Naloxone Access Laws and Unintended Effects on …Another opiate, methadone, was the sixth highest...
Transcript of Naloxone Access Laws and Unintended Effects on …Another opiate, methadone, was the sixth highest...
Naloxone Access Laws and Unintended E�ects on the
Opioid Crisis: Increase in Overdose Deaths and Drug
Abuse
Estrella Ndrianasy
February 10, 2019
Abstract
Naloxone Access Laws (NALs) are one of several policies intended to �ght the rampant
opioid epidemic by allowing the public to carry naloxone (Narcan), an overdose reversal
drug. All states have currently adopted NALs with New Mexico being the �rst one in
2001. This study extends the literature by examining the potential for moral hazard from
the ready availability of naloxone to opioid abusers and the general public. E�ects on
opioid overdose deaths, opioid rehabilitation admissions, and the legal supply of opioids are
analyzed via a �xed e�ects regression method and propensity score matching techniques.
The estimation framework accounts for potential biases in a state's decision to adopt NALs
and concurrent laws aimed at combating the crisis such as the Good Samaritan Laws and
Prescription Drug Monitoring Programs. Each year, opioid overdose deaths signi�cantly
increased by 130 to almost 190 and the supply of legal opioid drugs signi�cantly went
up from 3,200 to 4,000 more grams per 100,000 population due to NALs during the time
period analyzed. On the other hand, the e�ects of NALs on opioid rehabilitation admission
is inconclusive. The results, in particular the rise in opioid overdose deaths, seem to indicate
a moral hazard issue with more addicts misusing dangerous levels of opioids with naloxone
as a safety net.
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1 Introduction
The opioid epidemic is prevalent in the U.S. claiming over 60,000 lives in 2016 [Wonder, 2017].
The opioid crisis is fueled by misuse and abuse of prescription pain relievers. Oftentimes, the
addiction starts with legitimate needs for pain relievers whose euphoric e�ects can quickly turn
into dependency. Once addicted, the abuser may seek more opioids through �doctor-shopping�
wherein they attempt to obtain more of the drugs through multiple prescribers. Addicts also
acquire opioids through friends and family's prescriptions. At the other extreme, opioids are
available illegally where they present an even greater risk to the individual when laced with
the cheaper but powerful fentanyl, a synthetic opioid. Opioid overdoses are now the number
one drug killer in the US surpassing others such as cocaine and methamphetamine. Various
measures such as Prescription Drug Monitoring Programs, insurance and pharmacy bene�t
manager strategies, state legislation, clinical guidelines, safe storage and disposal, and naloxone
distribution were put in place to prevent doctors from over-prescribing opioids or patients from
abusing opioids [Haegerich et al., 2014]. Most of the measures were supply-side interventions
with the intent of cutting o� an addict's access to the substance, resulting in the substitution to
other less restrictive but oftentimes more dangerous alternatives like heroin [Alpert et al., 2017].
Naloxone distribution measures are oriented towards existing drug consumers, their friends and
families, and service providers by educating them on the overdose risk factors, signs of overdose,
appropriate response, and the administration of naloxone.
The administration of Naloxone Hydrochloride (naloxone) reverses an opioid overdose and
can prevent death. Naloxone is an opioid receptor antagonist that can be administered via
intramuscular, intravenous, and intranasal routes. It works by displacing opioid agonists, such
as heroin or oxycodone, from opioid receptors [Doe-Simkins et al., 2009]. Naloxone is a relatively
inexpensive medication with a price tag of $20 to $40. Naloxone is can also be obtained at no
cost from overdose prevention programs in 2016. It works within mere minutes, with prior
allergic reaction as the only contraindication [Illinois, 2017]. Most importantly, naloxone has no
e�ect in the absence of opioid consumption. Without any agonist properties, it has no potential
for abuse and minimal likelihood for diversion or misuse [Heller and Stancli�, 2007]. In the wake
of the opioid crisis, the immediate availability of naloxone is crucial. Additionally, naloxone is a
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prescription drug, but not a controlled substance. This implies that the prescription of naloxone
is legal whereas the dispensing of the drug by medical professional at the point of service is
subject to varying rules for each state. Naloxone Access Laws (NALs) are policies passed by
states to curb the opioid overdose epidemic. As of July 2017, all �fty states and the District
of Columbia have a form of NALs to prevent unintentional drug overdose deaths. Generally,
NALs removes some criminal, civil, and professional liabilities for prescribers, dispensers, and
laypersons administering the opioid antagonist.
This paper explores the potential e�ect for moral hazard. Even when accounting for timing
di�erences in passing NALs, the number of prescription opioids and heroin overdose deaths have
increased alarmingly in the past decade and a half. Drug user's perception of opioid consumption
posing less of a risk because of the availability of naloxone is the focus of this paper. Plausible
unintended e�ects of NALs are increased consumption of the opioid resulting in drug rehabili-
tation treatments and accidental overdose deaths. However, this could also be due to a success
of NALs leading to addicts seeking help in overcoming their addiction. It will be assumed that
no matter what drives the decision to seek rehabilitation, it must begin with some prior opioid
consumption turning to addiction on the part of addict. Moreover, there are some limitations
in the reliability of mortality data due to under-reporting and/or human error in accounting
for the true causes of deaths as documented in the literature, especially in the causes of drug
overdoses [Ruhm, 2018]. The analysis will rely on the International Classi�cation of Diseases-10
(ICD-10) to best account for the potential mortality cause discrepancies. Overall, this paper ex-
tends the literature by looking at the unintended e�ects of NALs, a public health e�ort intended
to reduce opioid overdose deaths. Most of the literature hails NALs as successes whereas the
evidence suggest an ever increasing trend in opioid deaths, particularly heroin. This study aims
to answer the mechanism behind this phenomenon while allowing for a national level as com-
pared to previous community and city level assessments for smaller pilot prevention programs
from the early and mid 2000s. The paper will be divided into the following sections: literature
review, identi�cation strategy, data description, results analysis, and discussion. Overall, the
results show the presence of moral hazard for opioid overdose deaths nationally. Further, the
total grams for legal opioid drugs per capita is signi�cantly increased due to the NALs, whereas
there was no e�ect on opioid rehabilitation treatment.
