Neural dynamics of in vitro cortical networks reflects experienced temporal patterns
- model connectivity of Neural Networks: - cortical ...lcn · Biological Modeling of Neural...
Transcript of - model connectivity of Neural Networks: - cortical ...lcn · Biological Modeling of Neural...
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Biological Modeling
of Neural Networks:
Week 11 – Continuum models:
Cortical fields and perception
Wulfram Gerstner
EPFL, Lausanne, Switzerland
11.1 Transients
- sharp or slow
11.2 Spatial continuum - model connectivity
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11 – Continuum models –Part 1: Transients
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Single population
full connectivity
review from Week 10-part 3: mean-field arguments
All neurons receive the same
total input current (‘mean field’)
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1s
1
0
ˆ ˆ|Is P t s t ds )( 0hgfrequency (single neuron)
Homogeneous network
All neurons are identical,
Single neuron rate = population rate A(t)= A0= const
Single
neuron
0 0( )g I A
Review from Week 10: stationary state/asynchronous activity
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N
Jwij
0
All spikes, all neurons
)(tI ext
0( ) ( ) ( )iI t J s A t s ds
fully
connected
All neurons receive the same total input current (‘mean field’)
Index i disappears
( ) ( )net f ext
ij j
j f
I t w t t I
Week 10-part 3: mean-field arguments
0 0 0 0[ ]extI J q A I
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h(t)
I(t) ? 0t
A(t) ))('),(()( tItIgtA
))()(())(()( dsstIsgthgtAA(t)
A(t) ))(()( tIgtA
potential
A(t) ))(()()( thgtAtAdt
d
t
2 2( ; )
( )t tn t t
A tN t
population
activity
Blackboard:
h(t)
Week 11-part 1: Transients in a population of uncoupled neurons
Students:
Which would you choose?
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Connections 4000 external
4000 within excitatory
1000 within inhibitory
Population - 50 000 neurons
- 20 percent inhibitory
- randomly connected
-low rate
-high rate input
Week 11-part 1: Transients in a population of neurons
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Population - 50 000 neurons
- 20 percent inhibitory
- randomly connected
100 200 time [ms]
Neuron # 32374
50
u [mV]
100
0
10
A [Hz]
Ne
uro
n #
32340
32440
100 200 time [ms] 50
-low rate
-high rate input
Week 11-part 1: Transients in a population of neurons
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low noise
I(t) h(t)
noise-free
(escape noise/fast noise) uncoupled population
low noise
fast transient
I(t) h(t)
(escape noise/fast noise)
high noise
slow transient ))(()( tIgtA
But transient oscillations ( ) ( ( ))A t F h t
( ) ( ( ), '( ))A t g I t I t
Week 11-part 1: Theory of transients for escape noise models
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noise model A
I(t) h(t)
(escape noise/fast noise)
high noise
slow transient ( ) ( ( ))A t F h t
( ) ( ( ))A t F h t
)()()( tIRththdtd
Population activity
Membrane potential caused by input
blackboard
In the limit of high noise,
Week 11-part 1: High-noise activity equation
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noise model A
I(t) h(t)
(escape noise/fast noise)
high noise
slow transient
( ) ( ( ))A t F h t
( ) ( ( ))A t F h t
)()()( tIRththdtd
Population activity
Membrane potential caused by input
( ) ( ) ( )ext netwI t I t I t
)()()( 0 tAqJtItI ext
0( ) ( ) ( ( ))extI t I t J q F h t
( ) ( ) ( ) ( ( ))extddt
h t h t R I t F h t
1 population = 1 differential equation
Week 11-part 1: High-noise activity equation
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Week 10-part 2: mean-field also works for random coupling
full connectivity random: prob p fixed
Image: Gerstner et al.
