Slide 1

My ERC Experience: Past, Present and Future Royal Irish Academy - Excellent Research: Ireland and the ERC Dr. David Hoey Dept. Mechanical, Aeronautical, and Biomedical Engineering Centre for Applied Biomedical Engineering Research (CABER), Materials and Surface Science Institute (MSSI). University of Limerick Excellent Science: Ireland and the ERC, Dublin 17/11/14 1

Slide 2

My Application European Research Council (ERC) Starting Grant 2013: Primary Cilium-Mediated Mesenchymal Stem Cell Mechanobiology in Bone 2 MSCs Osteoblasts Osteocytes Evaluation Panel Physical Sciences and Engineering PE8: Products and Processes Engineering Excellent Science: Ireland and the ERC, Dublin 17/11/14

Slide 3

The Past Why did I apply to the ERC? Intimidating New PI Competitiveness (IE) Financial 1.5 Million over 5 years SFI Support Programme Excellent for young researchers (new PIs) The suitability Broad scope Basic science (blue sky) Prestige Research excellence 3 Excellent Science: Ireland and the ERC, Dublin 17/11/14

Slide 4

The Present Credibility Institutional Internationally Facilities Laboratory Research Team Teaching Research More focus Ambitious / High risk 4 Excellent Science: Ireland and the ERC, Dublin 17/11/14

Slide 5

The Present 5 MSCs Osteoblasts Osteocytes Animal Cell Culture Single Cell PPrimary Cilium Biomaterials Excellent Science: Ireland and the ERC, Dublin 17/11/14 Multi-scale analysis of cilia-mediated bone formation Development of innovative techniques Hoey, D.A., Tormey, S., et al; Stem Cells. 2012

Slide 6

The Present 6 MSCs Osteoblasts Osteocytes Animal Cell Culture Single Cell PPrimary Cilium Biomaterials Excellent Science: Ireland and the ERC, Dublin 17/11/14 Multi-scale analysis of cilia-mediated bone formation Development of innovative techniques

Slide 7

The Present 7 MSCs Osteoblasts Osteocytes Animal Cell Culture Single Cell PPrimary Cilium Biomaterials Excellent Science: Ireland and the ERC, Dublin 17/11/14 Multi-scale analysis of cilia-mediated bone formation Development of innovative techniques Collaborators Prof. Chris Jacobs (Columbia, US) Prof. Peter Wang (Stanford, US) Prof. Kristen Verhey (Michigan. US) Prof. Masamichi Ohkura (Saitama University, Japan)

Slide 8

The Present 8 MSCs Osteoblasts Osteocytes Animal Cell Culture Single Cell PPrimary Cilium Biomaterials Excellent Science: Ireland and the ERC, Dublin 17/11/14 Multi-scale analysis of cilia-mediated bone formation Development of innovative techniques

Slide 9

The Future Create foundations for my career Develop my niche area Obtain research independence Grant applications Domino effect on other grants International Collaborators Preliminary data Excellent science Research awards High impact publications 9 Excellent Science: Ireland and the ERC, Dublin 17/11/14

Slide 10

Thank You Acknowledgements: Research Team Dr. Marie-Noelle Labour Niall Kelly Robert Thomas Brady Elena Stavenschi Michele Corrigan Kian Eichholz Gillian Johnson Anushree Dwivedi Siobhan Coyle Supported by: European Research Council Starting Grant (No. 336882) Science Foundation Ireland (No. SFI/13/ERC/L2864) IRCSET-Marie Curie International Mobility Fellowship in Science, Engineering and Technology Acknowledgements: Collaborators Prof. Christopher Jacobs Prof. Soren Christensen Prof. Fergal OBrien Prof. Daniel Kelly Dr. Julia Chen Dr. Kristen Lee 10 Excellent Science: Ireland and the ERC, Dublin 17/11/14