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2 Literature Review
NALs are widely depicted as successful policies in the �ght against the opioid epidemic in the
literature. Various pilot programs were implemented in large metropolitan areas in the early
2000s resulting in a reduction of unintended opioid overdose deaths by as much as nine per
cent in New York City [Heller and Stancli�, 2007, Worthington et al., 2006] to a high of 20%
in Chicago in 2001 [Maxwell et al., 2006]. Other programs such as the Project Lazarus in
Wilkes County, North Carolina, led a signi�cant drop of opioid overdose mortality from a high
of 46.6 to 29 per 100,000 inhabitants in just one year in 2010 [Albert et al., 2011]. Naloxone
distribution programs in other cities such as San Francisco DOPE program in 2010 led to a
greater awareness of the bene�ts provided by NALs [Straus et al., 2013]. The initiative also
led to a take-back initiative by the Drug Enforcement Administration in 2012, where 520 tons
of unwanted or expired medication were disposed o� by the public. The city of Baltimore,
Maryland, enacted a similar prevention program called Staying Alive resulting in 22 successful
overdose reversals performed by 19 out of 43 individuals recruited through street-based outreach
and advertising [Tobin et al., 2009]. Chicago's own program also led to a 20% decrease in heroin
overdoses in 2001, followed by a 10% decrease for 2002 and 2003, respectively through the
distribution of 3,500 naloxone vials resulting in over 300 overdose reversals [Maxwell et al.,
2006]. Overall, naloxone overdose prevention programs have overwhelmingly reported positive
outcomes of successful opioid overdose reversals via peer administration of naloxone [Dettmer
et al., 2001, Worthington et al., 2006, Maxwell et al., 2006, Sporer and Kral, 2007, Mueller et al.,
2015].
NALs have been successful in reducing opioid overdose unintentional deaths. There were
more than 64,000 drug overdose deaths estimated in 2016, with the largest increase stemming
from synthetic opioids such as fentanyl and fentanyl analogs with over 20,000 deaths [Wonder,
2017]. Heroin and natural and semi-synthetic opioids were second and third in number of drug
deaths with 15,446 and 14,427 respectively. Another opiate, methadone, was the sixth highest
killer with over 3,000 deaths, preceded by cocaine and methamphetamine. In the early 2000s,
several studies have documented the e�ects of NALs and GSLs on reducing the number of
opioid deaths in small pilot programs in large cities in the U.S and the world [Maxwell et al.,
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2006, Heller and Stancli�, 2007, Kerr et al., 2008, Piper et al., 2008, Tobin et al., 2009, Doe-
Simkins et al., 2009, Albert et al., 2011, Wheeler et al., 2012]. The success of NALs is closely
tied to a bystander's willingness to intervene and adequacy in the administration of naloxone
in the event of an overdose. Overall, participants in NALs training program programs have a
positive attitude towards peer administration as they feel empowered to help others by reducing
mortality and morbidity in minimizing delays to treatment, feel as they contribute in preserving
ambulance services for other medical emergencies, and most of all avoid authority involvement
[Kerr et al., 2008]. Nonetheless, some literature has suggested the potential for moral hazard
from the NALs due to the reduced expected cost of opioid consumption. The unintended e�ects
range from an increased consumption of non-prescription opioids to the transition to harder
drugs such as heroin, cocaine, and methamphetamine [Bachhuber et al., 2014, Seal et al., 2003,
2005]. Others look at competing drug laws, such as Medical Marijuana Laws, and �nd mixed
results in subsequent opioid distribution [Rees et al., 2017, Powell et al., 2015, DiNardo and
Lemieux, 2001]. Moreover, some suggest prescription opioids are potential gateway drugs where
misuse is considered a key feature of trajectories into injection drug use such as heroin [Lankenau
et al., 2012, Fiellin et al., 2013]. These are attributed to opioid overdose victims continuing or
even increasing drug abuse in order to alleviate withdrawal symptoms [Seal et al., 2003, Lagu
et al., 2006].
Naloxone then becomes a safety mechanism enabling at risk individuals to consume greater
amounts of opioids in the absence of consequences [Albert et al., 2011]. Moral hazard may result
in increased opioid addiction and overdose deaths, although the literature is fairly inconclusive.
In a survey of injection drug users in San Francisco, 35% felt comfortable using greater amounts
of heroin in the presence of naloxone while 46% of overdose victims were planning on using
heroin again to alleviate withdrawal symptoms [Seal et al., 2003]. The same authors also found
reduced heroin consumption later after adequate education and training in overdose reversal,
illustrating the mixed nature of the literature [Seal et al., 2005]. Another naloxone distribu-
tion program in Providence, Rhode Island, found rare adverse e�ects whereby the likelihood of
getting addicted on heroin actually increased in opioid addicts when symptoms of withdrawals
are precipitated, driving them to seek relief in additional substance abuse [Lagu et al., 2006].
Others highlight the potential for naloxone to increase polysubstance abuse, especially the as-
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cension to harder opiates such as heroin using prescription opioids as gateway drugs [Bachhuber
et al., 2014, Sporer and Kral, 2007, Kerr et al., 2008]. Additionally, there has been a signi�-
cant increase in the amount of substances distributed in the U.S., including methadone, heroin,
benzodiazepines and barbiturates, cocaine, other opioids, and their related overdoses [Walley
et al., 2013, Rees et al., 2017]. Finally, there is some evidence that competing laws such as
Medical Marijuana Laws, could have a reducing e�ect on prescription opioids misuse through
a substitution mechanism [Powell et al., 2015, DiNardo and Lemieux, 2001]. Another example
of a measure to combat the prescription opioid overdose deaths but yielded much higher heroin
fatalities is the OxyContin Reformulation of 2010, which marked the introduction of an abuse
deterrent opioid. The reformulation caused an opioid supply disruption that turned drug addicts
to much harder substances such as heroin and fentanyl, illicit and dangerous forms of opiates.
The measure marginally decreased prescription painkiller fatalities but signi�cantly increased
heroin and synthetic opioid (fentanyl) overdose deaths [Alpert et al., 2017]. Some law enforce-
ment entities also have at best a diverging and at worst a skeptical opinion on the e�ectiveness
of NALs, primarily focusing on their perceived enabling potential, especially with regards to
immunity from prosecution [Gaston et al., 2009, Banta-Green et al., 2013].
