ResumePersonal info

Full name : Mahmud Tareq Hassan Khan, Ph.D.

Present and mailing address : Bekkevollvegen 24, Tromsø 9012, Norway. Cell phone : +47-957-99-336; E-mails : mthkhan2002@gmail.com; mthkhan2002@yahoo.com Nationality : Norwegian

Research-gate profile : https://www.researchgate.net/profile/Mahmud_Tareq_Hassan_Khan Linkedin profile: https://no.linkedin.com/pub/mahmud-th-khan/53/a89/b39

Academic qualifications :Post-Doc – GenØk – Center for Biosafety, Tromsø, Norway (Sep. 2009-Dec. 2011) – Project responsibility:

Transcriptomics of model organismsPh. D. – University of Tromsø, Norway – 2009 (in Molecular & Structural Biology) –

Title of Thesis: Thermolysin – A Prototype Zn-Metalloproteinase: Bioinformatics, Structural Biology andDiscovery of Inhibitors

M. Pharm. (Thesis) – University of Science and Technology, Chittagong, Bangladesh - April, from 1997 to 2001(Officially) Title of Thesis: Study of the Pharmacological Activities of Mohot Ponchomul and Its’ Individual Ingredients(24 months)

B. Pharm. (Honors; with Thesis) – University of Science and Technology, Chittagong, Bangladesh – from 1993 to1997 (Officially)Title of Thesis: Pharmaco-Toxicological Study of Nigella sativa Linn. and Pharmacotaxonomic study andClinical Trials on Female UTI Patients and Male Normotensive Subjects (14 months)

Career tracks:1. Consultant, Drug Discovery, Tromsø, Norway, February, 2013 to today. 2. Assistant Professor (Research), Dr. Johnson’s group, Center for Pharmaceutical Biotechnology, University of

Illinois at Chicago, USA, December, 2011 to January 2013.3. Assistant Professor (Research), Department of Medicinal Chemistry and Pharmacognosy, College of

Pharmacy, University of Illinois at Chicago, USA, September, 2011 to January 2013.4. Research Associate, Dr. Johnson’s group, Center for Pharmaceutical Biotechnology, University of Illinois at

Chicago, USA, July, 2011, to December, 2011.5. Post-Doc Fellow and Group Leader, Transcriptomics group, GenØk - Center for Biosafety, University of

Tromsø, Research park at Breivika, Tromsø, Norway; Sep, 2009 to July, 2011.6. Visiting Scientist and Visiting Lecturer, Department of Pharmacognosy, Faculty of Pharmacy, Gazi

University, Ankara, Turkey, from Feb. 1 to 13, 2009.7. Research Fellow, Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Norway,

from Oct, 2005 to Aug, 2009.8. Researcher, Department of Biochemistry and Molecular Biology, University of Ferrara, Italy, from 2004-

2005;9. Senior Research Fellow, International Center for Chemical Sciences, HEJ Research Institute of Chemistry,

University of Karachi, Pakistan, from 2002-2004;10. Research Fellow, International Center for Chemical Sciences, HEJ Research Institute of Chemistry,

University of Karachi, Pakistan, from 2001-2002;11. Assistant Manager, Product Management Department, Al-Amin Pharmaceutical Ltd., Bangladesh, 2001;12. Product Officer, Product Management Department, Pharma Division, Advanced Chemical Industries (ACI),

Bangladesh Ltd., 2001;13. Research Fellow, World Health Organization, Bangladesh, from 1999-2001;14. Post-Graduate Student, Department of Pharmacy, University of Science and Technology, Chittagong,

Bangladesh, from 1997-1999;15. Graduate Student, Department of Pharmacy, University of Science and Technology, Chittagong, Bangladesh,

from 1993-1997.

Grants, Fellowships, Awards and Honors:2010-2011 Leiv Eiriksson Grant, Norwegian Research Council, Norway.2010 ‘Marquis Who's Who’ in Science and Engineering 2010-2011, USA.2011 ‘Marquis Who's Who’ in Medicine and Healthcare 2011-2012, USA.

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2010 “Travel Grant” from Functional Genomics Platform of Northern-Norway (FUGE-NN), Norway.2009 “Travel Grant” from Functional Genomics Platform of Northern-Norway (FUGE-NN), Norway.2009 “Visiting Scientist/Lecturer Fellowship” from the Scientific and Technological Research

Council of Turkey (TUBITAK) – Scientific Human Resources Development (BIDEB-2221),Feb 01-17.

2008 “Travel Grant” from Functional Genomics Platform of Northern-Norway (FUGE-NN), Norway.2007 “Most Cited Article Award” from Elsevier Science Publisher, for the article Bioorganic &

Medicinal Chemistry, 2005, 13(10): 3385-3395.2006 “Travel Grant” from Functional Genomics Platform of Northern-Norway (FUGE-NN), Norway.2004-2005 “Research Fellowship” from Associasione Veneta per la Lotta alla Talassemia (AVTL), Italy.2004 “Research Fellowship” from the Interuniversity Consortium for Biotechnology (CIB)

Fellowship, Italy.2004 “Travel Grant” from Higher Education Commission (HEC) of the Government of Pakistan to

attend PRICPS 2004, jointly by The Protein Society USA and the Protein Society of Japan.2004 “Young Investigator’s Award”, on Bioinformatics, PRICPS 2004, jointly by The Protein

Society USA and the Protein Society of Japan.2003-2004 The “UNESCO-MCBN (Molecular and Cell Biology Network)” Fellowship, Switzerland.2001-2003 The “South-South Fellowship”, Third World Academy of Science (TWAS), Italy.1999-2001 Research Fellowship, World Health Organization (WHO), Bangladesh.

Personal skills and working experiences: Experimental experiences:

1. In vivo: Several years working experiences with different in vivo methods and animal models, like mice, rats,guinea-pigs, rabbits, etc.

2. In vitro or in situ: Several years working experiences with different in vitro, in situ and on different isolatedtissues or organ based methods;

3. Protein chemistry and enzymology: competitive binding studies, kinetic experiments, radio probe-basedbinding assays, Electrophoretic mobility shift assay (EMSA), preparation and screening of chemical arrays,etc.

4. Preliminary experiences of protein cloning and expression;5. Molecular biology: DNA, RNA isolation and purification, cloning cDNA, different human and animal cancer

cell cultures, cell counting, PCR, real-time RT-PCR, FACS, electrophoresis, etc.6. Biophysical methods: SPR-based Biacore, general experiences with Calorimetry, etc.7. Analytical methods: HPLC, GC, Mass Spectrometry, LC-MS, general experiences with NMR, etc.8. Phytochemical methods: Isolation and purification of plant secondary metabolites, etc.

Softwares experiences:1. Homology-based modelling, analysis and bioinformatics: ICM, Swiss-Modeller, different model analysis

programs, CLC workbench, FASTA, BLAST, BioEdit, ClastalW, etc.2. Molecular modelling softwares: HyperChem, Spartan, Gaussian, etc.3. Molecular docking softwares: ICM, GOLD, MVD, MOE, Glide, etc.4. Pharmacophore modelling and screening: LigandScout, MOE, etc.5. Structure-based virtual screening: ICM, Glide, MVD, GOLD, etc.6. Ligand-based virtual screening: PipeLine Pilot, ICM, etc.7. Similarity-based screening and diversity analysis: PipeLine Pilot.8. ChemoGenomic studies: PipeLine Pilot.9. QSAR modelling: MVD, PipeLine Pilot, SigmaStat, etc.10. Molecular descriptors based modelling: AdrianaCode, PipeLine Pilot, SigmaStat, etc.11. Combinatorial library design: iLib Diverse, etc.12. De novo library design: Pantheon MUSE.13. Large molecular docking: HEX, PatchDock, ICM, etc.14. Biomolecular simulations: MD using AMBER.15. Visualization softwares: ICM, PyMol, Discovery Studio, MVD, VMD, Swiss PDB viewer, etc.16. Intermolecular Interactions analysis: LigPlot, LigX (MOE), etc.17. Statistical programs: SPSS, SigmaStat, SigmaPlot, R, etc.18. General and graphical programs: MS Office, EndNote, Open Office, SigmaPlot, Harvard Graphics, Adobe

PhotoShop, Adobe Elements, etc.19. Chemistry programs: CS ChemOffice, ACD Chem, MDL ISIS, etc.20. Operating systems: MS XP, Vista, Linux (Red Hat, Ubuntu), MAC OS, X Server, SSH, etc.

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Academic affiliations:a. Co-supervisor, PhD student, Department of Medicinal Chemistry and Pharmacognosy, College ofPharmacy, University of Illinois at Chicago, USA.b. Co-supervisors, number of MS and PhD students, Institute of Medical Biology, University of Tromsø,Norway.c. Co-supervisors, number of PhD students, Central University of Las Villas, Santa Clara, Cuba.d. Reviewer, Tenure Track appointment program, Center for Biotechnology & Microbiology, University ofPeshawar, Pakistan (2010-).e. External Reviewer (1st opponent), Doctoral Dissertation, Center for Biotechnology & Microbiology,University of Peshawar, Pakistan (2010-).f. External Reviewer (1st opponent), Doctoral Dissertation, Department of Pharmaceutical Sciences, Facultyof Engineering & Technology, Jadavpur University, Kolkata, India (2013-).

Professional affiliations:1. American Chemical Society (ACS);2. Society for Biomolecular Screening (SBS), USA;3. European Federation of Biotechnology (EFB);4. European Association of Pharma Biotechnology (EAPB);5. International Society for Computational Biology (ISCB), U. S. A.6. International Science Advisory Board (SAB), USA;7. European Society for Ethnopharmacology (ESE),8. French Society for Ethnopharmacology, 9. Swiss Genomic Society (SGS), 10. International Society for Ethnopharmacology (ISE), Netherlands,11. Canadian Society for Pharmaceutical Sciences (CSPS) [Membership # 524], 12. Japanese Society of Pharmacognosy (JSP) [Membership # 021-010-3930(1)], 13. Asian Network for the Research on Antidiabetic Plants (ANRAP), 14. Chemical Society of Pakistan (CSP), 15. Bangladesh Pharmaceutical Society (BPS), 16. Pharmacy Graduate Association (PGA), Bangladesh,17. Bangladesh Association for Scientists and Scientific Professions (BASSP), 18. Bangladesh Photographic Society (BPS), 19. Chittagong Photographic Society (CPS), Bangladesh, etc.

Journal Affiliations: Reviewer of – 1. Science, USA;2. Drug Discovery Today; USA;3. Nucleosides, Nucleotides & Nucleic Acids, USA;4. European Journal of Medicinal Chemistry, Italy;5. In Silico Biology, Germany;6. Food and Chemical Toxicology, Elsevier Science, Netherlands;7. Bioorganic and Medicinal Chemistry, Elsevier Science, Netherlands;8. Bioorganic and Medicinal Chemistry Letters, Elsevier Science, Netherlands;9. Molecules, MDPI, Switzerland;10. Medicinal Chemistry, Bentham Sci Publisher, Netherlands;11. Mini Reviews in Medicinal Chemistry, Bentham Sci Publisher, Netherlands;12. International Journal of Computational Biology (IJCB); 13. Minerva Biotechnology, Italy;14. Medical Reports;15. Phosphorus, Sulfur, and Silicon and the Related Elements, USA;16. Archives of Biological Research;17. Journal of Medical Systems;18. Chromatographia, Elsevier Science, Netherlands;19. Journal of the Science of Food and Agriculture;20. Recent Patents on CNS Drug Discovery;21. Journal of Biological Sciences;22. International Journal Pharmacology;23. E-book proposals, Bentham Science Publisher, Netherlands;

