Mycotoxins Phycotoxins
Transcript of Mycotoxins Phycotoxins
CURRICULUM VITAE
Name: Prof. Dr. Khayria Mahmoud Naguib.
Nationality: Egyptian.
Present position: Professor, of Food Toxins and Contaminants Department,
Food Toxins and Contaminants Department., National Research Center, Dokki,
Cairo, Egypt.
Scientific Environmental Achievement
o During the period from 1956 until 1976, I was working in the field of Food &
Dairy Microbiology where I had developed and was the leader of this branch
of research at the National Research Center (NRC). I was the head of the Food
& Dairy Microbiology unit from 1966 to 1976.
o The second period of my environmental research extended between 1976 –
2006. In 1976, I have introduced-and for-the first time in Egypt and the
Afro-Asian countries- a new area of research dealing with the
environmental toxicology mainly: "Mycotoxins". Ten years later, in
1986, I introduced the "Phycotoxins" research in Egypt and the Afro-
Asian countries as well.
o In 1986, I established the Mycotoxins and Food Safety Central Lab "MFSCL"
in NRC which considers the first lab in Egypt and the Afro-Asian countries
that deals with the food toxins and/or contaminants and is considered as well
as the reference lab for all the governmental and private sectors. This lab
extended the knowledge to the staff in Universities and Research Centers and
other concerned National and International Agencies in Egypt and Afro-Asian
countries through the National and/or International training courses and
workshops continuously held in Egypt covering the following areas:
Mycotoxins, Phycotoxoins and other food contaminants as Pesticides, Heavy
metals and amines. It was and still acts as an open university for specialized
concerned stuff in Egypt and the surrounding Afro-Asian countries. Moreover,
"MFSCL" acts as judging lab for different concerned agencies.
o I supervised 66 M.Sc. and Ph.D. Theses awarded during this period and
published 115 research papers in the aforementioned areas. With this
experience, I am an arbitrator in any disputes in food contaminants.
The following phases summarize my achievement in environmental research:
Phase I
o Research achievements during this period were devoted to monitor and
measure microbial contamination in Food & Dairy Products. I was the leader
of the groups who began the first scientific survey for the occurrence of
different health hazards including the pathogenic microorganisms in varies
Egyptian food products which include coliforms, aerobic and anaerobic
sporeformers coagulase-positive Staphylococci, Salmonella and Shigellae
microorganism. Furthermore, I investigated and strengthened my research
activities towards new food-borne pathogens (Campylobacter geguini, Enter
pathogenic Escherichia coli, Yersinia enterocolitica, Listeria monocytogenes).
This enabled the understanding of preventive actions to overcome such
environmental food hazard to the consumers. Due to the wide contamination
of Egyptian foods with pathogenic microorganisms, the research was extended
to determine the survival rates of such organisms in the products. In addition,
factors enhancing the rapid destruction of such microorganisms were
considered.
o Special attention was given to the studies of staphylococcal food poisoning.
The research in this area was developed in 1964 through the experience I got
during my post-doctor fellowship in Germany funded by the Alexander Von
Hamboldt Foundation, along with the aid of this organization in developing
my laboratory with the equipments needed for determining the staphylococcal
enterotoxins.
o In 1966, I successfully conducted a research program to industry to eliminate
microbial contamination in the production of safe food products. I solved the
environmental contaminant problems for different food products, which reflect
in both the public health and economic points of view. I was the first (may be
allover the world) who shed the light on the analyze hazards, identify
critical control points, establish preventive measures with critical limits
for each control point during this program. Such achievements are
recently known as "HACCP" concept (Hazard Analyses and Critical
Control Points) a system of food safety control.
Phases II
In this phase, I concentrated in 1976 my activity for the research on
"Mycotoxins" as a new area for the first time in Egypt and the Afro-Asian
countries, which have been started and developed in my laboratory through two joint
research projects with the Food and Drug Administration, Washington, funded by the
USAID (USA). The first project started in 1976 for three years, during which a highly
specialized laboratory for mycotoxins analysis was developed, equipped, and as well
provided with highly trained personal. This aided the First National wide sampling
plan intensive survey of aflatoxin residues in Egyptian foods and feeds, through
the project entitled “Aflatoxin residues in Egyptian foods and feeds derived from
plants and animal sources” by the end of this project three reports were presented. The
second project started in 1981 for three years too and dealt with organizing and
directing two International Symposiums & Workshops on MYCOTOXINS in
1981 and 1983.
Through these two International Conferences and Workshops, 307 & 420 participants
representing 38 & 44 countries respectively attended, I was able to promote a better
understanding for mycotoxin problems existing in Afro-Asian countries, educate
and lay the basis as well for developing and establishing effective mycotoxin
control programs with these countries through training and personal scientific
visits. Intensive training programs were conducted in 1981 & 1983 and
representative participants were trained on the determination of mycotoxins in
foods. Several specialized professors from USA, Canada, Europe and Japan presented
the plenary basic lectures which included: The general aspects of food safety, history
and awareness of mycotoxins, limits and regulations, conditions leading to
contamination, prevention and control, metabolism and transmission, screening
procedures, decontamination of mycotoxins in food and feeds, Societies Sponsoring
Mycotoxins and FAO mycotoxins Programs. Other methodology professionals from
different countries demonstrated the workshops and trained the participants on the
important aspects: Sampling techniques, preparation of standards, aflatoxins B1
methodology techniques (TLC, CB, BF). Aflatoxin M1, HPLC, densitomertic and
confirmatory techniques and the immunological methods. Laboratory analysis of food
samples by the workshop attendees applying the given techniques and methods.
It is worthy to report that mycotoxins had serious adverse effects on human
health. Its main toxic effects are carcinogenicity, genotoxicity, tetragencity,
hepatotoxicity, nephrotoxicity and immunosuppression. In this concern, we should
point to FAO estimation in 2003 which, reported that world losses of food crops due
to mycotoxins are in the range of 1000 million tons per year (25 % of the total world
crops) at a time when the production of agriculture commodities is barely sustaining
the increase production. A part from the economic problem due to losses in crops
yield and cases of markets by non-tariff barriers due to mycotoxins on human health
and animal wealth ought not to be neglected.
Being unavoidable environmental toxins- as INTERNATIONALLY
recognized- pose a unique challenge to the environment. Thus the emphases on safe
detoxification protocols are urgently needed. Accordingly, I strengthened my
scientific activities towards such vital topics. In 1992, I developed a practical unit for
safe and efficient detoxification of aflatoxins-contaminated corn through the National
Agriculture Research Project (NARP) funded by the USAID. Through these projects I
altered to eliminate the Ammoniation, High-pressure, High Temperature
procedure (HPHT) −which was already applied in some states of the USA and some
European countries− due to its serious adverse effects which was biologically
evaluated and proved. In the same concept, in 2000, I introduced the application of
some local adsorbent materials and plant extracts, which successfully acted as free
radical scavengers and antioxidants, providing protective effects against
mycotoxicosis. I submitted 2 patents in this area. Moreover, some American
pharmaceutical company developed certain products based on our previous
research in this area.
Phase III
In 1986, I introduced the field of PHYCOTOXINS for the first time in
Egypt and the Afro-Asian countries. Research on PHYCOTOXOINS and other
food contaminants "pesticides, heavy metals and biogenic amines" started 1986
through a joint research project “Sea Food Toxins” with the Food and Drug
Administration, Washington, and the New Jersey Marine Science Consortium, USA
and funded by USAID "under the umbrella of the Middle East Program on the
Red Sea". The objective of this project was to assess the magnitude of contamination
in fish, water and sediment with pesticides, heavy metals and biogenic amines in
some fishing area in Egypt. Ciguatera-toxin and PSP toxins produced by algae
grown on fish and shellfish harvesting areas were also studied for the first time
in Egypt and the Middle East. Three reports were presented. The project
achievements were presented during an International Conference entitled
"International Symposium and Workshop on Food Contamination: Mycotoxins and
Phycotoxins". This was held in Cairo 4-15 Nov. 1990. This International Symposium
covered the main basic topics regarding the phycotoxins, mycotoxins, pesticides and
heavy metals as the industrial chemical contaminants. These topics include:
See food toxins in Review, Recent methods for detecting Sea food toxins,
Immunological studies using Monoclonal antibodies for detection of Low Delta
Marine toxins, Structure, Chemical & Physical properties of Marine Dinoflagellate
Toxins associated with Diarrheic and Paralytic Shellfish Poisoning (DSP & PSP).
