NEOSOLTM WATER SOLUBLE INGREDIENTSNeoSol™ Ingredients are innovative solutions designed and developed for improving solubility of active ingredients and standardized extracts.

NeoSol™ is a proprietary new technology to achieve optimized natural extract solubility.

The supramolecular structures are based on combination and interaction of the active ingredient with carriers with different characteristics and functions under a special energetic influence.

The new complex increases active compounds availability, improving the physiological activity and efficacy.

NeoSol™ optimizes active compund solubilityMany substances and natural extracts have low solubility in water. Any substance or nutrient to exert benefits in the body need to be absorbed, crossing the physiological membranes and reaching the blood flow. Dissolution is fundamental for activity.

+

+

=

=

Carrier

Mix

1 µm

10 µm

Active Ingredients

Biocatalyst

Vibrational Energy

(solvent free)

Vibrational Energy

(solvent free)

New complex Multicompositum

NeoSolTM

Interactions and reduced particles size

Poor solubility = low absorption

Good solubility = high bioavailability

Several new NeoSolTM Ingredients under develepoment.

NeoSol™ is the result of a balanced combination of Nature and Science: highly purified natural ingredients and standardized vegetable extracts are transformed into technological products for superior performances in liquid formulation of dietary supplement and functional foods.

Produced with GMP certified active ingredients and in compliance with the highest quality standards.

NeoSolTM Active Ingredients are stable. Solvent-free process.

Allergen free, GMO Free, Irradiation free, Gluten free, Suitable for vegetarian.

LINNEA NEOSOLTM PLATFORMProduct Indication

NeoSol™ RCL40 Anti-aging Menopause Red Clover Isoflavone Aglycones Extract Antioxidant

NeoSol™ Ginkgo Anti-aging Anti-cellulite

Ginkgo Biloba 24/6 Extract Microcirculation Vascular protection

Ocular microcirculation Tinnitus and vertigo

Ag+

Ag+

Ag+

TiO2

+

++

Ag+

Ag+

Ag+

+

++

SiO2

Capsules

Soft gel

Cream

Wipes

Foam / Spray

SILVERA natural, ancient antimicrobic Silver antimicrobial activity has been widely recognized since ancient Greek

and Roman times.

Ionized Silver is commonly used for topical treatment of dermatological and

gynecological discomforts and skin disorders.

MECHANISM OF ACTIONSilver is a very efficient antibacterial but only the Monovalent Ion (Ag+) is active.

SylTechTM is the first technology capable of driving stabilized Silver monovalent ions

directly to the site of action for the maximum extend of antibacterial activity.

1

3

2

SylTechTM, effective Ag+ at a low concentration

Ag+ thousand times lower than other Silver preparations

Allergen free - No risk of resistance - No risk of Argyria

THE IMPORTANCE OF PARTICLE SIZEThe micro-technology ensures a special range of particles size, averaging

of 0.2-0.3 micron.

SylTechTM microcrystals achieve the maximum extent of interaction on tissue creating

a film layer.

Protective filmThe effective film barrier assists the natural repair of the tissue.

The tissue is isolated creating a microenvironment suitable for a fast spontaneous

cicatrisation.

Further microbial attacks are limited, creating the best conditions for the

regeneration of the local tissue.

SylTechTM COMBINED EFFECTSChemical, Physical and Physiological combined effects.

AntimicrobicMicro-Silver Ag+

Ready, Active, Safe

ProtectingMicro-System

Barrier effect, Hydrating, Tolerant

HealingMicro-Silver Ag+ System

Physiological response

Self-Generating

CLINICALClinical application of microparticles in infection disease and in mucosal healing

Foam & Gel

CLINICALClinical application of microparticles in infection disease and in mucosal healing

Foam & Gel

Study

Pilot Clinical Trial

Pilot Clinical Trial

Pilot Clinical Trial

Large Clinical Trial

Formulation

Spray foam

Cream gel (vulvar)

Spray Foam

Spray Foam

End points

Vulvitis

Vulvar disease

Vulvar dermatosis (lichen)

Vulvar dermatosis (lichen)

