NE 401 – Nuclear Medical Science, Syllabus, FS2011 v3 1

NE 401 – Nuclear Medical Science Fall 2011

Drs. Hyoung Lee and Xin Liu Text:

1. Physics of Radiology, 2nd Edition, Anthony B. Wolbarst, Medical Physics Publishing 2000.

2. Principles of Computerized Tomographic Imaging, A. Kak & M. Slaney, SIAM, 2001. Electronic version is available online.

Classroom Hours: 2:00-2:450 MWF, 211 Fulton Hall Office Hours: Dr. Lee: 9:00-11:00 AM Tuesday (219 Fulton Hall)

Dr. Liu: 9:00-11:00 AM Wednesday (223 Fulton Hall) Contact Information: Dr. Lee: 341-4585 (office), leehk@mst.edu

Dr. Liu: 341-4693 (office), xinliu@mst.edu

Prerequisite: NE 312 (Nuclear Radiation Measurement and Spectroscopy) or equivalent

Course Summary: Physics and technologies involved in various radiological imaging and treatment systems in the medical field, such as digital radiography, digital mammography, computed tomography and nuclear medicine instruments will be covered. Course Outline:

Text Section 1: Radiography (Dr. Lee) Production of X-rays Ch. 24 – 26 X-ray interactions Ch. 14, 26 Image Formation Ch. 27 – 29 Computed Radiography (CR) & Digital Radiography (DR) Ch. 36 Mammography, Fluoroscopy, Etc. Ch. 33, 37 Section 4: Computed Tomography (Dr. Liu) Introduction of CT system Ch. 38.1– 38.5

& Handout Algebraic & Iterative Reconstruction Ch. 38.6- 38.7

& Handout Central Slice Theorem & Fourier Reconstruction K&S 3.1 & 3.2

& Handout

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Filtered Back Projection Reconstruction Ch.38.8 K&S 3.3

& Handout Section 5: Measures of Image Quality (Dr. Liu) Contrast, Resolution & Noise Ch. 18.1– 18.6 Ch. 39.3-39.4

& Handout Radiation Dose Ch. 18.7, 39.5

& Handout Modulation Transfer Function Ch. 19.1-19.6

& Handout Noise Power Spectrum Ch. 19.7

& Handout Detective Quantum Efficiency Ch. 19.9

& Handout Section 2: Nuclear Medicine (Dr. Lee) Gamma Camera Ch. 41, 42 SPECT (Single Photon Emission Computed Tomography) Ch. 43 PET (Positron Emission Tomography) Ch. 43 Section 3: Radiation Therapy (Dr. Lee) The Course of Radiotherapy Handout

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Grading: Two 1-hour exams 50% Homework 20% Research project 30% (graded on both written report and oral presentation) A student cannot pass the course without having obtained at least 50%, average,

in the two exams. The final grades will be rounded to the nearest whole number and assigned as

follows: A - 90-100% B - 80-<90% C -70-<80% D - 60-<70% F -<60%

Research project: There will be two project teams. Each team is to select a research project relevant to some aspect of the nuclear medical science, conduct research, evaluate alternatives/choices, and document the results in a research report. The reports will be summarized and presented by each team in the last week of classes. Homework: Homework will be due by NOON on the assigned due date. Show your work - minimal answers will earn minimal credit. I am generally less interested in the specific answer than I am in seeing how you got there. There will be 6 homework assignments, out of which 5 scores from the top will be used to determine the final grade.

Tentative Dates: Midterm Exam 10/12/2011 Final Exam 11/30/2011 Research Proposals Due 12:00 PM 9/14/2011 Research Presentations 12/5/2011 Research Project Reports Due 12:00 PM 12/9/2011

Policies and Procedures:

Blackboard: Blackboard is the primary method of distributing printed and other material. Make-Up Tests: A missed test or other activity may be made-up at a later date if such is negotiated with the instructor before the absence occurs. Non-negotiated misses may not be made up.