Chemistry and Toxicology of Fresh Cyanobacteria (Blue-green algae)- Seafood
Toxins arising from spoilage due to improper storage and handling, Industrial
chemical contaminants in foods, Overview of agriculture chemicals and rural health,
International Regulatory Program of Pesticide Residues. Assessment of human
exposure to chemical contaminants in foods. Dietary intake, levels in food and
estimated intake of cadmium, lead and mercury, Advances in pesticide residues
analyses, Sampling and sample quantization of natural toxicants in foods & feeds.
International coordination and validation of analytical methods. Key elements of food
safety monitoring programs.
Mycotoxins in review, Perspectives on mycotoxin decontamination procedures,
Recent advances in analytical methods for mycotoxins, New mycotoxins of public
health significance, Rational for regulatory program for mycotoxins in human foods
and animal feed, Epidemiological studies related to mycotoxins.
Panel Discussions:
International Regulations and food safety monitoring program; Phycotoxoins,
Mycotoxins, Heavy metals and Pesticides.
Decontamination of mycotoxins management of groundnut aflatoxins problems in
developing countries.
Four hundred participants representing 30 countries attended and were trained on:
Phycotoxins: Marine algae field and Fresh water sampling techniques; collection,
preparation, purification, identification, toxicity testing, and immunological methods.
Mycotoxins: sampling, preparation, determination (HPLC, ELISA reader and TLC
techniques) and the immunological methods for aflatoxins and other mycotoxins.
Toxicity testing: Avian, Mouse and Brine Shrimp acute toxicity, Avian Embryo
toxicity and mutagenicity. Laboratory quality assurance.
It is of interest to report that in this Conference, a new discovery of carcinogenic
mycotoxins (FUMONISIN B1 from corn) was announced for the first time in the
world.
During 1993, in an extension to my activity and in cooperation with the
Faculty of Medicine-Ain Shams University (Prof. W. Anwar) and the International
Agency for Research on Cancer (IARC)- France (Prof. C. Wild), I conducted an
International Conferences entitled" First PAN African Environmental Mutagen
Society Meeting: Mycotoxins as mutagens and carcinogens, Jan. 23-26, 1993 Cairo,
Egypt. In this conference, more than 150 participants represented 16 countries
attended and the new trends in this area were presented. Moreover, this Conference
was followed by two International Workshops. Participates were trained on the
"Determination of a new biomarker (AFB1-Albumin adduct) for the early
detection of mycotoxin exposure". The second workshop dealt with
"Determination of mytogenic activity of mycotoxins using cell lines". Both
workshops introduced and transfer -for the first time- the knowledge regarding
the Environmental carcinogens and mutagens in Egypt and surrounding Afro-
Asian Countries.
Phase IV
Research on hyper-saline cyanobacterial activities in the Solar Lake, Sinai,
which started 1995 - 2000, through two joint research projects between Egyptian and
German Ministries for Scientific Research (NRC and Max Blank Institute)on Red Sea
program through two projects entitled: Microbial activities in marine interfaces
controlling sediment-water and particle-water fluxes. Neurotoxins derived from
marine organisms: identification and pharmacological characterization.
Based on the experience given in the fore-mentioned phases along with
the well-established laboratories and team of researchers, I arbitrate the disputes
in food contaminants. Such disputes mainly arised between governmental
laboratories and importers. Likewise, I aid exporters through applying food standards for
exports and imports and provide them with certificates, which indicate the safety of their
products.
It is worthy to report that, I contributed to the strengthening of scientific ties between
scientists in the Middle East and extending the peace concept among nations living in the
area
Scientific Environmental Activities
I. Establishments of Essential Environmental Labs.
1. The Food & Dairy Microbiology Unit (1966), National Research Center, Cairo.
2. In 1986 the first Central Laboratory on Mycotoxins and Food Safety
"MFSCL" in Egypt and the Afro-Asian countries with the collaboration of the
Food and Drug Administration (FDA), USA. The laboratory was established with
the help of the financial support of the USAID, equipped with all the needed
equipments and provided by efficient and well-trained trainees. This Lab. extends
the experience and scientific services for the researchers in different Universities,
Research Centers and the different concerned agencies in Egypt and the Afro-
Asian Countries through the holding of training workshops in the area of
environmental contaminants. It is considered as an Open University to extend this
knowledge and has well trained stuff who gives the experience to the concerned
governmental and private sectors. One of the major roles of the "MFSCL" Lab is
it
acts as the unique judging lab in different problems concerning food
contaminants
and food safety.
3. The Food Technology Pilot Plant with the financial support of USAID to solve
quality control, and food industry problems.
II. Principal investigator of the following projects:
1- Aflatoxin Residues in Egyptian Foods and Feeds Derived from Plants and
Animal Sources (1976-1981). PL 480 Research Project agreement No. 33-627-
F (Egypt & USA).
2- Sea Food Toxin (1986-1992) through the Cooperative Marine Technology
Program for the Middle East USAID Grant NEB. 1058-9-SS-5192-00 (Egypt
& USA).
3- Studies on Occurrence of Recently Known Pathogenic Bacteria
(Campylobacter geguini, Enteropathogenic Escherichia coli, Yersinia
enterocolitica, Listeria monocytogenes) in the Egyptian Foods and Factors
Inhibiting their Growth in
some Foods. Academy of Scientific Research and Technology, Egypt (1990-1993).
4- National Agriculture Research Project (NARP) “Decontamination of
Mycotoxins in Agriculture Commodities”, USAID, Project No. 66-D-2-7
(1992-1994) (Egypt & USA).
5- Microbial activities in marine interfaces controlling sediment-water and
particle-water fluxes (Egypt & Germany). Red Sea program 1995 till 2002.
6- Neurotoxins derived from marine organisms: identification and
pharmacological (Egypt & Germany) (Co-principle). Red Sea program 1995
till 2002.
7- Food safety proposed program for imported and exported foods to control
different contaminants project supplied by National Research Center(2008-
2010 ).
8- Cigarette eastern company project. Supplied by Cigarette eastern company, Egypt , 11-2008
till now.
III. International Conferences & Workshops:
Directed and head of the following International Conferences and Workshops on
Mycotoxins and Phycotoxins in Egypt:
1- International Symposium and Workshop on Mycotoxins, Cairo, Egypt, 1981*.
2- International Mycotoxin Conference, Egypt, 1983 (Follow up workshop on
Mycotoxins)*.
3- International Symposium and Workshop on Food Contaminants (Mycotoxins
and Phycotoxins), Egypt, 1990*, **
.
4- First PAN African Environmental mutagen society meeting: Mycotoxins as
Mutagens and Carcinogens, Jan. 23-26 1993, Cairo, Egypt.
IV. National Workshops:
Directing two local workshops held annually at the National Research Center Cairo,
Egypt:
1- Determination of Aflatoxins, Fumonisins, Ochratoxins and Biogenic amines in
Foods, Feeds, Tissues and Biological fluids using HPLC and ELISA
techniques.
2- Determination of Pesticides and Heavy metals in Foods, Feeds, Tissues and
Biological fluids by using Gas Chromatography and Atomic Absorption.
Participants represent the quality Control and Food Safety Agencies in Egypt
and the Surrounding Afro-Asian Countries.
V. Memberships of Scientific Associations: 1. Egyptian Association of Applied Microbiology
2. Egyptian Food Science Association
3. Egyptian Chemical Association
4. Egyptian Society of Natural Toxins
5. Egyptian Society of Toxicology
6. Egyptian Dairy Science Association
7. The Association of Official Analytical Chemists (AOAC)
* Prof. A. E. Pohland: Food & Drug Administration (FDA), Washingoton, USA.
** Prof. Robert B. Abel: Director of International Programs, Stevens Institute of Tehnology, Hoboken, USA.
VI. Other Environmental Achievements:
1. Awarded the “Alexander Von Humboldt” Fellowship in 1964-1966
(Germany).
2. Selected in 1983-1988 as vice chairman of the Scientific Committee of the
Association of Analytical Chemistry (AOAC), Washington DC., USA.
3. Selected in 1986 as a member of the Food Chemistry Committee
(Mycotoxins) International Union of Pure and Applied Chemistry (IUPAC),
USA.
