Neuro Unit 5: How do our choices change our brains?
description
Transcript of Neuro Unit 5: How do our choices change our brains?
![Page 1: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/1.jpg)
Neuro Unit 5: How do our choices change our brains?
Unit 5.2: Drugs of abuse alter synaptic transmission
![Page 2: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/2.jpg)
Do Now:
• Addictive drugs increase synaptic transmission in the reward pathway. Brainstorms ways that drugs could increase synaptic signaling.
![Page 3: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/3.jpg)
The Brain’s Reward CircuitHuman Brain Rat Brain
VTANAc
PFC
![Page 4: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/4.jpg)
The Brain’s Reward Circuit
VTA
NAc
Prefrontal Cortex
![Page 5: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/5.jpg)
Synaptic Transmission
Ca2+
1. Action Potential in VTA
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
4. Dopamine binds to postsynaptic receptors.
5. Ion channels open on postsynaptic membrane,
allowing ions to flow into cell.
6. Excess dopamine is pumped back into presynaptic cell.
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing dopamine into synaptic cleft
Dopamine
![Page 6: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/6.jpg)
How do drugs of abuse alter synaptic transmission???
![Page 7: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/7.jpg)
VTA
NAc
Prefrontal Cortex
Inhibitory Neuron
The Reward Pathway
![Page 8: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/8.jpg)
VTA
NAc
Prefrontal Cortex
Inhibitory Neuron
Cocaine & Amphetamines
NicotineMarijuana
AlcoholHeroin & Morphine
Heroin & Morphine
![Page 9: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/9.jpg)
Ca2+
Dopamine
Inhibitory Interneuron
AlcoholHeroin & Morphine
![Page 10: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/10.jpg)
Ca2+
Dopamine
Inhibitory Interneuron VTA
Nicotine &Marijuana
![Page 11: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/11.jpg)
Ca2+
Dopamine
VTA NAc
Cocaine & Amphetamines
Heroin & Morphine
![Page 12: Neuro Unit 5: How do our choices change our brains?](https://reader036.fdocuments.us/reader036/viewer/2022070420/56815f63550346895dce528c/html5/thumbnails/12.jpg)
Drug
Site of action in reward pathway
Drug Target (Receptor, Reuptake
pump, etc.)
Effect on VTA action potentials
Effect of dopamine
release and/or dopamine
Effect on NAc action
potentials
Cocaine VTA Dopamine reuptake pump
None Increase dopamine levels
Increase
Amphetamine VTA Dopamine reuptake pump
None Increase dopamine levels
Increase
Nicotine VTA Nicotinic receptors
Increase Increase dopamine release & levels
Increase
Alcohol Inhibitory interneuron
GABA receptors
Increase Increase dopamine release & levels
Increase
Heroin & Morphine
Inhibitory interneuron & NAc
Opiate receptors
Increase Increase dopamine release & levels
Increase
Marijuana VTA Cannabinoid receptors
Increase Increase dopamine release & levels
Increase