Naturopathic Oncology - Anti-Oxidants - Second in a Series
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Transcript of Naturopathic Oncology - Anti-Oxidants - Second in a Series
1
More Natural Approaches to Cancer Treatment
Workshop
Speaker: Serge Jurasunas
2
3
Serge Jurasunas N.D. MD (Hom)
- 40 years of practice, research and development of innovative medicine and alternative therapies in cancer.
Speciality: Nutrition, orthomolecular medicine, oxidative stress and antioxidant therapy, stem cells therapy, detoxification, mitochondrial repair, peripheral blood analysis.
Holiterapias
Institute
of
Integrative
MedicineLisbon
-
Portugal
Member: Society
of
Integrative
Oncology
(USA), AAAA Medicine
(USA), International
delegate
WOSAM
4
More natural therapies
in the
treatment
of
cancer
1 –
Adjuvant
clinical
nutrition
–
Nutritherapy
2 –
Targeting
cancer
through
natural angiogenic
inhibitor
5
Some common characteristics of cancer patients
- Antioxidants-vitamins, enzymes deficiency accentuated by chemotherapy.
- Wrong food diet.
- Poor appetite, poor digestion, malabsorption.
- Anorexia, malnutrition, decreasing quality of life, increasing mortality.
- Immune cells cannot function without vitamins, acidic milieu, poor oxygen.
-
Negatively affected or damaged GUT system (bacteria or yeast movement into blood stream).
6
Our body needs for an healthy function and life survival
Daily
needs
of
50 essential
nutritional
factors
- 8 aminoacids
(11 in
premature
child
born)- 13 vitamins
(100 milligrams)
- 20 minerals
(10 grams)- 20 trace elements
(60 milligrams)
- 12 to 15 grams
of
2 eventual fatty-acids- 1 source
of
energy
(carbohydrates, 400 grams)
Water
-
Oxygen
-
Light
Parallel
source
of
substances
normally
produced
by
the
body
but
beneficial for our
health:
-
Glutathione, coenzyme
Q10, SOD, N-cysteine, orotic
acid, choline, inositol and
nucleic
acids.
7
Peripheral Blood Analysis (nutritional and antioxidants deficiency)
- Abnormal, damages shape red cells
- Platelets aggregation
- Lipid ribbon and plaque
- Fragile and disintegrate WBC’s
- Red cells in rouleau
- Bacterial/fungal invasion
- Microclots
- Liver stress
- Kidney failure
Serge
Jurasunas
2008
Health status – Before and after chemotherapy
8
Photo 1 – vitamins-antioxidants deficiency.
Photo 2 – Large lipid ribbon after chemotherapy (colon cancer.
Dr. Serge
Jurasunas
–
Holiterapias
2006
9
Photo 3 - Red cells with strong rouleau (drug intoxication after chemotherapy)
Photo 4 – large compact lipid plaques – yeast form like candida invasion – after chemotherapy
Photo 5 – large colony of yeast- form like candida (PLFs) with compacted microclots.
Photo 6 – large colony of yeast form like budding sphere (overgrowth) impaired immune system – oxygen deficiency – bad cancer case
Dr. Serge
Jurasunas
–
Holiterapias
2006
10
Photo
7 -
Advanced
liver
cancer
treated
by
chemotherapy. Broken’s
RBC’s
–
rouleau
–
Platelets
aggregation
–
yeast-form
like
candida
invasion
spread
everywhere.
Photo
8 –
Agglutinate
red
cells
and
platelets
to form
a thrombus
(cancer).
Dr. Serge
Jurasunas
–
Holiterapias
2006
11
Enzyme Yeast Cells preparation as anticancer food supplementation36 years of experience
Attribution: Natural composition
Biological sources
Orthomolecular composition
High bioavailability
Rich in active enzymes
Developed by Dr. Siegfried Wolz –
Co-worker Nobel Prize Prof. Lunnen
(Germany)
-
Immunonutrition
-
12
Enzyme Yeast Cells Process
Enzyme Yeast cells is a pure liquid strain made from a fermentation process at low temperature (32º) using saccharomyces cerevisiaie, fresh fruit juices, essential fatty acid, oxygen to enhance the formation of krebs cycle substrate and respiratory chain enzymes in the mitochondria of the yeast cells.
Enzyme yeast cells preparation contain several billions of enzymatic mitochondria.