This paper extends the scarce and mixed literature of the unintended e�ects of NALs. From
an economics perspective, the potential issue of moral hazard is important to evaluate the
practical costs and bene�ts associated in the implementation of NALs. The moral hazard itself
seems to originate from the sense of safety provided by the presence of naloxone, which may cause
an opioid addict to continue misusing at his own and society's cost. This analysis follows the
literature by looking at the commonly used substance abuse outcomes: treatment/rehabilitation,
unintended overdose deaths, and the amount of opioids distributed for all states. The Treatment
Episode Data Set (TEDS), the National Vital Statistics System (NVSS) Multiple Cause of Death
Mortality deaths, and Automation of Reports and Consolidated Orders System (ARCOS) will
be used to conduct the analysis at the state level. The TEDS and NVSS data are maintained
by the CDC by the Substance Abuse and Mental Health Services Administration and National
Center for Health Statistics respectively. TEDS reports treatment information on addicts seeking
rehabilitation. NVSS records mortality data and their causes among other things. Finally, the
ARCOS data is an automated, comprehensive drug reporting system monitoring the �ow of DEA
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controlled substances from their point of manufacture through commercial distribution channels
to point of sale. This paper updates the literature by providing a national level analysis on the
e�ects of NALs since most states passed the measure into law in the early 2010s. Previous work
focused on small pilot programs limited with small sample size and weaker power for external
validity. Moreover, an extension of the di�erence-in-di�erence identi�cation strategy, a �xed
e�ects regression model, as well as a propensity score matching framework will be conducted to
analyze the impact of NALs on the opioid overdose epidemic.
3 Identi�cation Strategy
3.1 Fixed E�ects Model
A standard di�erence-in-di�erence (DID) setup is inadequate for instances where there are
multiple time periods and multiple groups. An expansion of the standard DID is possible by
including time and individual or group �xed e�ects. Moreover, the variation in treatment timing
is exploited to get a glimpse of the e�ects of the policy implementation. The expanded regression
model is as given below:
Yst = yeart + states + βNaloxonest + θXs + εst (1)
where Drugst is the outcome of interest referring to categories of drugs such as opioids and
heroin in state s and year t, yeart is the year �xed e�ect, states is the individual state �xed e�ect,
Naloxonest is a dummy equal to one if a state adopted NALs and 0 otherwise, Xs is a vector of
individual state covariates including other relevant drug related policies, εst is an error term. β
is the causal e�ect of interest and is interpreted as the average treatment e�ect of the adoption of
Naloxone laws. The �xed-e�ect construct aims to reduce the omitted variable bias unaccounted
for within the states such as di�ering demographics, prevalence of drug consumption, or the
existence of pill mills a�ecting the supply of opioids. The identifying assumption relies on
variations in opioid abuse and its corresponding predictors to be time-invariant. Moreover, it
is important that changes in within state factors a�ecting drug abuse are uncorrelated with
the state's decision to adopt the Naloxone Access Laws. In other words, the decision to adopt
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a Naloxone law may be endogenous. The potential for endogeneity is tentatively alleviated
through the preliminary �xed-e�ect model. This preliminary model assumes endogeneity due
to omitted variable is removed or at the very least reduced for interpretable results.
3.2 Propensity Score Matching
The interpretation of NALs e�ect is complicated by the wide variation of states with regards
to their characteristics and the timing of the law's adoption. The inherent di�erences between
states, included but not limited to the severity of their opioid epidemic, acts as a critical factor
in their decision to adopt NALs and other measure combating the crisis. This introduces biases
in the interpretation of law's e�ect at best and impossible at worst. The core of the issue lies
in creating appropriate treatment and control states. Simply put, a state's decision to adopt
NALs is endogenous to its speci�c opioid problem. Assuming that the opioid issue arises from
a combination of observable and unobservable factors within the state, a matching method can
be utilized to create treatment and control groups by relying not only on the timing of the
NALs adoption but on its characteristics. A common method widely used in the literature is
propensity score matching where states are matched into control and treatment groups based
on their observable characteristics. This method seeks in part to alleviate the issue of common
trend when comparing states before and after the adoption of a policy.
Each observation's propensity score derives from the conditional or predicted probability
of receiving treatment given pre-treatment characteristics. In this case, each state is given
a propensity score on their likelihood to adopt the NALs given their characteristics. States
are assigned to control and treatment groups based their population characteristics, adoption
of other opioids laws such as PDMPs and GSLs, and crime rates. Following Callaway and
Sant'Anna [2018], the standard DID construct with two time periods and no treatment in
period 1 is extended to multiple time periods. Let t = 1, ..., τ represent individual time periods
for each year analyzed, NALt denotes a binary variable equal to one if a state is treated at year
t and zero otherwise. Furthermore, let NALg be a binary variable denoting a state that is �rst
treated at year g, while C is a binary variable accounting for states that are never treated at any
point in time. Each state will have exactly one of either NALg or C equal to one, depending
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on whether it is receives treatment or not. The generalized propensity score pg(X) indicates
the probability of a state being treated conditional on having covariates X and conditional on
being treated or not. Following, the generalized propensity score for multiple time periods and
multiple states is de�ned as:
pg(X) = prob(NALg = 1|X, NALg + C = 1) = E(NALg|X, NALg + C = 1) (2)
The treatment outcomes are de�ned as Yt =
Yt(1) if NALt=1
Yt(0) otherwise
The observed outcome in each year t is Yt = NALtYt(1) + (1 − NALt)Yt(0). The actual
treatment e�ect is some part of the previous function as a state cannot be simultaneously a
treatment and a control. For a standard DID, the average treatment e�ect is the di�erence
between treated and control, which becomes a simple t-test between both groups. In the case of
multiple group and time periods, the �group average treatment e�ect� at time t for states �rst
treated at year g is expressed as in Callaway and Sant'Anna [2018] as:
ATE(g, t) = E[Yt(1)− Yt(0)|NALg = 1] (3)
Furthermore, it is assumed that {Ys1, Ys2, ..., Ysτ , Xs, NALs1, NALs2, ..., NALsτ}ns=1 is
independently and identically distributed. The outcomes are assumed to be independent of
selection into treatment conditional on a state characteristics, i.e. treatment is exogenous. Also,
the conditional parallel trend states that control and treatment observations would have followed
similar trends in the absence of treatment given state characteristics X. The average outcomes
for groups �rst treated at year g and control observations are assumed to have parallel trends at
year g and any other subsequent time periods, conditional on covariates X which will be time
speci�c.
E[Yt(0)− Yt−1(0)|X, NALg = 1] = E[Yt(0)− Yt−1(0)|X, NALg = 0]
The irreversibility of treatment condition assumes that once treated, a state will be treated
in the next time period. That is NALt = 1implies that NALt+1 = 1 for time periods t = 2, ..., τ .
