Modelling from Sequence to Gene Regulatory Network to Phenotype.

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Modelling from Sequence to Gene Regulatory Network to Phenotype

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Transcript of Modelling from Sequence to Gene Regulatory Network to Phenotype.

Page 1: Modelling from Sequence to Gene Regulatory Network to Phenotype.

Modelling from Sequence to Gene Regulatory Network to Phenotype

Page 2: Modelling from Sequence to Gene Regulatory Network to Phenotype.

Network Expression

The gene regulation network expresses as gene activation over time

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State Spaces

If the system state at a given time step is determined by the previous system state, the dynamics can settle into ‘basins of attraction’, in which the system is robust to perturbation.

But some changes can push the system to different behaviour.

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Page 4: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Page 5: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Perturbation

Page 6: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Page 7: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Perturbation

Page 8: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Page 9: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Perturbation

Page 10: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Page 11: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Perturbation

Page 12: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

The dynamics of the system have changed

Page 13: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

Perturbation

Page 14: Modelling from Sequence to Gene Regulatory Network to Phenotype.

System State After Single Perturbations

The system has changed again

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Such complex systems dynamics are being studied in modelsof gene regulation

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System State After Single Perturbations


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