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24. Pakistan Journal of Science and Industrial Research, Pakistan;25. Journal of Medicinal Food, USA;26. Journal of Biomedicine and Biotechnology;27. Chemical Biology & Drug Design, USA;28. Natural Product Communications, USA;29. International Journal of High Throughput Screening, USA;30. Journal of Receptor, Ligand and Channel Research, USA;31. Advances and Applications in Bioinformatics and Chemistry, USA;32. Drug Design, Development and Therapy, USA;33. Journal of Molecular Graphics and Modelling, Germany;34. Journal of Enzyme Inhibition and Medicinal Chemistry, UK;35. Pharmaceutical Biology, USA;36. Advances and Applications in Bioinformatics and Chemistry, USA;37. Letters in Drug Design & Discovery, The Netherlands;38. European Journal of Medicinal Chemistry, The Netherlands;39. International Journal of High Throughput Screening, USA;40. Journal of Receptor, Ligand and Channel Research, USA;41. European Journal of Chemistry, Turkey;42. Journal of Natural Pharmaceuticals, Turkey;43. Letters in Organic Chemistry, The Netherlands;44. Anti-Infective Agents, The Netherlands;45. Molecular Diversity, Switzerland;46. International Journal of Molecular Sciences, Switzerland;47. Journal of Medicinal Plants Research;48. Current Medicinal Chemistry, The Netherlands;49. Food Chemistry;50. International Research Journal of Agricultural Science and Soil Science (IRJAS) (ISSN: 2251-0044);51. ChemMedChem;52. Drug Design, Development and Therapy;53. Letters in Applied Microbiology;54. Journal of Theoretical Biology;55. International Journal of Biological Sciences;56. The Protein Journal;57. International Journal of Biological Macromolecules;58. International Research Journal of Pure and Applied Chemistry;59. Journal of Medical Microbiology;60. Colloids and Surfaces B: Biointerfaces;61. Carbohydrate Polymers;62. International Journal of Modern and Alternative Medicine Research;63. International Journal of Biological Macromolecules;64. Chemosphere;

Editorial appointments1. Annual Reviews of Phytomedicine, Bentham Science Publisher, Netherlands;2. Recent Trends on QSAR in the Pharmaceutical Perceptions, Bentham Science Publisher, Netherlands;

Guest Editors of - 3. Mini-Reviews in Medicinal Chemistry, Bentham Science Publisher, Netherlands4. Minerva Biotechnology, Italy5. Evidence-Based Complementary & Alternative Medicine (eCAM);6. Current Topics in Medicinal Chemistry (CTMC);

Technical Editors of -7. International Journal of Pharmacology;8. International Journal of Biological Chemistry;9. Research Journal of Phytochemistry;10. Trends in Molecular Sciences;11. Biotechnology;12. Scirus™ Topics Page.

Member Editorial Board of -13. Minerva Biotechnology, Italy;

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14. Journal of Natural Pharmaceuticals, Turkey;15. Scientifica (Pharmaceutics);16. Journal of Pharmacognosy;

Reviewer/Member Conference Committees of -17. International Conference on Engineering and Meta-Engineering: ICEME 2010, April 6th - 9th, 2010 – Orlando,

Florida, USA.18. The 3rd International Multi-Conference on Engineering and Technological Innovation: IMETI 2010, June 29th

- July 2nd, 2010 – Orlando, Florida, USA. Associate Editor of -1. ISTPress, Canada2. International Journal of Biophysics Research,3. Journal of Biotech Applications,4. Evidence-Based Complementary & Alternative Medicine (eCAM),5. World Research Journal of Biophysics;6. International Journal of Computational Biology;

Teaching Experiences:1. Course Lecturer. General Pharmacology, Bio-2031, to the M. Sc. students of the Department of Biology,

University of Tromsø, Norway, from Feb., 2006 to 2009.2. Course Lecturer. Pharmacology, Bio-3304, to the M. Sc. students of the Department of Biology, University

of Tromsø, Norway, from Aug., 2006 to 2009.

(Co-)Supervisions of Theses (Theses for PhD degree):1. Gerardo Maikel Casañola Martín, Thesis title: Discovery of Novel Tyrosinase Enzyme Inhibitors Integrating

Theoretical and Experimental Methods, Central University of Las Villas, Santa Clara, Cuba, Submitted: 2009.2. Inger Lindin, Thesis title: Protein kinase MK5: structure and design of potent inhibitors, University of

Tromsø, Norway, Possible date of submission: 2012.3. Yudith Cañizares Carmenate, Possible title of Thesis: Discovery of new thermolysin inhibitors by integrating

dry and wet evaluation; (PhD in Pharmaceutical sciences), Central University of Las Villas, Santa Clara,Cuba; Possible date (or year) of completion: December, 2013.

4. Shuyi Cao, Possible title of Thesis: Studies of bacterial SAICAR synthease. (PhD in PharmaceuticalBiotechnology), Center for Pharmaceutical Biotechnology (MC 870), College of Pharmacy, University ofIllinois at Chicago, Molecular Biology Research Building, 900 South Ashland Avenue, Room 3100, Chicago,IL 60607-7173, USA. Possible date (or year) of completion: December, 2013.

(Co-)Supervisions of Theses (Theses for Master degree):5. Yimingjiang Wuxiuer, Thesis title: Theoretical and experimental studies of Thermolysin inhibition,

University of Tromsø, Norway, Submitted: May, 2008.6. Tasmina Rahman, Thesis title: Comparative Pharmacological Studies between Spice and Non-spice

Ayurvedic Herbs; Jahangirnagar University, Bangladesh. Submitted: February, 2001.7. M. Rokonuddin, Thesis title: Clinico-pharmacological Study on the Renal Study of “Dasamool”.

Jahangirnagar University, Bangladesh. Submitted February, 2001 8. Shayla Afroz, Thesis title: Study Report on the Efficacy and Safety of Traditional Medicines Claimed to

Possess Anti-diarrhoeal, Analgesic and Diuretic Properties. Jahangirnagar University, Bangladesh. SubmittedFebruary, 2001

9. M. Shaphiullah, Thesis title: Pharmacological Studies of Extracts of Ludwigia hyssopifolia Linn. DhakaUniversity, Bangladesh. Submitted 2002.

10. M. S. Islam, Thesis title: Pharmacological Studies of the Root Extracts of Rumex maritimus. DhakaUniversity, Bangladesh. Submitted 2002.

11. Nushratun Nahar, Thesis title: Jahangirnagar University, Bangladesh. During 2000-2001.

Lectures delivered: Invited Lecture, Structural Bioinformatics in the Discovery of Novel Drugs. 9th Eurasia Conferenceon Chemical Sciences, Sep. 10, 2006, Turkey. Invited Lecture, Structural Bioinformatics in the Discovery of Novel Drugs. Faculty of Science andArts, University of Trakya, Sep. 15, 2006, Turkey. Lectures, Molecular Features & Inhibition of the Thermolysin Family of Enzymes. Department ofPharmacology, June, 2006, UiTø, Tromsø, Norway; Lipari Summer School of Proteomics, Aug., 2006, Lipari,

M.T.H. Khan Page 5

Italy; PhD School of Molecular and Structural Biology, Oct, 2006; and University Hospital Northern-Norway(UNN), Oct 06, 2006, Tromsø, Norway. Invited Lecture, Aspects of Bioinformatics in Drug Design at Post-Genomic Era, Jan. 17, 2006,University of Science and Technology, Chittagong, Bangladesh. Visiting Invited Lecture, Why Bioinformatics?, 30 July, 2007, University of DevelopmentAlternatives, Dhaka, Bangladesh. Oral Presentation, Novel Putative Psychrophilic and Thermophilic Zinc Metalloproteinases fromM4 sub-families, “Bioinformatics for Young Scientists (BFYS)” Sommarøya, Tromsø, May 11-13, 2007,Norway. Visiting Invited Lecture, Discovery and Designing Designer’s Drugs (D4): Then and Now. May 01-05, 2008, Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Germany. Visiting Invited Lecture, Molecular Modelling and Computational Chemistry: An Introduction,Faculty of Pharmacy, Gazi University, Ankara, Feb. 12, 2009, Turkey. Visiting Invited Lecture, Structural Bioinformatics in the Discovery of Novel Drugs, Faculty ofPharmacy, Gazi University, Ankara, Feb. 10, 2009, Turkey. Visiting Invited Lecture, Why Bioinformatics? Drug Design: Then and Now, Faculty of Pharmacy,Gazi University, Ankara, Feb. 05, 2009, Turkey. Center Lecture, microRNA – small in size, big in regulation; Center for PharmaceuticalBiotechnology (MC 870), College of Pharmacy, University of Illinois at Chicago, Molecular Biology ResearchBuilding, Chicago, Nov. 17, 2011, USA.

Professional Trainings/Workshops/Courses Attended: 1. Successfully completed the six weeks “In-plant Training” program in the production facilities of former

GlaxoWellcome (BD.) LTD. (presently GlaxoSmithKline, GSK, BD. Ltd.), Chittagong, Bangladesh, 1997.2. Successfully done 7 days training on “Marketing and Regularity Affairs” organized by Pharmacy Graduates

Association (PGA) in Dhaka (Bangladesh) from May 29 to June 4, 1999.3. Successfully done 7 days training on “Utilization of Polymer and Biopolymer Chemistry”, Dr. Shahadat Ali,

Wolongong University, Australia, 2001.4. Successfully done 7 days training on “Bio-inorganic Chemistry and their Medicinal Properties”, Dr. Mahroof

Tahir, St. Claud State University, Minnesota, USA, 2001.5. Successfully done 15 days training on “Scientific Integrity” organized by H.E.J Research Institute of Chemistry,

University of Karachi, Pakistan, August 1 to 15, 2002.6. Successfully done 7 days training on “Total Synthesis of Important Natural Alkaloids”, Prof. Ichiya Ninomya,

Kobe Pharmaceutical University, Japan, October, 2002.7. Successfully done 7 days training on “Diabetes and AGEing and their Complications”, conducted by Dr. Neesar

Ahmed, Department of Biological Sciences, Manchester Metropolitan University, UK, April, 2003.8. Successfully attended “International Workshop on Bioinformatics” organized by COMSTECH-PTCL Frontier

Technologies Research Center, Islamabad, Pakistan, April, 2003.9. Successfully attended “International Workshop on The Development of Medicines from Plants” organized by

H.E.J.-COMSTECH-TWAS, Karachi, Pakistan, September 8-13, 2003.10. Successfully attended seven days several workshops on “New Approaches to Structure and Function of Proteins in

Pacific-Rim”, organized jointly by the Protein Society, U.S.A., and the Protein Society of Japan, April 14-18,2004, Yokohama [Japan].

11. Earned 4 ECTS (European Credit Transfer System) credits from University of Bologna, Italy, on “How Complexis Functional Genomics?”, from 13 to 19 February, 2005 [Italy].

12. Two-Days workshop on “Molecular Modelling and Drug Design” organized by Department of Pharmacology,University of Tromsø, Norway, December, 2005 [Norway]

13. One-Week workshop on “Bioinformatics of Transcriptional Regulation”, Swiss Institute of Bioinformatics, Jan28-Feb1, 2008, Lausanne, Switzerland.

14. Two-Days industrial training on Biacore T100 Basic and Kinetic & Affinity Analysis, GE Healthcare, Uppsala,Sweden, March 4-5, 2008.

15. HESI workshop on evaluating biological variation in non-transgenic crops, Paris, France, Nov. 16-17, 2009.16. The Daphnia Genomic Consortium (DGC) congress, Leuven, Belgium, March 25-30, 2010.17. ICAAC Congress, organized by ASM, USA, McCormic Place, Chicago, Sep. 16-20, 201118. Advances in Drug Discovery through High-throughput Screening, organized by University of Illinois at Chicago

(UIC) Center for Clinical & Translational Science, Herman Auditorium, UIC, Chicago, USA, Sep. 22, 2011.19. Chicago Drug Discovery Consortium meeting, University of Illinois at Chicago (UIC), Herman Auditorium, UIC,

Chicago, USA, May 23, 2012.

Research Topics:

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Present Research Topics: Bioinformatics, Structural Bioinformatics, and Medicinal Chemistry Transcriptomics of Model organisms challenged with GM toxins; Discovery of novel Map kinase kinase5 (MK5) inhibitors using computational and experimental approaches; Modelling of biologically important macromolecules, like NPP6, different VP1 proteins, etc.; Molecular Insight of Thermolysin Family of Protein and Discovery of their Inhibitors; Molecular Recognitions for the Interactions of Inhibitors using Structural Bioinformatic approaches

Cholinesterases (AChE & BChE), Human Inosine monophosphate dehydrogenase (IMPDH), Methionyl-tRNA synthetase (metRS), 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK), -Sectretase (BACE1), HIV reverse transcriptase, Hydroxyphenyl pyruvate dioxygenase, Farnesyltransferase, HIV-1 aspartic protease, trypsin, thrombin, & urokinase, Human progesterone & estrogen receptors,

Molecular Modeling and Chemoinformatic Studies of Tyrosinase Inhibitors and their Docking Experimentsthrough Bioinformatic Approaches.

