MTHFR & Genetic Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into...
Transcript of MTHFR & Genetic Basics - Doctor Doni...What is MTHFR? Gene and enzyme that turns folic acid into...
By Dr. Doni Wilson
The Answers You Need to Take Control of Your Health
MTHFR & Genetic Basics
Genetics + Stress = Health
© 2017 Dr. Doni Wilson
© 2017 Dr. Doni Wilson
Footnote
© 2017 Dr. Doni Wilson
What are Stresses? Major Life Stresses
Daily StressesFood Sensitivities
InfectionsMedications
Physical TraumaLack of Sleep
Elevated Blood SugarLack of Nutrients
Toxins
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Genetics + Stress = Health
© 2017 Dr. Doni Wilson
How to Read a Genetic Report?
Letters, numbers and colors.Genes code for enzymes.
Genes have 2 strands and 2 possible SNPs.Heterozygous = 1 SNP (yellow)
Homozygous = 2 SNPs (red)
We all have some SNPs!
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What Are SNPs? Genetic variations.
Potential traffic jams.
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© 2017 Dr. Doni Wilson
What are Cofactors?
Nutrient(s) required for enzyme to function.
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What is MTHFR? Gene and enzyme that turns folic acid into folate.
“Folic acid” and “folate” are often used interchangeably, but they are different.
Folate is found in nature.Folic acid is synthetic.
MTHFR A1298CMTHFR C677T
© 2017 Dr. Doni Wilson
© 2017 Dr. Doni Wilson
Health Risks Associated with MTHFR? Migraines
Anxiety and DepressionMiscarriages and Neural Tube Defects
InsomniaCervical Dysplasia (abnormal pap smears)
Heart DiseaseDiabetesCancer
Alzheimer’s
© 2017 Dr. Doni Wilson
© 2017 Dr. Doni Wilson
How much does it affect me?
What is Methylation? “B Vitamin Cycle”
What our B vitamins are up to!
Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine).
Then SAM recycles back around to Homocysteine.
Negatively Affected by Stress.
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What is SAM?
Used in the body to do all sorts of good!
Protects our DNAHelps make healthy new cells
Makes and breaks down neurotransmittersand helps get rid of histamine (think of allergies).
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What is Homocysteine? Recycling SAM.
Connects up with Folate and B12.
Can also go down the glutathione pathway.Glutathione is a major anti-oxidant in our bodies -
a cell protector.
Can be measured in blood work.
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What can block Methylation?
InflammationMetalsAlcohol
LPS from gut bacteriaNitric Oxide (uncoupled)
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What can I do to address MTHFR?
• Avoid Folic Acid.• Eat foods high in folate.• Find out if you need Folate.• What is blocking methylation?• Do you have enough cofactors?• Address YOUR stress!
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What can I do to address MTHFR?
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What tests do I need to do? Genetic panelRun software
Blood test for Homocysteine
May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut
bacteria, nutrient levels, methylmalonic acid
© 2017 Dr. Doni Wilson
© 2017 Dr. Doni Wilson
Methylation Panel
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Organic Acids Panel
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Urine Sulfur Strips
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Cortisol & Neurotransmitter Panel
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Food Sensitivity & Stool Panels
Footnote
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Additional Panels
Will Supplements Help? Which?
Yes - Important to Individualize!
Vitamin B6, MagnesiumOther B vitamins
Minerals/Electrolytes
Methyl-Folate (5MTHF)Methyl-Cobalamin (B12)
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Will Supplements Help? Which?
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Dr. Doni’s 5-step Approach
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Remove Blocks
By decreasing “stresses” in our bodies, we improve
methylation.
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Stress
Inflammation
Decreased Methylation
Leaky Gut + Dysbiosis + Blood Sugar Issues
Oxidative Stress + Chronic Infection
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Address Downstream Pathways
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Sulfur & Glutathione
Nitric Oxideand
Histamine
Neurotransmitters© 2017 Dr. Doni Wilson
Support Cofactors First!
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MagnesiumMinerals/Electrolytes
Vitamin B6 Other B vitaminsHydroxo B12 trial
Molybdenum (if needed)
Assess Methylation
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Know your homocysteine level!
Add Methylation Supportonly IF needed !!
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5MTHF +
Methyl B12 +
B6 (P5P)
Genetics + Stress = Health
© 2017 Dr. Doni Wilson
© 2017 Dr. Doni Wilson
Stress Remedy Program
https://doctordoni.com/pdfs/Dr-Doni-Wilson_MTHFR-and-Genetic-Profiling-
Solutions-Package.pdf
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MTHFR 5 Step Approach Workshop
Dr. Doni’s 5-Step Approach
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Workshop Sessions
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1. Identify blocks and assess downstream pathways 2. Address blocks and cofactors 3. Assess progress 4. Implement methylation5. Assess progress6. Plan for continued success
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MTHFR 5 Step Approach Workshop
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