Each 10ml contain 100 billions of active yeast cells.
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Oxygen
E
B2
B12
B1
< 32ºC
17 vitamins –
14 minerals16 amino acids, enzymes of the redox system, biocatalysors
Proteins –
46/50g for 100g of dried yeastParticularly rich in vitamin B complexB1, B2, B3, B5, B6, B12.
Iodine, potassium, magnesium, copper, selenium, zinc, iron, chromium, phosphoric acid.
-Activation of Krebs cycle-Stimulation immune defense-Activation metallic enzymes-Against infection
Enzyme Yeast Cells contain a balanced combination
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Food
Aerobic Anaerobic
Glycolysis Glycolysis
Mitochondria
Cellularrespiration
PyruvateOxidation
Citric
Acidcyle
Respiratory
chain
Complete oxidationwaste
products
H2O
36 moles ATP
80% Energy672 calories
Fermentationreaction
cytosol
Blockage
of
the
respiratory
chain
Incomplete
oxidation
Waste products = carbon compound (lactic acid, CO2
2 moles ATP
20% energy35 calories
AcetylCoenzyme A
Oxphos
Complex IIIIIIIV
Complex VATP synthase
15
16
Nutritional elements found in Enzyme Yeast Cells
Dr. Moerman
(Nederland
) isolate
the
particular nutritional
elements
responsible for building
the
immune
system
and
activate
the
respiratory
chain
in
the
mitochondria.
1 –
Vitamina A2 –
Vit. B complex
3 –
Vitamin
C4 –
Vitamin
E
5 –
Citric
acid6 -
Iodine
7 –
Iron8 –
Sulphur
Vitamin
A 50,000 U To 100,000 I.U.B Complex 2 tablets
per
day (10g per
day)
Vitamin
C 1.250 mg 5-10g per
dayVitamin
E 400 I.U. 2,200 I.U.
Citric
acid 3 tablespoons
solution 2,200 I.U.Iodine 3 teaspoons
solution 2,200 I.U.
Iron 3 teaspoons
solution 2,200 I.U.
17
Enzyme Yeast Cells contain
Particularly high in active glutathione
(10mg/100ml of yeast preparation)methionine
Detox
–
antioxidant –
redox
value
cysteine
Particularly high in Q10 –
critical to mitochondria–
Booster of energy
–
Powerful liposoluble
antioxidant
Cytochrome
oxidase, coenzyme A, NADH, Superoxide dismutase (SOD)
Rich in nucleic acid, nucleus building substances: adenine nucleotides, ribonucleic acids –
Nucleotides repair damaged DNA and enhance T-cell
maturation, function, enhance NK cell activity.
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Enzyme Yeast Cells enhance immune systemMembrane contain defined polyssacharide
1-3D-glucan. (29-64%) –
(1-6)40% mannan)
1 –
macrophages (bind to macrophage beta-glucan
receptors)2 –
Lymphocytes
3 –
Natural Killer cells (N.K) -
Support the production of cytokines -
Tumor necrosis factor alpha (TNFa)
-
Interleukine
1 –
beta (Il-1-B)
Potent
macrophages
activator
A strong
Biological Response Modifier
Activate
the
regranulation
of
NK cells
and
restore
their
function.
Significantly
reduce
the
infection
related
mortality
rate in
cancer
patients
(4.8% vs 30% control
group
from
studies
in
Japan)
Immunomodulating
effects
–anti-inflammatory and bacterial property.
19
Activation of macrophage cells by Beta 1-3-D - glucans
YY
Interferon
–
Gamma
(IFN)
T.N.F.a
Interleukine
1 –
Beta (1L-1B)
T-cells Activating
a specific response building
special
antibodycommunication
Macrophages
(big
eater)
Receptors
Dextin 1
Complement3 receptor
Destroy
foreign
bodies, bacterias, fungi, necrotic
tissues, dead
tumor cells
Activate Natural Killer cells
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Application in cancer
1 –
Combination
Beta-glucan
+ antineoplasic
agentPotentialize
the
anti-tumor effect
2 –
Contreact
chemotherapy-induced
immunosuppressionResulting
in
higher
mortality
3 –
Protect
cancer
patients
from
5 –
Fluorouracil
induced
leukocytopenia
4 –
Contreact
corticosteroid
hormones
induced
immunosuppressive
effects
in cancer
patients.