M.T.H. Khan Page 7

List of Publications(A) Published papers: (with Impact Factors, according to JCR™ 2013)

Total or cumulative IF = 216.656

N Publication detailed IF147 Senol, F.S., Khan, M.T.H., Orhan, G., Gurkas, E., Orhan, I.E., Oztekin, N.S. & Ak, F. In

Silico Approach to Inhibition of Tyrosinase by Ascorbic Acid Using Molecular DockingSimulations. Current Topics in Medicinal Chemistry. 2014 May 23. [Epub ahead of print]

3.702

146 Le-Thi-Thu, H., Casanola-Martin, G.M., Marrero-Ponce, Y., Rescigno, A., Abad,C., Khan, M.T.H. A Rational Workflow for Sequential Virtual Screening of ChemicalLibraries on Searching for New Tyrosinase Inhibitors. Current Topics in MedicinalChemistry. 2014 May 23. [Epub ahead of print]

3.702

145 Orhan, I.E., Khan, M.T.H. Flavonoid Derivatives As Potent Tyrosinase Inhibitors - ASurvey Of Recent Findings Between 2008-2013. Current Topics in Medicinal Chemistry.2014 May 23. [Epub ahead of print]

3.702

144 Casañola-Martin, G.M., Le-Thi-Thu, H., Marrero-Ponce, Y., Castillo-Garit, J.A., Torrens,F., Rescigno, A., Abad, C., Khan, M.T.H. Tyrosinase Enzyme: 1. An Overview On APharmacological Target. Current Topics in Medicinal Chemistry. 2014 May 23. [Epubahead of print]

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143 Khan, M.T.H. Editorial: Tyrosinase Inhibitors – Computational Prediction, OrganicSynthesis, Isolation from natural Sources, and Biological Assay. Current Topics inMedicinal Chemistry. 2014 May 23. [Epub ahead of print]

3.702

142 Khan, M.T.H., Kovářová, M., Komers, K., Čegan, A. Modelling the interactions of newcarbamate derivates with acetylcholinesterase from electric eel utilizing dockingsimulations and scoring functions. Accepted, Current Topics in Medicinal Chemistry.

3.702

141 Khan, M.T.H., Okada, T., Murakawa, T., and Kurita, N. Molecular simulations on specificinteractions between β-Sectretase and its inhibitors for the treatment of Alzheimer’sdisease. Accepted, Current Topics in Medicinal Chemistry.

3.702

140 Okada, T., Murakawa, T., Khan, M.T.H., Komers, K., Kovářová, M., and Kurita, N.Molecular simulations on specific interactions between acetylcholinesterase and itscarbamate inhibitors to propose potent inhibitors. Accepted, Current Topics in MedicinalChemistry.

3.702

139 Dimitrova, P., Georgiev, M.I., Khan, M.T.H., Ivanovska, N. Evaluation of Verbascum speciesand harpagoside in models of acute and chronic inflammation. Central European Journal ofBiology, 2013, 8 (2), 186-194.

0.818

138 Casanola-Martin, G.M., Marrero-Ponce, Y., Le-Thi-Thu, H., Khan, M.T.H., Torrens, F.,Rescigno, A., Abad, C. Tyrosinase enzyme: 2. Inhibitors from natural and synthetic origins.Afinidad, 2013, LXX (Oct-Dec), 270-276.

0.230

137 Khan, M.T.H. Putative Molecular Interactions Involving Naturally Occurring Steroidal Alkaloidsfrom Sarcococca hookeriana Against Acetyl- and Butyryl- Cholinesterase. CurrentBioinformatics, 2013, 8, 416-428.

2.017

136 Senol, F.S., Orhan, I.E., Kurkcuoglu, M., Khan, M.T.H., Altintas, A., Sener, B., Baser, K.H.C. Amechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascenaMill.). Food Research International, 2013:53, 502–509.

3.005

135 Umesha, K., Sarojini, B.K., Raj, C.G.D., Bhanuprakash, V., Yogisharadhya, R., Raghavendra, R.,Khan, M.T.H. In vitro and in silico biological studies of novel thiazolo [3,2-a]pyrimidine-6-carboxylate derivatives. Medicinal Chemistry Research, May, 2013.

1.612

134 Orhan, I.E., Loizzo, M.R., Khan, M.T.H. Editorial, Therapeutic approaches to neuroprotectiveactivity by complementary and alternative medicines. Evidence-Based Complementary andAlternative Medicine, 2012; 2012:376068. doi: 10.1155/2012/376068. Epub 2012 Oct 17.

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133 Khan, M.T.H., Dedachi, K., Matsui, T., Kurita, N., Borgatti, M., Gambari, R., Sylte, I., DipeptideInhibitors of Thermolysin and Angiotensin I-Converting Enzyme. Current Topics in MedicinalChemistry, 2012;12(16):1748-62.

4.174

132 Casañola-Martín, G. M., Khan, M.T.H., Le-Thi-Thu, H., Marrero-Ponce, Y., García-Domenech,R., Torrens, F., Rescigno, A., Abad, C. Retrained Classification of Tyrosinase Inhibitors and “Insilico” Potency Estimation by Using Atom-Type Linear Indices: A Powerful Tool for Speed up

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the Discovery of Leads. International Journal of Chemoinformatics and Chemical Engineering(IJCCE), 2012, July-December, 2(2), 42-144.

131 Ghelue, M.V., Khan, M.T.H., Ehlers, B., Moens, U. Genome analysis of the new humanpolyomaviruses. Reviews in Medical Veriology 2012 Mar 28. doi: 10.1002/rmv.1711. [UnitedKingdom]

5.600

130 Kovářová, M., Khan, M.T.H., Komers, K., Pařík, P., Čegan, A., Zatloukalová, M. Kinetics of invitro inhibition of acetylcholinesterase by nineteen new carbamates. Current Enzyme Inhibition,2011, 7, 236-243 [The Netherlands]

0.530

129 Khan, M. T. H. Novel tyrosinase inhibitors from natural resources – their computational studies.Current Medicinal Chemistry, 2012, May, 19(14):2262-2272 (Invited review) [The Netherlands]

4.630

128 Hirakawa, T., Fujita, S., Ohyama, T., Dedachi, K., Khan, M. T. H., Sylte, I., Kurita, N. Specificinteractions and binding energies between thermolysin and potent inhibitors: Molecularsimulations based on ab initio molecular orbital method. J Mol Graph Model. 2012 Mar; 33:1-11[The Netherlands]

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127 Senol, F.S., Woźniak, K.S., Khan, M.T.H., Orhan, I.E., Sener, B., Głowniak, K. An in vitro andin silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract,furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits. PhytochemistryLetters, 2011 Dec; 4(4):462-67 [The Netherlands]

1.364

126 Samshuddin, S., Narayana, B., Sarojini, B.K., Khan, M.T.H., Yathirajan, H.S., Raj, C.G.D.,Raghavendra, R. Antimicrobial, analgesic, DPPH scavenging activities and molecular dockingstudy of some 1,3,5-triaryl-2-pyrazolines. Medicinal Chemistry Research, DOI 10.1007/s00044-011-9735-9. [Germany]

1.058

125 Dedachi, K., Khan, M. T. H., Sylte, I., Kurita, N. Specific interactions and binding free energiesbetween thermolysin and amino-acid dipeptides obtained by molecular simulations combined withab initio MO and classical vibrational analysis. Journal of Computational Chemistry, 2011 Aug 3.doi: 10.1002/jcc.21887. [Epub ahead of print] [USA]

4.050

124 Panero, A.B., Ghelue, M.V., Khan, M.T.H., Echevarría, J.E., Fedele , G., Moens, U. Presence ofBK virus in cerebrospinal fluid of neurological patients and mutation analysis of the completeVP1 gene in different patient groups. Journal of Cellular Physiology, 2011 Mar 3. doi:10.1002/jcp.22711. [Epub ahead of print] [USA].

4.586

123 Khan, M.T.H., Mischiati, C., Ather, A., Ohyama, T., Dedachi, K., Borgatti, M., Kurita, N.,Gambari, R. Structure-based Analysis of the Molecular Recognitions between HIV-1 TAR-RNAand Transcription Factor NFkB. In press Current Topics in Medicinal Chemistry [TheNetherlands].

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122 Khan, M.T.H., Yimingjiang, W., and Sylte, I. Binding modes, pharmacophore modelling, andpredictions of absorption, distribution and toxicity of thermolysin inhibitors. Accepted at Mini-Reviews in Medicinal Chemistry [The Netherlands].

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121 Khan, M.T.H.. Molecular Docking Calculations of Steroidal Alkaloids from Sarcococcahookeriana against Acetylcholinesterase and Butyrylcholinesterase and their Structure-ActivityRelationships. In press Current Bioinformatics [The Netherlands].

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120 Ilkay Orhan, I., Khan, M.T.H., Aslan, S., Kartal, M., Şener, S. Discovery of Selective and PotentAcetyl- and Butyryl-cholinesterase Inhibitors from Buxus sempervirens. Current Computer-AidedDrug Design, 2011, 7:276-286 [The Netherlands].

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119 Rahman, T., Rahman, K.A., Rajia, S., Alamgir, M., Khan, M.T.H. Choudhuri, M.S.K. Centralnervous system depressant effect of two spices ajowan (Carum copticum Karst.) and bay leaves(Cinnamomum tamala T.Nees.). Oriental Pharmacy and Experimental Medicine, 2010, 10(2):86-89 [Korea].

118 Casañola-Martín, G.M., Marrero-Ponce, Y., Khan, M.T.H., Khan, S.B., Torrens, F., Pérez-Jiménez, F., Rescigno, A., Abad, C. Bond-Based 2D Quadratic Fingerprints in QSAR Studies.Virtual and In Vitro Tyrosinase Inhibitory Activity Elucidation. Chemical Biology & Drug Design2010 Dec;76(6):538-45 [USA]

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117 Choudhary, M.I.; Shah, S.A.A.; Rahman, A.U.; Khan, S.-N., Khan, M.T.H. Alpha-glucosidaseand tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones. Steroids2010 Dec;75(12):956-966. [The Netherlands]

2.905

116 Kostenko, S., Khan, M.T.H., Sylte, I., Moens, U. The diterpenoid alkaloid Noroxoaconitine is aMAPKAP Kinase 5 (MK5/PRAK) inhibitor. Cellular and Molecular Life Sciences. Jul 17. [Epubahead of print] [Germany]

6.090

115 Marrero-Ponce, Y., Casañola-Martín, G. M., Khan, M.T.H., Torrens, F., Rescigno, A., Abad, C.Ligand-Based Computer-Aided Discovery of Tyrosinase Inhibitors. Applications of theTOMOCOMD-CARDD Method to the Elucidation of New Compounds. Current Pharmaceutical

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Design, 2010, 16:2601-2624 (Invited review) Jul 20. [Epub ahead of print] [The Netherlands]114 Khan, M.T.H., Khan, R., Yimingjiang. W., Arfan, M., Ahmed, M., Sylte I. Identification of novel

Quinazolin-4 (3H)-ones as inhibitors of Thermolysin, the prototype of the M4 family ofproteinases. Bioorganic and Medicinal Chemistry, 2010, 18:4317–4327 [USA].

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113 Khan, S.B., Khan, M.T.H., Seo, J., Jang, E.S., Han, H. Tyrosinase inhibitory effect of benzoicacid derivatives and their structure-activity relationship. Journal of Enzyme Inhibition andMedicinal Chemistry, 2010 Dec;25(6):812-7. [Epub ahead of print] [UK]

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112 Khan, M.T.H. Predictions of the ADMET properties of candidate drug molecules utilizingdifferent QSAR/QSPR modelling approaches. Current Drug Metabolism, 2010, 11: 285-295(Invited review) [The Netherlands]

3.989

111 Khan, M. T. H., Ather, A., Pinto, A.C., Macial, M.A.M. Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system. Brazilian Journal ofPharmacognosy, 19(1A):7-13 [Brazil]

110 Dedachi, K., Khan, M. T. H., Sylte, I., Kurita, N. A combined simulation with ab initio MO andclassical vibrational analysis on the specific interactions between thermolysin and dipeptideligands. Chemical Physics Letters 479 (2009) 290–295 [USA].