The overlap or matching condition assumes that for each value of X, there are both treated and
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control observations. Speci�cally, there will be a positive number of observations that will be
treated in period g and that there is concurrently a positive probability that an individual is
not treated given state covariates X. For all g = 2, ..., τ , it is assumed that p(NALg = 1) > 0
and 0 < pg(X) < 1 states that there is a matched control observation with similar X. Finally,
the balancing condition states that assignment to treatment is independent of the X covariates,
given the same propensity score between di�erent observations.
4 Data
This analysis combines several data sources to look at various outcomes of the opioid epidemic.
The Treatment Episode Data Set (TEDS) provides individual state information on the count
of individuals seeking opioid addiction rehabilitation from 2000 to 2014. TEDS removes all
identi�able information preventing the analysis from capturing individuals seeking treatment
across multiple time periods. Each observation is therefore considered unique. The second
outcome of interest is opioid overdose deaths coming from the National Vital Statistics Sys-
tem (NVSS) Multiple Cause of Death Mortality dataset. The International Classi�cation of
Diseases (ICD-10) is used to identify deaths with external causes of injury related to opioid
misuse. The ICD-10 codes used for opioids are X40-X44, X60-X64, X85, and Y10-Y14 from
years 2000 to 2014. Although the NVSS put restriction on identifying detailed mortality data
since 2005, aggregate information on state death count is still available. Finally, the supply
of legal controlled substances is analyzed through the Drug Enforcement Agency's statistical
reporting arm, the Automation of Reports and Consolidated Orders System (ARCOS) from
2006 to 2014. The ARCOS data is used to look at trends in the supply of legally sold opioids
especially in light of the NALs. Information on commonly distributed opioids such as Codeine,
Fentanyl, Hydrocodone, Hydromorphone, Meperidine, Methadone, Oxycodone, Oxymorphone,
and Tapendatol are analyzed at the state and national levels. Data on violent and property
crimes are obtained through the Uniform Crime Reporting (UCR) system for all years studied.
The UCR data is used as a proxy for the required law enforcement resources per state which
may be related to its corresponding opioid abuse levels. State demographics data come from
the Current Population Survey to provide a background on overall population characteristics.
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Table 1: Summary Statistics of Selected VariablesVariable (per 100,000
population)
N Mean Standard
Deviation
Minimum Maximum
Opioids Outcomes
Total Grams of Opioids 572 51,031.10 17,581.27 6,777.00 118,645.26
Opioid Overdose Deaths 918 756.48 864.76 13.00 5,403.00
Opioids Rehabilitation Admissions 640 80.47 88.19 0.43 651.33
Demographic Characteristics
White 867 107.54 106.02 16.48 590.51
Black 867 13.19 33.35 0.16 276.83
Hispanic 867 13.31 14.41 0.55 102.31
Male 867 65.67 61.32 11.89 302.63
Female 867 69.03 63.71 12.59 308.70
Married 867 53.91 49.91 10.31 272.92
Divorced 867 10.05 9.66 1.58 47.67
Single 867 62.34 59.75 10.66 276.96
Employed 867 64.14 62.06 12.34 295.36
Unemployed 867 4.03 4.13 0.40 25.89
Medicaid 867 20.13 21.56 1.34 116.95
Medicare 867 16.10 14.81 2.90 66.07
Below Federal Poverty Level 867 16.33 15.13 1.79 93.22
Education Level
Less than High School 867 19.01 16.70 3.58 83.09
High School 867 29.92 27.91 5.90 144.75
Some College 867 18.56 17.88 3.17 103.10
Associate 867 8.87 9.34 1.00 45.54
Bachelor's 867 16.86 16.93 2.09 87.87
Master's 867 6.39 8.14 0.72 67.98
Age
15 to 19 867 10.65 10.18 1.67 58.02
20 to 24 867 7.79 7.41 1.31 36.71
25 to 29 867 6.51 6.53 1.10 40.13
30 to 34 867 9.12 8.73 1.82 46.83
35 to 39 867 7.68 7.26 1.70 45.49
40 to 44 867 10.39 10.06 1.95 56.20
45 to 49 867 10.02 9.70 1.49 49.46
50 to 54 867 9.00 8.63 1.68 39.92
55 to 59 867 7.35 7.09 1.09 32.33
60 to 64 867 5.74 5.50 0.89 27.13
Over 65 867 14.35 13.50 2.60 64.15
Crime Rate
Property Crime 765 3,194.15 837.68 1,524.40 6,409.00
Violent Crime 765 411.22 216.80 78.20 1,637.90
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4.1 Summary Statistics
The data in table 1 show an average of over 50,000 grams for the most commonly legally dis-
tributed opioids over the between 2006 and 2014 across all states for every 100,000 population.
In 2018, the CDC provided guidelines on the lowest e�ective dosages when prescribing opioids,
with thresholds equal or greater to 50 morphine milligrams equivalents (MME) per day needing
to be carefully assessed, and titration of dosages greater or equal to 90 MME to be avoided or
referred to a pain specialist. For reference a 50 MME/day is equivalent to 50 mg of Hydrocodone
(10 tables of Hydrocodone/acetaminophen 5/300), 33 mg of Oxycodone, or 12 mg of Methadone.
At the rate of 50 MME/day, the opioid supply average of 50,000 grams translates to prescrip-
tions of over 1 million MME/day of hydrocodone, more than 1.5 million MME/day of oxycodone,
and greater than 4.5 million MME/day of methadone on average per 100,000 population in the
US for the time period analyzed. Second, there were on average a little more than 750 opioid
overdose deaths in per 100,000 population nationally from 2000 and 2014, with the number still
alarmingly rising. These deaths are categorized in ICD-10 as accidental, intentional self-harm,
and events of undetermined intents involving poisoning and exposure to noxious substances
such as nonopioid analgesics, antipyretics and antirheumatics; antiepileptic, sedative-hypnotic,
antiparkinsonism and psychotic drugs (not elsewhere classi�ed); narcotics and psychodysleptics
(hallucinogens), not elsewhere classi�ed; other drugs acting on the autonomic nervous system;
other and unspeci�ed drugs, medicaments and biological substances. Furthermore, the TEDS
data show an average of above 80 opioid rehabilitation admission per 100,000 population in the
US between 2000 to 2014. An opioid rehabilitation admission is de�ned as one where �opiates
and synthetics� were reported at admission regardless of whether such substance was primary,
secondary, or tertiary. This de�nition excludes non-prescription Methadone. Admissions in-
volving �opiates and synthetics� were reported in close to 12% of all drug admissions at a count
of about 2.2 million, and accounts for 7% of all primary substance abuse in the time period
analyzed.