4. Selected in 1987 as a chairman of Nutrition and Toxin Committee of the
International Congress of Nutrition in Seoul, Korea, The International Union
of Nutritional Sciences (IUNS).
5. Later on, I awarded the National State Esteem Prize for my achievements
in Environment and Advanced Technological Sciences (2005).
6. Represented Egypt in several International Conferences all over the world as
well as National Conferences.
Thesis supervised by Prof. Khayria Naguib:
A. Food Microbiology:
1- Microbiological and Chemical Studies on Domiati Cheese. M.Sc., Ain-Shams
University. Food Sci., Dept. (1965). (Mohamed Naguib).
2- Microbiological Studies on Pasteurized Market Milk. M.Sc., Ain-Shams
University. Food Sci., Dept. (1965). (Soheir El-Nockrashy).
3- Microbiological studies on Dye-Reduction and Keeping Quality Tests of Raw
Milk. M.Sc., Ain-Shams University. Food Sci., Dept. (1966). (Mohamed
Sabbour).
4- Factors Affecting the Microbiological Quality of Domiati Cheese. Ph.D., Ain-
Shams University. Food Sci., Dept. (1968). (Mohamed Naguib).
5- Microbiological and Chemical Studies on the Local Dried Milk of Sakka
Milk., M.Sc., Ain-Shams University Microbiology Dept. (1968), (Salem
Abdel-Ghani).
6- Studies on Some Pathogenic Bacteria in Milk and Some Dairy Products.
Ph.D., Ain-Shams University Microbiology Dept. (1973). (Mohamed
Sabbour).
7- Studies on the Microbiological and Keeping Quality of the Local Powdered
Milk. Ph.D., Ain-Shams University. Microbiology Dept. (1976). (Salem
Abd El-Ghani).
8- Effect of Some Preservatives on Some Milk Organisms. M.Sc., Ain-Shams
University. Microbiology Dept., (1977). (Nabil Fouad Tawfeek).
9- Microbiological and Chemical Quality of Local Market Rennet. M.Sc., El-
Azhar University. Food Sci., Dept. (1979). (Moustafa El- Shinawy).
10- Studies on Potentially Pathogenic Staphylococci Isolated From Dairy
Products. M.Sc., Ain-Shams University, Microbiology Dep., (1979). (Osama
Sharaf).
11- Selection of Starter Bacterial for Ras Cheese Production. M.Sc., Cairo
University, Microbiology Dept. (1980). (Elham Moustafa).
12- Preservation of Bacterial Starter Culturs for Dairy Industry. M.Sc., Cairo
University Food, Sci., Dept. (1980). (Kawther El-Shafei).
13- Microbiological Studies on Dried Milk and Effect of Storage. M.Sc., Cairo
University. Food Sci. Dept. (1980). (Ikram Mohamed)
14- Bacteriological Studies on Improvement of the Quality of Soft Cheese Made
from Dried Milk. M.Sc., Cairo University. Food Sci., Dept. (1980). (Zainab
Ibrahim).
15- Continuous Production of Bacterial Starter Culture for Dairy Industry. M.Sc.,
Cairo University. Food Sci., Dept. (1980). (Fatma Fathey)
16- Technical Comparison Between Soybean and Other Legumes. M.Sc., Zagazig
University. Food Sci. Dept. (1980). (Galal Mohamed)
17- Study on Conjugation of Gossibole with Proteins. M.Sc., El-Azhar University
(1981). (Ibrahim Foad).
18- Microbiological Studies on Certain Grains. M.Sc., Cairo University.
Microbiology Dept. (1981). (Badiaa Riad).
19- Studies on Strawberry. M.Sc., Suez Canal University (1982). (Sohair El-
Sayed)
20- Studies on the Use of Starters in the Manufacture of Cheese from Soybean
Milk. Ph.D., Ain-Shams University (1983). (Narges Hassan)
21- Effect of Preheating on Some Properties of Zabady Made from Buffelow’s
Milk. M.S., El-Azhar University (1983). (Effat Soliem)
22- Production of Fungal Protein Using Food Industry Wastes. M.Sc., Moshtohor
University (1983). (Hussein Azzaz).
23- Effect of Microbial Fermentation on Pesticide Residues in Milk. M.Sc., Ain-
Shams University (1983). (Assem Anwar)
24- Studies on the Processing of Some Legumes. Ph.D., Ain-Shams University
(1984). (Galal Mohamed)
25- Studies of the potential Hazard of Staphylococci in Egyptian Hard Cheese.
Ph.D., Ain-Shams University (1984). (Nabil Fouad Tawfeek)
26- Further Studies of Selection Starter of Ras Cheese. Ph.D., Cairo University
(1984). (Elham Moustafa).
27- Clean Milk Production. M.Sc., Ain-Shams University (1984). (Baher Abd El-
Khalil).
28- Studies on Producing Long Life Yoghurt. M.Sc., Cairo University (1984).
(Abou Baker Salim).
29- Studies on Soybean Protein and Used it in Some Dairy Products. M.Sc., Ain-
Shams University (1984). (Mousa Maaly Eid).
30- Studies on Some Microbiological Parameters on sousages. M.Sc., Ain-Shams
University (1984). (Ezzat Baumie).
31- Studies on Staphylococci and its Enterotoxin Isolated from Some Dairy
Products. Ph.D., Ain-Shams University (1985). (Osama Sharaf).
32- Utilization of By-Products of Sugar-Beet Industry in Production of Fungal
Protein and Enzymes. Ph.D., Zagazig University (1986). (Hussein Azzaz).
B. Mycotoxins :
33- Studies on Roquefort Cheese and Occurrence of Mycotoxins. M.Sc., El-Azhar
University (1979). (Ibrahim Hosny).
34- Effect of Processing on Aflatoxin M1 Content in Milk and Dairy Products.
M.Sc., Cairo University (1980). (El-Sayed Abd-Alla).
35- Studies on Aflatoxin in Milk and Dairy Products. M.Sc., El-Azhar University
(1981). (Ali Mahrous).
36- Effect of Aflatoxins on Some Hormonal Levels in Blood Plasma of
Mammals.M.Sc., Ain-Shams University (1982). (Kawther Mohamed).
37- Metabolism of Aflatoxin B1 in sheep. M.Sc., Ain-Shams University (1982).
(Mona Abd-El-Galil).
38- Effect of Aflatoxin on Some Physiological Aspects. M.Sc., Ain-Shams
University (1983). (Mosaad Attia Abdel-Wahhab).
39- Studies on Some Mycotoxins in Food. M.Sc., Cairo University (1983).
(Mohamed Nasr El-Dein).
40- Studies on the Metabolism of Aflatoxin B1. In Ruminants. M.Sc., Ain-Shams
University (1983). (Shaaban Abd-El-Fatah).
41- Farther Studies on Disease Problems Resulting from Mycotoxins in Poultry
with Special Reference to control and Prevention. Ph.D., Cairo University
(1983). (Anwaar Mitwally).
42- Studies on Some Mycotoxins in Some Vegetables During Processing. M.Sc.,
Cairo University (1984). (Mahmoud Abo-Donia).
43- Effect of Processing on Mycotoxins in Legumes. M.Sc., Cairo University
(1984). (Hassan Ahmed Amra).
44- Studies on Mycotoxins in Fruits. M.Sc., Cairo University. Food Microbiology
(1984). (Ali Shalaby)
45- Studies on Vomitoxin. Ph.D., Cairo. University. Food Micobiology (1984).
(El-Sayed Abd-Alla)
46- Studies on PR Toxin. Ph.D., El-Azhar University. Food Micobiology (1984).
(Ibrahim Hosny).
47- Influence of Mycotoxin Production Affecting Factors on F-2, F-2 and
Ochratoxin Contamination of Grains. Ph.D. Azhar University, Food Sci.
Dept. (1983). (Ali Badawey).
48- Studies on Tremorgens. Ph.D., Cairo University (1987). (Hassan Amra).
49- Studies on Stregmatocystin in Some Grains. M.Sc., Cairo University. Food.
Sci., Dept (1987). (Emman Hegazi).
50- The Biological and Chemical Evaluation of Aflatoxin contaminated Rations
After Chemical Treatments. Ph.D., Ain-Shams University. Animal Prod.