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109 Khan, M.T.H., Orhan I, Senol FS, Kartal M, Sener B, Dvorská M, Smejkal K, Slapetová T.Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and theirmolecular docking studies. Chemico-Biological Interactions, 2009 Oct 30;181(3):383-9. Epub2009 Jul 9 [USA].

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108 Khan, M.T.H. and Sylte, I. Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors. Letters in Drug Design & Discovery, 2009, 6, 428-436. [The Netherlands]

0.805

107 Khan, M.T.H. Molecular Interactions of Cholinesterases Inhibitors using In Silico Methods: Current Status and Future Prospects. New Biotechnology, 2009 Jun;25(5):331-46. Epub 2009 Apr 5. (Invited review) [The Netherlands]

2.000

106 Chattopadhyay D, Sarkar MC, Chatterjee T, Sharma Dey R, Bag P, Chakraborti S, and Khan,M.T.H. Recent advancements for the evaluation of anti-viral activities of natural products. NewBiotechnology, 2009 Jun;25(5):347-68. Epub 2009 Apr 5 (Invited review) [The Netherlands]

2.000

105 Khan, M.T.H. and Sylte, I. Determinants for psychrophilic and thermophilic features ofmetallopeptidases of the M4 family. In Silico Biology, 2009; 9(3):105-24. [Germany].

104 Khan, M.T.H., Fuskevåg, O.-M., Sylte I. Discovery of Potent Thermolysin Inhibitors UsingStructure-based Virtual Screening and In vitro Testing. Journal of Medicinal Chemistry 2009 Jan8;52(1):48-61 [Epub 2008 Dec 15] [USA].

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103 Khan, M.T.H. and Gambari, R. Imaging and prediction of biological activity of peptide nucleicacid by computer-aided approaches. Minerva Biotechnologica, 2008 December; 20(4):157-64[Italy].

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102 Penolazzi, L., Lampronti, I., Borgatti, M., Khan, M.T.H., Zennaro, M., Piva, R., Gambari, R.Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plantEmblica officinalis. BMC Complementary and Alternative Medicine 2008 Oct 30;8(1):59. [Epubahead of print] [UK].

1.940

101 Lampronti I, Khan, M.T.H., Borgatti M, Bianchi N, Gambari R. Inhibitory Effects of MedicinalPlant Extracts on Interactions between Transcription Factors and Target DNA Sequences.Evidence-based Complementary and Alternative Medicine. 2008 Sep;5(3):303-312 [UK].

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100 Casañola-Martín, G. M., Marrero-Ponce, Y., Khan, M.T.H., Torrens, F., Rescigno, A. Atom- andBond-Based 2D TOMOCOMD-CARDD Approach and the Ligand-Based Virtual Screening forDrug Discovery of New Tyrosinase Inhibitors. Journal of Biomolecular Screening, 2008 Nov 13:1014-1024. [USA]

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99 Rahman, T., Rahman, K. A., Rajia, R., Alamgir, M., Khan, M.T.H., Choudhuri, M.S.K.Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models.Oriental Pharmacy and Experimental Medicine, 2008, 8(2), 130-134. [Korea]

98 Khan, M.T.H., Yimingjiang, W., Sylte, I. Molecular Recognition of Thermolysin andHomologous Zn-Metalloproteinases. Minerva Biotechnologica, 2007, 19(4):139-150 (Invitedreview) [Italy]

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97 Ullah F, Hussain H, Hussain J, Bukhari IA, Khan, M.T.H., Choudhary MI, Gilani AH, AhmadVU. Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities ofmethanol extracts of Rhododendron collettianum. Phytotherapy Research. 2007 Nov;21(11):1076-81 [UK].

1.746

96 Previati M, Corbacella E, Astolfi L, Catozzi M, Khan, M.T.H., Lampronti I, Gambari R, CapitaniS, Martini A. Ethanolic extract from Hemidesmus indicus (Linn) displays otoprotectant activities

1.753

10

on organotypic cultures without interfering on gentamicin uptake. Journal of ChemicalNeuroanatomy. 2007 Nov;34(3-4):128-33. [The Netherlands]

95 Devkota KP, Khan, M.T.H., Ranjit R, Lannang AM, Samreen, Choudhary MI. Tyrosinaseinhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. NaturalProduct Research. 2007 Apr;21(4):321-7. [United Kingdom]

0.810

94 Casanola-Martin, G.M., Marrero-Ponce, Y., Khan, M.T.H., Ather, A., Sultan, S., Torrens, F.,Rotondo, R. TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors:evaluation of different classification model combinations using bond-based linear indices.Bioorganic and Medicinal Chemistry 2007 Feb 1;15(3):1483-503. [The Netherlands]

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93 G. Nosáová, J. Mokry, A. Ather, Khan, M.T.H. Antitussive Activity of the Ethanolic Extract ofPaederia foetida (Rubiaceae family) in Non-Anaesthetized Cats. Acta Veterinaria Brno 2007,76: 27–33. [Czech Republic]

0.403

92 Casanola-Martin, G.M., Marrero-Ponce, Y., Khan, M.T.H., Ather, A., Khan, K.M., Torrens, F.,Rotondo, R. Dragon method for finding novel tyrosinase inhibitors: Biosilico identification andexperimental in vitro assays. European Journal of Medicinal Chemistry 2007 Feb 23; [Germany]

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91 Marrero-Ponce, Y., Khan, M.T.H., Casanola-Martin, G.M., Ather, A., Sultankhodzhaev, M. N.,Torrens, F., Rotondo, R. Prediction of Tyrosinase Inhibition Activity Using Atom-Based BilinearIndices. ChemMedChem. 2007 Apr 16;2(4):449-478. [Germany]

3.232

90 Marrero-Ponce, Y., Khan, M.T.H., Casañola-Martín, G.M., Arjumand Ather, Sultankhodzhaev,M.N., García-Domenech, R., Torrens, F., Rotondo, R. Bond-based 2D TOMOCOMD-CARDDapproach for drug discovery: aiding decision-making in ‘in silico’ selection of new lead tyrosinaseinhibitors. Journal of Computer-Aided Molecular Design (2007) 21:167–188. [Germany]

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89 Khan, M.T.H. and Sylte, S. Predictive QSAR Modeling for the Successful Predictions of theADMET Properties of Candidate Drug Molecules. Current Drug Discovery Technologies, 4(3),2007, 141-149. [The Netherlands]

88 Casañola-Martín G.M., Marrero-Ponce Y, Khan, M.T.H., Ather A, Sultan S., Torrens F.,Rotondo, R. TOMOCOMD-CARDD Descriptors-Based Virtual Screening of TyrosinaseInhibitors. Evaluation of Different Classification Model Combinations Using Bond-Based LinearIndices. Bioorganic and Medicinal Chemistry 2007 Feb 1;15(3):1483-503 [The Netherlands]

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87 Khan KM, Maharvi GM, Khan, M.T.H., Jabbar Shaikh A, Perveen S, Begum S, Choudhary MI.Tetraketones: a new class of tyrosinase inhibitors. Bioorganic and Medicinal Chemistry 2006 Jan15;14(2):344-51. [The Netherlands]

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86 Khan, M.T.H., Khan SB, Ather A. Tyrosinase inhibitory cycloartane type triterpenoids from themethanol extract of the whole plant of Amberboa ramosa Jafri and their structure-activityrelationship. Bioorganic and Medicinal Chemistry 2006 Feb 15;14(4):938-43. [The Netherlands]

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85 Casañola-Martín GM, Khan, M.T.H., Marrero-Ponce Y, Ather A, Sultankhodzhaev MN, TorrensF. New tyrosinase inhibitors selected by atomic linear indices-based classification models.Bioorganic & Medicinal Chemistry Letters 2006 Jan 15;16(2):324-30. [The Netherlands]

2.650

84 Afroz S, Alamgir M, Khan MTH, Jabbar S, Nahar N, Choudhuri MS. Antidiarrhoeal activity ofthe ethanol extract of Paederia foetida Linn. (Rubiaceae). Journal of Ethnopharmacology 2006Apr 21;105(1-2):125-30. [The Netherlands]

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83 Azhar-Ul-Haq, Malik A, Khan, M.T.H., Anwar-Ul-Haq, Khan SB, Ahmad A, Choudhary MI.Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. andtheir structure-activity relationship. Phytomedicine. 2006 Mar;13(4):255-60. [The Netherlands]

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82 Khan, M.T.H., Choudhary MI, Atta-ur-Rahman, Mamedova RP, Agzamova MA,Sultankhodzhaev MN, Isaev MI. Tyrosinase inhibition studies of cycloartane and cucurbitaneglycosides and their structure-activity relationships. Bioorganic and Medicinal Chemistry 2006Sep 1;14(17):6085-8. [The Netherlands]

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81 Khan KM, Mughal UR, Khan, M.T.H., Zia-Ullah, Perveen S, Choudhary MI. Oxazolones: newtyrosinase inhibitors; synthesis and their structure-activity relationships. Bioorganic andMedicinal Chemistry 2006; 14(17):6027-33 [The Netherlands]

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80 Afroz S, Alamgir M, Khan, M.T.H. , Jabbar S, Nahar N, Choudhuri MS. Antidiarrhoeal activityof the ethanol extract of Paederia foetida Linn. (Rubiaceae). Journal of Ethnopharmacology.2006;105(1-2):125-30. [The Netherlands]

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79 Casanola-Martin GM, Khan, M.T.H. , Marrero-Ponce Y, Ather A, Sultankhodzhaev MN, TorrensF. New tyrosinase inhibitors selected by atomic linear indices-based classification models.Bioorganic & Medicinal Chemistry Letters. 2006;16(2):324-30

2.650

78 Khan KM, Saify ZS, Khan, M.T.H. , Butt N, Maharvi GM, Perveen S, Ambreen N, ChoudharyMI, Atta-Ur-Rahman, Supuran CT. Tyrosinase inhibition: conformational analysis based studieson molecular dynamics calculations of bipiperidine based inhibitors. Journal of Enzyme Inhibition

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and Medicinal Chemistry. 2005; 20(4):401-7. [The Netherlands]76 Sabudak T, Khan, M.T.H., Choudhary MI, Oksuz S. Potent tyrosinase inhibitors from trifolium

balansae. Natural Product Research, 2006 [United Kingdom]0.810

75 Rahman M, Choudhuri MSK, Khan, M.T.H., Jabbar S, Alamgir M. Neuropharmacological studyof hot water extract of the seeds of Vernonia anthelmintica Kuntze. Oriental Pharmacy andExperimental Medicine, 2006, 6(1): 34-38 [Korea].

74 Khan, M.T.H., Ather A. Molecules from nature: modulating the expression of estrogen receptorgenes in breast cancer cells. Current Bioactive Compounds, 2002, 2, 0-00 (Invited Review) [TheNetherlands]

73 Khan, M.T.H., Ather A, Thompson KD, Gambari R. Extracts and molecules from medicinalplants against herpes simplex viruses. Antiviral Research 2005, 67:107-119 [Invited Review, 2005TOP-Hot paper of Antiviral Research] [USA]

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72 Thompson K, Ather A, Khan, M.T.H. Antiviral activities of three Bangladeshi medicinal plantextracts against herpes simplex virus. Minerva Biotechnologica, 2005, 17(3), 193-199 [Italy]

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71 Nosalova G, Sutovska M, Mokry J, Kardosova A, Capek P, Khan MTH. Efficacy of herbalsubstances according to cough reflex. Minerva Biotechnologica, 2005, 17(3), 141-152 [Italy]

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70 Khan, M.T.H., Ather A, Gambari R. The role of metabolic engineering for the production ofsecondary metabolites of plants. Minerva Biotechnologica, 2005, 17(3), 127-131

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69 Khan, M.T.H., Gambari R. Preface. Minerva Biotechnologica, 2005, 17(3), 105 0.26868 Lampronti I, Bianchi N, Borgatti M, Fabbri M, Vizziello L, Khan, M.T.H., Ather A, Brezena D,

Tahir MM, Gambari R. Effects of Vanadium Complexes on Cell Growth of Human LeukemiaCells and on Protein-DNA Interactions. Oncology Report, 2005 [USA]

67 Costa-Lotufo LV, Khan, M.T.H., Ather A, Wilke DV, Jimenez PC, Pessoa C, de Moraes MEA,de Moraes MO. Studies of the anticancer potentials of plants used in Bangladeshi traditionalmedicine. Journal of Ethnopharmacology

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66 Khan, M.T.H., Choudhary MI, Khan KM, Rani M, Rahman AU. Structure-Activity Relationshipsof Tyrosinase Inhibitory Combinatorial Library of 2,5-Disubstituted-1,3,4-Oxadiazole Analogues.Bioorganic and Medicinal Chemistry, 2005, 13(10):3385-95

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65 Khan KM, Maharvi GM, Khan, M.T.H., Choudhary MI, Rahman AU. Synthesis and TyrosinaseInhibitory Studies of Vigra-II Series of compounds. Helvetica Chimica Acta, 2005 [Switzerland]

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64 Khan SB, Khan, M.T.H., Haq AU, Afza N, Malik A, Choudhary MI, Ahmed Z. Long ChainTyrosinase Inhibitory Esters from the Whole Plant of the Amberboa ramose Jafri. Chemical &Pharmaceutical Bulletin, 2005, 53(1): 86-89 [Japan].