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Late Homework: Late homework will be accepted at a 25% penalty up to the beginning of the class immediately following the due date. After that, it will be accepted and graded, but not counted for credit. A non-negotiated late research project will not be accepted. Collaborative Homework: Unless otherwise stated, all graded homework in this class is to represent each individual's own effort. Instances of copying (either electronic or by hand) will result in an instant zero for that assignment for every party involved. Further actions will be taken if this becomes repetitive. Academic Ethics: Any forms of academic dishonesty will be dealt with firmly and directly. See “http://registrar.mst.edu/documents/academic_reg2010-2012.pdf''. The University Standards of Conduct are attached to this syllabus and will be strictly enforced. Written Submission Standards: All hand-written homework must be submitted on 1/5" ruled engineering paper. Calculations should be reasonably formatted and the final answer(s) marked with an underline or box. A new page or a horizontal line should delineate each problem. Work should be presented in an easy-to-follow, linear order. Graphs and other figures should be well labeled, reasonably sized using an appropriate scale, and easy to read and comprehend. Grey lines on a grey background are not acceptable. Printouts of spreadsheets/input files should be appropriately sized and easy to parse. All multi-page homework submissions should be stapled together before being turned in. All homework pages must be numbered. Concerns and Complaints: I encourage all of my students to communicate with me in a frank and honest fashion. I promise to listen and do what I can to respond your worries and concerns in an open and fair fashion. If you feel you cannot talk with me, please feel free to talk to the Department Chair, Dr. Kumar. Additional Information:

Academic Alert System: http://academicalert.mst.edu Academic Dishonesty: http://registrar.mst.edu/academicregs/index.html Classroom Egress Maps: http://registrar.mst.edu/links/egress.html Disability Support Services: http://dss.mst.edu LEAD Learning Assistance: http://lead.mst.edu

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NE 401 Research Project Guidelines Fall 2011

1. A written proposal for your project is due 12:00PM September 14, 2011. 2. Final report is due 12:00 PM December 9, 2011.

3. The project presentations will take place during the last week of class (12/5). 4. Your report must address the following general areas.

a. Executive Summary - After you complete the rest of the report, provide a one page executive summary at the front, after the title page. This summary should highlight the main findings of your research.

b. Objective - What are you trying to accomplish? What are the expected results? Any inherent limitations/constraints?

c. Background - Survey of existing relevant work; pertinent regulations; approach taken to accomplish the objectives.

d. Findings/Results - Pertinent calculations; research results and analysis. e. Summary and Conclusions - Summarize the key results and conclusions of the

research. 5. There is no lower or upper limit of number of pages.

6. All assertions should be backed up by documented references, using the reference

style provided by the class style guide. Hard (journal and text) references are preferred as they are durable and peer-reviewed. Soft (web-based) references are acceptable, but may make up no more than 25% of your references.

7. If repeated calculations are involved, provide one sample in the main body and the rest as an Appendix. But, you must provide at least one sample of a complete calculation in the main body of the report.

8. Use of Appendices is recommended; remember, though, that the reader should not

have to read the Appendices in order to understand your report or to evaluate it. Appendices provide supplementary information - if it is required to understand the report, it belongs in the main body of the report.

9. Notation is important - be consistent and define all quantities/acronyms the first time they appear or use a table of nomenclature.

10. Your report should cover not only technical and regulatory aspects, but should also

include economic, social, ethical, aesthetic considerations as they apply to your topic.

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11. The length of your report sections should have a reasonable correlation to the importance of that section; e.g. your introduction should not make up half of your report.

12. You must be able to document/defend any statement you make in your report/presentation.

13. Provide a table of contents and format your report in accordance with the class style guide.

14. Number the Figures and Tables consecutively and place them as close as possible to the point of first mention in the text. Provide a concise, informative title for each table; name clearly (with units) the axes of each figure. Figures and Tables should be captioned, with enough information that an average reader will be able to follow the theme of the figure without having to go to the main body of the text.

15. Pay attention to precision, uncertainty, and significant figures.

16. The final report shall be in the form of a well-formatted PDF document submitted to the Blackboard by the due date.

A List of Possible Project

1) Measure of the image quality of MSTR x-ray imaging system

2) Measure of the image quality of MSTR neutron imaging system

3) Algorithms for fusion of neutron and x-ray images

4) CT reconstruction

Remember, the topic is not limited by above list. You can think of any nuclear medical science or radiation imaging related topics.

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