NEURO-ONCOLOGY€¦ · NEURO-ONCOLOGY MAYOMEDICALLABORATORIES.COM 800-533-1710 or +507-266-5700...
Transcript of NEURO-ONCOLOGY€¦ · NEURO-ONCOLOGY MAYOMEDICALLABORATORIES.COM 800-533-1710 or +507-266-5700...
NEURO-ONCOLOGY
M A Y O M E D I C A L L A B O R A T O R I E S . C O M 8 0 0 - 5 3 3 - 1 7 1 0 o r + 5 0 7 - 2 6 6 - 5 7 0 0
CONSULTATIVE SERVICE
70012 Pathology Consultation (appropriate stains and ancillary testing may be performed in order to render an accurate diagnosis)
The Mayo Clinic Deparment of Laboratory Medicine and Pathology offers a broad menu of testing for central nervous system (CNS), peripheral nerve sheath (PNS) and pituitary tumors. Our world renown neuro-oncology experts in pathology and genetics provide an integrated approach for testing and interpretation of results.
GLIOMA / GLIOBLASTOMAATRX Immunostain
BRAF V600E Immunostain
Glial Fibrillary Acidic Protein (GFAP) Immunostain
IDH1 Mutation (R132H) Immunostain
Ki67 (MIB-1) Immunostain
Olig2 Immunostain
p53 Immunostain
S-100 Protein Immunostain
1p/19q Deletion in Gliomas, FISH, Tissue*,+ [ID: GLIOF]
BRAF Mutation Analysis (V600E), Tumor* [ID: BRAFT]
Chromosomal Microarray, Tumor, FFPE*,+ [ID: CMAPT]
IDH1/2, Mutation Analysis* [ID: IDH]
MGMT Promoter Methylation, Tumor* [ID: MGMT]
Comprehensive Neuro-oncology Panel by NGS (coming in 2016)
NEURONAL / EMBRYONAL / MEDULLOBLASTOMAINI1/BAF47 Immunostain
Medulloblastoma panel: Beta catenin, YAP and GAB1 Immunostains
Neu-N Immunostain
Neurofilament (NF) Immunostain
Synaptophysin (SYNAPTO-B) Immunostain
Medulloblastoma, FISH, Ts (MYCN amplification, MYC ampification, chromosome 6 monosomy)* [ID: MEDF]
ATRX immunostain - loss of expression in astrocytoma cells
Pleomorphic xanthoastrocytoma (H&E image) Mutant IDH1 immunostain FISH: 1p deletion (oligodendroglioma)
*individually orderable+microarray is the preferred test but for small specimens 1p/19q FISH can be ordered
OncoScan Array PatternTriple Positive Glioma (IDH mut, TERT mut, 1p/19q codel)Eckel-Passow et al. NEJM 2015; 372:2499-2508
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MOLECULAR PATHOLOGY
ROBERT B. JENKINS, M.D., PH.D. BENJAMIN R. KIPP, PH.D.
CONSULTANTS
ANATOMIC PATHOLOGY
CATERINA GIANNINI, M.D., PH.D
MARK E. JENTOFT, M.D.
JOSEPH E. PARISI, M.D.
ADITYA RAGHUNATHAN, M.D.
01/2016
PITUITARY TUMORSAdrenocorticotropin Hormone (ACTH) Immunostain
Alpha Follicle Stimulating Hormone (FSH) Immunostain
Beta FSH Immunostain
Beta LH Immunostain
Beta Thyroid Releasing Hormone (TSH) Immunostain
Growth Hormone (GH) Immunostain
Prolactin Immunostain
OTHER PRIMARY CNS TUMORS (INCLUDING GERM CELL, CNS LYMPHOMA AND PERIPHERAL NERVE TUMORS)
Alpha-1-Fetoprotein (AFP) Immunostain
Alpha-B Crystallin Immunostain
BCL2 Immunostain
BCL6 Immunostain
CD3 Immunostain
CD20 Immunostain
CD 117, (c-Kit) Immunostain
CD56 (NCAM) Immunostain
OTHER PRIMARY CNS TUMORS (CONT’D)
Collagen IV Immunostain
Chromogranin Immunostain
Epithelial Membrane Antigen (EMA) Immunostain
Human Chorionic Gonadotropin (Beta-hCG) Immunostain
Inhibin Immunostain
Ki67 (MIB-1) Immunostain
MUM1 Immunostain
Placental Alkaline Phosphatase (PLAP) Immunostain
OCT-4 Immunostain
SOX-10 Immunostain
STAT6 immunostain
Epstein-Barr Virus (EBV) RNA Detection by In Situ Hybridization* [ID: 80786]
Germ Cell Tumor (GCT), Isochromosome 12p, FISH, Tissue* [ID: GCTF]
MYD88, L265P, Somatic Gene Mutation, DNA Allele-Specific PCR* [ID: 70138]
*individually orderable