Couchbase Connect

October 26, 2017

Mobile Brain Health Analytics

SyncThink®

Led development of EYE-SYNC platform

Your Speaker

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Daniel Beeler, CTO SyncThink

Joined the SyncThink research team in 2010

Background in optical astronomy

Expertise in image analysis

Likes things with two wheels

We have a Problem With Brain Health

SyncThink®

Epidemic of Brain Health Conditions

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1 in 4 Americans suffer from brain health conditions

Current methods are • subjective • inaccurate • time-consuming • easily learned or gamed

The need for a better solution is obvious…

• 3.8 Million sports-related concussions annually • 2015: $900M NFL settlement

• 6.4 Million children diagnosed with ADHD • Increasing 5% per year

• 47 Million dementia cases annually • $1T market by 2025

• Concussion • ADHD • Alzheimer’s / Dementia • Fatigue • Autism

SyncThink®5

SyncThink Monitors Eye Movement to Assess Visual Attention

Ernest Santin // 978.621.4142 // emsantin@syncthink.com

ConcussionPerformance During

Concussion Recovery

Normal Circular Eye

Tracking Performance

Eyes following

circular target

Eyes relative to target

Concussion injuries present distinct eye tracking abnormality

Eye movement variability analysis can be applied to measure disorientation or performance

SyncThink®

Our Solution is a Window to the Brain

Fast, Objective Testing

Mobile 60-second assessment cleared for use by the FDA.

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Proprietary Cloud Based Analytics Platform

HIPAA-compliant cloud

Identify risk, impairment, and monitor recovery

Easily identify eye tracking impairments and treatments

SyncThink®

SyncThink’s Broad Advantage

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Analytics Cloud for brain health

monitoring

First to Market in eye tracking

assessment

Only with FDA Clearance

for eye tracking impairment

World Class IP 12 patents issued

Proven Science from over 23 publications

Reliable No learning or effort effects

Mobile platform using Android

hardware

Objective metrics for visual attention

Normative Database from 10,000 subjects

SyncThink®8

Decade-long Clinical and Technology Development

2006 - 2012 Clinical Research

2013 - 2016 VR Platform

2017 - Mobile Delivery

Clinical Utility

Custom Hardware

FDA Clearance Cloud Sync

Oculus DK2 GearVR

SyncThink®

Distributed Workflow Connects Stakeholders

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Automated AnalysisTest Individual Select Assessment

Smooth Pursuit

0s 30s 60s

Training room / Office / Sidelines

Cellular Sync

EMR

Team physician

EYE-SYNC

Advanced analytics

˘̆

Measurement History

Radial Variability

Poor

1

2

3

4

5

Good

Po

or

Go

od

Tan

ge

ntia

l Vari

ab

ility

Eye Movement Traces

Left Eye

Right Eye

Radial Var 0.55

Tangential Var 0.51

Mean Phase Error - 0.60

Eye Movement Metrics

Tangential Variability

Mean Phase Error

Radial Variability

Mean Radial Error

Metrics Better Eye

0.51

0.55

-0.60

-0.09

Right Eye

0.71

0.59

-4.07

0.05

Left Eye

0.51

0.55

-0.60

-0.09

Circular Visual Tracking Report

Filename: Assessment%20Jul%2010,%202017%2010_10_35%20PM_hc.json

Date of testing: 21 July 2016

Disclaimer: The eye tracking information on this report is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.

Replication

SyncThink®

EYE-SYNC Has a Unique Set of Cloud Requirements

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HIPAA Compliance

Robust Mobility

Azure Scalability

Audits and Logging

Backup and Recovery

End-to-end encryption

Role provisioning

Android SDK

Two-way sync

Offline functionality

Partitions and permissions

Startup credits

Scale sets

Key vault

Operational Insights

SyncThink®

Deployment Was a Team Effort

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Professional Services

Couchbase Partners

4 Months: Implementation, Testing, Documentation

SyncThink®

NCAA

Professional Sports

Sports Medicine

SyncThink Has Added Over Two Dozen Mobile Accounts in 90 Days

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SyncThink®

Case Study: University of Texas

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Baseline assistance

Gameday Availability

SyncThink brings in several EYE-SYNC units for pre-season player evaluation. All units sync to one account and one unit is left with team physician

Stadium capacity is over 100,000 with unreliable cellular connectivity. EYE-SYNC is immediately available at the medical tent to provide fast, objective insights - later shared throughout the organization

SyncThink®

Case Study: Massachusetts General Hospital

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Ultra-mobile

Professional Security

MGH serves most professional teams in the Boston area. EYE-SYNC allows their sports medicine clinicians to provide evaluation in the clinic or training room at multiple locations

Sports medicine can collect sensitive data with elite players under secure and reliable conditions

SyncThink®

Next Steps: Automated QA and Advanced Analysis

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Usage Dashboard and Automated Alerts

Gateway-to-gateway replication of de-identified data allows QA to

construct usage / performance statistics in real-time and alert customer

success teams proactively

Powerful, Performant Data Aggregation

Advanced python analysis suite uses N1QL to query and compile,

advanced SyncThink metrics, visualizations, aggregations, and classifiers

N1QL

Questions