimidazole-2-yl) -
825 kg benzimidazole (RM-I)
Methyl iso butyl
ketone(2160kg) Loss (240kg)
2. 4’-Bromomethylbiphenyl-2-carbonitrial -
760kg
Stage-I (1238kg)
3. Potassium Hydroxide (760kg) Waste Water (6707L)(KBR
SOLN. SOLID BY SOLAR
EVOPRATION)
4. Methyl iso butyl ketone (MIBK) (2400kg) Water losses in drying-500 L
5 Hydro chloric acid (1100 kg)
5 DM Water ( 5000L)
TOTAL 10845 kg 10845 kg.
II STAGE
S.no Input Out put
1. I -STAGE MATERIAL-1238 KG N-Butanol (5580kg) Loss
(620kg)
2. N-Butanol (6200kg) Stage-I I (1115kg)
3 Sodium Hydroxide (1060kg) Waste Water (sodium chloride
soln.PH 6.5 TO 7.0) (9133L)
4. Hydoro Chlorice Acid (1000kg) Water losses in drying-500 L
5 DM Water (7450 L)
TOTAL-16948 KG 16948 KG
III STAGE
Sno Input Out put
1. I I -STAGE MATERIAL-1115 KG PURE TELMISARTAN-1000
KG
2. Methylene di chloride-5600 kg.
3 Ammonia soln.-300 KG Methylene chloride -5040 KG
4. Acetic Acid-600 KG Water losses in drying-400 L
5 DM Water 5500 L Waste water(Ammonium acetate-
5975 L
6 EVOPORATION LOSSES-700 L
TOTAL-13115 KG 13115 KG
Page 36 of 49
Pre-Feasibility Report
4. SUCRALFATE
CHEMICAL FOURMLA-C12H64Al16O7S8
MOLECULAR WT.-2086.75
Sucralfate Route of Synthesis Sucrose is reacted with chlorosulfonic acid in pyridine and Ammonium Hydroxide
get Ammonium Salt which is reacted with Aluminum chloro hydrate to get the
required product.
OH
8
OSO2ONH3
8
Chlorosulfonic acid
Py
Sucrose
40 to 45oC
Aluminium chloro hydrateOSO2OAl(OH)2
8RT, 12hr
NH3
Sucralfate
Page 37 of 49
Pre-Feasibility Report
FLOW CHART & MATERIAL BALANCE Production Qty. / Month-500kg
Batch Size in Kg – 100kg
No. of Batches per Month – 1
SUCROSE (200kg) SUCRAL FATE AMMONIUM
SALT(630 kg)
PYRIDINE(500kg) PYRIDINE(475kg) loss(25kg)
CHLOSULPHONIC ACID (560kg) Waste Water(290kg)
AMMONIUM HYDROXIDE(160kg)
SUCRAL FATE AMMONIUM SALT(630 kg) . . . SUCRALFATE (2444 KG)
ALUMINIUM CHLOROHYDRATE (814kg)
WATER (1000kg)
.
SUCRALFATE(1400kg) WET CACKE Waste Water(1044kg)
SUCRALFATE WET CACKE-
1400 KG
SUCRALFATE WET CACKE-1400 KG SUCRALFATE DRY -1000 KG
WATER EVOPORATE-400 KG
Condensation
Oxidization
Centrifuge
Drying
Milling
Packing
Store
Page 38 of 49
Pre-Feasibility Report
MATERIAL BALANCE SUCRALFATE
I STAGE
S. No INPUT OUT PUT
1. SUCROSE-
200 kg
SUCRALFATE AMMONIUM SALT -
630 kg
2. PYRIDINE
500 kg
PYRIDINE-
475kg loss -25 kg
3. CHLOSULPHONIC ACID
560 kg
WASTE WATER
290 L
4. AMMONIUM HYDROXIDE
160 kg
TOTAL 1420 kg 1420 KG
II STAGE
S. No INPUT OUT PUT
1. SUCRAL FATE AMMONIUM
SALT -630 kg
SUCRALFATE DRY-
1000 KG
2. ALUMINIUM CHLOROHYDRATE-
814 kg
WASTE WATER-
1044 L
3. WATER
1000 L
WATER EVOPORATE-
400 L
TOTAL- 2444 KG 2444 KG
5. Artemether
BRIEF MANUFACTURING PROCESS
Charge DHAM ( Dihydroarte misnin ) along with methanol and catalyst in
reaction vessel, check for TLC and if ok add water directly in the vessel to separate
the crude product; after filtration and drying the crude product is purified with
methanol, dried and packed. Final product obtained.