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63 Choudhary MI, Sultan S, Khan, M.T.H., Rahman AU. Microbial Transformation of 17-Ethynyland 17-Ethyl steroids: Tyrosinase Inhibition of 17-Ethynyl and 17-Ethyl Analogues. Steroid,2005 Nov;70(12):798-802. [United Kingdom]

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62 Lambertini E, Lampronti I, Penolazzi L, Khan, M.T.H., Ather A, Giorgi G, Gambari R, Piva R.Expression of Estrogen Receptor Receptor Gene in Breast Cancer Cells Treated withTranscription factor Decoy is Modulated by Bangladeshi Plant Extracts. Oncology Research andAnticancer Drug Design, 2005;15(2):69-79 [U.S.A.]

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61 Lampronti I, Khan, M.T.H., Bianchi N, Ather A, Borgatti M, Vizziello L, Fabbri E, Gambari R.Bangladeshi Medicinal Plant Extracts Inhibiting Molecular Interactions between NF-kappa andTarget DNA Sequences. Medicinal Chemistry, 2005; 1(4):327-33 [The Netherlands].

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60 Guerrero RO, Khan, M.T.H., Casanas B, Morales. Specific bioassays with selected plants ofBangladesh. Rev. Cubana Plant Med. 2004; 9(2):1-7. [Cuba]

59 Khan, M.T.H., Ather A, Choudhary MI, Rahman AU. Modeling of the Mushroom Tyrosinaseand Its Molecular Dynamic (MD) Simulations Experiments in Room and Elevated Temperaturesand the Docking Interactions with Nucleotides. Minerva Biotechnologica [Italy]

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58 Şabudak T, Khan, M.T.H., Choudhary MI, Oksuz S. Potent Tyrosinase Inhibitors from TrifoliumBalansae. Natural Product Research, 2004 [United Kingdom]

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57 Shaheen F, Ahmad M, Khan, M.T.H., Jalil S, Ezaz A, Sultankhodzhaev MN, Arfan M,Choudhary MI, Rahman AU. Alkaloids of Aconitum leave Royle and its Anti-inflammatory,Antioxidant and Tyrosinase Inhibition Activities. Phytochemistry, 2004 [United Kingdom]

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56 Thompson KD, Ather A, Khan, M.T.H. Antiviral Activities of Three Bangladeshi MedicinalPlant Extracts Against Herpes Simplex Viruses. Minerva Biotechnology, 2004 [Italy]

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55 Lampronti I., Khan, M.T.H., Bianchi N., Borgatti M., Gambari R. Inhibitory effects of medicinalplant extracts on interactions between DNA and transcription factors involved in inflammation.Minerva Biotechnology, 2004;16:93-9 [Italy]

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54 Karbassi F, Saboury AA, Khan MTH, Choudhary MI, Saifi ZS. Mushroom Tyrosinase Inhibitionby Two Potent Uncompetitive Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry,August, 2004; 19:349-353 [United Kingdom]

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53 Khan, M.T.H., Sultankhodzhaev MN, Choudhary MI, Rahman AU. Tyrosinase Inhibition Studiesof Diterpenoid Alkaloids and Their Derivatives. Structure-Activity Relationships. NaturalProduct Research, 2004 [United Kingdom]

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52 Khan, M.T.H., Rahman AU, Choudhary MI. In-silico Analysis of the Gene and ProteinSequences of the Enzyme Mushroom Tyrosinase (Polyphenol oxidase, PPO). Pakistan Journal ofBiotechnology. 2004; 1(1), 53-66 [Pakistan]

51 Ahmed VU, Ullah F, Hussain J, Farooq U, Khan, M.T.H., Choudhary MI. Tyrosinase Inhibitorsfrom Rhododenron colletinum and their Structure-Activity Relationship (SAR) Studies. Chemical& Pharmaceutical Bulletin 2004, 52(12), 1458-1461 [Japan].

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50 Lambertini E, Piva R, Khan, M.T.H., Lampronti I, Bianchi N, Borgatti M, Gambari, R. Effects ofextracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer celllines and expression of estrogen receptor alpha gene. International Journal of Oncology, 2004;24(2):419-23. [Greece]

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49 Datta BK, Datta SK, Chowdhury MM, Khan, M.T.H., Kundu JK, Rashid MA, Nahar L, SarkerSD. Analgesic, anti-inflammatory and CNS depressant activities of sesquiterpenes and a flavonoidglycoside from Polygonum viscosum. Die Pharmazie, March, 2004 [Germany]

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48 Khan KM, Maharvi GM, Khan, M.T.H., Choudhary MI, Rahman AU. A Facile and ImprovedSynthesis of Sildenafil (Viagra) Analogues through Solid Support Microwave IrradiationPossessing Tyrosinase Inhibitory Potential, their Conformational Analysis and MolecularDynamics Simulation Studies. Molecular Diversity, June, 2004 [Switzerland]

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47 Alamgir M, Khan, M.T.H., Jabbar S, Shariar M, Choudhuri MSK. Bioactivity study of theaqueous extract of Ocimum sanctum Linn. (Labiateae). July-September, 2003, Vol. XLVI (3),Hamdard Medicus, 34-37 [Pakistan]

46 Jabbar S, Khan, M.T.H., Choudhuri MSK, Sil BK. Bioactivity study of the individual ingredientsof the Dashamularishta. Pakistan Journal of Pharmaceutical Sciences 2004, 17(1): 9-17[Pakistan]

0.588

45 Choudhary MI, Sultan S, Khan, M.T.H., Yasin A, Shaheen F, Rahman AU. Biotransformation of(+) Androst-4-ene-3, 17-dione. 2004 Dec;18(6):529-35 Natural Product Report. [UnitedKingdom]

44 Choudhary MI, Musharraf MG, Khan, M.T.H., Shaheen F, Rahman AU. Biotransformation ofIsolongifolen-4-one. Helvetica Chimica Acta, 2004, 86: 3450-3460 [Switzerland]

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43 Khan KM, Maharvi GM, Abbaskhan A, Hayat S, Khan, M.T.H., Makhmoor T, Choudhary MI,Shaheen F, Rahman AU. Three tyrosinase inhibitors and antioxidant compounds from Salsolafoetida. Helvitica Chimica Acta, 2003, 86: 457-464 [Switzerland]

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42 Nosalova G, Khan, M.T.H., Morky J. Antitusive Activities of the fruit extract of Emblicaoffinalis Gaertn. Phytomedicine, 2003, 10: 583-589 [Germany]

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41 Lampronti I, Martello D, Bianchi N, Khan, M.T.H., Gambari R. In vitro Antiproliferative effectson human tumor cell line of extracts from the Bangladeshi medicinal plant Aegle marmelosCorrea. Phytomedicine, 10: 300-308, 2003 [Germany]

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40 Shaphiullah M, Bachar SC, Kundu JK, Begum F, Uddin MA, Roy SC, Khan, M.T.H.Antidiarrheal activity of the methanol extract of Ludwigia hyssopifolia Linn. Pakistan Journal ofPharmaceutical Sciences 2003; 16(1):7-11. [Pakistan]

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39 Jabbar S, Khan, M.T.H., Choudhuri MSK. Acute and chronic metabolic study of Buteamonosperma Kuntze. October-December, 2003, Hamdard Medicus. [Pakistan]

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38 Jabbar S, Khan MTH, Choudhuri MSK. Study of the aqueous extract of the whole plant ofSolanum xanthocarpum Burm. F. on the GI tract of Laboratory animals. April-June, vol. XLVI(2), 2003, 85-90, Hamdard Medicus. [Pakistan]

37 Khan, M.T.H. Mycosis. January-March, 2003, Hamdard Medicus. [Pakistan]

36 Rahman T, Khan, M.T.H., Choudhuri MSK. Pharmacological and NeuropharmacologicalActivity of Picrorrhiza kurroa in Mice. Bangladesh Journal of Life Sciences, 2003, 15(2): 47-51[Bangladesh]

35 Alamgir M, Choudhuri MSK, Jabbar S, Rajia S, Khan MTH. Effects of Ocimum sanctum Linn.(Labiateae) on the central nervous system of laboratory mice. International Journal of OrientalPharmacy and Experimental Medicine, 2002, 2(2), 101-105. [Korea]

34 Khan, M.T.H., Lampronti I, Martello D, Bianchi N, Jabbar S, Choudhuri MSK, Datta BK,Gambari R. Identification of pyrogallol as an antiproliferative compound present in extracts fromthe medicinal plant Emblica offinalis: Effects on in vitro cell growth of human tumor cell lines.International Journal of Oncology, 2002, 21: 187-192 [Greece]

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33 Gafur MA, Ahmed K, Roy BK, Khan MTH, Jabbar S, Chowdhury MH, Choudhuri MSK,Alamgir M. Effect of Nigella sativa Linn., Semecarpus anacardium L. and Butea monospermaKuntze on Isolated Rat Uterus. 2002, Journal of Science and Industrial Research. [Bangladesh]

32 Gafur MA, Ahmed K, Roy BK, Khan MTH, Jabbar S, Choudhuri MSK. The Effect of the CrudeExtracts of Nigella sativa Linn., Semecarpus anacardium L. and Butea monosperma Kuntze onGuinea-pig Ileums and Intact GIT of Rats. 2002, Journal of Science and Industrial Research.[Bangladesh]

31 Akhtar Y, Choudhuri MSK, Sattar M, Alamgir M, Jabbar S, Khan MTH. Asokarishta - studies onmetabolism and gastrointestinl motility. Hamdard Medicus, vol. XLV (3), July-September, 2002.[Pakistan]

30 Khan MTH, Jabbar S, Choudhuri MSK. Gastrointestinal and Diuretic effects of the aqueousextracts of the stem bark of Aegle marmelos Correa. Hamdard Medicus, January-February, 2002.[Pakistan]

29 Akhtar Y, Jabbar S, Hannan JMA, Alamgir M, Choudhuri MSK, Khan MTH.Neuropharmacological study of Asokarishta - a classical Ayurvedic formulation used for thetreatment of Dysmenorrhoea. International Journal of Oriental Pharmacy and ExperimentalMedicine, 2001, 1(1), 18-26 [Korea].

28 Neelutpol S, Choudhuri MSK, Khan MTH, Jabbar S. Biopharmaceutic and Skin Toxicity Studiesof Semecarpus anacardium Linn. Hamdard Medicus, 2001 [Pakistan].

27 Chakma TK, Rahman T, Khan MTH, Jabbar S, Choudhuri MSK. Screening of Some medicinalplants for their effects on the Gastrointestinal motility of the Laboratory animals. July-September,2001, Hamdard Medicus [Pakistan].

26 Khan, M.T.H., Jabbar S. Antidiabetic Plants of Bangladesh in the Perspective of ClinicalResearch. Hamdard Medicus, 2001, XLIX (4), 51-56 [Pakistan].

25 Jabbar S, Khan MTH, Choudhuri MSK. Acute and Chronic Metabolic Studies of Semecarpusanacardium Linn. on Experimental Animals. Hamdard Medicus, 2001 [Pakistan].

