Neuromics base presentation_12_12_2016
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Characterized, Tested and Discovery Ready …For Results you can Trust and Understand Image: Neurons+Astrocytes Co-cultures
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Transcript of Neuromics base presentation_12_12_2016
Characterized, Tested and Discovery Ready
…For Results you can Trust and Understand
Image: Neurons+Astrocytes Co-cultures
Our Cornerstone: “Hard to Find” Human Primary Cells and 3-D Tissue Models
Cells, 3-D Models and Custom Services
Related Solutions
Markers
Apoptosis
Proteins+Growth Factors
Gene Tools
ProteinGeneration +Purification
>160 peerReviewed
Publications
Results You Can Trust
3rd Party Service For Customer FeedbackNeuromics review summary5 74★4 27★3 1★102 reviewsSample Review
C. H.The order arrived quickly. The service was great!Product Name: Human Brain Microvascular Endothelial Cells, 500,000+ Cells, - (Cat# HEC02)Human Brain Microvascular Pericytes (HBMPVCs), 500,000+ Cells, - (Cat# HMP104)ENDO-Growth Media, - (Cat#MED001)Pericyte-Growth Media, - (Cat# PGB001)Organization: UCS
Free Replacement are Money BackEnables us to troubleshoot and get it right.With cells, it prevents us from being “one and done”
Results You Can TrustSample PublicationsXiugong Gao, Hsiuling Lin, Radharaman Ray, Prabhati Ray. Toxicogenomic Studies of Human Neural Cells Following Exposure to Organophosphorus Chemical Warfare Nerve Agent VX. Neurochemical Research. February 2013....Human hN2 neurons were obtained from Neuromics...Hsiao, Y.-S., Kuo, C.-W. and Chen, P. (2013), Multifunctional Graphene–PEDOT Microelectrodes for On-Chip Manipulation of Human Mesenchymal Stem Cells. Adv. Funct. Mater., 23: 4649–4656. doi: 10.1002/adfm.201203631.The hMSCs (Neuromics, Edina, MN) used in experiments were at passage 3-9. Each passage of hMSCs was maintained on the TCPS dishes with a pre-coating of Geltrex reduced growth factor basement membrane matrix (Invitrogen, CIBCO, NY). All hMSCs were maintained in the growth medium, Dulbecco's modified Eagle's medium-low glucose (DMEM-LG) supplemented with mesenchymal cell growth supplement (MSCGM, Lonza) containing L-glutamine, penicillin, and streptomycin, and incubated in an atmosphere containing 5% CO2 at 37 °C. The medium was replenished every 3 to 4 days…Figueroa Johnny D., Serrano-Illan Miguel, Licero Jenniffer, Cordero Kathia, Miranda Jorge D., and De Leon Marino.Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury. Journal of Neurotrauma. March 2016, ahead of print. doi:10.1089/neu.2015.4186.... catheters attached to an osmotic mini-pump. To facilitate delivery and uptake, siRNA aliquots were mixed (1:5, v/v) with the cationic lipid based transfection reagent i-FectTM (Neuromics, Edina, MN). Injections A group of animals were ...
Custom Services ExampleHigh Throughput Analysis of TBI Patients
Custom ServicesHigh Throughput Analysis of TBI Patients
100s of Patient Samples (Serum) Provided by
Program Sponsor
Proteostep 2DLiquid Fractionation
App. 2,000 Protein Samples for Arraying
Microarray Printing
Production of Required # of Arrays for Testing Samples
Only a Small Fraction of Samples Prove Clinically
Valid
Cell Lysates
Focus For 2017More Primary Human Cells
For example OligodendrocytesCells derived from diseased tissue
Add Content to 3-D Models
endothelial cells (high magnification) astrocytes (high magnification)
Compounds, Oligos and Small Molecules This model mimics the transport properties of the BBB due to the formation of tight junctions, higher expression of specific carriers, or great cell viability. This 3-D in vitro model is developed by culturing brain endothelial cells with pericytes and astrocytes layered in an insert. This model improves endothelial cell polarization and enhance the formation of tight junctions, provide better endothelial cell-to-cell contact that is important for barrier development, and prevent the dilution of secreted neurotrophic factors, and these conditions collectively led to the development of an in vitro model that can truly mimic the BBB.
Sampling of Customers
Human Schwann Cells-SCI Derived
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Pete Shuster-CEO and OwnerDirect Phone: 612-801-1007Email: [email protected]
5235 W 74th Street Suite 8Edina, MN, 55439www.neuromics.com
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