Laboratory Freeze DryersRoutine Processes

The Optimal Product forYour Freeze-Drying

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Alpha 1-2

Alpha 1-4 / 2-4

Beta 1-8 / 2-8

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Experience, expertise, adaptability and flexibility for all freeze-drying procedures

With 65 years of applications and manufacturing experience, we are proud to be considered as the leader in freeze dryer technology.Our solutions offer outstanding craftsmanship and unparalleled innovation in refrigeration and vacuum technology.We understand your samples and applications are unique and offer a broad range of modular accessories to reliably deliver a specific solution for your process requirements.

Guaranteed consistent results for routine freeze drying

Routine processes place continual demands on the operating system. A high degree of consistent, user-friendly, intuitive technical functions and operational flexibility are expected features. The basic equipment of the Alpha and Beta series, combined with their specially developed operator interface „LDplus“ (Lyo-Display), live up to the challenges of safe and suc-cessful freeze drying day after day.

Innovative technology gives results

• Compact,high-performancelaboratoryequipmentrequires little space

• Dryingchamberabovetheicecondenserchamber–forhigh sublimation performance and short process times

• Icecondenserchamberswithhigh-qualitystainlesssteel with internal condenser coils

• Modulardesignforvariousapplications

• Digitallydisplayedicecondensertemperatureandindirect determining of the product temperature corresponding to the vapour pressure curve above ice, vacuum control for optimization of process times

• Datainterfaceoptional,e.g.forprocessdocumentation software LyoLogplus

Graduated condenser power and freeze drying capacities

Depending on the area of application, the laboratory freezedryers of the LDplus series are available in different sizes and with a wide range of accessories.Laboratory freeze dryers are available with two different ice condenser temperatures:

The different basic units have various maximum ice capacities:

The information concerning the ice condenser temperatureand maximum ice capacity is part of the name of the laboratory freeze dryers. A Beta 2-8 LDplus freeze dryer, for example, is a double-stage system with an ice condenser temperatureof-85°Candamaximumicecapacityof8kg.

The illustrations on the following pages show examples of possible system configurations.

Please describe your particular application. We will gladly advise you without any obligation on your part!

Selection criteria

Temperature Typical area of application

–55°C aqueousproducts(single-stage compressor)

–85°C productscontainingsolvents(double-stage compressor) or products with a low freezing point

Anlagentyp Alpha Alpha Beta

Max. 2kg 4kg 8kgice capacity

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The system control is a simple, intuitive interface forfreeze drying processes. The interface combining functionality and convenient operation:

• graphicLCdisplaywithaclearlayout • Presentationofthemostimportantprocessparameters

• wideselectionoflanguagesalreadyintegrated

• vacuumcontrol

• detailedmessages

• communicationsinterfaceavailableasanoption

• Option:ProcessdocumentationsoftwareLyologplus

LDplus–Comfortableinterface

ControlSystemLDplus(Lyo-Display-plus)

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Configuration

Beta 1-8 / 2-8

Alpha 1-4 / 2-4

Alpha 1-2

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Freeze-drying system Alpha 1-2Laboratorysystemwith2kgcapacityIcecondensertemperature-55°C

1 Manifoldfor8flasks,roundbottomflasks,wide-neckfilter bottles or distributors for ampoules

2 3 shelves, ø 200 mm ≙ 920 cm2, distance between shelves = 85 mm

3 3 shelves, ø 200 mm ≙ 920 cm2, distance between shelves=85mm,additionalportsfor8flasks,roundbottom flasks,wide-neckfilterbottlesordistributorsforampoules

4 Stoppering device with 2 shelves, ø 200 mm ≙ 557 cm2

Freeze-drying system Alpha 1-4 / Alpha 2-4Laboratorysystemwith4kgcapacityIcecondensertemperature-55°C,-85°Crespectively