Overall, the Current Population Survey dataset shows a generally higher proportion of whites
at about 108 per 100,000 population, a slightly higher proportion of females compared to males
at 13.19 per capita, and the majority is employed. Close to every 20 people out of 100,000
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has less than a twelfth grade education, about 30 graduated high school, 19 has some college
education whereas about 17 obtained a bachelor's degree. The age distribution is rather even
among all age groups with a higher concentration of the US population concentrated at 40 years
old and up. Finally, the Uniform Crime Report dataset shows property crime rate to be an
average of 3,200 and violent crime at about 410 per 100,000 population, respectively. Property
crimes include burglary, larceny, and motor vehicle theft whereas violent crimes are comprised
of murder and non-negligent manslaughter, rape, robbery, and aggravated assault.
4.2 Parallel Trends Assumption
The parallel trend assumption asserts the enactment of a policy should have no e�ect on the
trends of the outcome of interests. Speci�cally, the adoption of NALs should be completely
random as to avoid the issue of selection bias. Per �gure 4, it is shown the bulk of states
passed the laws between 2013 and 2015. The gap between the �rst state (New Mexico) passing
the laws and the few last ones is about 16 years from 2001 to 2017. There seems to be no
pattern as to the timing of the adoption of the law, other than a collective movement from 2013
onward where states from all over the country decided to adopt the law at once. There were
no documented federal or state incentives to adopt the laws either to the author's knowledge.
Due to data limitation, only states that passed NALs in 2013 and 2014 are aggregated to verify
the parallel trends assumption for all three outcomes of interests. In �gure 1 ,the states passing
NALs in 2013 seem to have steadily followed an upward trend in opioid rehabilitation admission,
regardless of policy adoption; and thus parallel trend is assumed. Those adopting NALs in 2014
experienced an immediate sharp decline in rehab admission during the year of its policy adoption
and then returns to their previous levels. This patterns violates the common trend assumption
but provides insight into the potential spillover e�ects from other states passing NALs in the
previous years.
The picture is much of the same in �gure 2 for the opioid overdose deaths with steady decline
in both years considered, then a particularly large drop occurs followed by an immediate return
to its previous levels. It is important to note the opioid deaths might include heroin deaths. The
OxyContin reformulation of 2010 reduced the number of all opioid deaths while simultaneously
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Figure 1: Opioid Rehabilitation Admissions
Figure 2: Opioids Overdose Deaths
Figure 3: Total Grams of Legally Distributed Opioids
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Figure 4: Naloxone Access Laws E�ective Dates
increasing heroin overdoses due to a substitution e�ect [Case and Deaton, 2015]. The most
recent renewed uptick in opioid overdose deaths might be due to the rapidly increasing impact
of the deadly fentanyl. Overall, there seems to be little evidence to suggest a common trend.
Finally, the total grams of legally distributed opioids follows a steady trend of declining amount
prior and after the adoption of NALs in both years considered, as seen in �gure 3. There is
generally a decrease in the legal supply of opioid that can be due to physicians prescribing less
painkillers due to the various laws restricting their ability to do so, especially the PDMPs. The
CDC also advises alternative approaches in treating pain and heavily monitoring the allowable
dosage of opioids for treatment to 50 MME or 90 MME/day. In this case, the common trend
assumption seems plausible.
5 Results
5.1 Fixed-E�ects Regression
NALs have a negative although insigni�cant impact on opioid rehabilitation admissions as seen
in table 2. This result is consistent across various model speci�cations. These �ndings are on par
15
with the literature where various opioid driven policies have no impact on admission into reha-
bilitation. One plausible explanation is the lack of information on what drives an addict to seek
help. The vast majority of patients were admitted through court referrals and thus were involun-
tary. Second, the limits on Medicaid reimbursements for behavioral health an substance abuse
treatment is a deterrent to admitting patients needing help, thus e�ectively under-reporting
the total numbers of addicts impacted by NALs with non-fatal overdoses reversed by Naloxone
for instance. Essentially, the data on opioid rehabilitation admissions fails to re�ect the actual
extent of the epidemic, and perhaps clouds the potential e�ects of NALs.
Also, table 2 shows NALs positively and signi�cantly a�ect opioid overdose deaths. There
are about 140 more opioid deaths per 100,000 population due to NALs, all else being equal. Fur-
thermore, GSLs signi�cantly reduce opioid mortality by a factor of more than 210 less deaths
per capita. The con�icting e�ects of GSLs and NALs are signi�cant and consistent across all
speci�cations, and the interaction of all three policies of interests signi�cantly increase opioid
mortality rate. The signi�cant increase in opioid deaths by NALs seems to con�rm the hypothe-
sis of moral hazard where the presence of an overdose reversal drug as a safety net leads to riskier
behaviors, and ultimately resulting in fatal overdoses. Nevertheless, it is important to note that
opioid overdose deaths are generally trending upward during the time period analyzed. More to
the point, the widespread substitution to a harder narcotic, heroin, and the lacing of heroin with
fentanyl, are very likely a driving force behind the increase in opioid deaths. Nonetheless, it can
be said that policies such as NALs are also responsible for the ampli�cation of the magnitude of
an already growing opioid mortality rate. The deterrent e�ect of GSLs is a positive in curbing
the opioid epidemic by encouraging third parties to intervene with naloxone administration in
the event of an emergency.
