Modular Incubation System
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Transcript of Modular Incubation System
P: 555.123.4568 F: 555.123.4567123 West Main Street, New York, NY 10001
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Modular Incubation SystemDelivering infants a better start
P: 212.854.6196 F: 212.854.8725351 Engineering Terrace1210 Amsterdam AveNew York, NY 10027
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Indy BekerieAnnabelle Chu
Leeanna HyacinthMin Ye Shen
Kiet Vo
BME Senior Design 2011-2012Preliminary Findings and Business Plan
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Executive Summary
P: 212.854.6196 F: 212.854.8725351 Engineering Terrace1210 Amsterdam AveNew York, NY 10027
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• Company Overview― Develop technology to combat infant hypothermia
that is viable for low-resource countries― Advisors are leaders in the field of Biomedical
Engineering and renown neonatologists with firsthand experience in the field
• Market— NGOs, non-profits, and the hospitals of over 100
developing countries• Business Model
— Capital equipment model• Design and Development
— Overall Plan— Innovative Designs— Proof of Concept 1.0
• Heating sources• Temperature sensors
• IncuVive Financial Projections and Key Performance Indicators
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Company Overview• Our Technology
— Will produce the correct amount of heat, maintain temperature
— Can be coupled with a crib and cover— Incorporates accurate temperature sensors— Utilizes an innovative feedback mechanism
and alarm system
• Advantages Over Present Solutions— Feedback Mechanism— Affordable, reliable— Viable for low-resource countries
• Advantages Over Other Companies— Few other companies targeting developing
countries
+
=
An innovative solution to combat infant hypothermia
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The Market
• ~ 4 million annual infant mortality [3]– 18%-42% caused by hypothermia
» 720,000 to 1.68 million of neonate deaths can be
prevented annually
• ~ 144 developing countries [1]
• In Uganda– 80 per 1,000 live births [5]
– 15 to 18 neonates suffering from hypothermia can be
saved
P: 212.854.6196 F: 212.854.8725351 Engineering Terrace1210 Amsterdam AveNew York, NY 10027
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Market Strategies
Neonates
• Sub-district
hospitals
• Other rural
healthcare
facilities
• National and
Regional Hospitals
Consumers
Customers
• Ministry of Health
• NGOs • Donors
Target
• Uganda
• Other developing countries
[3] UNICEF. Progress for children: a world fit for children statistical review. New York, NY: United Nations Children`s Fund; 2007[5] Infant mortality rate, Uganda. Google.com/publicdata
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The Market
Our MIS Will• Incorporate a reliable feedback
mechanism• Revive current nonfunctional
incubators• Convert available cribs to modest
incubators
Competition
• Van Hemel Baby Incubator (~ $450)
• Medicine Mondiale’s Liferaft Incubator (~ $1,500)
• General Electric (GE) incubators ($15,000-$40,000)
Risks and Obstacles
• Secure funding for production
• Partnership with the Ministry of Health and the NGO’s
• Protection of Intellectual Property
• Larger medical device companies
P: 212.854.6196 F: 212.854.8725351 Engineering Terrace1210 Amsterdam AveNew York, NY 10027 |
P: 555.123.4568 F: 555.123.4567123 West Main Street, New York, NY 10001
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Business Model
IncuVive in Uganda• We plan to follow a capital equipment model. • The National Medical Store will be our main purchaser of our MIS; however, we also plan to
sell to NGO and private hospitals. • Each unit will be priced at $50 after subsidizations
Strategic Partnerships• Partnerships with NGOs such as UNICEF, ECHO, and the Gates Foundation will help offset
production costs and help sustain a low margin operation. • We will utilize partner distribution channels in order to quickly establish operations in new
markets.