24 Jabbar S, Khan MTH, Choudhuri MSK. Acute metabolic study of the individual ingredients ofthe Dashamulakwath. Hamdard Medicus, 2001 [Pakistan].

23 Chakma TK, Khan MTH, Alamgir M, Jabbar S, Choudhuri MSK, Gafur MA, Ahmed K. Effectsof Some Medicinal Plants and Plant Parts Used in Ayurvedic System of Medicine on IsolatedGuinea-pig Ileum preparations. In press, Hamdard Medicus, Vol. XLIV (2) April-June, 2001[Pakistan].

22 Khan, M.T.H., Matsui T, Matsumoto Y, Jabbar S. In vitro Angiotensin Converting Enzyme(ACE) inhibitory effects of some Bangladeshi Plant extracts. Die Pharmazie, 2001, 56(11), 902-903 [Germany]

0.812

21 Jabbar S, Khan MTH, Choudhuri MSK. The effects of the aqueous extracts of the Desmodiumgangeticum DC. (Leguminosae) on the central nervous system. Die Pharmazie, 2001, 56(6), 506-508 [Germany]

0.812

20 Khan MTH. Traditional Medicines and Plant Drugs in Hepatic Diseases, Hamdard Medicus, Vol.XLIV (2) April - June issue of year 2001 [Pakistan].

14

19 Khan MTH, Jabbar S, Choudhuri MSK, Gafur MA. Effects of the Crude extracts of Nigellasativa Linn. on Isolated Guinea-pig Tracheal Chain Preparations, Hamdard Medicus, October-December, 2000 (vol. 4) [Pakistan].

18 Shohel Rana, Chowdhury MH, Khan MTH. The Quality of Some Commonly Used DentifricePowders: A Comparative Study. Bangladesh Journal of Integrated Medicine, July, 2000[Bangladesh].

17 Jabbar S, Khan MTH, Choudhuri MSK. Acute metabolic study of the aqueous extract of thewhole plant of Solanum xanthocarpum Burm. f. Bangladesh Journal of Integrated Medicine, July,2000 [Bangladesh].

16 Neelutpol S, Choudhuri MSK, Khan MTH, Jabbar S. Metabolic study of Patrangasav - Aclassical Ayurvedic preparation. Bangladesh Journal of Integrated Medicine, July, 2000[Bangladesh].

15 Khan, M.T.H., Jabbar S. Diabetes mellitus: The treatment and complications. Hamdard Medicus,July-September, 2000, (Vol. XLIII, No. 3) [Pakistan].

14 Shahriar M, Choudhuri MSK, Sattar M, Khan MTH, Gafur MA. Pharmacological activities ofSymplicos recemosa Roxb. Hamdard Medicus, April-June, Vol. XLIII (2), 8-18 [Pakistan].

13 Khan MTH, Jabbar S, Choudhuri MSK, Gafur MA. Analgesic and anti-inflammatory activity ofthe aqueous extracts of the seeds of Nigella sativa Linn. On rodents Hamdard Medicus, 1999,XLII (4), 22-29 (September-December), [Pakistan].

12 Khan MTH, Jabbar S, Choudhuri MSK, Gafur MA, Ahmed K. Antimotility and antidiarrhoealeffects of Nigella sativa Linn., as an antagonist to 5-hydroxytryptamine (Serotonin). 2000, 37(9),September, 426-432, Indian Drugs [India].

11 Shohel Rana, Chowdhury MH, Khan MTH. Determination of Ciprofloxacin in it’s tablet formsby means of Fluoride estimation. Hamdard Medicus, April-June, 2000, Vol. XLIII, No. 2, 97-98[Pakistan]

10 Khan MTH, Jabbar S. Antimicrobial Activity of Nigella sativa Linn. and Semecarpusanacardium Linn. Against Escherichia coli in vitro, Hamdard Medicus, 1999, XLII (2) (April-June), 16-18 [Pakistan].

9 Jabbar S, Khan MTH, Choudhuri MSK, Gafur MA, Ahmed K. Effect of Semecarpusanacardium Linn. on acute experimental diarrhoea, Hamdard Medicus, 1999, XLII (1) (January-March), 48-53 [Pakistan].

8 Jabbar S, Khan MTH, Choudhuri MSK, Chowdhury MH, Gafur MA. Analgesic and anti-inflammatory activity of Semecarpus anacardium Linn., Hamdard Medicus, 1998, XLI (4),October-December, 73-80 [Pakistan].

7 Khan MTH, Jabbar S, Choudhuri MSK. Clinical Trials on Male Normotensive Subjects andFemale UTI Patients Treated with the Seeds of Nigella sativa Linn., Hamdard Medicus, 1998,XLI (3), July-September, 56-60 [Pakistan].

6 Khan MTH, Choudhuri MSK. Acute and Chronic Metabolic Study of Nigella sativa Linn.,Hamdard Medicus, 1998, XLI (1), January-March, 44-51 [Pakistan]

5 Khan MTH, Jabbar S, Choudhuri MSK, Chowdhury MH, Gafur MA, Ahmed K, Roy BK.Analgesic Property of Some Medicinal Plant Parts Used In Various Ayurvedic Preparations,USTA, 1997, 78-82 [Bangladesh]

4 Khan MTH, Jabbar S, Choudhuri MSK, Kawser H, Gafur MA. Comparative Study of theAnalgesic Activity of Some Medicinal Plant Parts with Some Other Standard Analgesic Agents,Tablet-Caplet, January, 1997, 20-23 [Bangladesh]

3 Khan MTH, Jabbar S, Choudhuri MSK, Gafur MA. Anti-inflammatory Evaluation of Nigellasativa Linn. on Rats Using Plethysmographic Method, Tablet-Caplet, January, 1997, 5-6[Bangladesh]

2 Khan MTH. Drug in Focus, Seminar Proceeding on Aspirin, September, 1995, 23-26[Bangladesh]

1 Khan MTH. Peptic Ulcer and Its’ Management, Tablet-Caplet, July, 1994, 13-15. [Bangladesh]

(B) Patent:[1] Rahman, A.U.; Choudhary, M.I.; Shah, S.A.A.; Khan, M.T.H. New Tyrosinase Enzyme Inhibitors from Fungal

Hydroxylation of Tibolone. Patent No. US 2009/0136434 A1. Dated 05-28-2009. [USA].

M.T.H. Khan Page 15

(C) Authored Book:[2] Khan, M.T.H. Thermolysin – A Prototype Zn-Metalloproteinase: Bioinformatics, Structural Biology and

Discovery of Inhibitors. 2009, University of Tromsø, Lundblad Media AS, Tromsø (ISBN 978-82-7589-241-4)[Norway]

(D) Books Edited:[3] Khan MTH and Ather A. Lead Molecules from Natural Products: Discovery and New Trends, Elsevier Science,

June 26, 2006 [the Netherlands].[4] Khan MTH. Bioactive Heterocycles III, series of Topics in Heterocyclic Chemistry, Springer Varleg, Germany,

May, 2007 [Germany].[5] Khan MTH. Bioactive Heterocycles IV, series of Topics in Heterocyclic Chemistry, Springer Varleg, Germany,

May, 2007 [Germany].[6] Khan MTH. Annual Reviews on Phytopharmaceuticals, Bentham Science Pub, 2010 (E-book) [the

Netherlands].[7] Khan MTH. Recent Advances in QSAR, Bentham Science Pub, 2010 (E-book) [the Netherlands].

(E) Chapters in Books:[8] Khan MTH. “Chakma Talika Cikitsa – The Therapeutic System of the Chakma Tribe of Chittagong Hill Tract of

Bangladesh” in “The Handbook of Ethnotherapies” Edited by, Gottschalk-Batschkus, C.E. and Green, J.C.,published from Institute for Ethnomedicine, Munich, October, 2002, pp. 373-386 [in both English and Germanlanguages, Germany] [http://www.institut-ethnomed.de/handbuch.html].

[9] Khan MTH, Ather A. Plants Used by the Chakma Talika Cikitsa in Bangladesh. Published by Institute forEthnomedicine, Munich, October, 2005, 469-482 [in both English and German languages, Germany][http://www.institut-ethnomed.de/].

[10] Khan MTH and Ather A. Preface. Lead Molecules from Natural Products: Discovery and New Trends, pp. XIII-XV, Eds. Khan MTH and Ather A, Elsevier Science, June 26, 2006 [the Netherlands].

[11] Mischiati C, Sereni A, Khan MTH, Lampronti I, Gambari R. Effects of plant extracts on gene expressionprofiling: from macrorrays to microarray technology. Lead Molecules from Natural Products: Discovery and NewTrends, Chapter 2, pp. 21-34, Eds. Khan MTH and Ather A, Elsevier Science, June 26, 2006 [the Netherlands].

[12] Lampronti I, Khan MTH, Bianchi N, Feriotto G, Mischiati C, Borgatti M and Gambari R. Effects of medicinalplant extracts on molecular interactions between DNA and transcription factors. Lead Molecules from NaturalProducts: Discovery and New Trends, Chapter 3, pp. 35-44, Eds. Khan MTH and Ather A, Elsevier Science,June 26, 2006 [the Netherlands].

[13] Lampronti I, Khan MTH, Bianchi N, Lambertini E, Piva R, Borgatti M, Gambari R. Plants with antitumorproperties: from biologically active molecules to drugs. Lead Molecules from Natural Products: Discovery andNew Trends, Chapter 3, pp. 45-64, Eds. Khan MTH and Ather A, Elsevier Science, June 26, 2006 [theNetherlands].

[14] Khan MTH and Ather A. Metabolomics – systematic studies of the metabolic profiling. Lead Molecules fromNatural Products: Discovery and New Trends, Chapter 22, pp. 423-422, Eds. Khan MTH and Ather A, ElsevierScience, June 26, 2006 [the Netherlands].

[15] Khan MTH, Ather A. Potentials of Phenolic Molecules from Natural Sources and their Derivatives as Anti-HIVAgents. Invited as chapter (no. 12) in Biotechnology Annual Review, Vol. 13, Ed. El-Gewely, M. R., ElsevierScience, 2007 [the Netherlands].

[16] Khan MTH. Recent advances on the sugar-derived heterocycles and there precursors as Inhibitors againstGlycogen Phosphorylases (GP). In Carbohydrates in Heterocyclic Chemistry, vol. Ed. El-Ashry, in series “Topicsin Heterocyclic Chemistry” Springer-Varlag GmbH, March, 2007 [Germany].

[17] Khan MTH, Sylte, I. Structural Bioinformatics in the Discovery of Novel Drugs. Accepted as full manuscript inthe Proceeding 9th Eurasia Conference on Chemical Sciences, Antalya, Turkey, going to publish from Springer-Varlag, Sep., 2007 [Germany].

[18] Khan MTH. Tyrosinase Inhibitors of Heterocyclic Origin. Bioactive Heterocycles III, series of Topics inHeterocyclic Chemistry, Springer Varleg, Germany, May, 2007 [Germany].

[19] Khan MTH, Ather A. Microbial Transformation of Nitorgenous Compounds – An Update. BioactiveHeterocycles III, series of Topics in Heterocyclic Chemistry, Springer Varleg, Germany, May, 2007 [Germany].

[20] Khan MTH, Ahmed M, Ather A. Bioactive Diterpenoid Alkaloids from Aconitum Species. BioactiveHeterocycles III, series of Topics in Heterocyclic Chemistry, Springer Varleg, Germany, May, 2007 [Germany].

[21] Khan MTH. Molecular Modelling of Alkaloidal Ligands – A Critical Review. Bioactive Heterocycles IV, seriesof Topics in Heterocyclic Chemistry, Springer Varleg, Germany, May, 2007 [Germany].

[22] Khan MTH. Quinoline Analogues in Cancer. Bioactive Heterocycles IV, series of Topics in HeterocyclicChemistry, Springer Varleg, Germany, May, 2007 [Germany].

16

[23] Khan MTH. Anticancer Marine Alkaloids. Bioactive Heterocycles IV, series of Topics in HeterocyclicChemistry, Springer Varleg, Germany, May, 2007 [Germany].

[24] Chattopadhyay D, Khan MTH. Phenolics and Polyphenols: Source of Complimentary Antivirals, in RecentAdvances in Phytopharmaceuticals, Elsevier Science, 2007 [the Netherlands].

[25] Khan MTH, Ather A. Analytical Techniques Used in Metabolomics, in Recent Advances inPhytopharmaceuticals, Elsevier Science, 2007 [the Netherlands].

