Nair H et al. Lancet 2010; E pub April 16
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M ostcom m on respiratory pathogen w orldw ide 50 -90% ofbronchiolitis 40% ofpneum onia 40 -60% ofallinfants infected in the firstyear 85 -100% infected by age 2 (0.5-2% hospital) R einfection is com m on 66,000-199,000 deaths globally in infants< 5 yr N o adequate treatm entexists Nair H et al. Lancet 2010; E pub April 16 RSV Epidemiology
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RSV Epidemiology. Nair H et al. Lancet 2010; E pub April 16. Viral segmentation for CAAP hospitalizations among children less then 5 years- Over 40 % of Hospitalizations were attributed to RSV. 1.9 % Mortality Rate 113/5,965. Dagan et.al –IMAJ March 2010. - PowerPoint PPT Presentation
Transcript of Nair H et al. Lancet 2010; E pub April 16
Most common respiratory pathogen worldwide
50 - 90% of bronchiolitis
40% of pneumonia
40 - 60% of all infants infected in the first year
85 - 100% infected by age 2 (0.5-2% hospital)
Reinfection is common
66,000-199,000 deaths globally in infants< 5 yr
No adequate treatment exists
Nair H et al. Lancet 2010; E pub April 16
RSV Epidemiology
RSV Hospitalizations Similar in All Premature Infants Irrespective of GA
* Infants of 36 weeks GA without other medical conditions.GA = gestational age.
Boyce TG et al. J Pediatr. 2000;137:865-870.
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Healthy term* <28 Wk 29-32 Wk 33-35 Wk
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• Retrospective study of enrollees in Tennessee Medicaid, Jul 1989-Jun 1993, 3 years old
• Chart shows hospitalizations among infants 6 months old
Zhong Gu
slides 6-8 might be better placed if inserted right before slide 12.
Viral segmentation for CAAP hospitalizations among children less then 5 years- Over 40 % of Hospitalizations were attributed to RSV
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RSV HMPV Adenovirus Rhinovirus Influenza A Parainfluenza
Dagan et.al –IMAJ March 2010
Dagan et.al –IMAJ March 2010
1.9 % Mortality 1.9 % Mortality Rate Rate
113/5,965113/5,965
1.9 % Mortality 1.9 % Mortality Rate Rate
113/5,965113/5,965