5 Manifoldfor8flasks,roundbottomflasks,wide-neck filter bottles or distributors for ampoules

6 3 shelves, ø 250 mm ≙ 0.15 m2, distance between shelves=79mm,additionalportsfor12flasks, roundbottomflasks,wide-neckfilterbottlesor distributors for ampoules

7 2dryingchamberswith24portsforflasks,roundbottom flasks,wide-neckfilterbottlesordistributorsforampoules; 3 shelves optional, ø 250 mm ≙ 0.15 m2, distance between shelves = 79 mm

8 5 shelves, ø 360mm ≙ 0.5 m2, distance between shelves=70mm;(specialadapterplateavailable)

9 Stoppering device with 2 shelves, ø 250 mm ≙ 900 cm2;additionalportsfor8flasks,roundbottom flaskswide-neckfilterbottlesordistributorsforampoules

Freeze-drying system Beta 1-8 / Beta 2-8Laboratorysystemwith8kgcapacityIcecondensertemperature-55°C,-85°Crespectively

10Manifoldfor8flasks,roundbottomflasks,wide-neckfilter bottles or distributors for ampoules

11 5 shelves, ø 250 mm ≙ 0.25 m2, distance between shelves = 79 mm

12dryingchamberswith24portsforflasks,roundbottom flasks,wide-neckfilterbottlesordistributorsforampoules; additional 3 shelves, ø= 250 mm ≙ 0.15 m2, distance between shelves = 79 mm

13 5 shelves, ø= 360 mm ≙ 0.5 m2, distance between shelves=70mm;(specialadapterplateavailable)

14 Stoppering device with 4 shelves, ø 250 mm ≙ 0.18 m2

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5 987

141311 12

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Technical Data

Icecondenser-Max.capacity- Performance

- Temperature-ChambervolumeMax.producttemperaturewhendryinginsidetheicecondenser chamber

Refrigeration system

Dimensions of base unit (w x h x d)

Weight

Power supply

Alpha 1-2 (other voltages upon request)

Nominal power of the basic unitMax.ambienttemperature(unitisair-cooled,highertemperatures upon request)

Alpha 2 - 4

4kgmax.4kg/24happrox.-85°Capprox. 6,5l

approx.-35°C

2x0.51kW

width: 390mmheight: 415 mm

depth: 540 mm approx.55kg230 V/50 Hz

220 V/60 HZ

208V/60 Hzapprox.0.95kW

+10°Cbis+25°C

Alpha 1 - 4

4kgmax.4kg/24happrox.-55°Capprox. 6,5l

approx.-20°C

0.51kW

width: 390mmheight: 415 mm

depth: 540 mm approx.42kg230 V/50 Hz

220 V/60 HZ

208V/60 Hzapprox.0.53kW

+10°Cbis+25°C

Alpha 1 - 2

max.2.5kgmax.2kg/24happrox.-55°Capprox. 3,5l

approx.-20°C

0.43kW

width: 315 mmheigh: 345 mm

depth: 460 mm approx.28kg

230 V/50 Hz

approx.0.34kW

+10°Cbis+25°C

Icecondenser-Max.capacity- Performance

- Temperature-ChambervolumeSample temperature when pre-freezing inside the ice condenser chamber

Refrigeration system

Dimensions of base unit (w x h x d)

Weight

Power supply (other voltages upon request)

Nominal power of the basic unitMax.ambienttemperature(unitisair-cooled,highertemperatures upon request)

Beta 2-8

8kg6kg/24h

approx.-85°Capprox. 11l

approx.-35°C

2x0.51kW

width: 780 mmheigh: 415 mm

depth: 540 mm approx.78kg230 V/50 Hz

220 V/60 HZ

208V/60 Hzapprox.1kW

+10°Cbis+25°C

Beta 1-8

8kg6kg/24h

approx.-55°Capprox. 11l

approx.-20°C

0.51kW

width: 780 mmheigh: 415 mm

depth: 540 mm approx.63kg

230 V/50 Hz

220 V/60 HZ

208V/60 Hzapprox.0.58kW+10°Cbis+25°C

Useful accessories for your freeze dryer

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Cooling bath

Ifliquidsaretobedriedinflasksinalayermorethan1cmthick,thenwerecommendusingashell-orspin-freezingar-rangement (see Figure) in a cooling bath. The rotation spreads theliquidontheinnerwallsoftheflaskwhereitfreezes.Thefreezing process produces a thinner layer and increases the potential area for sublimation, which considerably reduces the overall drying time.