[26] Khan MTH, Gambari, R. Medicinal Plants as Natural Sources of Anti-HIV Drugs, in Recent Advances inPhytopharmaceuticals, Elsevier Science, 2007 [the Netherlands].

[27] Khan, M.T.H. and Sylte, I. Structural Bioinformatics in the Discovery of Novel Drugs. Invited Chapter,Innovations in Chemical Biology, Ed. Bilge Sener, Springer, 2008 (in press). [Germany].

[28] Chattopadhyay, D. and Khan, M.T.H. Ethnomedicines and ethnomedicinal phytophores against Herpesviruses.Biotechnol Annu Rev. (Invited review) 2008, 14:297-348 [The Netherlands]

[29] Khan, M.T.H. Advances in ADMET Predictions and Modelling: Rapid Drug Discovery Efforts In 21 st Centuries.Frontiers in Drug Design & Discovery, 2009, 4, 333-350 (Invited review) [The Netherlands]

[30] Khan, M.T.H. Traditional medicines as the source of immuno-modulators and -stimulators and their safetyissues. In Press “Current Advances in Ethnomedicinal Plants” (Eds. Rai, M. K. & Acharya, D.), ScientificPublisher. [USA]

[31] Umamaheswari, M., Chattopadhyay, D., Chatterjee, T.K., Bag, P., Sen, D., Khan, M.T.H. Antioxidant Activitiesof Phytoconstituents of Selected Medicinal Plants with their Structure Activity Relationship. In press AnnualReviews on Phytopharmaceuticals, Bentham Science Publisher, 2010 [The Netherlands].

[32] Casañola-Martin, G.M., Le-Thi-Thu, H., Marrero-Ponce, Y., Khan, M.T.H., Torrens, F., Rescigno, A., Abad, C.QSAR-based CMs and TOMOCOMD-CARD Approach for the Discovery of New Tyrosinase Inhibitors. In pressRecent Trends on QSAR in the Pharmaceutical Perception, Bentham Science Publisher, 2010 [The Netherlands].

[33] Khan, M.T.H. Natural products as potential resources for antifungal substances - A critical survey. in SoilScience, Ed. Mahandra Rai, Springer (Invited chapter) [Germany].

(F) Submitted for publications or manuscripts:[34] Okada, T., Murakawa, T., Khan, M.T.H., Komers, K., Kurita, K. Ab initio fragment molecularorbital calculations on specific interactions between acetylcholinesterase and its carbamate inhibitors.Submitted to Journal of Medicinal Chemistry.

[35] Greiner-Tollersrud, L., Stensland, T. B., H. M. F. R., Evjen, G., Khan, M.T.H. and Greiner-Tollersrud, O.K.Ectonucleotide pyrophosphatase/phosphodiesterase 6 is a myelin specific alkaline lysosphingomyelinase withunusual Asn-linked glycan structures. Revision submitted to Journal of Biological Chemistry [USA].

[36] Khan, M.T.H. Mapping of putative molecular interactions of some -Sectretase (BACE1) inhibitors from naturalresources for the treatment of Alzheimer’s disease. Submitted to Journal of Biomolecular Structure &Dynamics.

[37] Casañola-Martín, G. M., Khan, M.T.H., Le-Thi-Thu, H., Marrero-Ponce, Y., García-Domenech, R., Torrens, F.,Rescigno, A., Abad, C. Retrained Classification of Tyrosinase Inhibitors and “In silico” Potency Estimation byUsing Atom-Type Linear Indices: A Powerful Tool for Speed up the Discovery of Leads. Submitted at SAR andQSAR in Environmental Research [U.K.]

[38] Khan, M.T.H., Kovářová, M., Komers, K., Čegan, A. Docking simulations of 19 new carbamates withacetylcholine esterase from electric eel. Submitted to Bioorganic and Medicinal Chemistry.

[39] Kovářová, M., Khan, M.T.H., Komers, K., Pařík, P., Čegan, A., Zatloukalová, M., Skopal, F. Nineteen newcarbamates with phenyl and substituted phenyl groups as cholinesterase inhibitors. Submitted to Journal ofEnzyme Inhibition and Medicinal Chemistry.

[40] Khan, S., Khan, M.T.H., Kardar, M.N. Some new Tyrosinase Inhibitors from the Fruits of Madhuca latifolia.Submitted for publication at Journal of Natural Products.

[41] Arfan, M., Khan, R., Shah, M.I.A., Imran, M., Khan, M.T.H. Synthesis of Thiadiazine Thione Analogs asLeishmanicidal Agents and their Structure-Activity Relationships. Submitted for publication at Bioorganic andMedicinal Chemistry [USA].

[42] Umesha, K., Sarojini, B.K., Raj, C.G.D., Bhanuprakash, V., Raghavendra, R., Khan, M.T.H. One Pot Synthesis,Characterization, Antimicrobial and Antiviral Studies on New Thiazolopyrimidine Carboxylate Derivatives.Submitted to European Journal of Medicinal Chemistry [The Netherlands].

[43] Lampronti, I., Brognara, E., Borgatti, M., Bianchi, N., Khan, M.T.H., Mancini, I., Gambari, R. Alteration ofTNF-α induced secretion of chemokines and cytokines in cystic fibrosis bronchial epithelial IB3-1 cell line treatedwith extracts from Saraca asoka. Submitted to Jour Biomedical Sci.

[44] Ahmad, M., Ahmad, W., Khan, M.A., Alam, S., Nisar, M., Zeeshan, M., Ahmad, H., Khan, M.T.H., Shaheen, F.Pharmacologically active new norditerpenoid alkaloids from the aerial parts of Aconitum laeve Royle. and theirstructure-activity relationships. Submitted to European Journal of Medicinal Chemistry [The Netherlands].

M.T.H. Khan Page 17

[45] Khan, M.T.H., Orhan, I., Şener, B., Sylte, I. Competitive Thermolysin Inhibitory Flavonoids: High ThroughputScreening, Structure-Activity Relationships and Docking Studies. Submitted for publication at Bioorganic andMedicinal Chemistry [USA].

[46] Khan, M.T.H., Devkota, K.P., Lenta, B.N., Sewald, N., Sylte, I. Novel Thermolysin Inhibitory SteroidalAlkaloids from Sarcococca hookeriana and their Putative Molecular Interactions using Docking Studies.Manuscript.

[47] Khan, M.T.H., Vinogradova, V.I., Rakhimov, S.B., Sultankhodzhaev, M.N. Tyrosinase Inhibition Studies ofDerivatives of N-Benzyl Cytisine and 1-Phenyltetrahydroisoquinoline: Structure-Activity Relationships andDocking Studies. Manuscript.

[48] Marrero-Ponce, Y.; Khan, M.T.H.; Casañola-Martin, G. M.; Ather, A.; Sultankhodzhaev, M. N.; Torrens, F.;Rotondo, R. Prediction of Tyrosinase Inhibition Spectra for Chemicals Using Novel Atom-Based Bilinear Indices.ChemMedChem. Submitted for publication. [Germany]

[49] Casañola-Martin, G. M.; Marrero-Ponce, Y.; Khan, M.T.H.; Ather, A.; Khan, K.; M.; Sultankhodzhaev, M. N.;Torrens, F.; Rotondo, R. Dragon Method to Finding Novel Tyrosinase Inhibitors. Biosilico Identification andExperimental in vitro Assays. Eur. J. Med. Chem. Submitted for publication. [France]

[50] Casañola-Martin, G. M.; Khan, M.T.H.; Marrero-Ponce, Y.; Ather, A.; Sultan, S.; Torrens, F.; Rotondo, R.TOMOCOMD-CARDD Descriptors-Based Virtual Screening of Tyrosinase Inhibitors. 1. Evaluation of DifferentClassification Model Combinations Using Group, Atom-Type and Total Bilinear Indices. Bioorg. Med. Chem.Submitted for publication. [U.S.A.]

[51] Choudhary MI, Ranjit R, Khan MTH, Devkota KP, Rahman AU. Prolyl Endopeptidase and Tyrosinase Inhibitorsfrom Daphne bholua - An Important Nepalese Medicinal Plant. Submitted for publication in Natural ProductResearch [UK].

[52] Khan MTH, Ather A, Gambari R. Investigation of Nuclear Factor-kappa beta and DNA interactions usingmacromolecular docking and simulation experiments. Submitted for publication in Protein Science [USA].

[53] Khan MTH, Vinogradova VI, Rakhimov SB, Sultankhodzhaev MN, Choudhary MI, Rahman AU. TyrosinaseInhibition Studies of N-Benzyl Derivatives of Cytizine and 1-Phenyltetrahydroisoquinoline Derivatives. StructureActivity Relationships. Submitted for publication in Natural Product Report [United Kingdom].

(G) Abstracts in Seminar Proceedings:[54] “Pharmacological and Toxicological Study of the Seeds of Nigella sativa Linn” presented in SAGA, 1998.

[Bangladesh][55] “Bioactivity study of the individual ingredients of the Dashamularishta – A classical Ayurvedic preparation”

Presented in Tenth Asian Symposium on Medicinal Plant, Spices and Other Natural Products (ASOMPS X), June18-23, 2000, organized by Department of Chemistry, University of Dhaka. [Bangladesh]

[56] “Effects of the aqueous extracts of the bark of Aegle marmelos Correa. on the central nervous system of rodents”Presented in ASOMPS X, June 18-23, 2000. [Bangladesh]

[57] “Antidiabetic Plants of Bangladesh Used in the Treatment of Diabetes Mellitus” Presented in the Asian Networkof Research on Antidiabetic Plants (ANRAP) Conference, June 15-17, 2000. [Bangladesh]

[58] “Specific bioassays of some medicinal plant extracts of Bangladesh” Presented in Memorias del X Congreso ItaloLatinoamericano de Etnomedine, 2001. [Nicaragua]

[59] “Antiviral activity of four Bangladeshi medicinal plants’ extracts against Herpes Simplex Virus (HSV)” presentedin 24th International Symposium on Natural Products Chemistry, November, 2001, organized by the Institute ofChemistry, Autonomous University of Mexico. [Mexico]And, Presented in the 2nd International and 12th National Chemistry Conference, February 4-6, 2002, Organized byCenter of Excellence in Analytical Chemistry, University of Sindh, Jamshoro. [Pakistan]

[60] “Identification of pyrogallol as an antiproliferative compound from Emblica officinalis” presented in “FirstBangladesh-Pakistan Binational Seminar on Natural Product Chemistry”, Organized by H.E.J Research Instituteof Chemistry, University of Karachi, Pakistan, September 24-26, 2002. [Pakistan]

[61] “Bioprospecting studies on an important Nepalese medicinal plant Paris polyphylla Sm.” presented in “1st

Bangladesh-Pakistan Binational Seminar on Natural Product Chemistry”, September 24-26, 2002. [Pakistan][62] “Microbial transformation of Tibolone and Cortexolone” presented in “1 st Bangladesh-Pakistan Binational

Seminar on Natural Product Chemistry”, September 24-26, 2002. [Pakistan][63] “Microbial transformation of 5--Androstane and establishment of structure activity relationship through enzyme

inhibition studies” presented in “1st Bangladesh-Pakistan Binational Seminar on Natural Product Chemistry”,September 24-26, 2002. [Pakistan]

[64] “Natural tyrosinase inhibitors and antioxidants” presented in “1 st Bangladesh-Pakistan Binational Seminar onNatural Product Chemistry”, September 24-26, 2002. [Pakistan]

[65] “Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plantEmblica offinalis: Effects on in vitro cell growth of human tumor cell lines” Presented as oral presentation in The

18

3rd World Congress on Medicinal and Aromatic Plants for Human Welfare (WOCMAP III), February 3-7, 2003,Chiang Mai. [Thailand]And, accepted as oral presentation in the “Second Annual Scottish Phytotherapy Research Conference”, March,2003, Glasgow. [United Kingdom]

[66] “Search for New Lead for Tyrosinase Inhibitors” presented in “3 rd International and 13th National ChemistryConference” jointly organized by Department of Chemistry and H. E. J. Research Institute of Chemistry,University of Karachi, Pakistan, in December 28-31, 2002. [Pakistan]

[67] “Gas-chromatography/Mass spectrometry (GC/MS) for the Identification of Bioactive Molecules in Extracts fromMedicinal Plants” presented at IV Congress of Mass Spectrometry in the Study of Genome and Protein, December9-12, 2002, Vitorchianos (Viterbo). [Italy]

[68] Mokry J, Nosalova G, Khan MTH. Antitussive effect of Emblica officinalis in conscious cats. Bratisl Lek. Listy,2002, 103(9): 327.