Neuronal Dynamics (2014)
random: number K
of inputs fixed
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Quiz 1, now
Population equations
[ ] A single cortical model population can exhibit transient oscillations
[ ] Transients are always sharp
[ ] Transients are always slow
[ ] in a certain limit transients can be slow
[ ] An escape noise model in the high-noise limit
has transients which are always slow
[ ] A single population described by a
single first-order differential equation (no integrals/no delays)
can exhibit transient oscillations
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Biological Modeling
of Neural Networks:
Week 11 – Continuum models:
Cortical fields and perception
Wulfram Gerstner
EPFL, Lausanne, Switzerland
11.1 Transients
- sharp or slow
11.2 Spatial continuum - from multiple to continuous populations
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11 – part 2 :
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)(tAi
i k
Blackboard
Week 11-part 2: multiple populations continuum
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( , ) ( ( , ))A x t F h x t
( , ) ( , ) ( , )ddt
h x t h x t R I x t
Population activity
Membrane potential caused by input
( , ) ( , ) ( , )ext netwI x t I x t I x t
( , ) ( ', ) ( ', ) 'netwI x t d w x x t A x t dx
( , ) ( , ) ( , ) ( ') ( ( ', )) 'extddt
h x t h x t R I x t d w x x F h x t dx
1 field = 1 integro-differential equation
Week 11-part 2: Field equation (continuum model)
max
F
F
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Exercise 1.1 now (stationary solution)
Consider a continuum model,
Find analytical solutions:
- spatially uniform solution A(x,t)= A0
Next lecture at
10:45
If done: start with Exercise 1.2 now (spatial stability)
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i k
Week 11-part 2: coupling across continuum
x y
Mexican hat
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i k
Week 11-part 2: cortical coupling
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Biological Modeling
of Neural Networks:
Week 11 – Continuum models:
Cortical fields and perception
Wulfram Gerstner
EPFL, Lausanne, Switzerland
11.1 Transients
- sharp or slow
11.2 Spatial continuum - from multiple to continuous populations
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11 – part 3 :
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Week 11-part 3: Solution types (ring model)
Coupling: Input-driven regime
Bump attractor regime
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x0
A(x) I. Edge enhancement
Weaker lateral connectivity
I(x)
Possible interpretation
of visual cortex cells:
(see final part this week)
Field Equations:
Wilson and Cowan, 1972
Week 11-part 3: Solution types: input driven regime
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0
A
II: Bump formation:
activity profile in the absence of input strong lateral connectivity
Possible interpretation
of head direction cells:
(see later today)
Field Equations:
Wilson and Cowan, 1972
Week 11-part 3: Solution types: bump solution
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Exercise 2.1+2.2 now (stationary bump solution)
Consider a continuum model,
Find analytically the bump solutions
w(x-y)
Next lecture at
11:28
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)(),( AtA
Continuum: stationary profile
Comparison simulation of neurons
and macroscopic field equation
Spiridon&Gerstner
See: Chapter 9, book:
Spiking Neuron Models,
W. Gerstner and W. Kistler, 2002
Week 11-part 3: Solution types: bump solution
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Week 11-part 3: Solution types (continuum model)
time
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Biological Modeling
of Neural Networks:
Week 11 – Continuum models:
Cortical fields and perception
Wulfram Gerstner
EPFL, Lausanne, Switzerland
11.1 Transients
- sharp or slow
11.2 Spatial continuum - model connectivity
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11 – part 4:
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Basic phenomenology
x0
A(x) I. Edge enhancement
Weaker lateral connectivity
I(x)
Possible interpretation
of visual cortex cells:
contrast enhancement in
- orientation
- location
Field Equations:
Wilson and Cowan, 1972
Week 11-part 5: uniform/input driven solution
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Continuum models: grid illusion
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Continuum models: Mach Bands
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Week 11-part 4: Field models and Perception
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Week 11-part 4: Field models and Perception
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Week 11-part 4: Field models and Perception
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Biological Modeling
of Neural Networks:
Week 11 – Continuum models:
Cortical fields and perception
Wulfram Gerstner
EPFL, Lausanne, Switzerland
11.1 Transients
- sharp or slow
11.2 Spatial continuum - model connectivity
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11 – part 5:
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Basic phenomenology
0
A II: Bump formation
strong lateral connectivity
Possible interpretation
of head direction cells:
always some cells active
indicate current orientation
Week 11-part 5: Bump solution
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rat brain
CA1
CA3
DG
pyramidal cells
soma
axon
dendrites
synapses electrode Place fields
Week 11-part 5: Hippocampal place cells
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Main property: encoding the animal’s location
place field
Week 11-part 5: Hippocampal place cells
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Main property: encoding the animal ’s heading
Preferred firing direction
r (i
i
Week 11-part 5: Head direction cells
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Main property: encoding the animal ’s allocentric heading
Preferred firing direction
r (i
i
0
90
180
270 300
Week 11-part 5: Head direction cells
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Week 11-part 5: Head direction cells
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11.1 Transients
- sharp or slow
11.2 Spatial continuum - model connectivity
- cortical connectivity
11.3 Solution types - uniform solution
- bump solution
11.4. Perception
11.5. Head direction cells
Week 11-Continuum models
The END