Dept. (1988). (Mona Abd El-Gallil).
51- Some Physiological Aspects of Aflatoxin Treated Sheep. Ph.D., Ain-Shams
University. Animal Prod. Dept. (1988). (Kawther Mohamed).
52- Studies on Stregmatocystin in Dairy Products. M.Sc., Cairo University. Food
Sci., Dept (1988). (Yehia Hassan).
53- The Role of Afatoxins as a Potential Hazard in Different Diseases in Egypt..
M.Sc. Degree in Microbiology and Immunology -Faculty of Medicine - Ain
Shams Univ., Microbiology & Immunology Department (1998). (Sherine
Fawzi Hefez).
54- Effect of Aflatoxin B1 Treatment on Pregnancy, New born and Milk
Production in Mammals. Ph.D., Ain-Shams University. Animal Prod. Dept.
(Scientific Channel between Egypt & USA) (1989). (Mosaad Abdel-
Wahhab).
55- Decontamination of some mycotoxins in local and Imported dried fruits.
Ph.D. Cairo Univ. Food Sci. Dept. (2000). (Emman Megazy).
56- Studies on the Mycology and Mycotoxins of Peanut and Peanut products.
Suez Canal Univ. Faculty of Science, Microbiology. (Scientific Channel
between Egypt & USA) (2002). (Amal Mohamed Moustafa).
57- The Effect on Processing On Ochratoxin A Level in Green Coffee Beans. M.
Sc. Cairo Univ. Biochemistry Dept. (2002). (Nehad EzzEl-Din Amamed
Mohamed).
58- Studies on fumonisin B1 in corn and corn based products. Ph.D. Faculty of
Agriculture, Cairo University. Food Sci. Dept., (2003). (Heba, T. Mehasseb).
59- Studies on Sterigmatocystin in Some Foods Based on Wheat. M.Sc., Ain-
Shams University, Faculty of Agriculture, Food Science Dept.(2004). (Tarek
Ahmed El- Desoki).
60- EL-Desoky T.A.; Abdallah M.A.; Abdou H.M., Abdel-Galil M.M. and Naguib K.M.
(2006).Screening methods for the detection of sterigmatocystin in wheat. J. Union Arab
Biol. Cairo. 15; 107-122.
61- Study on use of Sorghum maize free from mycotoxins in food industry. Al-
Azhr University, Faculty of Agriculture, Food Science Dept. (2008). (Sherief
Ramzy Mohamed).
C. Marine and Fresh water Toxins and Other Chemical Contaminants:
62- Correlation Between Freshness Indices and Degree of Fish Decomposition.
Ph.D., Ain Shams University. Food Sci. Dept. (1986). (Ali R. Shalaby).
63- Specified Deviced Techniques for Detecting Fish Contaminates. Ph.D., Ain
Shams University. Food Sci. Dept. (1986). (Mahmoud Abou Donia).
64- Studies on the Production and Quality Control of Fish Meal. M.Sc. Suez
Canal University Food Sci. Dept (1988). (Ahmed M. Ayesh).
65- Identification and Detection of Some Pesticide Residues and Heavy Metals in
Fish, Water, Sediment Collected From River Nile (El-Malek El-Saleh) and
Qaroun Lake. M.Sc., Cairo University Food Sci. Dept (1990). (Heba, T.
Mehasseb)
66- Fish meal Production, Biological Evaluations and Elimination of its Toxic
Amines. Ph.D., Cairo University. Food Sci. Dept (1992). (Ahmed M. Ayesh).
67- Studies on Algal Toxins in Fish, Shell Fish and Water. M.Sc., Cairo
University. Food Sci. Dept (1992). (Emad M. Ali).
68- Distribution Pattern of Freshwater Algae and their toxins in Raw and
Municipal water in Port-Said Province. Ph.D., Suez Canal Univ. Botany Dept.
(2002). (Abeer Shaker Amin).
PUBLICATIONS:
A. Food Microbiology:
1. Khayria Naguib and Ahmed, Z. F. (1962). Guar flour utilization as a stabilizer in
ice- cream making and its effect on some physical and microbiological
properties of the products. Egypt Pharm. Bull. 44 (4).
2. Khayria Naguib and Janoschek, A. (1965). The resistance of propionic acid
bacteria to Sodium chloride. Deutche Molkerei – Zeitung, 86-20.
3. Khayria Naguib (1966). Microbiological quality of pasteurized milk in Cairo. First
Egyptian Microbiological Congress Cairo, Egypt.
4. Khayria Naguib (1966). Improvement of microbiological properties of pasteurized
milk and a simultaneous study of the line of the production in central factory.
First Egyptian Microbiological Congress, Cairo.
Results of No. 3 & No. 4, were Successfully Applied in Misr Food and Dairy
Company and the Microbiological Problem Facing them in Production of
Pasteurized Milk was Completely Dissolve.
5. Kahyria Naguib and Abd El-Ghani, S. (1972). Spray dried milk of the Sakha
plant. I. Quality control studies. J. Milk and Food Tech. 35, 1, 35-38.
6. Khayria Naguib and Abd El-Ghani, S. (1972). Spray dried milk of the Sakha plant
II. Identification of predominating microorganisms. J. Milk and Food Tech. 35,
1, 45- 48.
7. Khayria Naguib and Negm, A. (1972). Microbiological and chemical studies on
zabady. Milchwissenchaft 27 (9), 572- 573.
8. Khayria Naguib and Negm, A. (1972). Acetaldehyde and diacetyl production in
zabady and zabady cultures. Milchwissenschaft 27 (12), 756-758.
9. Khayria Naguib and Hussein, L. (1972). The Effect of hydrogen peroxide
treatments on the bacteriological quality and nutritive value of milk.
Milchwissenschaft 27 (12), 758-762.
10. Khayria Naguib (1972). Sorbic acid and potassium sorbate as fungicide for
Gouda cheese during ripening and storage. Milchwissenschaft 27 (11), 702-
704.
11. Khayria Naguib (1972). Hydrogen peroxide treatment of milk for Domiati
cheese. the Aust. J. of Dairy Techn. 27 (2), 56-60.
12. Khayria Naguib and Sabbour, M. M. (1972). The Viability of Salmonella
typhimurium in Ice-Cream. Zbt. Bakt. Abt. 11, Bd. 128, 5, 93-96, 1972.
13. Khayria Naguib and Sabbour, M. M. (1972). The Viability of Salmonella
typhimurium in Zabady. J. Microbiol. 112, 97-101.
14. Khayria Naguib and Shouman, T. (1972). Identification and typing of clostridia
in raw milk in Egypt. J. Appl. Bacteriol. 35, 525-530.
15. Khayria Naguib and Shouman, T. (1973). Occurrence of Clostridia in White
Pickled Cheese. Zbt. Bakt. Abt. 11, Bd. 128, S. 84-87.
16. Khayria Naguib (1973). Evaluation of Bacto-Strip Techniques for the Detection
of Coliforms in Pasteurized Milk. Zbt. Bakt. Abt. 11, Bd. 128, S. 88-92.
17. Naguib, M. M.; Khayria Naguib and El-Sadek, G. M. (1973). The Survival of
Coagulase-Positive Staphylococci and Coliforms in Domiati Cheese.
Mikrobiologi. Ja, 10 (2), 243-248.
18. Khayria Naguib and Naguib, M. M. (1974). Factors affecting the quality of
Domiati cheese. I. Effect of heat treatment. Egypt. J. Diary Sci. 2, 55-73.
19. Khayria Naguib and Naguib, M. M. (1974). Factors affecting the quality of
Domiati cheese. II. The selection of single strain starters and determination of
their rates of addition for cheese manufacture. Egypt. J. Dairy Sci. 2, 161-167.
20. Naguib, M.M.; El-Shibiny and Khayria Naguib (1975). Microbioogical and
chemical quality of Egyptian market rennet. Egypt. J. Dairy Sci. 3, 153-160.
21. Naguib, M.M.; El-Nockrashy, S.; Sabbour, M.M. and Khayria Naguib. (1978).
Occurrence of coagulase-positive Staphylococci in Egyptian raw milk and dairy
products. 1. Ras, Karish and Domiati cheeses. Res. Bull. 878, Ain-Shams Univ.,
Fac. of Agric.
