Moran Eye Center Researcher Dr. Wolfgang Baehr and Collaborators Discover Vital Relationship between...
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8/10/2019 Moran Eye Center Researcher Dr. Wolfgang Baehr and Collaborators Discover Vital Relationship between Thyroid
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Moran Eye Center Researcher Dr. Wolfgang Baehr and
Collaborators Discover Vital Relationship between Thyroid
Hormones and Macular Degeneration
SALT LAKE CITY--(BUSINESS WIRE)--The University of Utah's John A. Moran Eye Center
announced today that Wolfgang B. Baehr, Ph.D. -- Professor of Ophthalmology, Adjunct Professor of
Biology and Neurobiology and Anatomy -- and a team of six researchers from the University of
Oklahoma Health Sciences Center, and researchers from the National Eye Institute (NEI) have
discovered a link between lower levels of thyroid hormones and reduced damage to photoreceptor
cone cells in mouse models with retinal degeneration. Age-related macular degeneration and other
retinal diseases are the result of damage to cone cells in the eyes.
The study, titled "Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse
models of retinal degeneration," is featured in the Proceedings of the National Academy of Sciences,
one of the world's most-cited multidisciplinary scientific publications.
Photoreceptor cells, found in the back of the eye (the retina), are made up of rods and cones that
respond to light, colors and shapes. They are necessary for human sight. In many retinal diseases,
including age-related macular degeneration, vision loss occurs because the cone cells degenerate.Unfortunately, there is currently no cure available for macular degeneration.
Thyroid hormones are essential to proper development and differentiation of all cold feet thyroid
https://www.youtube.com/watch?v=nyWshvP4VU4https://www.youtube.com/watch?v=nyWshvP4VU4 -
8/10/2019 Moran Eye Center Researcher Dr. Wolfgang Baehr and Collaborators Discover Vital Relationship between Thyroid
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cells in the human body. The process of producing thyroid hormones and delivering them to the
retina through the bloodstream is called thyroid hormone signaling. In previous studies, researchers
discovered that excess thyroid hormone signaling caused cones to degenerate and die. Dr. Baehr,
together with the Oklahoma and NEI researchers, discovered that when thyroid hormone signaling
was reduced in mouse models, cones were preserved and the retina did not degenerate in mouse
models with retinal degeneration.
What is the potential significance for patient care? This discovery may one day provide doctors with
an additional approach to the management of patients with retinal degeneration. "This is a great
honor for me and the Moran Eye," Baehr said. "Working with such talented researchers will further
our understanding of photoreceptor signaling and disease progression. We hope to discover ways to
sustain cone viability in the eyes of individuals with macular degeneration and other retinal
diseases."
In addition to Baehr, the study was co-authored by Hongwei Ma, Arjun Thapa, Xi-Quin Ding and
Lynsie Morris of the University of Oklahoma Heath Sciences Center; and T. Michael Redmond of the
Laboratory of Retinal Cell and Molecular Biology at the National Eye Institute. The research was
supported by generous grants from the National Eye Institute, the National Center for Research
Resources, and the Oklahoma Center for the Advancement of Science and Technology.
"Dr. Baehr has received international respect and acclaim, making him an indispensable asset to our
team," said Dr. Randall J Olson, Moran Eye Center CEO and Chair, Department of Ophthalmology
and Visual Sciences, University of Utah Health Care. "Being published in Proceedings of the
National Academy of Sciences is an accomplishment in itself, but more importantly, he and the other
researchers have hypothesized and then discovered promising results that someday could be a
crucial link in treating diseases of the retina."
About Moran Eye Center
The Moran Eye Center is the largest eye care and vision research center in the Intermountain West,
and is part of the University of Utah Hospitals and Clinics. With collaborators from around the
world, research advancements provide new diagnoses, novel treatments and creative newprocedures designed to cure blinding eye diseases. Treatments and procedures at the Moran Eye
Center address a wide range of eye problems, such as age-related macular degeneration, glaucoma,
cataracts, cornea, neuro-ophthalmology, oculoplastic surgery and external eye diseases. The Moran
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8/10/2019 Moran Eye Center Researcher Dr. Wolfgang Baehr and Collaborators Discover Vital Relationship between Thyroid
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Eye Center provides the latest advances in LASIK and refractive surgery, as well as a full range of
optometry services, including contact lenses and eyeglasses.
About Wolfgang Baehr, Ph.D.
Dr. Baehr is the Ralph and Mary Tuck Professor of Ophthalmology and Visual Sciences, Moran Eye
Center, with adjunct appointments in Neurobiology and Anatomy and Biology. Dr. Baehr received
the prestigious ALCON Award in 2013 and will receive the Proctor Medal at the 2014 annual
meeting of the Association for Research in Vision & Ophthalmology (ARVO) Conference. Moran CEO
Dr. Randall J Olson said this about Dr. Baehr receiving the Proctor Medal: "This award is the oldest
and most prestigious recognition of visual research in the country. It is fitting that Dr. Baehr is being
honored for his contributions toward improving our understanding of retinal disease. His work hasfar-reaching impacts for bettering the visual health of people around the world."