Page 39 of 49
Pre-Feasibility Report
FLOW CHART & MATERIAL BALANCE FOR ARTEMETHER
DI HYDROMISNIN (1110 KG) METHANOL(4950)
LOSS(550) METHANOL (5500kg)
MDC+HYDROMISNIN(6860 KG)
SODIUM BORO HYDRIDE( 155 )kg
DM WATER(4000L) WASTE WATER(4155
L )
Methylene chloride(5750 KG)
MDC +HYDROMISNIN(6860 KG) MDC5175 KG+
LOSS 575 KG
TRI METHYL ORTHO ACETATE (1100 KG) ARTHEMETHER
SULARY 7710 KG METHANOL 3500 KG + LOSS 1000 KG
METHANOL 5000 KG
DM WATER 5000 L
ARTHEMETHER SULARY 2950 KG ARTEMETHER WET
CACKE 1400 KG
WASTE WATER
(1550 KG)
ARTEMETHER WET CACKE (1400 KG) ARTEMETHER DRY
1000 KG
WATER EVOPORATE
400 KG
Reduction
CONDENSION
Centrifuse
Drying
Milling
Store
Page 40 of 49
Pre-Feasibility Report
Material balance
I STAGE
S.No Input Out put
1. DI HYDROMISNIN 1110 KG METHANOL 4950 KG LOSS 550 KG
2. METHANOL 5500 kg MDC+ HYDROMISNIN 6860 KG
3. Water 4000 L WASTE WATER 4155 L
4. SODIUM BORO HYDRIDE 155 kg
5 Methylene chloride 5750 KG
TOTAL 14515 kg 14515 KG
II STAGE
S.No Input Out put
1. MDC+ HYDROMISNIN 6860 KG MDC (R)-5175 KG + LOSS-575 KG
2. TRIMETHYL ORTHO ACETATE
1100 KG
ARTEMETHER -1000 KG
3. METHANOL 5000 KG METHANOL-3500 KG+ LOSS-1000
4. WATER 5000 L WATER EVOPORATION LOSS-400 L
5. WASTE WATER 6310 KG
TOTAL- 17960 KG 17960 KG
6. Arteether
BRIEF MANUFACTURING PROCESS
Charge DHAM ( Dihydroarte misnin ) along with ethanol and catalyst in reaction
vessel, check for TLC and if ok add water directly in the vessel to separate the crude
product; after filtration and drying the crude product is purified with methanol, dried
and packed. Final product obtained.
Page 41 of 49
Pre-Feasibility Report
FLOW CHART & MATERIAL BALANCE FOR ARTEETHER
DI HYDROMISNIN (1110 KG) METHANOL(4950) LOSS(550)
METHANOL (5500kg) MDC+HYDROMISNIN(6860 KG)
SODIUM BORO HYDRIDE( 155 )kg
DM WATER(4000L) WASTE WATER(4155 L )
Methylene chloride(5750 KG)
MDC+HYDROMISNIN-6860 KG METHYLENE CHLORIDE+ ARTEETHER LAYER-6750KG
ETHANOL -3330 L WASTE WATER 6250 KG
PARA TOLUNE SULPHONIC ACID-310 KGS
WATER 2500 L
METHYLENE CHLORIDE+ ARTEETHER LAYER-6750KG METHYLENE CHLORIDE-5175+LOSS 575 KG
REDUCTION
DISTILITION
PACKING
STORE
Page 42 of 49
Pre-Feasibility Report
Material balance
I STAGE
S.No Input Out put
1. DI HYDROMISNIN 1110 KG METHANOL 4950 KG LOSS 550 KG
2. METHANOL 5500 kg MDC+ HYDROMISNIN 6860 KG
3. Water 4000 L WASTE WATER 4155 L
4. SODIUM BORO HYDRIDE 155 kg
5 Methylene chloride 5750 KG
TOTAL 14515 kg 14515 KG
II STAGE
S.No Input Out put
1. MDC+ HYDROMISNIN 6860 KG MDC (R)-5175 KG + LOSS-575 KG
2. ETHANOL - 3330 L ARTEETHER -1000 KG
3. PARA TOLUNE SULPHONIC ACID-
310Kgs
WASTE WATER 6250 KG
4. WATER 2500 L
5.