[69] “Search for New Lead Molecules for Tyrosinase Inhibitors and Study of Their Structure-Enzyme InhibitionRelationship” poster presentation at “7th International Symposium on Protein Structure Function Relationship”,organized by H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan, in January 20-23, 2003.[Pakistan]

[70] “Synthesis and Structure Activity Relationship of Tetraketones Through Tyrosinase Inhibition” posterpresentation at “7th International Symposium on Protein Structure Function Relationship”, organized by H. E. J.Research Institute of Chemistry, University of Karachi, Pakistan, in January 20-23, 2003 [Winner of the 3 rd Prize].[Pakistan]

[71] “The Bioinformatic Analysis of The Gene Sequence of Mushroom Tyrosinase” presented at “1st International andNational Symposium on Biotechnology” organized by Center for Advanced Studies in Biotechnology, Universityof Sindh, Jamshoro, Pakistan, in March 22-23, 2003. [Pakistan]

[72] “Search of Tyrosinase Inhibitors Through Structures-Enzyme Inhibition Relationship” Submitted for OralPresentation at “7th International Conference on Trends in Biochemistry and Molecular Biology” organized byInstitute of Biochemistry and Biotechnology, University of Punjab, Lahore, Pakistan, in April 2-5, 2003[Pakistan]

[73] Ahmed M, Shaheen F, Jalil S, Khan MTH, Choudhary MI, Rahman AU. “Swatinine, a new norditerpenoidalkaloid from Aconitum leave Royle, and anti-inflammatory and tyrosinase inhibition studies on diterpenoidalkaloids”, presented at 9th International Symposium on Natural Products (9th ISNPC), jointly organized byPakistan Academy of Science and International Center for Chemical Sciences, on January 10-13, 2004 [Pakistan]

[74] Iqbal S, Khan KM, Saify ZS, Khan MTH, Maharvi GM, Ullah Z, Choudhary MI, Rahman AU, Perveen S.“An Economical synthesis of Dicoumarin possessing Tyrosinase inhibitory potential”, presented at 9 th

International Symposium on Natural Products (9th ISNPC), jointly organized by Pakistan Academy of Science andInternational Center for Chemical Sciences, on January 10-13, 2004 [Pakistan]

[75] Mukhtar N, Malik A, Iqbal K, Khan MTH, Choudhary MI. “Tyrosinase inhibiting sphingolipids fromConyza canadensis”, presented at 9th International Symposium on Natural Products (9 th ISNPC), jointly organizedby Pakistan Academy of Science and International Center for Chemical Sciences, on January 10-13, 2004[Pakistan]

[76] “Swatinine, A new Norditerpenoid Alkaloid from Aconitum leave Royle andTyrosinase Inhibition Studies onDiterpenoid Alkaloids”, presented at the “4th International and 14th National Chemistry Conference”, organized bythe Chemical Society of Pakistan – Punjab Chapter, on the theme “Quality Through Innovative Chemistry”,P.C.S.I.R. Complex, Lahore, on May 16-18, 2004 [Pakistan].

[77] “Vigra and Its’ Analogues as Tyrosinase and Lipoxigenase Inhibitors”, presented at the “4 th International and14th National Chemistry Conference”, organized by the Chemical Society of Pakistan – Punjab Chapter, Lahore,on May 16-18, 2004 [Pakistan].

[78] “Microbial Transformation of Tibolone”, presented at the “4 th International and 14th National ChemistryConference”, organized by the Chemical Society of Pakistan – Punjab Chapter, Lahore, on May 16-18, 2004[Pakistan].

[79] “Molecular Dynamic (MD) Simulation and 3D-QSAR and QSPR Studies of Bioactive Small OrganicMolecules”, presented at the “4th International and 14th National Chemistry Conference”, organized by theChemical Society of Pakistan – Punjab Chapter, Lahore, on May 16-18, 2004 [Pakistan].

[80] “In-silico Analysis of the Gene and Protein Sequences of the Enzyme Mushroom Tyrosinase (PolyphenolOxidase, PPO)”, organized by the Chemical Society of Pakistan – Punjab Chapter, Lahore, on May 16-18, 2004[Pakistan].

[81] Mischiati C, Sereni A, Ather A, Khan MTH, Lampronti I, Gambari R. Bangladeshi Plant Extracts on GeneExpression Profiling: from Macro- to Microarray Technology. Accepted for presentation at the ISMAP, 2004[Brazil]

[82] Khan MTH, Ather A, Gambari R. “Investigation of Nuclear Factor-kappa beta and DNA interactions usingmacromolecular docking and simulation experiments”. Accepted for poster presentation at “RECOMB04”

M.T.H. Khan Page 19

organized by San Diego Supercomputer Center (SDSC), University of San Diego, San Diego, USA, in March 10,2004 [USA];The 1st Pacific-Rim International Conference on Protein Science (PRICPS 2004), organized jointly by the ProteinSociety, U.S.A., and the Protein Society of Japan, April 14-18, 2004, Yokohama [Japan];Accepted for presentation at the “15th European Symposium on Quantitative Structure-Activity Relationships &Molecular Modelling”, Istanbul, Turkey, on 05-10 September 2004 [Turkey].Presented at the “4th International and 14th National Chemistry Conference”, organized by the Chemical Society ofPakistan – Punjab Chapter, Lahore, on May 16-18, 2004 [Pakistan].Accepted for presentation at the “EMBO/FEBS Worksop on AFM Applications in Biology”, 2004 [Portugal].Submitted as full paper to ISMB 2005, Annual Meeting of ISCB, Detroit, Michigan, June 25-29, 2005 [USA]

[83] Khan MTH, Adekoya O, Gani ABSMO, Mischiati C, Ather A, Borgatti M, Sylte I, Gambari R. Canmultiscale modeling explain the unnatural interactions of HIV-1 TAR RNA with human transcription factors?Computers in Scientific Discovery III, Feb. 6-9, 2006, University of Ghent [Belgium].

[84] Khan MTH, Adekoya O, Sylte, I. Sequence analysis of the assigned members of the M4 family of thepeptidases compared to thermolysin, the prototype of the clan, BIOFORUM 2006, University of Liege, Liege[Belgium].

[85] Khan MTH, Sylte, I. Structural Bioinformatics in the Discovery of Novel Drugs. Abstract in Abstract book,9th Eurasia Conference on Chemical Sciences, Sep. 9-13, 2006, Antalya [Turkey].

[86] I. Lampronti, M. Manservigi, F. Rinaldi, Khan M.T.H., R. Argnani, R. Manservigi, R. Gambari. In vitroantiviral activity of Emblica officinalis extracts and GC/MS identified compounds. 11th World Congress onAdvances in Oncology, and 9th International Symposium on Molecular Medicine, October 12-14, 2006,Hersonissos, Crete [Greece].

[87] Devkota, K.P., Khan, M.T.H., Lenta, B.N., Sylte, I., Choudhary, I.S., Sewald, N. Cholinesterase InhibitingSteroidal Alkaloids from Sarcococca hookeriana and their Docking Studies [UK].

[88] Orhan I, Khan, M.T.H., Aslan S, Kartal M, Şener B, Sylte I. Molecular docking studies on the alkaloid (+)-buxabenzamidienine from Buxus sempervirens L. with anticholinesterase effect. Accepted as abstract (poster), 7th

Joint Meeting of AFERP, ASP, GA, PSE & SIF, Athens, Greece, 3-8 August, 2008 and PG76, Planta Medica,2008, 74, 1166-67 [Germany].

[89] Khan, M.T.H., Sylte I. Discovery of Potent Thermolysin Inhibitors Using Structure-based Virtual Screeningand In vitro Testing. (poster) The 7th Annual Meeting on High Performance Computing and Infrastructure inNorway (NOTUR2008), June 3–5, 2008, Tromsø, Norway. Presented as poster at the EuroQSAR 2008,September 22-26, Uppsala [Sweden].

[90] Khan, M.T.H., R. Khan, W. Yimingjiang, M. Arfan, M. Ahmed, I. Sylte. Utilization of Chemical Arrays andCombinatorial Synthesis of Quinazolin-4(3H)-ones as a Novel Class of Thermolysin Inhibitors: MolecularDocking and Pharmacophore Modelling. PhD School Open Day, Sep 19, 2008 [Norway].

[91] Kurita, N., Dedachi, K., Khan, M.T.H., Sylte, I. Specific Interactions between Thermolysin and DipeptideLigands Obtained by Fragment Molecular Orbital Calculations (PP377). The World Association of Theoreticaland Computational Chemists (WATOC), 2008, September 14-19, Sydney, Australia.

[92] Dedachi, K., Khan, M. T. H., Sylte, I. and Kurita, N. Molecular Mechanics and Fragment Molecular Orbitalcalculations on Specific Interactions between Thermolysin and Dipeptide Ligands. International Symposium onPathway/Network to Disease and Drug Discovery Specially Focused on Nuclear Receptors and MetabolicSyndrome, 2008, October. 22-24, Tokyo, Japan.

[93] I. Orhan, F. S. Senol, M. T. H. Khan, T. Ben Hadda, B. Bennani, A. Kerbal, B. Sener. AcetylcholinesteraseInhibitory Potentials of Several Synthetic Spiro-Heterocycles. (Poster P-87), 9th International Symposium onPharmaceutical Sciences (ISOPS-9). June 23-26, 2009, Ankara, Turkey.

[94] I. Orhan, M. T. H. Khan, F. S. Senol, M. Kartal, M. Dvorska, K. Smejkal, T. Slapetova, M. Zemlicka, G.Toker, B. Sener, I. Sylte. Flavonoids as Strong Inhibitors of Thermolysin, Acetylcholinesterase andButyrlycholinesterase Enzymes. (Poster P-189), 9th International Symposium on Pharmaceutical Sciences(ISOPS-9). June 23-26, 2009, Ankara, Turkey.

[95] Hirakawa, T., Fujita, S., Dedachi, K., Khan, M.T.H., Sylte, I., Kurita, N. Specific interactions and bindingfree energies between thermolysin and dipeptide-like molecules: ab initio fragment MO calculations. Chemistry,Biology and Information (CBI) 2010 Meeting, Tokyo, Japan, Sep 15-17.

[96] Fujita, S., Hirakawa, T., Oyama, T., Dedachi, K., Khan, M.T.H., Sylte, I., Kurita, N. Molecular simulationson the specific interactions between Thermolysin and its inhibitors. (4P108) Molecular Science Meeting 2010,Osaka, Japan, Sep 14-17.

[97] Cao, S., Khan, M.T.H., Johnson, M.E. QM/MM calculations to study of the mechanism of SAICARSynthetase. College of Pharmacy research days, University of Illinois at Chicago, USA, March 8-9, 2012.

Academic referees:1. Prof. Michael E. Johnson

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Professor Emeritus, Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, Molecular Biology Research Building, 900 South Ashland Avenue, Room 3100, Chicago, IL 60607-7173, USA; Phone: +1-312-996-9114; Email: mjohnson@uic.edu

2. Prof. M. Mahroof TahirChairperson & Professor, Department of Chemistry, College of Science and Engineering, St. Cloud StateUniversity, St. Cloud, MN 56304, United States of America; Phone: +1-320-308-3198; E-mail:mmahroof@stcloudstate.edu

3. Dr. Noriyuki KuritaAssociate Professor, Toyohashi University of Technology, Department of Knowledge-Based InformationEngineering Tempaku-cho, Toyohashi, 441-8580, Japan; Tel.: +81-532-44-6875, Fax: +81-532-44-6875; E-mail: nkuri0303@yahoo.co.jp; kurita@cs.tut.ac.jp

4. Prof. M. Shahabuddin K. ChoudhuriDean and Professor, Department of Pharmacy, Life Science Institute, Jahangirnagar University, Savar,Dhaka, Bangladesh; E-mail: mskchoudhuri@yahoo.com

Updated: 16/10/2015.

M.T.H. Khan Page 21