Nano Based polymers and applications in Drugs Delivery
Transcript of Nano Based polymers and applications in Drugs Delivery
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NANO BASED POLYMERS AND
APPLICATIONS
(DRUG DELIVERY)
Presented By:
Mr. Anil Kumar
M.Phil./ Ph.D. Nano-science (2012-13)
Centre for Nano-science
Central University of Gujarat
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NANO POLYMERS FORMATION
Bulk Material
Macro Micro Nano
MoleculesMonomers
units
Å
Nano
Polymers
Small Bulk Material
or Micro Polymers
Å
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Bottom Up Approaches Top Down Approaches Nano
Lysis of Bulky Materials:- Synthesis of
Materials (Nano
Composites):-1. Chemolysis. (Use organic
solvents )
2. Thermolysis. (ΔG = ΔH –
TΔS)
3. Radiation. (Break chemical
bonds, phenolic ,
polystyrene)
4. Diffusion. (stirrer with high
speed)
5. Enzymolysis. (cellulase,
pectinase, ribulase..etc.)
6. Biodegradation. (bacteria,
fungi, algae ..etc.)
1. Self Assembling. (Inter or
Intra Molecular
Interaction)
2. Crystallization. ( Solid
and Liquid )
3. Precipitation. ( Liquid and
Liquid recovery of salt
and metals)
4. Sol-Gel. (NM + Organic
Solvent + Gel)
5. Molecular
Interaction.(Ionic
Interaction)
6. Biosynthesis. (Recovery
Na
no
po
lym
ers
Techniques Applied formation To
Nano Polymers
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Model of Surface-to-volume
Comparisons…
Neglecting spaces between the smaller boxes, thevolumes of the box on the left and the boxes on the rightare the same but the surface area of the smaller boxesadded together is much greater than the single box.
Single Box Ratio
6 m2
1 m3 = 6 m2/m3
Smaller Boxes Ratio
12 m2
1 m3 = 12 m2/m3
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PROPERTIES
Structural :- Platelets, Fibers, Spheroids, Linear, Branch, Network..etc.
Physical & Chemical:- Like as Stiffness, Strength, Stability, etc. (2D,3D).
Typical Structures are:
• Linear (end-to-end, flexible) .
• Branched(one end free, other attached to stalk polymer).
• Network (similar to highly cross-linked structures,termosetting polymers).
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Polymer has a Multidisciplinary
Field of Science & Technology
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Nano Based Polymers Types
Chemical Synthetics
- Polyglycolic acid (PGA)
- Polylactic acid (PLA)
- PGA-PLA
- Polydioxanone (PDO)
- Polycaprolactone
- PGA-polycaprolactone
- PLA-polycaprolactone
- Polydioxanone-polycaprolactone
Natural
- Elastin
- Gelatin collagen
- Fibrillar collagen
- Collagen blends
- Fibrinogen
- Heamoglobine
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NANO BASED SOME POLYMERS AND APPLICATIONBroad Fields Nano Size Polymers Applications
Chemicals PVC. (Poly vinyl chloride) Raincoats, shower curtains, water pipes
PMMA. (Poly methyl
methacrylate)
Plastic base glasses
PE. (Polyethylene) Grocery bags, shampoo, bottles, children’s toys,
bulletproof vests
PS. (Polystyrene) Comb, TVs body,. radio knobs. drinking cups foamy
PP. (Polypropene) packaging, textiles (e.g. ropes, thermal underwear,
carpets), stationery, plastic parts laboratory,
equipment, loudspeakers,
PPS. (Poly phenylene
sulfide)
Resist chemical and thermal attacks
ABS. (Poly acrylonitrile
butadiene styrene)
Very strong and lightweight polymer. It is strong
enough to be used to make automobile body parts
PNBR. (Polymer Nitrile
Buna-N rubber)
Cleaning of lab equipment, sophisticated,
instruments and examination gloves.
Biological Immunogenic Immunoglobulin (IgA, IgD, IgE, IgG, IgM)
Antigenic Epitope, Motifs, TCR (CD4,CD8), MHC
Lipids Emulsions Mixture (HC+H2O)
Liposomes Micelle, Amphipathic
Metals Nanoshell Cover (Sphere) of NP
Nanocomposites NP + Polymer
Fibers Nanosphere Careers Nanoparticles(amino, carboxyl, surfaces)
Nanocapsule Fiber Coat (Medicine coat, cover)
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Outline Process of Nano-Vector
Nano polymer mostly can be very effective to be Designing a
Drug as name “NANO VECTOR” by using of Nano Polymers and
Nano Materials in size nano range and also Applied for induced
tumor cells available in Critical Organs of Body such as
Brain, Lung, Heart...etc. These vector designed a typical
types, who are search to target site, that target site a specific
receptor Presented in outer cell membrane of the tumor cell
receptor made be become Biomolecules it bind by various ways
and released to NP into tumor cells. Where It are do The tumor
Cells Remove or Destroyed as may be possible without surgery
Because Some Tumor Cell have arises to another Tumor Cell by
Cell Cycling, here break Cell Cycling by This Nano Vector will as
a processing inhabit of protein synthesis of tumor cell.
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DNA Strand in nm
Nano-Vector
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DNA Strand
Nano-Vector
Nanoparticle
(Drugs)
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DNA Strand
Nano-Vector
Nanoparticle
(Drugs)
Covering of NP by DNA Polymer
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DNA Strand
Nano-Vector
Covering of NP by DNA Polymer
Covered of NP by DNA Polymer
Nanoparticle
(Drugs)
DNA Strand
NP
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vector with
Drugs
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vector with
Drug
Moieties Target
(Receptors)
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Nanovector
with Durg
Moieties Target
(Receptors)
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vector with
Durg
Moieties Target
(Receptors)
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vector with
Durg
Moieties Target
(Receptors)
Nano vector with various
moiety receptors
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Assembled Nano Vector (Drug)
Thank You
for a kind Attention