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![Page 1: Neurologic Complications following Regional Anesthesia in ... deficits - Dr. Munnur.pdf · Neurologic Complications following Regional Anesthesia in Obstetrics ... CT or Myelography](https://reader033.fdocuments.us/reader033/viewer/2022050902/5aa3781c7f8b9ab4208e59e7/html5/thumbnails/1.jpg)
Neurologic Complications following
Regional Anesthesia in Obstetrics
Uma Munnur, M.D
Associate Professor
Department of Anesthesiology
Baylor College of Medicine
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Neurologic Complications
Immediate
Motor block, unexpectedly high block, prolonged
block, seizures
Prolonged or delayed
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Etiology
Obstetric etiology
Traumatic nerve injury
Spinal Origin
Spinal cord compression
Hematoma
Abscess
Meningitis
Bacterial
Chemical
Relation to the local
anesthetic
Transient Neurologic
Symptoms (TNS)
Cauda equina syndrome
Cerebral origin
Headache and decreased
ICP
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Obstetric Anesthesia Claims
1990 to present, claims for maternal nerve injury
–greater than 20% (89)
Radiculopathy – 54% (48/89)
Spinal cord injury – 18% (16/89)
Paraplegia in 10/16
Arendt, Current Opinion in Anesth, 2009
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Obstetric Etiologies
Peripheral nerve injuries
Cephalo-pelvic disproportion
Difficult labor
Instrumental delivery
These nerve injuries have to be ruled out before considering an anesthetic implication.
Trauma to the lumbosacral trunk
commonest peripheral nerve lesions of child birth.
Postpartum foot drop may result from fetal brow compression of the lumbosacral trunk.
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Obstetric Etiologies
In-correct or prolonged
positioning
Compression of
• Lateral cutaneous nerve
• Common peroneal nerve.
Abnormal presentation
Macrosomia or prolonged
labor
Post-partum femoral
Obturator neuropathy.
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Obstetric Etiologies Evaluation
Review anesthesia record
Pain or paresthesias before delivery
Stirrups time
Fetal birth weight
Length of labor
Forceps use
Mapping sensory and motor deficits
Neurology consult and EMG for prognosis
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Obstetric Etiologies: Management
Foot-drop splint – ambulatory patients
Foot pushboard at night
Spontaneous recovery depending on nerve
damage
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Pressure Subjected Peripheral Nerves
In Pelvis
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Total New Preexisting
Lateral femoral
cutaneous 24 8
Femoral 22 0
Common Peroneal† 3 0
Lumbosacral plexus 3 0
Sciatic 2 1
Obturator 3 0
Radicular 5 0
Other 1 1
Total 63 10
Distribution of Nerve Injuries in Laboring
Parturients
Wong, Ob & Gyn, 2003
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Post Partum Sensory and Motor Deficits
Ong, A&A, 1987
Analgesia Technique # Deliveries # ND Incidence of ND
None 8198 2 1 / 4099
Inhalational Analgesia 4766 3 1 / 1589
Epidural 9403 34 1 / 277
General Anesthesia 864 3 1 / 288
Other 596 3 1 / 199
TOTAL 23,827 45 1 / 530
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Identification of Lumbar Interspinous Space
Ultrasound vs palpation
121 obstetric pts
Agreed 55%
Ultrasound usually higher than palpation
One or two spaces higher than intended
Whitty, IARS, 2008
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Identification of Lumbar Interspinous
Space
Van Gessell et al
59% dural punctures 1-2 spaces higher than
assumed
Broadbent et al
Experienced anesthetists
85% of observations space was 1-4 segments
higher
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Complications of Epidural
Obstetric Analgesia
Intravascular injection 1:5,000
Intrathecal injection 1:2,900
Subdural injection 1:4,200
High or total spinal 1:16,200
Jenkins, IJOA, 2005
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Epidural hematoma 1:168,000
Deep epidural infection 1:145,000
Persistent neurologic injury 1:240,000
Transient neurologic injury 1:6,700
Event Rates for Complications
Ruppen, Anesthesiology, 2006
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Epidural Catheter-Induced Traumatic
Radiculopathy
7 cases during 12 month period – Yoshii, Reg
Anesth, 1994
24-44% transient paresthesias
