MONONUCLEAR MONONUCLEAR PHAGOCYTE PHAGOCYTE

SYSTEMSYSTEM(MPS)(MPS)

Distribution and Functional Significance

of MPS cells

Mononuclear Phagocyte Mononuclear Phagocyte System (MPS) cells:System (MPS) cells:

MonocyteMonocyte MacrophageMacrophage Kupffer cellKupffer cell Microglia cellMicroglia cell Langerhans cellLangerhans cell Dendritic cellDendritic cell OsteoclastOsteoclast Multinuclear giant cellMultinuclear giant cell

MONOCYTEMONOCYTE Largest leukocyte, 12 Largest leukocyte, 12

micrometers, or moremicrometers, or more Round/oval, to Round/oval, to

indented/horshoe-shapedindented/horshoe-shaped 3-8% of blood leukocytes3-8% of blood leukocytes LIR, additions are made to the LIR, additions are made to the

resident population of resident population of phagocyte CT by emigration of phagocyte CT by emigration of more monocytes from blood more monocytes from blood and transformation to and transformation to macrophagesmacrophages

MONOCYTEMONOCYTE CIR, macrophages may be CIR, macrophages may be

closely packed and appear closely packed and appear like epitheloid cellslike epitheloid cells

On too large foreign objects On too large foreign objects too resistant to intracellular too resistant to intracellular digestion, monocytes digestion, monocytes coalesce to form huge coalesce to form huge multinucleated massesmultinucleated masses

Foreign body giant cellsForeign body giant cells

MACROPHAGEMACROPHAGE Production of cytokines,

chemotactic factors, & other molecules participating in inflammation & defense

CT, lymphoid organs, lungs, bone marrow

antigen processing & presentation

If particles penetrate skin, macrophages enter lymph, & flow into lypmh nodes located along the course of the flow

Particles are then trapped into the network of sinuses lined by tissue macrophages

with Conidia

KUPFFER CELLKUPFFER CELL Production of cytokines,

chemotactic factors, & other molecules participating in inflammation & defense

Found in LIVER sinusoids

antigen processing & presentation

KUPFFER CELLKUPFFER CELL form an effective particulate filtration system that almost no bacteria from the GIT succeed in entering the general systemic circulation through portal bloodPhagocytosis: 1/100 of a second

MICROGLIA CELLMICROGLIA CELL CNS macrophages/brain

macrophages Production of cytokines,

chemotactic factors, & other molecules participating in inflammation & defense

Found in nerve tissue of CNS antigen processing &

presentation

LANGERHANS CELLLANGERHANS CELL Found in SKIN

(subcutaneous tissue) antigen processing &

presentation In local inflammations w/

subcutaneous tissue, local macrophages divide in situ, then form macrophages before the attack and destroy process

DENDRITIC CELLDENDRITIC CELL Found in LYMPH NODES antigen processing &

presentation antigen-presenting cells

(macrophages, B lymphocytes, and dendritic cells) are able to activate resting helper T-cells when the matching antigen is presented

macrophages and B cells can only activate memory T cells, BUT dendritic cells can activate both memory and naive T cells

Are the most potent of all the antigen-presenting cells

DENDRITIC CELLDENDRITIC CELL

with Conidia

OSTEOCLASTOSTEOCLAST Digestion of BONE Found in BONE (fusion of several

macrophages)

Macrophage of Bone Macrophage of Bone Marrow and SpleenMarrow and Spleen

Last line of defense of the macrophage system

Phagocytosis of unwanted debris in blood including old and abnormal RBC

MULTINUCLEAR GIANT MULTINUCLEAR GIANT CELLCELL

Segregation and digestion of Segregation and digestion of foreign bodies foreign bodies

found in found in CONNECTIVE TISSUE CONNECTIVE TISSUE (fusion of several macrophages)(fusion of several macrophages)

Foreign body giant cellsForeign body giant cells monocytes coalesce to form monocytes coalesce to form

huge multinucleated masseshuge multinucleated masses

SKIN APPENDAGESSKIN APPENDAGESGeneral Functions &

Descriptions

HairHair Sebaceous glandSebaceous gland Sweat glandSweat gland NailNail

SKIN APPENDAGESSKIN APPENDAGES

HAIRHAIR

SEBACEOUS GLANDSEBACEOUS GLAND

SWEAT GLANDSWEAT GLAND

NAILNAIL