22. EL-Nockrashy, Soheir, Sabbour, M.M. and Khayria Naguib (1978). Occurrence
of coagulase-positive Staphylococci in Egyptian raw milk and dairy products. 2.
Ice Cream and Zabady. Res. Bull. 945, Ain- Shams Univ., Fac. of Agric.
23. Sabbour, M. M., Naguib, M. M., El-Nockrashy, S. and Khayria Naguib (1979).
Occurrence of coagulase-positive Staphylococci in Egyptian raw milk and dairy
products. 3. Counts and types of Staphylococci prevailed in raw milk. Egypt. J.
Food Sci. 7 (1), 1-5.
24. Khayria Naguib, Naguib M. M., Sabbour, M. M. and El-Nockrashy, S. (1979).
Occurrence of coagulase-positive staphylococci in Egyptian raw milk and dairy
products. 4. Identification of cultures isolated from Sllo and Mannitol Salt Agar
Media.Research Bulletin, No. 983, Ain-Shams Univ., Fac. of Agric.
25. Khayria Naguib; Sabbour, M. M., Mahmoud, S. A. Z., Hazem, A. and Sharaf, O.
M. (1979). A survey of the incidence of coagulase-positive staphylococci in
pasteurized milk and imported dried milk in Egypt. Identification of the isolated
cultures. Res. Bull. 1183, Ain-Shams Univ., Fac. of Agric.
26. Mahmoud, S. A. Z., Khayria Naguib, Sabbour, M. M., Hazem, A. and Sharaf,
O.M. (1979). Occurrence of coagulase- positive staphylococci in Egyptian sour
and butter milk. Identification and classification of the isolates. Res. Bull. 1184,
Ain-Shams Univ., Fac. of Agric.
27. Mahmoud, S. A. Z., Khayria Naguib, Sabbour, M. M. Hazem, A. and Sharaf, O.
M. (1979). Incidences of Staphylococci in Egyptian raw milk. Res. Bull. 1185,
Ain-Shams Univ., Faculty of Agric.
28. Mahmoud, S. A. Z., Sabbour, M. M., Naguib, M. M., Khayria Naguib, Hazem,
A. and Sharaf, O. M. (1980). Production of coagulase, hemolysins and
thermonuclease by staphylococci and Micrococci from milk and dairy products.
Arch. Fur Lebensmittelhygiene 31 (1), 5-6.
29. Mahmoud S.Z., Khayria Naguib, El-Nockrashy, S. and Tawfeek, N. (1984). Use
of hydrogen peroxide as dairy preservative. Egypt. J. Dairy Sci. 12 (2), 163-172.
30. Khayria Naguib, Mahmoud, S. A. Z., El-Nockrashy, S. and Tawfeek, N. (1985).
Use of Nisin as Dairy Preservative. Egypt. J.Dairy Sci. 13 (2), 167-176.
31. Mahmoud S.Z., Khayria Naguib, El-Nockrashy, S. and Tawfeek, N. (1985). Use
of potassium nitrite as a dairy prservative. Egypt. J. Dairy Sci. 13 (2), 167-176.
32. Khayria Naguib, S.Z. Mahmoud, S. Z., El-Nockrashy, S. and Tawfeek., N
(1985). Effect of Formaline on Some Desirable and Non-Desirable
Microorganisms. Egypt. J. Dairy Sci. 13, 159-166.
33. Mahmoud, S. Z., Naguib, M. M., El-Nockrashy, S., Rifaat, A. A., Tawfeek, N.
and Khayria Naguib (1985). Survey of Staphylococcus aureus in market
Egyptian Ras cheese and the presence of Enterotoxins type A and B. Egypt. J.
Food Sci. 13, 15-19.
34. Khayria Naguib, M. El-Sawy, Rawia F. Gamal and O.M. Sharaf. (1986).
Incidence of Staphylococcus aureus and their enterotoxins (A or B) in some
Egyptian soft dairy products. Annals Agric. Sci., Fac. Agric., Ain-Shams Univ.
31 (1), 41-46.
35. El-Sawy, M.; Gamal R. F., Khayria Naguib ; Sharaf, O. M. (1986).Viability of
Staphylococcus aureus and presence of TN-ase and enterotoxins in Egyptian
Zabady during manufacturing and storage at different temperatures. Annals
Agric. Sci., Fac. Agric., Ain-Shams Univ. 31 (1), 53- 67
36. Gamal, R. F., El-Sawy, M., Naguib, Kh. and Sharaf, O. M. (1986).Survival of
enertoxigenic Staphylococcus aureus type A in Egyptian butter Egypt. J.
Microbiol. Special Issue, 37-46.
37. Naguib,M. M., Mahmoud, S. Z., Sabbour; M. M., Rifat, A. A, Tawfeek, N. and
Khayria Naguib (1987).Growth and Enterotoxin Production of Enterotoxigenic
Staphylococcus aureus in Ras Cheese During Ripening. Egypt. J. Food Sci. 15
(2), 133-139.
2. Mycotoxins:
38. Naguib, N.M.; Khayria Naguib, Pohland, A.E. and Cambell. (1978). Aflatoxin
residues in Egyptian foods. 1. Rice, corn and peanut. 12th Int. congr.
Microbiology, Munchen, No. H.4, P 167.
39. Mahrous, A.B., Nguib, M.M., Khayria Naguib, Pohland, A.E. and Cambell.
(1978). Aflatoxin residues in Egyptian foods. 2. Milk and dairy products. 12th
Int. Congress. Microbiology, Munchen, No. H.5, P 168.
40. Naguib, M.M., Khayria Naguib and El-Khadem, M. (1979).Aflatoxin residues in
Egyptian foods. 3. Lentils and broad beans. Second Arab Conference for Food
Science and Technology, Riyad, P. 83.
41. Naguib, M. M., El-Arian, A. F., El-Tawab, G., Khayria Naguib and Mahrous, A.
B. (1979)..Aflatoxin residues in Egyptian foods. 4. The comparative annual
occurrence in raw and pasteurized milk. Egypt. Society of Appl. Microbiol..
Annual Meeting, 27, 311-16.
42. Khayria Naguib, Naguib, M.M., Pohland, A.E. and Campbell, A.D. (1979).
Aflatoxin in Egyptian foods. 5. Dried fruits; figs, dates and raisin. 4th
International IUPAC Symposium on Mycotoxins and Phycotoxins, Lausane,
No. 316.
43. Naguib, M.M., Khayria Naguib, Pholand, A.E. and Campbell, A.D. (1979).
Aflatoxins in Egyptian foods. 6. Beans, Peas and Cowpeas. 4th International
IUPAC Symposium on Mycotoxins and Phycotoxins, Lausane, No. 317.
44. El-Khadem, M., Naguib M.M., Khayria Naguib, Ahmed, N.M. and Pholand,
A.E. (1979). Effect of storage temperature and relative humidity on Egyptian
peanut Mycoflora. 4th International IUPAC Symposium on Mycotoxins and
Phycotoxins, Lausane, No. 210.
45. Naguib, M.M., Khayria Naguib, El-Khadem, M. and Pholand, A.E. (1979).
Effect of storage temperature and relative humidity on aflatoxin development in
Egyptian peanut. 4th International IUPAC Symposium on Mycotoxins and
Phycotoxins, Lausane, No. 210.
46. El-Khadem, M., Khayria Naguib and Naguib, M.M. (1983). Aflatoxins in
foodstuff in Egypt. II. Broad beans mycoflora and toxicity. Proceeding of the
International Symposium on Mycotoxins.
47. Naguib, M.M. and Khayria Naguib. (1983). Metabolism of aflatoxin B1 in
buffaloes. Proceeding of the International Symposium on Mycotoxins, Cairo,
Egypt.
48. Khayria Naguib, Naguib, M.M., Nour, M.A., El-Khadem and Hosny, I.M.
(1983). Studies on mycotoxins in local Roquefort cheese. Proceeding of the
International Symposium on Mycotoxins, Cairo, Egypt.
49. Matter, M. M., Khayria Naguib and Naguib, M. M. (1983). Biological effect of
aspergillus flavus on Iribolium castanum. Proceeding of the International
Symposium on Mycotoxins, Cairo, Egypt.
50. Abd El-Salam, M. M., El-Shibiny, S., Naguib, M.M., Khayria Naguib and
Mohamed, A.A. (1983).Effect of injested and intraruminal ingested aflatoxin B1
on the chemical composition of buffalo milk. Proceeding of the International
Symposium on Mycotoxins, Cairo, Egypt.
