Mouse Nomenclature - Washington University Department of...
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Transcript of Mouse Nomenclature - Washington University Department of...
Wild-type…
• Not exactly wild…
• Inbred is 20 consecutive generations of sib mating
• C57BL/6J
• C57Bl = parent strain
• 6 = line
• J = Jackson Lab code
• Lab codes are where cross was carried out
• J – Jackson
• Mcw – Medical College of Wisconsin
• Kyo – Kyoto University
• Mit: MIT
Crossing Strains
• Progeny of hybrids, designated by F1
• Intercrossing two F1s -> F2
• D2B6F1
• DBA/2 mother & C57BL6/J father
• D2B6F2
• offspring of a D2B6F1 cross
Genes & Loci
• First letter capitalized
• Italicized
• Example
• Apc = adenomatosis polyposis coli
• Mutant allele name may be placeholder for unknown gene
• Leprdb used to be Dbdb
• Loci: D8Mit17 = 17th locus to mouse chromosome 8 by MIT
Alleles
• Named by phenotype
• Superscripted
• Italicized
• Dominant = first letter uppercase
• Recessive = all lowercase
• Examples:
• ApcMin = dominant, multiple intestinal neoplasia allele of the adenomatosis polyposis coli gene.
• Leprdb = recessive, diabetes allele of the leptin receptor gene.
Resources
• http://www.informatics.jax.org/mgihome/nomen/
• https://www.jax.org/news-and-insights/jax-blog/2013/august/top-seven-tips-for-understanding-mouse-nomenclature
• http://www.informatics.jax.org/mgihome/nomen/strains.shtml