5 –
Beta-glucans
can
affect
biological
responsed
to bacterial lipopolyssacharide
(LPS) inducing
pro-inflammatory
mediators
–
immunosuppressor
–
angiogenesis
–
P53 down-regulation.
21
LitteratureBeta-Glucan, a specific
biologic
response modifier
that
uses antibodies
to target
tumors
–
J.Immunol.1999.
The
beta-Glucan
receptor, dectin
1, is
predominantly
expressed
on
the
surface
of
cells
of
the
J. Immunol.2002.
Abel G., Czop
I.K. (1992) stimulation
of
human
monocyte
B-glucan
receptors
by
glucan
particules
induces
production
of
TNFa
and
IL 1B. Int.J. Immunopharmacol. 14-1363-1373.
Mansell
P.W.A., ichinose
H., Reed
R.J. Krementz
E.T., Mc
Names
R., Di
Luzio
N.R. (1975) Macrophages
–
mediated
destruction
of
human
malignant
cells
in
vivo –
J. Natl
Cancer
Institute
54-571-580.
Williams D-L Ha-T-Li
C. Kalbfleish
J.H., Laffan
JJ, Ferguson
D.A. (1999) Inhibiting
early
activation
of
the
tissue
nuclear factor –
KB and
nuclear factor Interleukin
6 with
(1→3) –
B-
D glucan
increases
long-term
survival
in
polymicrobial
sepsis
–
Surgery
126-54-65.
Duan
X, Acherly
M., Vivier
E, Anderson P. (1994) Evidence
for involvement
of
beta-glucan
–
binding
cell
surface
lectins
in
human
natural killer
cell
function
–
cell
immunol. 157: 393-
402.
Lee
D.Y., Ji
I.H., Chang
H.I., Kim
C.W. (2002) High
Level
TNF alpha
secretion
and
macrophage
activity
with
soluble
beta-glucans
from
saccaromyces
cerevisae
–
Biosci
–
Biotechnol
–
Biochem
66: 233.238.
22
NK cells are able to destroy cancer cells by attaching to the cell’s membrane and injecting cytoplasmic granules. A NK cell destroy in 5 minutes time a cancer cell and move to another.
A single NK cell can repeat this process with up to 27 cells in its lifetime.
Regranulation of NK cells by beta-glucan retore their ability to destroy cancer cells.
However, when the NK cell is weak, the cancer cell can also destroy white cells.
Therefore it needs to be activated and addition of Enzyme Yeast Cells may increase their activity.
23
One activate NK cell attacking 3 cancer cells
24
Results
of the
Freiburg university study
Myoglobin ug/l 1 h post
560
194
- 65 %
Before
the
intake
of Enyzme
Yeast
Cells
After six
weeks
of Enyzme
Yeast
Cells
intake
25
Results
of the
Freiburg university study
Muscle stressTotal-Creatinkinasis U/l 1 h post
Fibrinogen mg/dl 1 d post
Before
the
intake
of Enzyme Yeast
CellsAfter six
weeks
of Enzyme Yeast
cells
intake
253135 199314
- 64 % - 27 %
26
Enzyme Yeast Cells
Protection of DNA and cell membrane
Protection of mitochondria
Repair damaged DNA
Increase cell respiration
Yeast cells are identical to the human body cell by 70% with the same repair mechanism.
Enzyme yeast cell
Human cell
SODCatalaseGlutathioneCytochromeOxidaseNADHCoenzyme A
Mitochondria
27
Enzyme Yeast Cells Preparation
-Contain thiny
and fragile walled young oxygen yeast cells.-
Uniformly formed cells –
clearly cells
wall on which light is reflected.
Orally administered enzyme yeast cells reach the small intestine, open, release billions of enzymes, including natural vitamins, minerals etc. for fast absorption, body’s nourishment.
Total Biological Rejuvenation
Photo taken from a drop of the liquid enzyme yeast cells preparation
Serge
Jurasunas
2008
28
Indication of Enzyme Yeast cells
Enzyme Yeast
Cells
-Restore nutritional status
-Improve oxygen supply to tissue
-Restore damaged intestine –
Regulation of bowel function
-Strengthen the immune system
-Anti-inflammatory effect –
Reduce excessive fibrogenesis – prevent thrombosis
-Increase energy level and prevent fatigue (during chemo)
-Stimulation of the nerve resistance –
Reduce depression
-Promote detoxification
-Increase cellular respiration
-Prevent or counteract anorexia
Overall increase Quality of
Life
29
Conclusion
-Enzyme yeast cells preparation is not a simply mixed combination ingredients but are simply integrated in the cells with high
bioavailability.
