Naticol® key points • Natural and UNIQUE fish collagen peptides• Very high purity degree of collagen

protein: 99,8% dry matter • E-free (clean label), GMO free, Fat free,

carbohydrates free, purine free• Highly bio-available and bioactive• Clinically and scientifically proven• Water-soluble and excellent organoleptical

profile (neutral taste and flavor)• Produced in Europe under ISO 9001 / ISO 22000 standards

Fish Collagen Peptides

Naticol® fish collagen peptides to promote health, beauty and well-being

Interest in proteins across functional food and drinks continues to grow, with a rising demand for natural and healthy ingredients, particularly in sports, weight management and sarcopenia prevention. WEISHARDT, a world leader in health protein production, innovates by offering pure fish collagen peptides, Naticol®. The range of Naticol® products is designed for use in all functional food and beverages and also in nutritional supplements.

Naticol®’s efficacy is proven by scientific studies conducted in different areas: skin beauty (2 clinical studies), musculoskeletal condition,, weight management and much more. It is the health ingredient of choice for your finished product formulation anywhere in the world. Naticol® is pure protein (> 99% protein). As a protein, it will contribute to maintain the bone /muscular mass and to develop the muscular mass (EFSA claims). The power of protein is undeniable and particularly, the efficacy of Naticol®, which shows high bioavailability and bioactivity in many domains: health, beauty and overall well-being.

Naticol® in functional foodsFrom gummies to capsules and tablets, Naticol®, natural and water-soluble, will bring a high added value to your products. WEISHARDT, a world leader in health protein production, offers an opportunity for functional foods and beverage producers to taste various Naticol® drinks, and to discover tasty sugar free collagen gummies. WEISHARDT, a world leader in health protein production, successfully met the challenge to incorporate in one product the pleasure without calories, and the health benefits from Naticol®.

Collagen and Naticol®

Collagen is a fibrous macromolecule which is widely distributed in the organism and which represents

25- 30% of the total protein in the human body. Collagen is present in tendons and ligaments, cartilages,

various membranes as those which are at the base of superficial tissues or epithelium, or those which

ensure the filtration of blood in the kidneys. Collagen can also be found in special tissues which must be

resistant and present particular properties like the cornea. Thus, collagen is one of the most abundant

proteins in our organism. It takes part in the vital functions of almost all tissue systems and organs.

Consequently, particular attention has to be paid to collagen.

Naticol®, a natural ingredient produced by WEISHARDT, a world leader in health

protein production, is composed of a UNIQUE collagen peptide profile (including di

and tripeptides), resulting from the hydrolysis of α1 and α2 chains of type 1 collagen.

Indeed, Naticol® is obtained from a rigorous selection of fish skins and specific white

biotechnology process (enzymatic proteolysis), resulting from WEISHARDT’s know-

how. This biotechnology allows a UNIQUE collagen peptide distribution and amino-acid

sequences. The uniqueness and specificity of the peptides contribute to the biological

functionalities which are validated by in vitro / in vivo models and by human clinical

studies.

Scientific studies conducted by French universities showed that Naticol® is highly

assimilated. Naticol® presents excellent organoleptical properties, its neutral taste does not alter the

formulation of functional food products such as beverages. Naticol® dissolves easily in aqueous phases

and emulsions water-oil. It is a stable health ingredient which can be included into all formulations and

which is available in two forms: fine powder and microgranulated.

“ The uniqueness

and specificity of the peptides

contribute to the biological

functionalities which are validated by in

vitro / in vivo models and by human

clinical studies.”

Fish Collagen Peptides

Evolution of the gross elasticity (Ua/Uf) on the abdomen as a function of treatments. Naticol® induced a significant increase of the gross elasticity (mean ± SEM, *: p<0.05).

Beauty from withinCollagen is a substance organized into fibrils which can be found into dermal connective tissues (skin

70%). It contributes to skin firmness and smoothness. Collagen plays the role of a frame for the skin.

However, due to intrinsic (hormones, genetics) and extrinsic factors (nutrition, stress,

smoking, UV pollution…), collagen structure can be disorganized and destroyed.

Indeed, all of these factors generate oxidative stress through the production of reactive

oxygen species (ROS). This oxidative stress leads to a cascade of events including

inflammation, and to qualitative and quantitative loss of collagen (collagen fibers are

fewer and depleted).

