MNW leerlijn BioinformaticsBioinformatics & Systems Biology

Faculty of Sciences & Faculty of Earth

and Life Sciences

Jaap Heringa – 12 sep 2011

Teachers(Bioinformatics & Systems Biology)

dr. Sanne Abeln (UD Bioinformatics)

dr. Anton Feenstra (UD Bioinformatics)

prof. dr. Jaap Heringa (Prof. Bioinformatics)

dr. Frank Bruggeman (UD Systems Biology)

dr. Douwe Molenaar (UHD Systems Bioinformatics)

prof. dr. Bas Teusink (Prof. Systems Bioinformatics)

- the people

From anatomy to dynamics to systems biology and bioinformatics

time

Statics, anatomy,

architecture

Dynamics, mechanics

Informatics

(Cybernetics – Wiener,

1948)

(Cybernetics has been defined as the science

of control in machines and animals, and

hence it applies to technological, animal and

environmental systems)

Genomics, bioinformatics,

systems biology

Bioinformatics & Systems Biologyas interdisciplinary sciences

Mathematics Statistics

Computer ScienceInformatics

BiologyMolecular biology

Medicine

Chemistry

Physics

Bioinformatics&

Systems Biology

Bioinformatics & Systems BiologyThe big bang…

The Human Genome Project

From DNA…

OH BRAD,THEY SAY THERE’SDNA IN MY BODY!

WHO CARES, DARLING,...WHO CARES...

.....acctc ctgtgcaag acatgaaaca cccgatttac nctgtggttc cccagatgg gtcctgtccc aggtgcacct gcaggagtcg gcccaggac tggggaagcc tccagagctc aaaaccccac tggtgacac aactcacaca tgcccacggt gcccagagcc aaatcttgt gacacacctc ccccgtgccc acggtgccca agcccaaat cttgtgacac acctccccca tgcccacggt cccagagcc caaatcttgt gacacacctc ccccgtgccc cggtgccca gcacctgaac tcttgggagg accgtcagtc tcctcttcc ccccaaaacc caaggatacc cttatgattt ccggacccc tgaggtcacg tgcgtggtgg tggacgtgag cacgaagac cctnnngtcc agttcaagtg gtacgtggac gcgtggagg tgcataatgc caagacaaag ctgcgggagg gcagtacaa cagcacgttc cgtgtggtca gcgtcctcac gtcctgcac caggactggc tgaacggcaa ggagtacaag gcaaggtct ccaacaaagc aaccaagtca gcctgacctg ctggtcaaa ggcttctacc ccagcgacat cgccgtggag gggagagca atgggcagcc ggagaacaac tacaacacca gcctcccat gctggactcc gacggctcct tcttcctcta agcaagctc accgtggaca agagcaggtg gcagcagggg acatcttct catgctccgt gatgcatgag gctctgcaca ccgctacac gcagaagagc ctctc.....

It’s the network stupid!

next generation sequencing (baseclear)mammaprint (agendia)

Research in Bioinformatics

model + algoritme

clinical trials(chdr)

Theme 1: Sequence based research

http://zeus.few.vu.nl/programs/shmrwww/example/

Reversible oligomerization

Irreversible fiber formation

Theme 2: Structure based research

Theme 3: Function based researchthe network level

Een revolutie in de biologie…

Bioinformatics & Systems Biology

data

knowledge

hoe gaan we die data organiseren en gebruiken?Hoe gaan we om met de complexiteit van biologische systemen?

Systeembiologie is de biologie van de toekomst…

Bioinformatics and Systems Biology

Bioinformatica probeert biologische componenten te interpreteren (labelen)

• voorspel structuur of functie van een eiwit

• reconstueer netwerk topologie• er is meestal geen tijdscomponent

Systeembiologie probeert de processen door de tijd te begrijpen

• meestal op netwerkniveau

Contact

Master Bioinformatics

Jaap Heringaj.heringa@vu.nl

Sanne Abelns.abeln@vu.nl

Anton Feenstrak.a.feenstra@vu.nl

Bas Teusinkb.teusink@vu.nl

Douwe Molenaard.molenaar@vu.nl

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