51. Khayria Naguib, Naguib, M.M., Sahab, A.F. and Diab M.M. (1983). Studies on
fungi associated with onion bulbs. I-Screening During Harvest, Transportion
and Storage. International Symposium on Mycotoxins, Cairo, Egypt.
52. Khayria Naguib, Naguib, M.M., Sahab, A.F., Diab, M.M. and Abd-Alla A. El-
Sayed. (1983). Studies on fungi associated with onion bulbs. II-Pre-Sumptive
Screening for Mycotoxins. International Symposium on Mycotoxins, Cairo,
Egypt.
53. Khayria Naguib, Naguib, M. M., El-Kersh, T. and Abdallah, E. (1983). Studies
on fungi associated with onion bulbs. III-Toxicity and Mutagenicity of the
Isolates Using the Bioassay Methods. International Symposium on Mycotoxins,
Cairo, Egypt.
54. Naguib, M. M., Khayria Naguib, Alyan, A., El-Shemy, N. and Amra, H. (1983).
Fate of aflatoxin B1 residues during processing and storage of beans (Phaseolus
vulgaris) and cow-peas (Vigna sinensis). International Mycotoxin Symposium
on Mycotoxins, Cairo, Egypt.
55. Khayria Naguib, Naguib, M. M., El-Khadem, E., Alyan, A. and Ibrahim, M. N.
(1983). Effect of processing on the stability of aflatoxin B1 on broad beans.
International Symposium on Mycotoxins, Cairo, Egypt.
56. Khayria Naguib, El-Lethy, A., Naguib, M. M., El-Khadem, M. and Riad, B.
(1983). Mycological studies on corn and wheat. International Symposium on
Mycotoxins, Cairo, Egypt.
57. Metwally, M. M., Naguib, M.M., Khayria Naguib, Abdel Nabi, A. and
Abdallah, E. (1983). A Comparison Between Aflatoxin M1 Extraction Methods
for Milk and Dairy Products. International Symposium on Mycotoxins, Cairo,
Egypt.
58. Metwally, M. M., Khayria Naguib, Naguib, M. M., Abdel Nabi, A. and Abd-
Alla, E. (1983). Effect of Milk Heat Treatment (Drying, Pasteurization and
Boiling) on Aflatoxin M1 Content. International Symposium on Mycotoxins,
Cairo, Egypt.
59. Metwally, M. M., Khayria Naguib, Naguib, M. M., Abdel Nabi, A. and
Abdallah, E. (1983). The effect of making ras cheese and krish cheese on the
aflatoxin M1 content of milk. International Symposium on Mycotoxins, Cairo,
Egypt.
60. Khayria Naguib, Naguib, M. M., Alian, A., El-Shimy, N. and Shalaby, A. R.
(1983). Fate of aflatoxin B1 in orange juice during process and storage. J. Egypt.
Soc. Toxicol. 2,110-121.
61. Naguib, M. M., Khayria Naguib, Alian, A., Sahab, A. F., El-Shimy, N. and
Shalaby, A. R. (1985). Fungal flora associated with orange citrus spoilage fruits
with Special References to Aflatoxin Production. J. Egypt. Soc. Toxicol. 2, 98-
109.
62. Naguib, M. M., Khayria Naguib, Sahab, A. F., El-Shwah, E.T., Sallam, Y.I. and
Abou Donia, M. A. (1985). Fungal flora associated with tomato fruits spilage
and their Potential Production of Mycotoxins. J. Egypt. Soc. Toxicol. 12, 11-15.
63. Khayria Naguib, Naguib, M. M. Diab, A. M., Sahab, A. F. and Amra, H. (1988).
Occurrence of aflatoxins in several groundnut cultivars infected with strains of
Aspergillus flavus. Proceeding International Workshop on aflatoxin
contamination of groundnut. ICRISAT Centre, Hyderabad, India.
64. Khayria Naguib, Metwally, M. and Abdallah, E. (1988). Toxicity of
Deoxynivalenol Using Bioassay Techniques. 7th International IUPAC
Symposium on Mycotoxins and Phycotoxins. Tokyo, Japan.
65. Khayria Naguib, Metwally, M. and Abdallah, E. (1988) A Survey on the
occurrence of deoxynivalenol in wheat and corn. 7th International IUPAC
Symposium on Mycotoxins and Phycotoxins. Tokyo, Japan.
66. Metwally, M., Khayria Naguib and Abdallah., E. (1988). Fate of deoxynivalenol
(DON) during processing of bread and macaroni from contaminated flour. 7th
International IUPAC Symposium on Mycotoxins and Phycotoxins. Tokyo,
Japan.
67. Sahab, A.E.; M. Metwally, Khayria Naguib and El-Sayed Abd-Alla. (1988).
Fungal flora associated with wheat cultivars with special references to
vomitoxin production. 7th International IUPAC Symposium on Mycotoxins
and Phycotoxins. Tokyo, Japan.
68. Khayria Naguib, A.E. Sahab, M. Metwally and El-Sayed Abd-Alla. (1988).
Fungal Flora Associated with Corn Cultivars with Special References to
Vomitoxin Production. 7th International IUPAC Symposium on Mycotoxins
and Phycotoxins. Tokyo, Japan.
69. Metwally, M., Khayria Naguib and Abdallah, E. (1988). Deoxynivalenol in
Milk: Thin layer chromatography method and nontransmission to milk. 7th
International IUPAC Symposium on Mycotoxins and Phycotoxins. Tokyo,
Japan.
70. Sahab, A.E.; M. Metwally, Kh. Naguib and El-Sayed Abd-Alla (1989). Isolation
and identification of associated fungi with wheat grains with special references
to vomitoxin roduction. Fungal flora associated with wheat cultivars with
special references to vomitoxin production. Afr. J. Agric. Sci.16 (1+2), 53-66.
71. Abd El-Wahhab, M. A. and Khayria Naguib. (1990). Aflatoxicosis in Rabbits 1.
Histopathological study in liver of rabbits treated with aflatoxin B1. The
International Symposium on Mycotoxins and Phycotoxins 56. p82. Cairo,
Egypt.
72. Amin, S.O.; W.E. Abdelaal, M.A. El-Fouly, M.A. Abdel-Wahhab and Khayria
Naguib. (1991). Aflatoxicosis in rabbits II. Histopathological and histochemical
study of mammary gland during pregnancy and lactation as affected by
aflatoxin B1 administration. Egypt. J. Anim. Prod. 28 (2), 179-189.
73. Abdallah, E., Badawey, A., Faheid, S. M. M. and Khayria Naguib (1992). Effect
of chemical leavening agent on aflatoxin B1 content during cookies preparation.
Bull. Nutr. Inst. 12, (1), 111-121.
74. Abd-Alla, E., Badawey, A., Narges, H. M. and Khayria Naguib
(1992).Correlation of zinc and phytic acid content with aflatoxins production on
soybean. Bull. Nut. Inst. 12, 111-121.
75. Shalaby, A. R., Badawey, A. and Khayria Naguib. (1993). Rapid micro-method
for the extraction and determination of aflatoxin in animal and human liver
tissues. Bull. Nut. Inst. 13, 45-55. غير موجود اصلا ع النت
76. Gommaa, M. N., Ayesh, A. M., Soliman, K. M. and Khayria Naguib. (1994).
Assessment of toxicity of aflatoxins products detoxified by high pressure
ammoniation. The Afr. J. Mycol. Biotechnol. 2 (3), 228- 236.
77. Mayura K., Abdel-Wahhab, M. A., Sarr, A. B., McKenzie, K. S., Edwards, J. F.
Khayria Naguib, Amin, S. O., Phillips, T. D. (1995). Selective chemisorbents
of aflatoxin B1 by HSCAS: Prevention of developmental toxicity in the rats.
34th Annual Meeting, Baltimore, MD USA; The Toxicologist 15 (1).
78. Gommaa, M. N. E., Ayesh, A.M., Abdel-Galil, M. M. and Khayria Naguib.
(1997). Effect of High pressure ammoniation procedure on the detoxification of
aflatoxins. J. Mycot. Res.13, 23-34.
