Multimodal recordings and signal processing in epilepsy · MC-PH, Info F Bartolomei, PU-PH A...
Transcript of Multimodal recordings and signal processing in epilepsy · MC-PH, Info F Bartolomei, PU-PH A...
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Institut de Neurosciences des Systèmes
Christian-G. Bénar
Institut de Neuroscience des Systèmes, Marseille
Multimodal recordings and signal processing in epilepsy
Séminaire GIPSA LAB, 23 Mars 2017
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Institut de Neurosciences des Systèmes
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The « Institut de Neurosciences des Systèmes »
Theoretical Neuroscience Group V Jirsa
Patho-Physiology of Networks C Bernard
Dynamics Cognitive processes D Schon
Dynamical Brain Mapping C Bénar
Clinical Neurophysiology F Bartolomei
Dir. V Jirsa, co-dir. P Chauvel
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Institut de Neurosciences des Systèmes
The Marseille MEG Platform
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http://meg.univ-amu.fr
- Within the clinical neurophysiology department
- 4D system (248 magnetometers)
- Open platform (neuroscience)
- Day hospital (2 patients a week)
JM Badier Eng AMU
S Chen Eng Inserm
B Colombet Tech AMU
- Member of France Life Imaging
- Part of 2 « Federation hospitalo universitaire » (Epinext, Dhune)
- Part of Labex BLRI, convergence project ILCB; collaboration CREx; Fédération sciences du cerveau et de la cognition; collaborations INT, LNC, LPC;
MEG sensors
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Institut de Neurosciences des Systèmes
Dynamap/MEG team
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Dynamap
JM Badier CG Bénar S Chen B Colombet
B Giusiano, MC-PH, Info
F Bartolomei, PU-PH
A McGonigal, PH
R Carron, MC-PH
S Medina, Eng, PhD
N Roehri, Eng, PhD
F Pizzo, MD, PhD
S Lagarde, MD, PhD
J Régis, PU-PH
I Lambert, MD, PhD
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Institut de Neurosciences des Systèmes
Context: presurgical evaluation of epilepsy
• 0.5 to 1% of population has epilepsy
• ~30% are pharmacoresistant
→ can be considered for surgery
• Aim of presurgical evaluation is to delineate the tissues to be resected in order to stop seizures
SEEG
EEG
Phase 1: non-invasive
Phase 2: invasive
Surgery
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Institut de Neurosciences des Systèmes
Theme: Multimodal brain mapping
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MEG fMRI
Intracerebral EEG
Axis 1: Links between non-invasive modalities
Axis 2: Compare non invasive/ invasive
EEG
Cognition
Epilepsy
Surgery
Dynamap
Use of simultaneous recordings: EEG-MEG, EEG-fMRI, MEG-SEEG
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Neurovascular coupling
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Spike sorting
Parametric GLM => higher correlation with putative interneurons Cpnsistent with coupling with high gamma activity ( Logothetis et al 2001)
PC INT
Multimodal recordings in a animal model of epilepsy; Collab. with P Quilichini, A Ivanov, A Ghestem, C Bernard (Physionet), I Vanzetta (INT); F Wendling, S Blanchard LTSI, O David J Warnking GIN, H Benali Multimodel ANR project
Saillet et al J Neurophysiol 2016
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MEG epileptic discharge
Anywave software meg.univ-amu.fr 8
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Comparison MEG/EEG
SEEG
EEG MEG
Gavaret et al Brain Topogr 2014 MEG reveals bilateral sources confirmed by SEEG 9
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SEEG shows complex networks at seizure onset
Bartolomei et al 2001
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Example of SEEG network dynamics
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Schwartz et al Epilepsy Res 2011
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The epileptogenicity index
EI is higher for -Smaller time of involvement in seizure
-Higher ratio of energy high freq/low freq
Bartolomei et al 2008 12
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Overview
1. High frequency oscillations on SEEG
2. Interictal/preictal networks in SEEG and MEG
3. Simultaneous MEG/SEEG recordings
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1. SEEG HIGH FREQUENCY ACTIVITIES
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Rationale
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Urrestarazu et al Brain 2007 Bénar et al Clin Neurophysiol 2010 See also Jmail et al 2011, 2016
-High frequency activity are a marker of epilepsy - hard to visualize + filtering can produce ringing (« false ripples ») - time frequency representation need to balance energy across frequencies
Projet ANR TechSan ‘FORCE’ (PI P. Kahane), collaboration GIN, LTSI Rennes (F Wendling), CRN Lyon (JP Lachaux), Micromed company
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The « 1/f » issue: the zHO method
17 Roehri et al IEEE TBME 2016
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Time-frequency detectors
18 Roehri et al IEEE TBME 2016; see also Jmail et al 2017
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-30 patients studied (2930 contacts: 100.5 [89-109] per patient) -5 min NREM slow wave sleep -quantify Seizure Onset Zone with Epileptogenicity index (EI) -quantify interictal period with spike, HFO and HFO co-occuring with spikes rates -partial ROC analysis to determine which markers better predicts the EZ
Application to patients
Roehri et al. in prep 19
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2. INTERICTAL/PREICTAL NETWORKS
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A) PREICTAL NETWORKS IN SEEG
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Institut de Neurosciences des Systèmes
Preictal SEEG
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Courtens et al Brain Connect 2016
h2 Pijn et al 1989, Wendling et al 2001
Beginning of seizure = period of decrease of connectivity, Wendling et al 2003 → what about the preictal phase ?