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Business Model
Expansion and Distribution• Our main source of income will come from market expansion. • Our device will be assembled locally and transported by a third party. • After setting up distribution in Uganda we plan to immediately expand into surrounding
countries.
www.infoplease.com/atlas/country/uganda.html
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Short Term Plan
December 2011
• Proof of Concept completed
• Finalize preliminary prototype idea
January 2012
• Start first prototype• Start circuitry and
code for feedback system
March 2012
• Complete construction and testing of first prototype on animals
• Test durability, power efficiency, feedback/fail-safe mechanism
• Start second prototype
May 2012
• Finish second prototype
• Complete integrated heating unit and feedback mechanism
• Apply for IRB approval for field testing in Mulago Hospital, Uganda
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Design Ideas
Heating Mat + PCM Feedback System
• Monitor and display temperature of either mat or environmental temperature
• Monitor and display temperature of infant
• Automatically adjust heat setting to maintain infant’s temperature in the normal range
• Alarm if abnormal temperature readings (too high or too low)
• Automatic shut off if temperature is too high to prevent overheating
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Design Ideas
Feedback System
• Monitor and display temperature of either mat or environmental temperature
• Monitor and display temperature of infant
• Automatically adjust heat setting to maintain infant’s temperature in the normal range
• Alarm if abnormal temperature readings (too high or too low)
• Automatic shut off if temperature is too high to prevent overheating
Space Heater
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Design Ideas
Feedback System
• Monitor and display temperature of either mat or environmental temperature
• Monitor and display temperature of infant
• Automatically adjust heat setting to maintain infant’s temperature in the normal range
• Alarm if abnormal temperature readings (too high or too low)
• Automatic shut off if temperature is too high to prevent overheating
Warm Water Pump
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Decision MatrixMethods of Heating
Heater Heating Pad Warm Water PumpCRITERIA WEIGHT Value Value Value Affordable 100 300 3 400 4 200 2Portable 100 300 3 300 3 200 2Durable 90 270 3 180 2 180 2Easy to Maintain 100 300 3 200 2 200 2Intuitive, Easy to Use 70 210 3 210 3 140 2
Sterilizable, Easy to Clean, Diminishing Contamination
100 300 3 300 3 200 2
Low Power (e.g. runs on batteries >= 24 hrs)
70 210 3 350 5 210 3
Preferably made with materials available in Uganda 20 60 3 40 2 60 3
High Infant Visibility 90 270 3 270 3 180 2Comfortable 80 240 3 240 3 240 3Safe 100 300 3 300 3 200 2 totals: 2760 33 2790 33 2010 25
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PoC- Saline Bag ControlMethods• A bag of saline with a thermometer inserted was
heated to 37 °C in a water bath. The saline was placed on an inactive mat and allowed to cool down.
• The temperature of the saline was recorded every minute with a calibrated thermistor inserted into the saline until the temperature dropped to 34 °C
• Use phase change material (PCM) between the neonate and the heating unit to prevent burns
• Maintain the baby at a temperature of about 37 °C while heating unit is off
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PoC- Phase Change Material (PCM)Methods• The PCM was activated in a microwave, then placed
on the inactive mat with thermistors placed at specific locations.
• Meanwhile a bag of saline was heated to 35 °C in a water bath and placed on the PCM.
• The experiment was repeated with thermistors.