Stiffer nylon catheter greater incidence than
polyurethane
Open end (single pore) greater than closed end
catheters
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Traumatic Nerve Injury
Motor Root Injury
Lower Motor Neuron
Paralysis
Sensory Root Injury
Painful paresthesias
Peripheral Nerve Injury Intrinsic Maternal Palsy
from Positioning
Segmental DistributionCord or Root injury
Peripheral Distribution
Segmental Distribution
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Conus Medullaris Injury
7 pts injury with spinal and CSE
Persistent neurologic sequelae
MRI -spinal cord injury
Pain, sensory deficit, foot drop, & bladder
dysfunction
Reynolds, Anesthesia, 2001
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Word of Caution
Pencil-point spinal needles must be advanced
further than cutting needles before the orifice is
within the subarachnoid space, at which point the
tip may impinge on the spinal cord
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Thorough History & Physical
Examination
Review
Anesthesia Record
Paresthesias
Pre-existing Neurologic disease
Early Neurology consultation
EMG, Nerve conduction studies
Traumatic Nerve Injury - Evaluation
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Minor Neurologic Injury
Observation
Recovery within a few days to a few months
Major Neurologic Injury
Follow Recommendations of Neurology and
Physiotherapy
Traumatic Nerve Injury - Management
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Epidural Hematoma
Incidence 0.2-3.7:100,000 obstetric epidurals
Features:
Severe backache
Neurologic deficit
Tenderness
Unexplained fever
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Epidural Hematoma
LMWH and Obstetric neuraxial blocks
No reported cases
Loo, IJOA, 2000
If platelet count 80-100 epidural placed
66% academic practitioners
55% private practitionersBeilin, A&A, 1996
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Evaluation and Treatment
History & Physical examination
Verify Coagulation profile and Platelet count
Early Neuro-surgical Consultation
MRI of Spine
CT or Myelography if MRI is unavailable
Spinal cord decompression (within 8hr)
Epidural Hematoma
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Severe Back Pain
Local Tenderness
Fever with Chills
Leucocytosis
Paresthesias
Urinary Retention
Irreversible Paraplegia
Epidural Abscess
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Risk Factors for Epidural Abscess
Prolonged catheterization 1-4 days
Venous trauma or difficult insertion
Opioid without local anesthetic
Diabetes or immunosuppression
Body fluids in bed
Poor aseptic technique
Reynolds,, Neurologic complications, 701
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Evaluation
History & Physical Examination
Labs – WBC count and differential
Early Neuro-surgical Consult
Myelogram, CT Scan
MRI –gadolinium enhancement
Epidural Abscess
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Epidural Abscess
Treatment:
Antibiotics
Percutaneous needle drainage- Tabo,
Anesthesiology, 1994
Emergent laminectomy and
drainage under direct vision
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Bacterial Meningitis
Fever, headache, photophobia
Confusion, drowsiness, vomiting
Neck stiffness, elevated WBC
Positive kernig’s sign
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Bacterial Meningitis- Risk Factors
Entry point-blood borne or dural
puncture
Streptococcus viridans
No face mask
Vaginal infection
Bacteremia
Epidural blood patch
Reynolds, Neurologic complications, 701
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Case Reports of Meningitis in OB
Patients
Labor
Spinal 9
CSE 7
Unintentional dural
puncture 3
Uncomplicated epidural 6
Cesarean Section
Spinal 11
Epidural 1
Reynolds, Neurologic complications, 701
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Routine epidural turns deadly- April
2,2003
Julie LeMoult
Strep Meningoencephalitis
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Aseptic Meningitis
Fever, headache, nuchal rigidity, and photophobia
Onset 24hr after dural puncture
CSF
Opalescent and sterile
Variety of white cells in increased number
Treatment Symptomatic
Empiric Antibiotics
Usually subsides without sequelae - few days
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Management
CSF analysis & Microscopy
Increased CSF pressure
