Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October...
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Transcript of Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October...
![Page 1: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/1.jpg)
Multi-dimensional Dynamic Visualization of Clinical DataJianmei Wang
Roche Products Limited
October 9 2015
![Page 2: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/2.jpg)
January 23 1930
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January 29 1930
![Page 4: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/4.jpg)
January 23 1930
![Page 5: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/5.jpg)
January 29 1930
![Page 6: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/6.jpg)
Background
Software tool: Not open source. Uses Adobe Flash. Online tool Google Motion Chart offers limited functionality
“Joy of Stats”
by Hans Rosling
![Page 7: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/7.jpg)
Opportunity
Roche Data Visualization Tool: A new software tool to create animated graphics to visualize time series data from clinical trial
Now Future
• Long tables of summary data over time
• Long listings of individual patient data over time
• Line plots or 1 variable at a time
• Large dataset embedded in animated graphics
• Many questions can be answered in the visualization without a new outputs
![Page 8: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/8.jpg)
Example 1. Neutrophil depression in a paediatric studyBackground: Drug cause depression of neutrophil count, potentially increasing risk of infections. A better understanding of the abnormal labs is needed.
Table 1 Patients with a Depression in Neutrophils to CTC Grade 3 or Worse
Current output:
![Page 9: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/9.jpg)
Example 1. Demo of Animated Graphics
Study day
![Page 10: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/10.jpg)
Example 2. Different aspect of treatment response in two clinical studies
Background: Disease activity measured in composite score. Drug effect not fully captured by the score.
Active
Current outputs:
One component at a time
![Page 11: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/11.jpg)
Example 2. Demo of Animated Graphics
![Page 12: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/12.jpg)
Demo of Graphics Tool
![Page 13: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/13.jpg)
More Information: http://rochewiki.roche.com/confluence/display/RDVT/Home
![Page 14: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/14.jpg)
Recommendation from the tool designers
• Explain it well the first time
• Treat the animated graphic analysis as exploratory analysis
• Follow data sharing guideline, as the underlying data is embedded in the .svg output files
• Use animation only when it adds value
Inappropriate
animation could distract from the message
![Page 15: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/15.jpg)
Potential use
• Data monitoring for safety and data quality?
• Communication?
• Exploratory analysis?
• Quick review of large datasets?
![Page 16: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/16.jpg)
Thanks!
Internal collaborator: Jeff Tomlinson, Olivier Harari
Sponsor: Roche global medical affairs
Developer: BrainyPro Inc.
![Page 17: Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October 9 2015.](https://reader036.fdocuments.us/reader036/viewer/2022062806/5697bfac1a28abf838c9ba95/html5/thumbnails/17.jpg)
Doing now what patients need next