Finally, table 2 illustrates how the implementation of NALs results in a signi�cant increase in
the legal supply of opioid by an amount of about 3,000 grams to close to 4,000 grams per 100,000
population. In a scenario of 50 MME/days dosages, NALs resulted in per capital prescriptions
of between 60,000 and 80,000 of hydrocodone, between 91,000 and 120,000 of oxycodone, and
between 250,000 to over 330,000 of methadone during the time period analyzed. Year and state
�xed e�ects were used to mitigate issues of linear trends. However, the interpretation of such
16
Table 2: Fixed E�ect-Regression Results
Outcomes (per100,000 population)
Policies (1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Opioid Rehabilitation
Admission
NAX 2.402(5.747)
1.238(6.172)
2.171(5.753)
-2.499(7.096)
GSL 3.219(6.202)
-2.627(8.123)
PDMP 4.285(4.543)
4.173(4.563)
All Policies 10.01(10.08)
Number of Observations 600 600 600 600
Overall R-Squared 0.905 0.905 0.905 0.906
Opioid Overdose Deaths
NAX 133.1***(39.66)
187.1***(41.40)
133.4***(39.70)
139.8**(47.41)
GSL -166.3***(41.83)
-241.4***(56.06)
PDMP -15.50(30.88)
-7.685(30.43)
All Policies 137.7*(67.77)
Number of Observations 600 600 600 600
Overall R-Squared 0.955 0.953 0.955 0.953
Total Grams of Opioid
Drugs
NAX 3239.3*(1295.6)
2893.1**(1342.2)
3209.9*(1300.1)
3957.4**(1519.1)
GSL -2292.4(1294.3)
-2091.3(1889.0)
PDMP -463.5(1243.9)
-279.3(1248.4)
All Policies -300.9(2327.6)
Number of Observations 333 333 333 333
Overall R-Squared 0.938 0.939 0.939 0.939
Standard Errors in parentheses* p<0.05, ** p<0.01, *** p<0.001
17
Table 3: Propensity Score Matching Average Treatment E�ectsOutcomes
(per 100,000 population)
Nearest
Neighbor
Matching
Kernel
Matching
Strati�cation
Matching
Opioid Rehabilitation
Admission-46.75(44.51)
-38.83(36.29)
-63.14*(28.64)
Opioid Overdose Deaths 369.0*(158.2)
333.6*(151.0)
366.2*(170.7)
Total Grams of Opioid
Drugs1573.0(5385.0)
4980.9(5264.7)
5735.7(4808.5)
Standard Errors in parentheses* p<0.05, ** p<0.01, *** p<0.001
an increase could be potentially due to a legitimate need for opioids used as painkillers for an
aging population for instance. There has also been a shift in medicine leading to a preference for
opioids to treat pain since the mid nineties. While taking those potential factors into account,
it is also crucial to note that opioid misuse is one of the leading causes for the epidemic. The
availability of more naloxone would encourage a higher consumption of opioids, either prescribed
legitimately or not. This could be in the form of doctor shopping and various forms of drug
seeking behaviors. In that sense, the hypothesis of NALs culminating in riskier behavior is
plausible.
5.2 Propensity Score Matching
The propensity score results matching closely match those of the �xed e�ects regression models
although they are of much larger magnitudes. The average treatment e�ects via various matching
techniques are found in table 3 after randomly assigning treatment and control groups for the
states analyzed. The results suggest NALs have a signi�cant and negative e�ects on opioid
rehabilitation admissions with 63 less per 100,000 population. This could stem from addicts
being able to maintain harmful habits by resorting to naloxone injection in the event of an
emergency. Namely, naloxone is used in lieu of treatment in order to survive an overdose.
Opioids overdose deaths are still signi�cantly impacted by NALs with almost double the size of
the e�ects when using a matching technique. The results in table 3 show there are between 330
to 360 more opioid deaths from NALs per capita, all else being equal. Finally, matching lead to
18
NALs having a positive but insigni�cant impact on the legal supply of opioid.
6 Discussion
Higher rates of opioids mortality and consumption of narcotics, as evidenced by a higher supply
of legally distributed opioid, lend credibility to the likelihood of moral hazard from the adop-
tion of Naloxone Access Laws. The study shows signi�cant and positive e�ects for overdose
deaths and legal distribution of opioids while it �nds no impact on rehabilitation admission
from the opioid law. The lack of information on the cause for seeking addiction treatment is
a data limitation. There are also no information on the degree of access to naloxone for each
state, preventing the study from knowing whether an attempt was made to reverse an overdose.
Overall, these weaknesses were mitigated by assuming complete access to naloxone, if not by
third parties then by �rst responders.
The administration of naloxone is a reactionary measure to an already present addiction
at its worst possible outcome, an overdose. The link between NALs and opioid rehabilitation
admission seems therefore unlikely as emergency treatment is the direct response to a non fatal
overdose rather than rehabilitation. Instead, the relationship between NALs and rehabilitation
rests in determining the actual reason for seeking cure. Also, this issue is further exacerbated
by government reimbursement restrictions for substance abuse treatment, not to mention the
social stigma associated with addiction. A bipartisan bill known as the Medicaid Coverage for
Addiction Recovery Expansion Act was introduced in 2017 to ease the restrictions on Medicaid
reimbursements for substance use disorder treatment centers with up to 40 beds for stays of up
to 60 consecutive days.
Most importantly, this paper aims to study the likelihood of moral hazard from enacting
NALs. According to the results, this hypothesis is plausible from the increasing opioid mortality
rates and the growing legal supply of opioids, excluding illicit narcotics such as heroin. Of
course, the establishment of causality between possession of naloxone and an addict's decision
to undertake riskier behavior is impossible without case by case evidence. However, the growing
trend of overdose deaths coinciding with the implementation of NALs suggest a strong correlation
that should be cause for worry. This study suggests that amid the broader opioid crisis and its
19
plethora of factors, NALs carry a non-negligible responsibility in its worsening. The mechanism
for the e�ectiveness of naloxone is two fold: overdose inducing levels of opioid consumption,
followed by timely and appropriate use of naloxone for reversal. Opioids overdose deaths occur
in either the absence of naloxone, dangerously high level of opioid consumption, or lack of
knowledge on the use of naloxone. To prevent more deaths, there needs to be more education on
the use and limitations of naloxone. Initiatives such as Syringe Services Programs widely known
as needle exchange programs (NEPs) providing medically supervised and safer consumption sites
are a step in the right direction in empowering people su�ering from addiction. The Centers
for Disease Control and Prevention also supports such community e�orts by providing federal
funding to state and local communities via the Consolidated Appropriations Act of 2016.
Finally, the growing supply of legally distributed opioids in relation to the enactment of
NALs is cause for concern. The more opioid is available, the more opportunities there are
for misuse. The safety net of naloxone might encourage more doctor shopping to increase
consumption. Take-back initiatives such as the Drug Enforcement Administration's National
Prescription Drug Take Back Day programs to safely dispose of drug are opportunities to reduce
the supply of legally available drugs, and hopefully reduce the need for naloxone in the event of a
drug overdose. Furthermore, regulations aimed at prescribers to curb over prescription of opioids
could greatly impact the epidemic. In the future, research on NALs can be extended by looking
separately at the components of the law, speci�cally the level of liability protection a�orded
by the law. More insight can be gleaned from understanding the di�erences in the criminal,
civil, or professional immunity the law provide, especially with states varying widely in their
restrictions. NALs might have a di�erential impact on laypersons, prescribers, and dispensers
of the opioid antagonist that could paint a very di�erent picture of the opioid epidemic.