CoolingbathCB18-40 Rotator for round bottomflasksFigure1:Shell-Freezinginflasks

Specialrackfor mictrotiter-plates

Round-bottomflask Wideneckedbottleswithintegra-ted particle filter

AmpouleManifold

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Service Representatives

The Martin Christ freeze-drying systems are successfully usedworldwide. An international network of representatives existsto provide assistance and service. Specialists directly from ourcompany are available within Germany for assistance.

Our hotline is always accessible, 24 hours a day, 365 days ayear

Location of selected Martin Christ international representatives

Please check www.martinchrist.de/contact/distributors for a detailed list of Martin Christ representatives.

Vancouver

San Diego

Mexico City

Montreal

New York

Oslo

Copenhagen

LondonBrussels

Madrid

Tunis

Cairo

Dubai

Delhi

Mumbai

Chennai Bangkok

Beijing

Seoul

Shanghai

Hong Kong

Tokio

Perth

Adelaide

Sydney

Singapur

Riyadh

Moscow

Johannesburg

IstanbulRom

Paris

Osterode

Bogota

Lima

Sao Paolo

Buenos AiresSantiago

Auckland

SystemsmadebyCHRISTaresuccessfullyusedinmorethen70countriesworldwide.Aninternationalnetworkofrepresentatives exists to provide required services. Specialists directly from our company are available for assistance as well.

We are at your service at all times!

Service and Representatives

Selected CHRIST agencies abroad

You can find an overview of our representatives abroad together with a list of contact persons at www.martinchrist.de

WarsawKiev

Lisbon Athen

Dhaka

TonawandaVienna

PragueBudapest

Basel

Helsingborg

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Service Representatives

The Martin Christ freeze-drying systems are successfully usedworldwide. An international network of representatives existsto provide assistance and service. Specialists directly from ourcompany are available within Germany for assistance.

Our hotline is always accessible, 24 hours a day, 365 days ayear

Location of selected Martin Christ international representatives

Please check www.martinchrist.de/contact/distributors for a detailed list of Martin Christ representatives.

Vancouver

San Diego

Mexico City

Montreal

New York

Oslo

Copenhagen

LondonBrussels

Madrid

Tunis

Cairo

Dubai

Delhi

Mumbai

Chennai Bangkok

Beijing

Seoul

Shanghai

Hong Kong

Tokio

Perth

Adelaide

Sydney

Singapur

Riyadh

Moscow

Johannesburg

IstanbulRom

Paris

Osterode

Bogota

Lima

Sao Paolo

Buenos AiresSantiago

Auckland

With a unique and highly diversified range of equipment and accessories, we offer freeze dryers and vacuum concentrators for everyareaofapplication.Challengeus!

Our product range

Pilot freeze dryers for development and optimisation of processes with ice condenser capacities between 4and12kg

Freeze dryers for industrial production with ice condenser capacitiesbetween20and500kgandindividualsystemcustomisation, including loading and unloading systems

Freeze dryers for routine applications and the field of researchand development with ice condenser capacities between 2and24kg

Rotational vacuum concentrators for routine applications up tohigh-endconcentrationtasksinthefieldofpharmaceuticalresearch

Martin Christ Gefriertrocknungsanlagen GmbHAn der Unteren Söse 50 · D-37520 Osterode am HarzGermanyTel. +49 (0) 55 22/50 07- 0 · Fax +49 (0) 55 22/50 07-12www.martinchrist.de · info@martinchrist.de 03

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