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b

-4 0 1 2 3 4 5 64

5

6

7

8

9

0 1 2 3 4 5 6 7 87

8

9

10

Time in culture (weeks)

Time in anaerobic jar (weeks)

log10(cfu)

log10(cfu)

a

Time post-infection (weeks)

Time post-infection (weeks)

Time post-infection (weeks)

a

log10(cfu)inlungs

Survival(%

)

log10(c

fu)inlungs

0 2 4 6 8 10 12 14 164

5

6

7

e

0 4 8 12 16 20 240

20

40

60

80

100

0 2 4 6 8 10 12 14 163

4

5

6b

c

d

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0

10

20

30

40

Fluorescenceindex(foldbackground)

0 50 100 150Time (h)

d

cICL1 (act)cICL1 (rest)

pICL1 (act)pICL1 (rest)

wild-type (act)wild-type (rest)

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0 5 10 15 203

4

5

6

7

8

0 5 10 15 20 25 30 35 400

20

40

60

80

100

Time post-infection (days)

Time post-infection (days)

log10(cfu)inlungs

Survival(%)

a

b

2

3

4

5

0 50 100 150

2

3

4

5

0 50 100 150

Time (hrs)

Wild type

icl

icl (pICL1)

Time (h)

Time (h)

log(cfu)

log(cfu)

Resting

Activated

a

b

87%

41%

92%

52%

63%

1.2%

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