-Enzyme yeast cells natural ingredients work in synergy with each other and as an “Whole food” to increase the body’s defense
resistance and inhibit some factors of tumor growth.
Enzyme yeast cells are the perfect anticancer food
30
A new approach to cancer: Angiogenesis
-Angiogenic
agents to target proangiogenic
factors.
-Inhibit vascularization
of the tumor and destroy by apoptosis existing vessels.
-Selective therapy to tumor
-Result reduced tumor resistance
-Overall increasing effectiveness of standard chemo-
regimen
31
Abnormal vessels make trouble
32
1 - The effect of the liquid cartilage extract (LCE) as an angiogenic inhibitor
-A concentrate hydrosoluble extract of liquid cartilage using special patented technique.
-Contain biologically active mucopolysacharides and proteins with strong antiangiogenic property.
-Orally taken shown to be biovailable and non-toxic on long term administration on the contrary of Avastin or Thialidomide.
LCE targets many different aspects of the angiogenic cascade
Interfere with VEGF binding and signaling to VEGF receptor.Inhibit MMP’s
–
2.9.12 activity.Stimulate apoptosis of endothelial cells.Promote angiostatin
production in the vicinity of tumor.
33
Tumor
Liquid Cartilage Extract InhibitAngiogenic Cascade
MMP’SInhibition of MMP’S
(L.C.E.)
Apoptosis
ofexisting
vesselsL.C.E.
MMP’S
Receptor
Inhibition
of
the
VEGF receptor
VEGF
L.C.E.
Angiogenicfactors
COX2 ActivityInhibition byAntioxidants
Inflammation
Decreasing
Macrophages
Increased
Oxidative
Stress
Increase
Signals
toCancer
Cells
Conjointly
Professor Serge
Jurasunas
2008
Promote
angiostatin
production
in
vicinity
of
tumor
34
Does antiangiogenic therapy enhance the effectiveness of cytotoxic drugs?
Yes, it does!1 –
Animal studies show that radiotherapy is enhanced by
antiangiogenic
therapy (1).
2 –
Experimental animal studies show that cytotoxic
chemotherapy can be enhanced by combining it with antiangiogenic
therapy (2).
3 -Anti-angiogenesis therapy increase flow and oxygen delivery as well as a drug delivery to a tumor (3)
(1)
Teicher
BA, Dupuis
N., Kusumuto
T, Robinson
MF, Liu
F, menon
K, -
Antiangiogenic
agents
can
increase
tumor oxygenation
and
response to radiation
therapy
–
Radiation
Oncology
Investigation
2 –
269 –
276 –
1995.(2)
Teicher
BA, Holden
AS, Ara G, Sotomayor
EA, Huang
ZD –
Potentiation
of
cytotoxic
cancer
therapies
by
TNP –
470 alone
and
with
other
anti-angiogenic
agents
–
Int. J. Cancer
57.920-925.1994.(3) Teicher
BA, Dufins
NP, Robinson
MF, Emi
Y. Golff
D. Antiangiogenic
treatment
(TNP –
470/Minocyline) increases
tissue
levels
of
anticancer
drugs
in
mice
L.L.C. lung
carcinoma –
Oncol
Res
27:237.243 -
1995
35
Comparable
effects
of
chemotherapy
with
a direct
targeting of
cancer
by
a antiangiogenic
therapy
Chemotherapy Radiation60 days30 90
days30 60 90
Antiangiogenic therapy
Cancer
cells
recover
increase
their
resistance
make
more vascularization
Less
vascularization
inhibition
-
starving
36
Clinical application of L.C.E. at Holiterapias Institute with successful response in cancer patient during a 12 years period.This include a wide variety of different cancer types such: prostate, multiple myeloma, lung, colorectal, breast, ovaries, melanoma pancreas.
-Benefit survival extension.
-Significative
reduction of tumor size.
-Decrease of metastasis specially bone metastasis.
-Elimination of secondary nodules.
-Our patients take L.C.E. during several years without toxicity.