TOTAL- 13000 KG 13000 KG
3.6 Raw materials required with estimated Quantities
S.No. Chemicals Quantity /Month (In KG)
1. Methoxatrate ester 555.5
2. Acetone 1666.67
3. Hcl 10% 55.5
4. Sodium hydroxide 10% soln. 55.5
5. Rosuvastatin ester 286
6. Hydrochloric acid 0.3 n 66
7. Sodium hydroxide soln. 5% 100
8. Toluene 160
9. Methanol 8060
10. Calcium chloride 54
11. 2-n-propyl-4-methyl-6-(1’-methylbenzimidazole-2-yl) -
benzimidazole (RM-I)
825
12. 4’-bromomethylbiphenyl-2-carbonitrial 760
13. Potassium hydroxide 760
14. Methyl iso butyl ketone (MIBK) 2400
15. Hydro chloric acid 1100
Page 43 of 49
Pre-Feasibility Report
16. N-butanol 6200
17. Sodium hydroxide 1060
18. Hydoro chloric acid 1000
19. Methylene di chloride 5600
20. Ammonia soln. 300
21. Acetic acid 600
22. Sucrose 100
23. Pyridine 250
24. Chlosulphonic acid 280
25. Ammonium hydroxide 80
26. Aluminium chlorohydrate 407
27. Di hydromisnin 555
28. Sodium boro hydride 77.5
29. Methylene chloride 5750
30. Trimethyl ortho acetate 550
31. Di hydromisnin 555
32. Sodium boro hydride 77.5
33. Ethanol 1665 liter
34. Para tolune sulphonic acid 155
3.7 Resource optimization – Utilize & Recycling
The plant will work to optimize the resource utilization. The domestic and RO reject water
will be recycled and reused which reduce water requirement significantly. There will be
recover ≥96% solvent and unit will follow solvent guideline.
3.8 Availability of water and its source, Energy/Power requirement
3.8.1 Water
Water requirement of the project for domestic and industrial activity during operation phase
will be 8.3 KLD. The water requirement will be met through outsourcing.
Table 3.3: Water Requirement
S. No. Purpose Water Requirement in KLD
Existing Proposed Total
1. Process 2.50 1.5 4.0
2. Laboratory 0.25 0.25 0.5
3. Boiler Make up 1.0 1.0 2.0
4. Cooling towers Make
up
0.25 0.25 0.50
5. Domestic Usage 0.5 0.50 1.00
Total 4.5 3.5 8.0 KLD
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Water balance
3.8.2 Power Requirement
Ajmer Vidyut Vitran Nigam Limited (AVVNL), Rajasthan.
3.8.3 Fuel Requirement
For boilers:- Wood fire 20 MT. /Month
DG sets ;- HSD 200 LPM
3.9 Quantity of wastes to be generated (liquid and Solid)
Proposed unit already works on Zero Liquid discharge system, therefore no effluent will
generated.
Water consumption
Fresh water – 8.0 KLD
DM
Plant –
4.0
Utility
2.5
Domestic
Usage 1.0
Laboratory
0.5
Boiler
Make up
2.0
Cooling
towers
Make 0.5
up
ETP
3.7 KLD
Dispose
through
soak pit
0.6 KLD
Process waste
water – 1.8
KLD
DM Waste
water 1.3
KLD
Boiler blow
down 0.1 KLD Cooling
tower waste
0.1 KLD
Loss in Drying
0.9 KLD
Laboratory
W/W 0.4
After treatment used
in plantation
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3.9.1 Waste Water Generation and utilization
Table 3.5: Wastewater generation and Treatment Method
S. No Unit
Effluent Generation in KLD Treatment
Method Existing Proposed Total
1 Process waste 0.50 1.30 1.8
Through ETP
(3.7 KLD)
2 Laboratory 0.2 0.2 0.4
3 DM Waste 0.8 0.5 1.3
4 Boiler Blow down 0.05 0.05 0.10
5 Cooling tower
waste
0.05 0.05 0.10
6 Domestic Usage 0.30 0.30 0.60 Through Soak
pit
Total 1.9 2.4 4.3 KLD
3.9.2 Solid waste generation and Disposal
Table 3.6: Solid waste generation and Disposal
S. No. Name of the Solid
Waste
Total Quantity Disposal Method
1 Spent Carbon 0.59 MT/Annum CTDF, Udaipur
2 ETP Sludge 1.0 MT/Annum CTDF, Udaipur
Gaseous emissions & control
Flue gas emissions
There will be flue gas emission from one boiler and one DG set. The fuel consumption detail
and air pollution control measures are covered in below table.