Subjects

15 women

12 women

20 women

40 women

Duration

20 days

15 days

30 days

60 days

Status

Completed

Completed

Published OJOG (2015), 5, 239-243

Q3 2015

Vaginal capsules and gel

On going multidisciplinary Clinical Trials evaluating the effectiveness in infection disease and in mucosal healing

in relation to the treatment of:

• Gynaecological lesions and infections (vulvar, vaginal)

• Dermatological disease (acne, labial herpes, wounds)

• Proctologic diseases (anal fissures, haemorrhoids)

Pilot Clinical Trial

Pilot Clinical Trial

Large Clinical Trial

Pilot Clinical Trial

Vaginal Hard Capsules

Vaginal Softgel capsules

Vaginal Softgel Capsules

Vaginal gel (internal)

Vaginal syntomatic ectropion Bacterial Vaginosis

Vaginal syntomatic ectropion Bacterial Vaginosis

Vaginal syntomatic ectropion Bacterial Vaginosis

Vaginal Atrophy Symptoms (Dryness, Dyspareunia)

10 women

15 women

60 women

15-20 women

30 days

30 days

30 days

30 days

Completed

Q3 2015

Start Q4 2015- Q1 2016

Q3 2015

EU Approved indication:“Vaginal capsules/foam/gel for the treatment of vulvar-vaginal diseases, bacterial and viral infections (HSV-2) and

co-adjuvant treatment of post-partum lesions“

Vulvar Spray Foam Medical device CE Class IIb for external use

Vulvar GelMedical device CE Class IIb for external use

Vaginal CapsulesMedical device CE Class IIb for internal use

Vaginal SoftgelsUnder development

Vaginal Gel with NeoSol™ RCL40 Under development

Wipes with HamamelisUnder development

APPLICATION PLATTFORM Gynecology

Indications

• Vulvitis and vulvar dermatosis (lichen)

• Post-partum lesions (episiotomy)

• Vulvar redness, irritation post-coitum, iperhydrosis

• Day surgery lesions (colposcopy)

• Coadjuvant genital warts and herpes simplex (HSV-2) treatment

• Vaginitis

• Ectropium

• Bacterial infections and candidiasis

• Vaginal atrophy: dryness, dyspareunia

• Bacterial and mycosis infection in menopause

• Vulvar discomforts

• Inflammation of vulvar mucosae

• Burning and hitching vulvitis

• Hygiene of local lesions

DermatologyTopical Face Acne CreamMedical Device CE Class III

Herpes Labial CreamMedical Device CE Class III

Topical Repair Spray PowderMedical Device CE Class IIb

Indications

• Acne

• Skin Impurities

• Adjuvant local treatment of herpes simplex (HSV-1) labial

• Exudative wounds

• Athlete’s foot & diabetic feet

• Pressure ulcer

• Small cuts

EU Approved indication:“Antibacterial topical treatment on cutaneous impurities and acne therapy, with coadjuvant hydrating actions”.

ProctologyProctology Gel + HamamelisUnder development

Wipes + Hamamelis Under development

OphtalmologyEye GelUnder development

Mini Wipes + HamamelisUnder development

Oral careHigh Density Aphte Gel Oral Gel MouthwashUnder development

Indications

• Hemorrhoids • Anal fissures

• Inflammation of perianal tissue • Proctitis

• Post-surgery lesions

• Adjuvant relief for hemorrhoids

• Anal fissures

• Hygiene of local lesions

• Inflammation of perianal tissue

• Periocular inflammation • Periocular dermatitis

• Coadjuvant post-surgery infection

• Periocular inflammation • Coadjuvant post-surgery and infection infection

• Hygiene of periocular area

• Aphte • Oral mucositis

• Oral dermatitis • Stomatitis

• Post-surgery lesions • Implantology

• Periodontal inflammation • Post-surgery lesions

LINNEA SOLUTIONSOur traditional experience in Natural is now extended to new natural solutions for targeted therapeutic

areas: Medical Device patented system.