-Suggested in anti-cancer dormancy therapy
37
Therapy Posology Produced by
Enzyme
Yeast
CellsImmunokomplex
with
additional
concentrate wild
fruits, vegetables
extracts, betacarotene
40 to 60ml per
day
(up
to 600 billions
of
enzyme
yeast
cells) mixed
in beetroot
juice, apple
juice. Divided
in
3 intake per
day.
Dr. Wolz. Zell GmbhGermany
Liquid
Cartilage
Extract Frozen
vial
of
30ml concentrate
1 vial
under
the
tongue each
morning
before
breackfast
Atrium
BiotechnologiesQuebec
-
Canada
The two natural products work with synergistic effects with various therapeutic options. The anticancer diet by Serge Jurasunas is suggested to combine more effectiveness.
38
Example of clinical improvement of a patient with liver metastasis and chemotherapy doing our anticancer food treatment including
Enzyme Yeast Cells2/12/08
3/26/08
Dr. Serge
Jurasunas
–
Holiterapias
2006
39
Patient
female
–50 years
old
with
a metastasic
recurrency
from
breast cancer
(2000) in
2004 with
multiple
lesions
dissiminated
in
the
skeleton.
Strong
pains
and
after
one
year
of
a new
protocol
of
chemotherapy
a new bone
scan
(May
2005) showed
more lesions
disseminated
in
comparaition
of
2004. Poor
response and
evolution
of
the
disease.
The
complete case fully
illustrated
is
available
in
English
and
French.
X ray of the spine
After 3 months of combined therapy + chemotherapy.
Total elimination of the very large lesions in the illium and spine.
Dr. Serge
Jurasunas
–
Holiterapias
2006
40
10/11/2005 – bad physical condition – metastases to bone skeleton – PSA 354 nl/ml Treatment – L.C.E. (Comitris) – Antioxidant compound (Anoxe) 18g per day – Enzyme Yeast cells.
12/01/2006 - PSA 53.6 nl/ml - after 3 months PSA 1.4 nl/mlAfter 5 months elimination of almost all the bone metastases.
Patient male – 73 years old – Prostate Cancerclinical story: adenocarcinoma of the prostate – Gleason 7 (3+4) - Advanced case – No surgery or chemotherapy/radiation.
Dr. Serge
Jurasunas
–
Holiterapias
2006
41
Patient female – 62 years oldClinical story: carcinoma left breast 1988Partial resection– chemotherapy
2005 – Recurrence: Lung metastasis – However the patient refuse more chemotherapy with the alternative option of CAM.
22/11/2005 - CA 15.3 – 617-U/ml - ACE – 1.25 ng/ml
15/09/2005 – CA.15.3 – 446 U/ml - ACE – 1.23 ng/ml
25/09/2006 – CA 15.3 – 50.2 U/ml - RBC - 5.16 – Hemo 14.9 – WBC’s 4700
06/02/2007 – CA 15.3 – 32 U/ml - RBC - 5.16 – Hemo 14.9
42
Female
52 years
(pharmacist)
Clinical
story: February
2004 - Pancreatic
cancer
with
abdominal
large
metastasis, multiple
liver metastasis.
Under
chemotherapy: Follow
our
strategy
program
including
L.C.E., Enzyme
Yeast
Cells
and
antioxidants
(no adverse effects).
3 April
2008: Good
physical
condition, good
quality
of
life
New
hospital check-up shown
total elimination
of abdominal and
liver
metastasis
and
reduce
pancreatic
tumor.
43
For more information:
-Liquid Cartilage Extract as a natural nutritional adjuvant to conventional therapies: Serge Jurasunas –
8th Congress for Nutri x Phytotherapy –
March 2007
–
Brussels –
Belgium.
-The therapy of Enzyme Yeast Cells in cancer disease, CFS and Aging process. Serge Jurasunas –
Booklet.
-Mitochondria and Cancer –
Townsend letter –
August/Sept 2006 –
Serge Jurasunas.
-A new combination therapy as support to conventional treatment –
Townsend Letter –
Special issue “Alternative Therapies for cancer”
-More clinical cases.
Holiterapias InstituteRua da Misericórdia, 137 –
1º -
Lisbon
–
Portugal
Tel: 00351 213471117 –
Fax: 00351 213471119Email: [email protected]
www.sergejurasunas.com