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Appendix
24
Table 4: Opioid Rehabilitation Admission Fixed E�ects Results
Variables(1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Opioid Related Policies
NAX2.402
(5.747)
1.238
(6.172)
2.171
(5.753)
-2.499
(7.096)
GSL3.219
(6.202)
-2.627
(8.123)
PDMP4.285
(4.543)
4.173
(4.563)
NAX*GSL*PDMP10.01
(10.08)
Demographic Characteristics
White0.250
(0.262)
0.245
(0.262)
0.216
(0.264)
0.233
(0.265)
Black1.819**
(0.658)
1.783**
(0.662)
1.759**
(0.661)
1.682*
(0.662)
Amerindian1.143*
(0.483)
1.167*
(0.485)
1.113*
(0.484)
1.084*
(0.483)
Asian0.757*
(0.299)
0.748*
(0.299)
0.717*
(0.302)
0.717*
(0.302)
Hispanic-0.936*
(0.461)
-0.882
(0.473)
-0.963*
(0.462)
-0.898
(0.476)
Male3.376***
(0.958)
3.426***
(0.964)
3.384***
(0.959)
3.196***
(0.943)
Married0.433
(0.833)
0.381
(0.840)
0.387
(0.834)
0.534
(0.803)
Divorced4.549**
(1.465)
4.526**
(1.4657)
4.424**
(1.471)
4.518**
(1.465)
Single-2.146**
(0.767)
-2.171**
(0.769)
-2.171**
(0.767)
-2.080**
(0.758)
Unemployed-1.426
(1.307)
-1.399
(1.309)
-1.362
(1.309)
-1.487
(1.302)
Education Level
Less than High School1.028
(0.828)
0.995
(0.831)
1.026
(0.828)
1.043
(0.829)
High School Degree1.114
(0.711)
1.090
(0.713)
1.237
(0.723)
1.245
(0.726)
Bachelor's Degree-1.214
(1.025)
-1.181
(1.028)
-1.196
(1.025)
-1.128
(1.029)
Master's Degree4.603**
(1.514)
4.602**
(1.515)
4.737**
(1.521)
4.813**
(1.520)
Professional Degree7.850*
(3.483)
7.761*
(3.490)
8.427*
(3.537)
8.634*
(3.523)
N 600 600 600 600
Overall R-Squared 0.955 0.953 0.955 0.953Standard errors in parentheses
* p<0.05, ** p<0.01, *** p<0.001
25
Table 5: Continued Opioid Rehabilitation Admission Fixed E�ects Results
Variables (1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Age Levels
20 to 24 -0.724
(1.473)
-0.717
(1.474)
-0.700
(1.474)
-0.727
(1.472)
25 to 29 2.484
(1.652)
2.476
(1.653)
2.558
(1.654)
2.435
(1.654)
30 to 34 -4.572**
(1.484)
-4.525**
(1.488)
-4.466**
(1.488)
-4.701**
(1.461)
35 to 39 0.0178
(1.645)
0.0714
(1.649)
0.135
(1.650)
0.128
(1.653)
40 to 44 -2.858
(1.484)
-2.799
(1.490)
-2.806
(1.485)
-2.990*
(1.462)
45 to 49 -2.014
(1.300)
-1.947
(1.308)
-1.873
(1.309)
-1.960
(1.305)
50 to 54 -5.726***
(1.393)
-5.706***
(1.395)
-5.617***
(1.398)
-5.714***
(1.389)
55 to 59 -0.656
(1.469)
-0.687
(1.471)
-0.799
(1.477)
-0.813
(1.479)
60 to 64 6.159***
(1.659)
6.210***
(1.663)
6.189***
(1.659)
6.099***
(1.648)
Other Covariates
Medicaid Recipient 1.172**
(0.433)
1.163**
(0.434)
1.120*
(0.437)
1.039*
(0.440)
Employer Provided
Insurance
-2.991***
(0.698)
-2.994***
(0.698)
-3.005***
(0.698)
-3.041***
(0.697)
Below Federal Poverty
Level
-1.172*
(0.569)
-1.170*
(0.569)
-1.107
(0.573)
-1.045
(0.577)
Larceny Theft 0.0453***
(0.00895)
0.0456***
(0.00898)
0.0464***
(0.00902)
0.0461***
(0.00907)
N 600 600 600 600
Overall R-Squared 0.955 0.953 0.955 0.953
Standard errors in parentheses* p<0.05, ** p<0.01, *** p<0.001
26
Table 6: Opioid Overdose Deaths Fixed E�ects Results
Variables(1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Opioid Related Policies
NAX133.1***
(39.66)
187.1***
(41.40)
133.4****
(39.70)
139.8**
(47.41)
GSL-166.3***
(41.83)
-241.4***
(56.06)
PDMP-15.50
(30.88)
-7.685
(30.43)
NAX*GSL*PDMP137.7*
(67.77)
Demographic Characteristics
White1.658
(1.720)
1.922
(1.697)
1.740
(1.729)
2.120
(1.703)
Black-9.751*
(4.471)
-8.899*
(4.414)
-9.635*
(4.480)
-8.811*
(4.409)
Asian0.495
(1.981)
0.782
(1.954)
0.598
(1.993)
0.835
(1.960)
Amerindian3.036
(3.307)
1.798
(3.276)
3.089
(3.311)
1.643
(3.273)
Male-5.014
(6.090)
-5.971
(6.010)
-4.965
(6.095)
-7.027
(6.022)
Divorced1.981
(9.004)
0.843
(8.882)
2.327
(9.036)
1.173
(8.891)
Single-6.322
(5.302)
-7.168
(5.232)
-6.275
(5.307)
-6.737
(5.226)
Unemployed3.727
(8.908)
2.045
(8.793)
3.311
(8.953)
1.388
(8.813)
Education Level
Less than High School21.69**
(7.731)
20.66**
(7.627)
22.03**
(7.766)
20.69**
(7.642)
High School Degree18.74**
(5.711)
18.69***
(5.631)
18.67**
(5.717)
18.84***
(5.622)
Some College21.80**