Increased Protein and WBC
Decreased Glucose
Appropriate Antibiotics
Bacterial Meningitis
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Ischemia
Pressure on blood vessels
Dual blood supply to the terminal part of
spinal cord
Major supply – artery of Adamkiewicz
Minor supply- iliolumbar and lateral sacral
arteries
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Anterior Spinal Artery Syndrome
Causes - severe arterial hypotension
Necrosis of the anterior two thirds of the
spinal cord below the lesion
Features
loss of motor function
loss of pain and temperature
sparing of vibration and joint sensation
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Cauda-Equina Syndrome
Signs and symptoms
Bowel and bladder dysfunction
Motor and sensory deficit
Saddle sensory loss
Etiology
Maldistribution
Excessive doses of 5% lidocaine
Loo, AAS, 1999;43:371-9
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Cauda Equina Syndrome
6 Cases of CES reported to Swedish
Pharmaceutical Insurance (1993-97)
Recommendation
Hyperbaric lidocaine – no greater than 2%
Total dose limited to 60 mg
Loo, AAS, 1999;43:371-9
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Transient Neurologic Symptoms
(TNS)
Lidocaine Spinal Anesthesia 16 - 40%
Pain or Sensory abnormalities in the lower back, buttocks or lower extremities
Starts within a day –Resolves over a week
Risk Factors
Obesity
Lithotomy
Out patient status
Lidocaine
11.9%
Tetracaine
1.6%
Bupivacaine
1.3%
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TNS in Obstetric Patients
Incidence very low
Cephalad spread of LA
Increased elasticity of musculoskeletal system due to
relaxin potentially protective
Wong, Reg Anesth and Pain Medicine, 1999
Aouad, A&A, 2001, 401-4
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Dose and Lidocaine concentrations
No effect on TNS
Management
EMG, Nerve conduction studies, SSEP are
Normal
NSAIDs and Oral Opioid analgesics
Transient Neurologic Symptoms (TNS)
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Inherited Neuropathy
28 yr s/p C/S under epidural-rt foot drop
and lateral foot numbness
L5 root injury and referred to neurology
5 months later seen in clinic after recovery
8 yr ago lt foot with similar symptoms
Heriditary neuropathy with liability to
pressure palsies (HNPP)
A&A, 2005, 100, 547-8
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HNPP
16:100,000 population
Autosomal dominant with variable
penetrance
Second or third decade
Painless focal neuropathies at common
entrapment sites after minor trauma or
compression
Resolve in days to months
Neuromuscular disorders, 1997, 8; 529
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Cranial Nerve Palsy with PDPH
Abducent nerve most susceptible
Facial nerve palsy
Cranial nerve VIII dysfunction
Without blood patch risk for permanent tinnitus
Visual field defects
Trigeminal nerve disturbance- transient
effect
High spinal block
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Hearing Loss
Dural puncture
0.4%-9.1% transient decrease in low frequency
Unilateral
Perilymphatic pressure decreases in cochlear aqueduct
14% parturients with spinal 24g Sprotte (Hussain, 1996,
Otolaryngology)
Resolution after blood patch
Seminars of Perin, 2002, 154-68
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Cranial Subdural Hematoma
Reduced CSF pressure-rupture of bridging
meningeal veins
Reported after:
Dural puncture with epidural needle
Spinal needle
Myelography
Diagnostic lumbar puncture
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Subdural Hematoma
Davies, BJA, 2001
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Frequency of Systemic Toxic Reactions
Author Epidural STR Rate
Pre-1982 rate
Blundell, 1955 790 87 110
Bonica, 1957 3,637 116 320
Moore, 1978 6,729 13 20
Kenepp, 1981 4,003 40 100
Post-1982 rate
Tanake, 1993 17,439 20 11
Brown, 1995 16,870 2 1.2
Auroy, 1997 30,413 4 1.3
Regional Anesthesia and Pain Medicine,
2002, 556-561
Rate = frequency per 10,000
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Closed Claims Data Experience
Mulroy, Regional Anesthesia and Pain Medicine,
2002, 556-561
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Conclusion
Close follow- up after neuraxial anesthesia
Aseptic and meticulous technique
Avoid upper lumbar interspace at all times
Consult Neurology/ Neurosurgery as needed