Multi-Compartment Pharmacokinetics
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Transcript of Multi-Compartment Pharmacokinetics
Multi-Compartment Pharmacokinetics
Chapters 19 and 20http://www.boomer.org/c/p4/
One versus Two Compartment
• Rapid Equilibrium versus Slower Equilibrium
http://www.boomer.org/c/p4/c19/c1901.html
Multi-Compartment Pharmacokinetic Model
• Deviation from One Compartment Model• Models and Parameters• Equations• Parameter Estimation• Effect of Changing Parameters• Apparent Volumes of Distribution• Dosage Calculations• Oral Administration
Multi-Compartment Pharmacokinetic Model
This Equation is
A. The integrated equation for concentration after an IV bolus
B. The differential equation for concentration after an IV bolus
C. The integrated equation for concentration after an oral dose
A Two Compartment Model becomes One when
A. k12 and k21 are fastB. k21 is faster than
k12C. CLD is fastD. All of the above
Varea is Calculated using
A. The dose and the intercept values (A and B)
B. The dose, AUC and beta
C. V1 and the microconstants
Achieving and maintaining a specified Cp is
easier with a 2C drug
A. TrueB. False
Non Compartmental Analysis
• Linear (First-order) Kinetics• No Model ‘Requirement’• New Parameters – AUMC, MRT, MAT• Faster Calculation with Spreadsheet or SAS
Non Compartmental Analysis
The mean residence time can be calculated as
A. AUMC/AUCB. AUC/AUMCC. AUMC2
D. Dose/AUC
An estimate of ka can be calculated from
A. AUCB. AUMCC. MRTD. MAT
Do you usually have your laptop AND
phone connected to WiFi in this room?
A. TrueB. False
Have you had problems connecting to the WiFi in this room?
A. NeverB. OccasionallyC. Often
Have you had problems
connecting to the WiFi in this room
during in-class Quiz or Exams
A. TrueB. False