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Sr. No. Stack
Attached
To
Stack
Height (m)
Type of Fuel Air
Pollution
Control
Measures
Parameter
1 Baby Boiler
30 MTR Wood
Briquettes
Cyclone Dust
Collector
PM
SO2
NOX
2 D.G. Set
Diesel - PM
SO2
NOX
3.10 Schematic representations of the feasibility drawing which give information of EIA
purpose.
The applicability of the S.O 1533 for the proposed project was explored by
considering different possibilities & provision made in the said notification.
Considering the products & project location of the proposed project it is noticed that the
proposed project falls under Category 5 (f) “A” of the Schedule-I of EIA Notification
SO 1533 and its amendments.
As per the provision of the SO 1533, it is necessary to get Environmental Clearance by
applying to Moef.cc, New Delhi along with the Environmental Impacts Assessment
Study Report for the proposed project prior to commissioning of the project
activities.
Therefore, the EIA is required to conduct to comply with provisions of SO 1533 made for
Category 5(f) “A” of schedule –I of the notification.
4.0 SITE ANALYSIS
The project proponent did not consider any other alternative site for proposed project.
4.1 Connectivity
Nearest Highway- State Highway-9 (1.0 KM) North
Nearest Airport- Dabok Udaipur Airport (30.0KM) South west
Nearest Railway station- Fatehnagar 5.0 KM North East
The nearest habitation from the site is Basani, Basni kala, Fatehnagar.
4.2 Land Form, Land use and Land ownership.
The land is registered by the name of “US Amino Private Limited”. The area where unit is
proposing expansion is already used for industrial activity and is almost flat terrain. The
total land area of the project is 4129 SQM and due to expansion there will be no additional
land acquired.
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4.3 Topography
The topography of the study area is mostly plain and gradually slopes towards east. There
will be no change in topography of area due the proposed project.
4.4 Existing Land use pattern
Table 4.1 Land Use Pattern
S No. Particulars Area Sq. M Percentage
1 Total Plant Area 615 14.89
2 Total Garden and Plantation Area 3017 73.1
3 Roads & Open Area 497 12.02
Total 4129 SQ. M. 100%
Fig. 4.1 Plant Layout
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4.5 Existing Infrastructure
Proposed expansion project has the basic Infrastructure there. The existing plant has capacity
to produce expanded quantity of product and there is no requirement of additional
infrastructure for the said expansion.
5.0 PLANNING BRIEF
Proposed plant activities will start after getting statutory clearance form related authorities.
The project will complete within one year. Further proposed project activities will take
care of all the rules and regulation of statutory authority and provide the control
measure and devices to achieve the standard norms.
6.0 Corporate Social Responsibilities:-.
The applicant shall spend 1.0 lacs/ Annum for five years for the development of the area. It is
proposed to provide drinking water facility in surrounding villages and schools by hand
pump/dug well/water tank, health camps and free medicine clothes distribution to poor
villagers.
6.1 Amenities /Facilities
Education- schools including middle, secondary and higher secondary schools, social welfare
hostels. Medical and Health- Community Health Centre, & Primary Health center are
available near villages.
6.2 Connectivity
The project site is very well connected by road through State Highway no. 9 and
Southern railways.
6.3 Drinking water Management
All the villages are electrified and drinking water facilities are extended to all villages.
6.4 Social Infrastructure available
Well-developed social infrastructure facilities are available at nearby habitations.
6.5 Power Requirement & Supply/Source
All the villages are electrified and drinking water facilities are extended to all villages.
7.0 REHABILITATION AND RESETTLEMENT (R & R) PLAN
Rehabilitation & Resettlement (R&R) plan is not require to proposed project.
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8.0 PROJECT SCHEDULE & COST ESTIMATES
8.1 Likely date of start of construction and likely date of completion
Construction is not required because the proposed expansion will be executed in existing
infrastructure. Proposed project activities will be started after getting statutory
clearance from related authorities.
Environment clearance 31st March, 2018 Consent to establish and consent to operate by 31st
April, 2018
Start production from 1th
June, 2018
8.2 Estimated Project Cost along with analysis in terms of economic viability of project
Proposed activity will provide benefits to the local people in terms of financial and
social welfare. Project cost for the proposed Expansion projects is Rs.85 lacs which includes
the cost of new plant machinery.
9.0 ANALYSIS OF PROPOSAL (FINAL RECOMMENDATIONS)
• Local people will get direct financial benefit by way of employment.
• Local people will get some contracts of supply and services to get indirect
income.
• Company will contribute in improving education and health facilities in nearby area.