79. Amra, H. A., Miller, M., Sahab, A. F. and Khayria Naguib. (1997). Fusarin and
Fumonisin Production by Fusarium moniliforme isolated form stored Egyptian
Corn. J. Vet. Pharmacol. Therap. 20 (1), 272-273.
80. Soliman, K. M., Ayesh, A. M., Manal, A. M. and Khyria Naguib (1998). Fix-A-
Tox in Agriculture: I. Effect of Aflatoxin decontamination by a selective
chemosorbent material on the Oreochromis Niloticus with considered fish
processing efficiency. J. Egypt. Ger. Soc. Zool. 25, 1-19.
81. Mayura, K., Abdel-Wahhab, M. A. McKenzie, K. S., Sarr, A. B., Edwards, J. F., Naguib,
K. and Phillips, T. D. (1998). Prevention of Maternal and Developmental Toxicity in
Rats via Dietary inclusion of Common Aflatoxin Sorbents: Potential for Hidden Risks.
Toxicol. Sci. 41, 175-182.
82. Ayesh, A. M., Gommaa, M. N .E. and Khayria Naguib. (2000). Aflatoxins percent
recovery of CB and immunoaffinity column procedure in black and green tea. J. Egypt.
Soc. Toxicol. 22, 35-40.
83. Khayria Naguib (2000). Mycotoxins: problems and future strategies. Egyptox-Workshop
on Environmental Chemistry and Toxicology. In Collaboration Ministry of State for
Scientific Research. National research Center, Dokki, Cairo, Egypt with UNESCO.
pp.15- 24.
84. Abdel-Wahhab, M. A., Amer, H. A., Hassan, N. S., Hassan, A. M. and Khayria
Naguib.(2002). Effects of garlic and cabbage extracts on fumonisin-induced toxicity in
rats. J. Egypt. Soc. Toxicol. 26, 1- 12.
85. Abdel-Wahhab, M. A., Hassan, A. M., Amer, H.A and Khayria Naguib. (2002).
Antioxidant effects of garlic and cabbage on fumonisin-induced developmental toxicity
and sphingolipids metabolism in rats. J. Egyt. Soc. Toxicol. 26, 23-29.
86. Khayria Naguib and Abdel-Wahhab, M. A. (2002). Antioxidant properties of certain
natural products against mycotoxocosis. (Special edition) Herbal Medicine P. 24-26.
87. Abdel-Wahhab M. A., Hassan A. M., Amer H. A. and Khayria Naguib. (2004).
Prevention of Fumonisin-induced maternal developmental toxicity in rats by certain
plant extracts. J. Appl. Toxicol. 19(6), 469- 474.
88. Nehad, E. A., Farag, M. M., Kawther, M. S., Abdel-Samed, A. K. and Khayria Naguib
(2005). Stability of OTA during processing and decaffination in commercial roasted
beans. J. Food Add. Cont. 22 (8), 761 -767.
89. Tarek A. El-Desoky, Abdallah, M. A., Abdou, H. M., Abdel-Galil, M., and Naguib, Kh.
M. (2006). Screening methods for the detection of Sterigmatocystin in Wheat. J. Union
Arab Biol. Cairo, Vol (15B): 107-122.
89. Nehad, E. A., Farag, M. M., Kawther, M. S., Abdel-Samed, A. K. and Khayria Naguib
(2007).An exposure and intake assessment of ochratoxin A from imported coffee beans
in Egypt. World journal of Agricultural Sciences 3 (3) : 285-294.
90. Ahmed A. El-Kady, Hafiza A. Sharaf, Mahmoud A. Abou-Donia, Samir Abbès, Jalila
Ben Salah-Abbès, Khayria Naguib, Ridha Oueslati and Mosaad A. Abdel-Wahhab
(2009).
Adsorption of Cd2+ ions on an Egyptian montmorillonite and toxicological effects in rats.
Applied Clay Science, Volume 44, Issues 1-2, April 2009, Pages 59-66
III. Marine Toxins and Other Chemical Contaminants:
90. Khayria Naguib, Ayesh A., Abdel-Baki, M. M. and El-Zayet, F. (1988).
Biogenic Amines and Bacterial Counts during Fish Meal Processing. The 102nd
AOAC Annual International Meeting, Florida, USA.
91. El-Zayet, F., Abdel-Baki, M. M., Khayria Naguib and Ayesh, A. (1988). Simple
Method for the Determination of Biogenic Amines in Fish Meal. The 102nd
AOAC Annual International Meeting, Florida. USA.
92. Abdel-Baki, M. M., El-Zayet, F., Khayria Naguib and Ayesh A. (1989). Quality
Assessment of Fish Meal Used in Egypt. The 14th International Congress of
Nutrition, Seoul-Korea.
93. Abdalla M. A., Hassan I. M., Shalaby A. R. and Khayria Naguib. (1990).
Physicochemical and Bacteriological Changes Occuring During Storage of
Sardine Fish. The 14th International Congress of Nutrition, Seoul-Korea.
94. Abdalla M. A., Hassan I. M., Shalaby A. R. and Khayria Naguib.
(1990).Correlation between biogenic amines, chemical changes and stability of
sea bream fish during storage at –80 o
C. The 14th International Congress of
Nutrition, Seoul-Korea.
95. Hassan I. M., Abdallah M. A., Shalaby A. R. and Khayria Naguib (1990).
Relation between salting and chemical changes of mullet and sardine fish with
emphasis on biogenic amines. International Symposium and Workshop on Food
Contaminants: Mycotoxins and Phycotoxins, Cairo, Egypt.
96. Hassan I. M., Abdallah M. A., Shalaby A. R., and Khayria Naguib. (1990).
Physicochemical and Bacteriological Changes Associated with Degradation of
Mullet and Sea Bream Fish. International Symposium and Workshop on Food
Contaminants: Mycotoxins and Phycotoxins, Cairo, Egypt.
97. Hassan I. M., Abadllah M. A., Shalaby A. R. and Khayria Naguib. (1990).
Biogenic amines as indicator of fish freshness. International Symposium and
Workshop on Food Contaminants: Mycotoxins and Phycotoxins, Cairo, Egypt.
98. Hassan I. M., Abdallah M. A., Shalaby A. R. and Khayria Naguib. (1990). Fate
of biogenic amines and other chemical indices during canning process of
sardine fish. International Symposium and Workshop on Food Contaminants,
Mycotoxins and Phycotoxins, Cairo, Egypt.
99. Khayria Naguib, Naguib M. M., Amra, H. A. and Abdallah, E. M. (1990).
Survey of ciguatoxin like- compounds in different Egyptian fish. International
Symposium and Workshop on Food Contaminants: Mycotoxin and
Phycotoxins, Cairo, Egypt.
100. Khayria Naguib, Naguib M. M. and Amra H. A. (1990). Application of stick
enzyme immunoassay (S-EIA) in Ciguatoxin like-compounds in Egyptian fish.
International Symposium and Workshop on Food Contaminants: Mycotoxin and
Phycotoxins, Cairo, Egypt.
101. Morsi. K. M., Afify, S., Khayria Naguib, Badei A. Z. M. and Ayesh A. M.
(1992). Effect of dietary fish meal and biogenic amines on chicks. Egypt. J.
Comp. Pathol. Clin. Pathol. 5(2), 12-16.
102. Khayria Naguib, Ayesh, A. M. and Shalaby A. R. (1995). Studies on the
determination of biogenic amines in foods 1.Development of a TLC method for
the determination of eight biogenic amines in fish. J. Agric. Food. Chem., 43,
134-139.
103. Gomaa, M. N. E., Abou Arab, A. A. K., Badawy, A. and Khayria Naguib.
(1995). Distribution pattern of some heavy metals in Egyptian fish organs. J.
Food Chem. 35, 385-389.
104. Abou Arab, A. A. K., Gomaa, M. N. E., Badawy, A. and Khayria Naguib.
(1995). Distribution of organochlorine pesticides in the Egyptian aquatic
ecosystem. J. Food Chem. 54, 141-146.
105. Amra H. A., Ayesh A. M., Abou-Arab A. A. K. and Khayria Naguib. (1995).
Survey of Ciguatoxin-like Substances in imported scomberomorous and
sardinalla species from Egyptian markets. J. Egypt. Ger. Soc. Zool. 17 (A), 69-
77.