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Networks across frequency bands
23 Courtens et al Brain connect 2016
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B) INTERICTAL NETWORKS IN MEG
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MEG ICA networks
Malinowska et al Hum Brain Mapp 2014 25
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Co-occurrence testing
Cf Bourien et al 2005 for co-occurrence in SEEG 26
• significant direction (pairs of spikes)
• spike co-occurrences (significance with non-parametric technique)
Malinowska et al Hum Brain Mapp 2014
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Source localisation on components
ICA1
ICA7
ICA6
ICA1
ICA6
ICA7
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L
MEG
SEEG
Malinowska et al, Hum Brain Mapp 2014
MEG ICA networks
-> very good concordance between MEG and SEEG leaders 28
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L
MEG
SEEG
L
MEG ICA networks
Malinowska et al, Hum Brain Mapp 2014
-> only part of network can be retrieved 29
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Limitations of separate recordings
• Separate MEEG/SEEG recordings may not
record the exact same activity (fluctuations
across brain states)
• Separate recordings do not allow using single
trial fluctuations as source of information
(as in simultaneous EEG-fMRI)
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=> The next step is to record them simultaneously !
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3. SIMULTANEOUS RECORDINGS
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EEG-MEG-SEG: feasibility
Dubarry et al, NIMG 2014
23 EEG; 72 SEEG; 248 MEG Sampling rate 2035 Hz
32 Limitation in number of SEEG channels
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Evoked activity
Dubarry et al, NIMG 2014 33
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Source localization (Brainstorm)
Dubarry et al, NIMG 2014
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Single trial analysis
Dubarry et al, NIMG 2014
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Noise issues
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Observation of both high and low frequency noise
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Improving the system
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Fixation of cables + MR-compatible 256 channels amplifier
Badier et al under review
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Example: Sensitivity
Bénar et al GRETSI 2015, Badier et al under review 38
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Visibility of deep mesial structures? (1)
39 PhD work of Francesca Pizzo
H
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A3-A4
B5-B6
Higher coherence with contacts in amygdala
Comp. 3
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Visibility of deep mesial structures? (2)
Francesca Pizzo
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Large scale network
Francesca Pizzo
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Local correlation
Francesca Pizzo
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Application (2): Validation of signal processing
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Dynamap2
MEG-ICA
SEEG
S Medina, N Roehri, AS Dubarry, M Woodman
beamformer surface
depth
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Application (3): Clinical Interest
Gavaret et al Epilepsy Res 2016
SEEG-triggered spike average permit to localise a region outside of SEEG implantation 44
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Translation to clinical research: the AnyWave software
B Colombet JM Badier M Woodman S Medina N Roehri
GARDEL: SEEG semi-automatic labelling
High frequency oscillations
http://meg.univ-amu.fr/AnyWave/download.html
Dynamap1
Epileptogenicity index
Independent component analysis
VIBRATIONS ANR Project
3D Viewer
Colombet et al J Neurosci Meth 2015
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Multiplatform, modular
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Acknowledgements
Postdocs, students N Jmail AS Dubarry M Woodman U Malinowska S Courtens J Wirsich N Roehri S Medina F Pizzo
Engineers JM Badier S Chen B Colombet P Marquis Neuroscientists FX Alario C Liegeois Chauvel
Neurologists F Bartolomei P Chauvel M Gavaret A Trébuchon da Fonseca Neurosurgeons J Régis R Carron
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PhD position in MEG signal processing for foreign student!!!
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