In a clinical study conducted by Hospital of Nice/ CPCAD, oral administration of

Naticol® (5g/d) for 8 weeks showed a significant 20% decrease of the face skin fatigue (residual skin

deformation) and also a 22% decrease of the abdomen last amplitude (p< 0,05). This last result may

support product development dedicated to women after child birth (no breast-feeding) and men/women

after weight loss.

“ A significant 20%

decrease of the face skin fatigue (residual

skin deformation) and also a 22% decrease of the abdomen last

amplitude (p< 0,05)”

Gross elasticity Ua/UF on the abdomen skin

Naticol® PlaceboBaseline 0,86 0,858Week 4 0,865 0,864Week 8 0,882 0,868

0,845

0,85

0,855

0,86

0,865

0,87

0,875

0,88

0,885

Naticol® Placebo

Gross elasticty Ua/Uf on the abdomen skin

Baseline

Week 4

Week 8

*

Fish Collagen Peptides

Musculoskeletal conditionWith advancing age the musculoskeletal system loses both bone through osteoporosis, and muscle

through sarcopenia. Osteoporosis is characterized by reduced bone mass and microarchitectural

deterioration of bone tissue, with a consequent increase in the risk of fracture. Worldwide, the total

number of hip fractures is expected to surpass 6 million by the year 2050 fracture, (Kannus P, Parkkari J,

Sievänen H, et al. epidemiology of hip fractures. Bones 1996; 18:57). Sarcopenia is considered to be one

of the major factors responsible for functional limitation and motor dependency in elderly people. Both

processes play crucial roles in frailty syndrome and the outset of disabilities in elderly subjects.

With its scientific Research partner, INSERM Toulouse (National institute for Health

and medical Research), WEISHARDT, a world leader in health protein production, has

evaluated the effects of its fish collagen peptides Naticol®, on muscle and bone condition.

In this study, ovariectomized female mice having developed a model of osteoporosis

were used. The mice received a normal daily diet containing 2.5% Naticol® for 14 weeks.

The results of this study demonstrated the positive effects of ingestion of Naticol® on the

muscular mass. Moreover, muscular force was increased by 17 %! The results of this in

vivo study also showed that the mineral bone density tended to increase.

“ The results

of this study demonstrated the

positive effects of ingestion of

Naticol® on the muscular mass.”

Fish Collagen Peptides

Weight managementToday, any debate on health must consider the

problems associated with being overweight

or obese, a problem afflicting western

nations. Overweight and obesity represent

an important public health issue. Being overweight or obese can lead

to both chronic and severe medical conditions. More recently, in-vivo

studies conducted by INSERM- Toulouse regarding weight management

showed that in a high fat diet, Naticol®, the fish collagen peptides

produced by WEISHARDT, may decrease by 33% the fat mass gain

and maintain the lean and total water mass compared to control

mice group, after 9 weeks.

“ May decrease

by 33% the fat mass gain”

Fish Collagen Peptides

Innovation : Gelatine Flakes and Instant gel WEISHARDT, the world’s health protein provider, invites you to discover its 2 innovative texturing solutions :

Gelatin Flakes and Instant Gel. These new clean label products can replace leaf gelatin. Gelatin Flakes

and Instant Gel offer guaranties in term of availability, are easier to use and allow for costs saving in

formulations.

> Gelatin Flakes and Instant Gel are available immediately.

WEISHARDT today

WEISHARDT is a French company with more than 170 years of experience

in the field of the collagen. It is a world leader in the production and sale

of collagen products.

Weishardt’s innovative fish collagen peptide products are registered

under the trademark Naticol® and are mainly directed to functional food

& beverage applications, cosmetofoods, nutraceutical and well-being

products.

WEISHARDT is supported by Europe and Region Midi- Pyrenees to invest

more than US$ 2 million grant for research in fish collagen peptides.

Innovation is the key force of the company that continuously looks for

innovative and new health solutions to provide to its customers.

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For more information, please contact :

WEISHARDT INTERNATIONALRond-Point Georges Jolimaître - BP 259

81305 Graulhet Cedex - FRANCE (FR)

Tel : + 33 (0)5 63 42 14 41 welcome@weishardt.com