MRI showing plaque of multiple sclerosis.

Left: Coronal section of cerebrum showing multiple sclerosisPlaques at the apex of both lateral ventricles.Right: HE/LFB stain of axial section of pons showing severalMultiple sclerosis plaques.

Left: Sharp edge of demyelination in MS plaque. Right: Macrophage infiltrate and astrogliosis in MS plaque.

Axial section of pons and cerebellum showing discolorationAnd softening of central pontine myelinolysis.

Axial whole-mount section of cerebrum stained with LFBShowing caudal-to-rostral gradient of demyelination in adrenoleukodystrophy.

Loss of myelin and perivascular inflammatory infiltrate in affectedRegion of white matter in adrenoleukodystrophy (HE stain).

Cerebral white matter showing Globoid cells of Krabbe’s disease (HE stain).

Subpial collection of Rosenthal fibers in a cerebral gyrus from an infant who died of Alexander’s disease.