SylTechTM PLATFORMWhat we offer

Patent use

Regulatory supportEU certification and approved Indications

Medical Device Dossier available for non EU countries

Product SupplyCustomized Formulation

Customized production and packaging

Clinical development

Marketing support

* SylTech is a patented technology by NMTECH Ltd.

SylTechTM formulations are suitable for being consistently promoted to medical profession, encouraging patient reccommendation, as unique new approach to infection and mucosal healing.

MARKETING MODEL

Clinical evidence

Scientific research and clinical

investigation

Clinical support

Professional awareness

by scientific publications

and KOL

Doctor detailing

Recomendation through healthcare

professionals

NIOSKINTM NIOSOME ACTIVE INGREDIENTSNioSkin™ ingredients are innovative solutions designed and developed for improving skin absorption and with proven effectiveness.

Niosomes are a new and effective delivery system made of ultradeformable non-ionic vesicles. Niosomal technology encapsulates biologically active molecules of natural origin in special natural carrier to pursue an optimal bioavailability, enhancing skin penetration through the stratum corneum.

THE ULTRA DEFORMABLE NIOSOMENiosome vesicles are elastic and can squeeze through the pores (20nm) in stratum corneum. These pores are less than one-tenth of the diameter of vesicles (200 nm).

NioSkin™ guarantees effective ingredients absorption.

Clinical tests• Corneometric skin hydratation panel test 15 subjects • Trans Epidermal Water Loss (TEWL) panel test 12 subjects • Skin Elasticity panel test 12 subjects • High Resolution Ultrasound Skin-Imaging panel test 20 subjects

Active ingredients

Epidermis

CorneocyteStratum Corneum (15 µm)

Lipid regions (20-40 nm)

Flexible Niosome (150-200 nm)

Poor penetration Maximum skin penetration

NioSkin™ Delivery System

LINNEA NIOSKINTM PLATFORM

Product Indication

NioSkin™ RCL40 Anti-aging Skin whitening Red Clover Isoflavone Aglycones Extract Antioxidant Skin tone lightening

NioSkin™ HMRLignan Anti-aging Skin protection Picea Abies Purified Lignan Soothing for sensitive skin DNA damage protection 7-Hydroxymataresinol Extract Antioxidant

NioSkin™ Ginkgo Anti-aging Microcirculation enhancer

Ginkgo Biloba 24/6 Extract Anti-cellulite

NioSkin™ Bilberry Anti-aging Microcirculation enhancer European Bilberry Anthocianins Extract Heavy legs Eye swelling Couperose Dark eye circles

NioSkin™ is the result of a balanced combination of Nature and Science: highly purified natural ingredients and standardized vegetable extracts are transformed into technological products for superior performances in cosmetics.

Produced with GMP certified active ingredients and in compliance with the highest quality standards.

NioSkinTM Active Ingredients are stable and self-preservative.

No artificial preservative are added. Allergen free, Nichel free, GMO Free. Not tested on animals.

About Linnea Located in the Swiss canton of Ticino, Linnea is a high-quality manufacturer of Botanical Extracts

and Active Pharmaceutical Ingredients of Natural Origin in Bulk form.

Linnea Ingredients are suitable for the use in the Pharmaceutical, Health-Food and Cosmetic Industries.

The company employs a team of experienced professionals specialized in the extraction

and purification of plant materials and in the synthesis of fine chemicals.

Best solutions, everywhereLinnea’s service is tailored to the needs of its customers.

With our extensive knowledge of international requirements and dispatch procedures, prompt efficient

delivery is guaranteed just about anywhere in the world.

Thanks to the company’s competence and reliability, Linnea exports its products to more than 60

countries across 5 continents and supplies more than 200 clients per year.

Headquarters Linnea SA Via Cantonale CH-6595 Riazzino (TI) Switzerland Tel: +41 (0)91 850 5050Fax: +41 (0)91 850 5070 info@linnea.ch www.linnea.ch

US office Linnea Inc. 435 McCartney Street Easton, PA 18042USATel: 888-253-0044 (US) or +1 610-253-7950Fax: +1 610-253-7970dstanek@linnea.chwww.linnea-us.com