106. Ayesh A. M., Amra H. A., Abu-Arab A. A. K. and Khayria Naguib (1995).
Detection and determination of eight biogenic amines in frozen mackerel
(Scomberomorous Sp.) and sardine (Sardinella Sp.) using HPLC. J. Egypt. Ger.
Soc. Zool. 17 (A), 121-135.
107. Gamaa, M. N. E., Khayria Naguib, Hassan, M., Aly, E. M. (1995). Shellfish
poisoning in Egyptian marine environment. J. Union Arab Biol. 3 (A), 197-211.
108. Abou-Arab A. A. K., Ayesh A. M., Amra H. A. and Khayria Naguib. (1996)
Characteristic levels of some pesticides and heavy metals in imported fish, J.
Food Chem. 57 (4), 487-492.
109. Soliman, K. M., Abou-Arab, A. A. K., Badawy, A. and Khayria Naguib.
(1998). Heavy metal contamination levels in Egyptian vegetables and fruits and
removal by washing procedure. Bull. Nut. Inst. 17 (2), 120-144.
110. Abou-Arab, A. A. K., Soliman, K.M., Amra, H.A. and Khayria Naguib. (1998).
Pesticide residue contents in Egyptian vegetables and fruits and removal by
washing. Bull. Nut. Inst. 18 (2), 117-138.
111. Abou-Arab, A. A. K., Soliman, K. M., El-Tantawy, M. E., Badeae, R. Ismail
and Khayria Naguib. (1999). Quantity estimation of some contaminants in
commonly used medicinal plants in the Egyptian market
112. Gomaa, M. N., Rawi, S. and Khayria Naguib (1999). Toxicological studies of
cyanobacterial toxin of Oscillatoria limnetica isolated from the solar lake in
Sinai. J. Egypt. Soc. Toxicol. 21, 15-21.
113. Aly, M. S., Naguib, M. M., Khayria Naguib (2000). Relationship between
algosphere and free water bacteria in Solar Lake (Sinai). Egypt. J. Phycol. 1,
195-201.
114. Gomaa, M. N., Abo–Elenein, N. M., Khayria Naguib, Sayed, R. (2000).
Neurotoxicity of sea anemone Gyrostoma Hellanthus from the Red Sea. J.
Egypt. Soc. Toxicol. 22, 75-81.
115. El-Kady. A.A., Sharaf, A.A., Aboudonia M. A., Naguib, Kh., and Abdel-
Wahhab, M.A. (2008). Egyptian montmorillonite adsorbs Cd+2
and almonirates
its toxicity in rats. Accepted in Applied Clay Science.
116. El-Kady. A.A., Sharaf, A.A., Aboudonia M. A., Naguib, Kh and Abdel-
Wahhab, M.A. (2009). Egyptian montmorillonite adsorbs Cd+2 and almonirates
its toxicity in rats. Applied Clay Science. 44(1-2), 59-66.
117. M.A. Abdel-Wahhab, M.I.M. Ibrahim, T.A. Abo-Elhawa, K.M. Naguib.
(2011). Modification and validation for the procedure of immunoaffinity
column and HPLC method for the determination of aflatoxin B1 in tobacco.
S292 Abstracts / Toxicology Letters 205S (2011) S180–S300.
118. K.M. Naguib, N.S. Hassan, A. A. El-Nekeety, M.I.Ibrahim, S.R. Mohamed,
M.A. Abdel-Wahhab.(2011). Safety use of ozone gas in the degradation of
aflatoxin in tobacco and prevention its toxicity in rats. Abstracts / Toxicology
Letters 205S (2011) S60-S179.
119. Mosaad A. Abdel-Wahhab1, Khaled Gamil, Ahmed A. El-Kady, Aziza A. El-
Nekeety, and Khayria M. Naguib.(2011). Therapeutic Effects of Korean Red
Ginseng Extract in Egyptian Patients with Chronic Liver Diseases. J. Ginseng
Res. 35,(1), 69-79.
120. El-Desouky, T.A.; Sharoba, AMA.; A I El-Desouky, El-Mansy HA and Khayria
Naguib. (2012). Effect of Ozone Gas on Degradation of Aflatoxin B1 and
Aspergillus Flavus Fungal. Environment Analytic Toxicol. Volume 2, Issue 2,
1-6.
121. El-Desouky, T.A.; Sharoba, AMA.; A I El-Desouky, El-Mansy HA and Khayria
Naguib. (2012). Evaluation of ozone gas as an anti-aflatoxin B1 in wheat grains
during storage. Journal of Agroalimentary Processes and Technologies 2012, 18
(1), 13-19.
122. El-Desouky, T.A ; May, M. Amer and Khayria Naguib. (2012).Effects of pan bread
making on zearalenone levels in artificial contaminated wheat flour. In press in
Journal Hungarian journal of industry and veszprém. 40(2):107-111.
123. El-Desouky, T.A. and Khayria Naguib. (2013). occurrence of zearalenone
contamination in some cereals in Egypt. Journal of Agroalimentary Processes and
Technologies, 19 (4), 445-450.
124. El-Desouky, T.A.; Sharoba, AMA.; A I El-Desouky, El-Mansy HA and Khayria
Naguib. (2013). Effect of ozonation of wheat grain on quality bread factory. Journal
of Agroalimentary Processes and Technologies, 19 (1), 1-9.
125. El-Desouky T.A, May, M. Amer and Khayria Naguib. (2013). Effect of fenugreek
seeds extracts on growth of aflatoxigenic fungus and aflatoxin B1 production. Journal
of Applied Sciences Research, 9(7): 4418-4425.
126. Sherif S. Mohamed, El-Desouky.T.A, Sherif R. Mohamed., Khayria M.
Naguib, Mustafa Helmy. (2015). Antioxidants compounds from rice straw extracts
and their effect on Diazinon insecticide hazard. Middle East Journal of Applied
Sciences, 5(3), 687-694.
127. El-Desouky.T.A, Sherif R. Mohamed., Sherif S. Mohamed and Khayria M.
Naguib (2015). Protective effect of aqueous extract pomegranate peel against
sterigmatocystin toxicity in rat. Journal of Drug Delivery & Therapeutics. 5(5):9-18.
128. Sherif R.M, El-Desouky, TA.,Ahmed M.S.H, Sherif S.M ,Naguib K.H.
(2016). Modified Rice Straw as Adsorbent Material to Remove Aflatoxin B1 from
Aqueous Media and as A fiber Source in Fino Bread. journal of toxicology. Volume
2016, Article ID 6869582.
129. Osman MA, Salama A, Naguib KHM, Sherif SR (2017) Fungi and
Mycotoxins Associated with Egyptian Sorghum Grains. MOJ Toxicol 3(3): 00052.
DOI: 10.15406/mojt.2017.03.00052.
130. Goda, A.A., Naguib, K.M., Mohamed, M.M., ...Gissendanner, C.R., El Sayed,
K.A. (2016). Astaxanthin and docosahexaenoic acid reverse the toxicity of the maxi-
K (BK) channel antagonist mycotoxin penitrem A. Marine Drugs, 2016, 14(11), 208.
131. Deabes, M.M., Khalil, W.K.B., Attallah, A.G., El-Desouky, T.A., Naguib, K.M.
(2018).Impact of silver nanoparticles on gene expression in Aspergillus flavus
producer aflatoxin B1. Open Access Macedonian Journal of Medical
Sciences, 2018, 6(4), pp. 600–605.
132. Deabes, M.M., Allayeh, A.K., Seif, M.M., Rasmey, A.-H.M., Naguib, K.M.
(2020). Antiviral, antifungal, and antibacterial potential activities of Ephedra Sinica in
Vitro. Jordan J. of Biological ciences, 13(3), pp. 313-320.
133. Deabes, M.M., Aboulthana, W.M., Ahmed, K.A., Naguib, K.M.
(2021). Assessment of the ameliorative effect of Bacillus subtilis against the toxicity
induced by aflatoxin B1 in rats. Egyptian Journal of Chemistry, 64(4), pp. 2141–2164.
134. Deabes, M.M., El-Fatah, S.I.A., Salem, S.H., Naguib, K.M. (2021).
Antimicrobial activity of bioactive compounds extract from Saussurea costus against
food spoilage microorganisms. Egyptian Journal of Chemistry, 2021, 64(6), pp. 2833–
2843.
Patent:
Patent Entitled modified rice straw to remove AFB1 from aquies media 2017.