(7.061)
21.83**
(6.962)
22.19**
(7.109)
21.47**
(6.995)
Bachelor's Degree5.614
(8.929)
3.838
(8.815)
5.897
(8.953)
3.854
(8.816)
N 640 640 640 640
Overall R-Squared 0.953 0.955 0.953 0.955
27
Table 7: Continued Opioid Overdose Deaths Fixed E�ects Results
Variables (1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Age Levels
15 to 19 -19.63
(10.52)
-16.04
(10.41)
-19.88
(10.54)
-15.51
(10.41)
20 to 24 -6.317
(11.14)
-5.841
(10.99)
-6.604
(11.17)
-4.710
(11.00)
25 to 29 -17.61
(12.70)
-15.69
(12.53)
-18.13
(12.75)
-15.60
(12.55)
30 to 34 -4.456
(10.62)
-3.446
(10.48)
-4.853
(10.66)
-3.234
(10.49)
35 to 39 -12.77
(12.14)
-12.31
(11.97)
-13.37
(12.21)
-12.84
(12.01)
40 to 44 -4.215
(10.52)
-2.408
(10.39)
-4.548
(10.55)
-2.312
(10.39)
45 to 49 -14.08
(9.522)
-14.62
(9.389)
-14.85
(9.652)
-15.19
(9.490)
50 to 54 -4.744
(10.30)
-3.409
(10.16)
-5.347
(10.37)
-2.634
(10.22)
55 to 59 -28.47**
(10.33)
-25.64*
(10.21)
-28.06**
(10.37)
-24.78*
(10.22)
60 to 64 -25.38*
(11.12)
-24.29*
(10.97)
-25.62*
(11.14)
-22.84*
(10.98)
Over 65 -27.74
(14.80)
-22.05
(14.66)
-28.06
(14.83)
-22.36
(14.65)
Other Covariates
Medicaid Recipient -1.156
(2.993)
-0.730
(2.953)
-0.975
(3.017)
-1.435
(2.993)
Medicare Recipient 10.69
(14.22)
5.742
(14.08)
10.64
(14.24)
6.323
(14.05)
Employer Provided
Insurance
5.266
(4.842)
5.765
(4.776)
5.257
(4.845)
5.656
(4.766)
Below Federal Poverty
Level
1.655
(3.888)
1.766
(3.834)
1.504
(3.903)
2.549
(3.860)
Aggravated Assault -0.884**
(0.298)
-1.118***
(0.300)
-0.896**
(0.299)
-1.195***
(0.302)
N 640 640 640 640
Overall R-Squared 0.953 0.955 0.953 0.955
28
Table 8: Total Grams of Legally Distributed Opioid Fixed E�ects Results
Variables(1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Opioid Related Policies
NAX3239.3*
(1295.6)
2893.1**
(1342.2)
3209.9*
(1300.1)
3957.4**
(1519.1)
GSL-2292.4
(1294.3)
-2091.3
(1889.0)
PDMP-463.5
(1243.9)
-279.3
(1248.4)
NAX*GSL*PDMP-300.9
(2327.6)
Demographic Characteristics
White229.5
(125.2)
229.1
(124.6)
230.9
(125.4)
228.5
(125.6)
Black-648.7*
(316.7)
-627.1*
(315.6)
-652.4*
(317.3)
-630.3*
(317.0)
Male-248.8
(295.4)
-311.6
(296.3)
-244.0
(296.1)
-303.2
(300.1)
Married238.5
(249.2)
273.8
(249.0)
233.0
(250.1)
273.5
(252.0)
Single526.1*
(250.5)
521.3*
(249.5)
531.9*
(251.4)
524.2*
(251.1)
Unemployed386.1
(298.8)
404.7
(297.8)
370.1
(302.4)
94.6
(302.1)
Education Level
High School Degree161.1
(223.1)
168.8
(222.3)
143.5
(228.4)
155.9
(228.5)
Associate343.4
(361.8)
335.1
(360.4)
339.0
(362.6)
331.0
(362.1)
Bachelor's Degree-559.1
(299.6)
-587.4*
(298.8)
-562.4
(300.2)
-590.7*
(300.3)
N 333 333 333 333
Overall R-Squared 0.938 0.939 0.938 0.939
29
Table 9: Continued Total Grams of Legally Distributed Opioid Fixed E�ects Results
Variables (1)
NAX
(2)
GSL
(3)
PDMP
(4)
Full Model
Age Levels
15 to 19 -252.2
(360.0)
-229.5
(358.8)
-252.0
(360.6)
-230.8
(360.2)
20 to 24 -1304.3**
(450.5)
-1279.6**
(448.9)
-1308.2**
(451.3)
-1284.4**
(451.0)
25 to 29 268.2
(465.5)
357.5
(466.3)
263.1
(466.4)
351.8
(468.6)
30 to 34 -1096.4*
(491.5)
-1050.6*
(490.2)
-1077.5*
(494.9)
-1044.6*
(496.2)
35 to 39 -1091.9*
(484.4)
-1067.0*
(482.7)
-1097.9*
(485.5)
-1069.0*
(485.0)
40 to 44 -477.8
(408.3)
-443.1
(407.1)
-483.7
(409.3)
-450.8
(409.9)
45 to 49 -116.1
(435.7)
-98.46
(434.0)
-136.6
(439.9)
-114.3
(439.8)
50 to 54 -575.5
(405.2)
-544.9
(404.0)
-563.9
(407.1)
-541.4
(407.4)
55 to 59 -562.7
(407.8)
-537.0
(406.4)
-530.1
(417.7)
-516.9
(417.0)
60 to 64 849.1
(473.0)
875.2
(471.4)
860.6
(474.8)
877.9
(475.1)
Over 65 -595.4
(528.5)
-520.2
(528.1)
-583.0
(530.4)
-514.8
(531.0)
Other Covariates
Medicaid Recipient -88.13
(105.6)
-67.89
(105.8)
-86.55
(105.9)
-65.21
(107.3)
Medicare Recipient 233.8
(494.3)
178.9
(493.3)
230.2
(495.2)
176.2
(495.2)
Below Federal Poverty
Level
-356.9*
(173.6)
-377.6*
(173.3)
-358.8*
(174.0)
-378.8*
(174.0)
Aggravated Assault 39.88**
(13.73)
35.34*
(13.92)
38.55**
(14.21)
34.84*
(14.54)
N 333 333 333 333
Overall R-Squared 0.938 0.939 0.938 0.939
30