Results
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Saline on PCM Saline on PCM with Heating Mat
Conclusion
• The PCM cannot raise the saline’s temperature to 37 °C
• The PCM can only maintain the saline’s temperature above 35 °C for about one hour with no external heat supply
• Other insulating materials
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Temperature Sensors
ModelRange ˚
CAccuracy ˚
C Price/unit
Red spirit
305 mm White, Red spirit filled
-20 to 150 1.5 $5.15
Thermistor (NTC)
Negative Temperature Coefficient --- --- ~$0.25
Integrated Circuit (LM34) LM34CAZ
−40˚ to 110˚ ± 0.25 $8.33
Digital 2210DR32.0 to
43.9± 0.1
$10.00
Water Bath TemperatureRed spirit NTC LM34 Digital
21.1 19.85 21.21 ---42 40.95 42.63 43.7
36.8 37.79 37.65 3834 35.18 34.78 34.9
Ambient TemperatureRed spirit NTC LM34 Digital
20.0 19.95 21.14 ---20.0 19.69 21.03 ---20.0 19.76 21.05 ---
Left Armpit Measurement Approximating Body Temp.Red spirit
NTC LM34 DigitalOral Reading
w/ Digital34 34.31 35.08 35.5 35.934 34.51 35.31 35.7 36
34.2 34.77 35.64 35.8 36.134.2 35.02 35.73 35.8 36.234.2 35.15 35.96 36 36.234.2 35.17 35.98 36 36.2
Most viable for• Water: LM34• Skin: Digital*• Ambient: NTC
Red spirit
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Long Range Plan
Continue development of new products
Initiate first assembly station in Uganda
Develop extensive rapport with NGOs, WHO, UNICEF
Apply for funding and grants and
start manufacturing
Continue R&D Build final prototype
Design and build 1st and 2nd prototype
Product SelectionProof of Concept testing
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Financial Projections
Phase I $ in thousands 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021# of units ($) 0 0 10 150 300 500 1000 1500 2000 2500Unit Sales ($50/unit) 0 0 500 7500 15000 25000 50000 75000 100000 125000
Revenue ($) 500 0 4000 18000 33000 53000 103000 153000 203000 253000R&D ($) 0 1000 700 700 800 900 1000 1100 1350 1500
Material cost ($) 150 500 600 300 15300 15500 16000 16500 17000 17500Production Cost ($) 350 500 500 100 19400 19000 18000 17000 16000 15000Wages ($) 0 0 1500 22500 30000 60000 85000 120000 145000 160000Transportaton ($) 0 0 100 200 300 400 1000 1000 1000 1000Total Cost ($) 500 4000 8400 24800 66300 96300 121500 156100 180850 195500Net Income ($) 0 -4000 -4400 -6800 -33300 -43300 -18500 -3100 22150 57500
Phase II Phase III / Phase IV
128000103000780005300028000180001050035000500Funds from NGO ($50/unit) and
500500500500500Internatiional Device Approval ($)
5001000500020000
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Financial Projections
2010 2012 2014 2016 2018 2020 20220
50000
100000
150000
200000
250000
300000
Financial Projection
CostRevenue
Year
Dol
lars
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Estimated Usage of Our Modular Incubation System
Estimated MIS Usage projection based on a conservative 10% outreach to all neonatal deaths from hypothermia. A more in-depth explanation is in DS2: Basic summary of problem. As you can see, the curve is sigmoidal and saturated at roughly 72,000 neonates per year.
Estimated MIS Usage projection based on a conservative 10% outreach to all neonatal deaths from hypothermia. A more in-depth explanation is in DS2: Basic summary of problem. As you can see, the curve is sigmoidal and saturated at roughly 72,000 neonates per year.
P: 555.123.4568 F: 555.123.4567123 West Main Street, New York, NY 10001
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Future Plans
• Further testing of the ability of the space heater and warm water pump to raise and maintain the temperature of a saline bag.
• Investigate and compare the functionality of other insulating materials.
• Begin fabrication of feedback mechanism
• Explore alarm system
• Finalize what products we will implement in our Modular Incubation System
⁻ Method of Heating ⁻ Temperature Sensors⁻ Insulating Material (if necessary)
P: 555.123.4568 F: 555.123.4567123 West Main Street, New York, NY 10001
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Acknowledgments• Instructors
– Dr. Elizabeth Hillman, Ph.D. , Biomedical Engineering Dept., Columbia University– Dr. Aaron Kyle, Ph.D. , Biomedical Engineering Dept., Columbia University– Mr. Keith Yeager– Sarah De Leo (TA)
• Advisers and Consultants– Dr. Lance Kam, Ph.D., Biomedical Engineering Dept., Columbia University– Dr. Margaret Nakakeeto-Kijjambu, MD, Mulago Hospital– Dr. Richard Polin, MD, CUMC Pediatrics– Dr. Rakesh Sahni, MD, CUMC Pediatrics– Dr. Helen Towers, MD, CUMC Pediatrics– Dr. Yvonne Vaucher, MD, UCSD– Dr. David Vallancourt, Ph.D., Electrical Engineering Dept., Columbia University
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