Nanopharmaceutics Toc

N E W J E R S E Y • L O N D O N • S I N G A P O R E • B E I J I N G • S H A N G H A I • H O N G K O N G • TA I P E I • C H E N N A I

World Scientific

NANOPHARMACEUTICSThe Potential Application of Nanomaterials

Editor

Xing-Jie LiangNational Center for Nanoscience and Technology of China

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British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library.

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Copyright © 2013 by World Scientific Publishing Co. Pte. Ltd.

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Printed in Singapore.

NANOPHARMACEUTICS

The Potential Application of Nanomaterials

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v

b1335 Nanopharmaceutics: The Potential Application of Nanomaterials

Preface

Considerable advances of basic and application researches have taken place in the field of pharmaceutics in last decade. The newly recognized research thrust on nanomedicine is expected to have a revolutionary impact on the human health. In 21st century, we see the coming of the Nano-Age, how it can save the life of a human being is still a challenge to the world. The tremendous research on biomedical applications of nano-materials has been advancing rapidly, particularly in the development of unique nanostructures for nanomedicine. Most of the advances have occurred in nanodiagnostics and nanopharmaceuticals, particularly drug delivery using nanobiotechnology as well as monitor biocompatibility and toxicity of nanomaterials for clinical use.

This book focuses on significant aspects of nanomaterials for phar-maceutical applications based on the new development for cancer treat-ment, imaging diagnosis, formulation of new drug and biomolecules for therapeutic applications. Some of the novel strategies introduced in the book aim to provide multi-functionality for a wide variety of approaches to combine all together in one platform to further design effective nano-structures for pharmaceutical applications.

The book is composed of 20 chapters that address the specific nano-platforms used for delivery, imaging, therapy and toxicity of nanomateri-als for pharmaceutical applications. Some of the chapters focus on the formulation of drug and biomolecules for delivery and gene silencing, protein nanostructure and nano-scaled proteomic analysis for cancer treatment. There is also a mention about the formulation of hydropho-bic/hydrophilic drug such as cisplatin and their use for cancer treatment. There are chapters on the metal and polymeric based nanomaterials and contrast agents for imaging tumors. It significantly describes the interac-tion of nanomaterials with cells and immune system and their significant role to design effective drug delivery system. This book also focuses on biological activity of nanomaterials for clinical application such as ortho-pedic implants’ improvement with nanotechnology, and addresses the toxicity of nanomaterials for human and environmental concern.

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vi Preface

We hope this book will provide some tools for understanding nano-technology and inspire researchers to develop a new generation of phar-maceutics with inventive non-traditional approach by employing nano-scale science for the human benefit. The editor extends his thanks and appreciation to the contributors for their valuable input and patient efforts towards the compilation of this book. The editor would also like to thank his colleagues in the joint Lab of Nanotechnology for Bioapplication established with Life Technologies Inc. at the National Center for Nanoscience and Technology for the encouragement and support towards the publication of this book.

Editor

Xing- Jie Liang (Ph.D)Laboratory of Nanomedicine and Nanosafety

National Center for Nanoscience and TechnologyChinese Academy of Sciences, Beijing, P.R. China

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vii


Contents

Preface v

Chapter One Innovative Treatments for Cancer: The Impactof Delivering siRNAs, Chemotherapies, and Preventative Agents Using Nanoformulations 1

Sara S. Hook, Dorothy Farrell, George W. Hinkal, Krzystof Ptak, Nicholas J. Panaro, and Piotr Grodzinski

Chapter Two Nano-Emulsions: Overview and Applications 21 Xiang Li, Nicolas Anton and Thierry Vandamme

Chapter Three Protein Nanopharmaceuticals — Concepts and Safety Considerations 49 Eva Horn Møller, Lene Jorgensen and Natalie

J. Medlicott

Chapter Four Nanoscaled Proteomic Analysis 65 Yan Xu and Lee Jia

Chapter Five Tumor Targeting Potential of Lipid-Based Nano-Pharmaceuticals (LNPs) 83

Kshitij Gupta, Amichai Yavlovich, Anu Puri, Robert Blumenthal

Chapter Six Novel Methods of Lipidic Nanoparticle Preparation and Drug Loading 115

Yoshie M

Chapter Seven Biomedical Properties Study of Modified Chitosan Nanoparticles for Drug Delivery Systems 129

Mohammad Reza Saboktakin

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viii Contents


Chapter Eight Dendrimers as Nanovectors for Nucleic Acid Delivery 173

Xiaoxuan Liu, Qi Wang, Ling Peng

Chapter Nine Drug Delivery Systems for Platinum Drugs 201 Vien T. Huynh, Wei Scarano, Martina H. Stenzel

Chapter Ten Improving Platinum Efficiency: Nanoformulations 243

Rolando Carmona and Xing-Jie Liang

Chapter Eleven Design Principles of Nanoparticles as Contrast Agents for Magnetic Resonance Imaging 275

Liang Shan, Xinbin Gu, Paul Wang

Chapter Twelve Perfluorocarbon Nanoparticles: A Theranostic Platform Technology 293

G. M. Lanza, P. M. Winter, S. D. Caruthers, M. S. Hughes, G. Hu, D. Pan, A. H. Schmieder, C. T. N. Pham, S. A. Wickline

Chapter Thirteen Potential Toxic Effects of Nano-Oxides 347 Mingsheng Xu, Hongzheng Chen,

Minmin Shi, Gang Wu, Daisuke Fujita, and Nobutaka Hanagata

Chapter Fourteen Electron Spin Resonance Spectroscopy for Studying the Generation and Scavenging of Reactive Oxygen Species by Nanomaterials 375

Jun-Jie Yin, Baozhong Zhao, Qingsu Xia, and Peter P. Fu

Chapter Fifteen Nanotechnology: A New Approach to Improve Orthopedic Implants 401

Hongjian Zhou, Fangfang Sun, Jaebeom Lee

Chapter Sixteen In Situ Controlled Release of Dopamine for Treatment of Parkinson’s Disease 445

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Contents ix


Chapter Seventeen Novel Nanotechnology Strategies for the Treatment and Prevention of HIV Infection 467

Jian Jun Tan, Xiao Hui Sun, Xue Ting Ma, Jian Qing Guan, and Cun Xin Wang

Chapter Eighteen Interaction of Nanoparticles with the Immune System and their Significance in Drug-Design and Development 491

Anil Kumar, Bhargavi M. Boruah and Xing-Jie Liang

Chapter Nineteen Nano-Carbon-Based Systems for the Delivery of Bioactive Agents: Pros and Cons 535

Tapas R. Nayak and Giorgia Pastorin

Chapter Twenty Nanostructures with Biocompatibleand Biodegradable Characteristics 571

Jie Meng

Index 591

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